scholarly journals R2 * and quantitative susceptibility mapping in deep gray matter of 498 healthy controls from 5 to 90 years

2021 ◽  
Author(s):  
Sarah Treit ◽  
Nashwan Naji ◽  
Peter Seres ◽  
Julia Rickard ◽  
Emily Stolz ◽  
...  
Keyword(s):  
Gray Matter ◽  
Susceptibility Mapping ◽  
Healthy Controls ◽  
Quantitative Susceptibility Mapping ◽  
Deep Gray Matter

Hemisphere, gender and age-related effects on iron deposition in deep gray matter revealed by quantitative susceptibility mapping

2015 ◽  
Vol 28 (10) ◽  
pp. 1267-1274 ◽  
Author(s):  
Nan-Jie Gong ◽  
Chun-Sing Wong ◽  
Edward S. Hui ◽  
Chun-Chung Chan ◽  
Lam-Ming Leung
Keyword(s):  
Gray Matter ◽  
Susceptibility Mapping ◽  
Iron Deposition ◽  
Quantitative Susceptibility Mapping ◽  
Age Related ◽  
Gender And Age ◽  
Deep Gray Matter

scholarly journals Iron Deposition in Gray Matter Nuclei of Patients With Intracranial Artery Stenosis: A Quantitative Susceptibility Mapping Study

2022 ◽  
Vol 12 ◽  
Author(s):  
Huimin Mao ◽  
Weiqiang Dou ◽  
Xinyi Wang ◽  
Kunjian Chen ◽  
Xinyu Wang ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Gray Matter ◽  
Iron Content ◽  
Partial Correlation ◽  
Susceptibility Mapping ◽  
Artery Stenosis ◽  
Healthy Controls ◽  
Partial Correlation Analysis ◽  
Quantitative Susceptibility Mapping

Purpose: This study aimed to use quantitative susceptibility mapping (QSM) to systematically investigate the changes of iron content in gray matter (GM) nuclei in patients with long-term anterior circulation artery stenosis (ACAS) and posterior circulation artery stenosis (PCAS).Methods: Twenty-five ACAS patients, 25 PCAS patients, and 25 age- and sex-matched healthy controls underwent QSM examination. Patients were scored using the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) to assess the degree of neural function deficiency. On QSM images, iron related susceptibility of GM nuclei, including bilateral caudate nucleus, putamen (PU), globus pallidus (GP), thalamus (TH), substantia nigra (SN), red nucleus, and dentate nucleus (DN), were assessed. Susceptibility was compared between bilateral GM nuclei in healthy controls, ACAS patients, and PCAS patients. Partial correlation analysis, with age as a covariate, was separately performed to assess the relationships of susceptibility with NIHSS and mRS scores.Results: There were no significant differences between the susceptibilities for left and right hemispheres in all seven GM nucleus subregions for healthy controls, ACAS patients, and PCAS patients. Compared with healthy controls, mean susceptibility of bilateral PU, GP, and SN in ACAS patients and of bilateral PU, GP, SN, and DN in PCAS patients were significantly increased (all P < 0.05). In addition, mean susceptibility of bilateral TH and SN in PCAS patients was significantly higher than in ACAS patients (both P < 0.05). With partial correlation analysis, mean susceptibility at bilateral PU of ACAS patients was significantly correlated with mRS score (r = 0.415, P < 0.05), and at bilateral PU in PCAS patients was correlated with NIHSS score (r = 0.424, P < 0.05).Conclusion: Our findings indicated that abnormal iron metabolism may present in different subregions of GM nuclei after long-term ACAS and PCAS. In addition, iron content of PU in patients with ACAS and PCAS was correlated with neurological deficit scores. Therefore, iron quantification measured by QSM susceptibility may provide a new insight to understand the pathological mechanism of ischemic stroke caused by ACAS and PCAS.

Quantitative susceptibility mapping in β-Amyloid PET-stratified patients with dementia and healthy controls – A hybrid PET/MRI study

2020 ◽  
Vol 131 ◽  
pp. 109243
Author(s):  
Solveig Tiepolt ◽  
Michael Rullmann ◽  
Thies H. Jochimsen ◽  
Hermann-Josef Gertz ◽  
Matthias L. Schroeter ◽  
...  
Keyword(s):  
Susceptibility Mapping ◽  
Amyloid Pet ◽  
Healthy Controls ◽  
Quantitative Susceptibility Mapping ◽  
Β Amyloid ◽  
Mri Study
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