scholarly journals Longitudinal dentate nuclei iron concentration and atrophy in Friedreich ataxia: IMAGE-FRDA

2018 ◽  
Author(s):  
Phillip G. D. Ward ◽  
Ian H Harding ◽  
Thomas G. Close ◽  
Louise A Corben ◽  
Martin B Delatycki ◽  
...  
Keyword(s):  
Iron Concentration ◽  
Friedreich Ataxia ◽  
Susceptibility Mapping ◽  
Disease Stage ◽  
Healthy Controls ◽  
Quantitative Susceptibility Mapping ◽  
Rates Of Change ◽  
Longitudinal Biomarker ◽  
Baseline Disease Severity

AbstractBackgroundFriedreich ataxia is a recessively inherited, progressive neurological disease characterised by impaired mitochondrial iron metabolism. The dentate nuclei of the cerebellum are characteristic sites of neurodegeneration in the disease, but little is known of the longitudinal progression of pathology in these structures.MethodsUsing in vivo magnetic resonance imaging, including quantitative susceptibility mapping, we investigated changes in iron concentration and volume in the dentate nuclei in individuals with Friedreich ataxia (n=20) and healthy controls (n=18) over a two-year period.ResultsThe longitudinal rate of iron concentration was significantly elevated bilaterally in participants with Friedreich ataxia relative to healthy controls. Atrophy rates did not differ significantly between groups. Change in iron concentration and atrophy both correlated with baseline disease severity or duration, indicating sensitivity of these measures to disease stage. Moreover, atrophy was maximal in individuals early in the disease course, while the rate of iron concentration increased with disease progression.ConclusionsProgressive dentate nuclei pathology is evident in vivo in Friedreich ataxia, and the rates of change of iron concentration and atrophy in these structures are sensitive to the disease stage. The findings are consistent with an increased rate of iron concentration and atrophy early in the disease, followed by iron accumulation and stable volume in later stages. This pattern suggests that iron dysregulation persists after loss of the vulnerable neurons in the dentate. The significant changes observed over a two-year period highlights the utility of quantitative susceptibility mapping as a longitudinal biomarker and staging tool.

scholarly journals MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping

NeuroImage ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 2625-2635 ◽  
Author(s):  
Berkin Bilgic ◽  
Adolf Pfefferbaum ◽  
Torsten Rohlfing ◽  
Edith V. Sullivan ◽  
Elfar Adalsteinsson
Keyword(s):  
Iron Concentration ◽  
Normal Aging ◽  
Susceptibility Mapping ◽  
Brain Iron ◽  
Quantitative Susceptibility Mapping ◽  
Brain Iron Concentration

Quantitative susceptibility mapping in β-Amyloid PET-stratified patients with dementia and healthy controls – A hybrid PET/MRI study

2020 ◽  
Vol 131 ◽  
pp. 109243
Author(s):  
Solveig Tiepolt ◽  
Michael Rullmann ◽  
Thies H. Jochimsen ◽  
Hermann-Josef Gertz ◽  
Matthias L. Schroeter ◽  
...  
Keyword(s):  
Susceptibility Mapping ◽  
Amyloid Pet ◽  
Healthy Controls ◽  
Quantitative Susceptibility Mapping ◽  
Β Amyloid ◽  
Mri Study

scholarly journals Quantitative Susceptibility Mapping of the Basal Ganglia and Thalamus at 9.4 Tesla

2021 ◽  
Vol 15 ◽  
Author(s):  
Vinod Jangir Kumar ◽  
Klaus Scheffler ◽  
Gisela E. Hagberg ◽  
Wolfgang Grodd
Keyword(s):  
Basal Ganglia ◽  
Functional Anatomy ◽  
Susceptibility Mapping ◽  
Paramagnetic Susceptibility ◽  
Substantial Contribution ◽  
Hemispheric Differences ◽  
Quantitative Susceptibility Mapping ◽  
Ultra High Field

The thalamus (Th) and basal ganglia (BG) are central subcortical connectivity hubs of the human brain, whose functional anatomy is still under intense investigation. Nevertheless, both substructures contain a robust and reproducible functional anatomy. The quantitative susceptibility mapping (QSM) at ultra-high field may facilitate an improved characterization of the underlying functional anatomy in vivo. We acquired high-resolution QSM data at 9.4 Tesla in 21 subjects, and analyzed the thalamic and BG by using a prior defined functional parcellation. We found a more substantial contribution of paramagnetic susceptibility sources such as iron in the pallidum in contrast to the caudate, putamen, and Th in descending order. The diamagnetic susceptibility sources such as myelin and calcium revealed significant contributions in the Th parcels compared with the BG. This study presents a detailed nuclei-specific delineation of QSM-provided diamagnetic and paramagnetic susceptibility sources pronounced in the BG and the Th. We also found a reasonable interindividual variability as well as slight hemispheric differences. The results presented here contribute to the microstructural knowledge of the Th and the BG. In specific, the study illustrates QSM values (myelin, calcium, and iron) in functionally similar subregions of the Th and the BG.

Abstract TP348: Quantitative Serial Neuroimaging of Iron in the Intracerebral Hemorrhage Pig Model

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Muhammad E Haque ◽  
Refaat E Gabr ◽  
Xiurong Zhao ◽  
Khader M Hasan ◽  
Ponnada A Narayana ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Autologous Blood ◽  
Iron Concentration ◽  
Susceptibility Mapping ◽  
Pig Model ◽  
Large Animal ◽  
Quantitative Susceptibility Mapping ◽  
Secondary Damage ◽  
Susceptibility Maps ◽  
The Brain

Objective: To serially quantify changes of iron concentration within hematomas in the intracerebral hemorrhage (ICH) pig model using non-invasive R2* and quantitative susceptibility mapping (QSM) MRI methods. Introduction: Hemolysis-related release of hemoglobin/heme/free iron after ICH causes cytotoxic injury. An accurate post hemorrhage assessment of iron would be valuable to develop strategies to prevent secondary damage. The T2* relaxation rate (R2* =1/T2*) on MRI depends on the regional oxy- versus deoxyhemoglobin. Post-ICH excess of deoxyhemoglobin has been applied as a quantitative marker to estimate iron in the brain. However, quantitative susceptibility mapping (QSM) is a new MRI technique that can quantify iron concentration within the hematoma by measuring induced magnetic susceptibility. Using R2* mapping and QSM in a large animal ICH model, we measured spatiotemporal changes in iron concentration in the brain. Methods: Lobar ICH was induced by infusion of 2.5 ml autologous blood in 8 Yorkshire pigs with average age/wt of 4-6wk/12.5±2.5kg. MRI was obtained at days 1 and 7. A 3D anatomical and multi-echo gradient echo images were obtained on a clinical 3.0 T Philips Ingenia MRI system. Parametric R2* and susceptibility maps were generated. Regions of interest were placed within hematoma and contralesional CSF. Results: R2* measurements in the hematoma at day 1 and day 7 were 41.3 ± 7.3 and 37.7 ± 7.7 s -1 , respectively, whereas the corresponding susceptibility measurements were 0.75± 0.3 and 0.70 ± 0.5 ppm. The CSF R2* were 5.53 ± 2.1 and 6.85 ± 2.4 s -1 , whereas susceptibility showed 0.06 ± 0.16 and 0.02 ± 0.03 ppm at the two time points. Both R2* and QSM showed no significant change in iron concentration within the hematoma ROI with p-value of 0.18 and 0.72 over a week. Absence of hyperintense regions remote from the hematoma in susceptibility maps suggested lack of diffuse iron deposition. Good correlation was observed between R2* and QSM (correlation coefficient 0.83 and 0.78 within hematoma, and -0.66 and -0.07 within CSF, at day 1 and 7, respectively). Conclusion: R2* and especially QSM, with their ability to provide quantitative iron content, are valuable tools to test new ICH treatments particularly targeting iron in this large animal model.

Iron concentration linked to structural connectivity in the subthalamic nucleus: implications for deep brain stimulation

2020 ◽  
Vol 132 (1) ◽  
pp. 197-204 ◽  
Author(s):  
Alexey Dimov ◽  
Wahaj Patel ◽  
Yihao Yao ◽  
Yi Wang ◽  
Rafael O’Halloran ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Iron Concentration ◽  
Susceptibility Mapping ◽  
Strong Positive Correlation ◽  
Quantitative Susceptibility Mapping ◽  
Deep Brain

OBJECTIVEThe objective of this study was to investigate the relationship between iron and white matter connectivity in the subthalamic nucleus (STN) in patients undergoing deep brain stimulation (DBS) of the STN for treatment of Parkinson’s disease.METHODSNine Parkinson’s disease patients underwent preoperative 3T MRI imaging which included acquisition of T1-weighted anatomical images along with diffusion tensor imaging (DTI) and quantitative susceptibility mapping (QSM). MR tractography was performed for the seed voxels located within the STN, and the correlations between normalized QSM values and the STN’s connectivity to a set of a priori chosen regions of interest were assessed.RESULTSA strong negative correlation was found between STN connectivity and QSM intensity for the thalamus, premotor, motor, and sensory regions, while a strong positive correlation was found for frontal, putamen, and brain stem areas.CONCLUSIONSQuantitative susceptibility mapping not only accurately delineates the STN borders but is also able to provide functional information about the STN functional subdivisions. The observed iron-to-connectivity correlation patterns may aid in planning DBS surgery to avoid unwanted side effects associated with DBS.

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