scholarly journals VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression

2018 ◽  
Author(s):  
Bo Tang ◽  
Jilin Wu ◽  
Michael X. Zhu ◽  
Xuemei Sun ◽  
Jingjing Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Positive Feedback ◽  
Feedback Regulation ◽  
Tumor Stage ◽  
Regulation Mechanism ◽  
Advanced Tumor Stage ◽  
Dependent Manner ◽  
Advanced Tumor ◽  
Gastric Cancer Progression

AbstractAlthough VPAC1 and its ligand vasoactive intestinal peptide (VIP) are important in gastrointestinal physiology, their involvements in progression of gastrointestinal tumor have not been explored. Here, we found that higher expression of VIP/VPAC1 was observed in gastric cancer compared to the adjacent normal tissues. The increased expression of VIP/VPAC1 in gastric cancer correlated positively with invasion, tumor stage, lymph node, distant metastases, and poor survival. Moreover, high expression of VIP and VPAC1, advanced tumor stage and distant metastasis were independent prognostic factors. VPAC1 activation by VIP markedly induced TRPV4-mediated Ca2+ entry, and eventually promoted gastric cancer progression in a Ca2+ signaling-dependent manner. Inhibition of VPAC1 and its signaling pathway could block the progressive responses. VPAC1/TRPV4/Ca2+ signaling in turn enhanced the expression and secretion of VIP in gastric cancer cells, enforcing a positive feedback regulation mechanism. Taken together, our study demonstrate that VPAC1 is significantly overexpressed in gastric cancer and VPAC1/TRPV4/Ca2+ signaling axis could enforce a positive feedback regulation in gastric cancer progression. VIP/VPAC1 may serve as potential prognostic markers and therapeutic targets for gastric cancer.

scholarly journals Prognostic Significance of Preoperative and Postoperative Complement C3 Depletion in Gastric Cancer: A Three-Year Survival Investigation

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Jinning Ye ◽  
Yufeng Ren ◽  
Jianhui Chen ◽  
Wu Song ◽  
Chuangqi Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Significance ◽  
Hospital Costs ◽  
Disease Free Survival ◽  
Tumor Stage ◽  
Complement C3 ◽  
Advanced Tumor Stage ◽  
Advanced Tumor ◽  
Prolonged Hospital

Objectives. The role of complement system in predicting prognosis of gastric cancer (GC) remains obscured. This study aims to explore the incidence of complement C3 depletion and associated outcomes in GC patients. Methods. between August 2013 and December 2013, 106 patients with gastric adenocarcinoma were prospectively analyzed. Plasma levels of complement C3 and C4 were detected at baseline, one day before surgery, and postoperative day 3, respectively. Patients with low C3 levels (<0.75 mg/mL) were considered as having complement depletion (CD), while others with normal C3 levels were included as control. The 3-year overall survival (OS), disease-free survival (DFS), and other outcomes were compared between both groups, with the CD incidence explored meanwhile. Results. The CD incidence was 28.3% before surgery but increased to 37.7% after surgery. Preoperative CD was related to prolonged hospital stay (22.7 versus 19.2 day, P=0.032) and increased postoperative complications (33.3% versus 14.5%, P=0.030) and hospital costs (P=0.013). Besides, postoperative C3 depletion was significantly associated with decreased 3-year OS (P=0.022) and DFS (P=0.003). Moreover, postoperative C3 depletion and advanced tumor stage were independent predictive factors of poor prognosis. Conclusions. Complement C3 depletion occurring in gastric cancer was associated with poor short-term and long-term outcomes.

Mucinous Gastric Cancer Presents with More Advanced Tumor Stage and Weaker β-Catenin Expression than Nonmucinous Cancer

2010 ◽  
Vol 17 (11) ◽  
pp. 3053-3058 ◽  
Author(s):  
Min-Gew Choi ◽  
Chang Ohk Sung ◽  
Jae Hyung Noh ◽  
Kyoung-Mee Kim ◽  
Tae Sung Sohn ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Stage ◽  
Advanced Tumor Stage ◽  
Advanced Tumor

scholarly journals A Positive Feedback Loop of SLP2 Activates MAPK Signaling Pathway to Promote Gastric Cancer Progression

Theranostics ◽  
2018 ◽  
Vol 8 (20) ◽  
pp. 5744-5757 ◽  
Author(s):  
Wenhui Ma ◽  
Zhuoluo Xu ◽  
Yutian Wang ◽  
Wenyi Li ◽  
Zhigang Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Positive Feedback Loop ◽  
Gastric Cancer Progression

Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion

2016 ◽  
Vol 469 (5) ◽  
pp. 505-513 ◽  
Author(s):  
Zhi-Feng Miao ◽  
Xing-Yu Liu ◽  
Hui-Mian Xu ◽  
Zhen-Ning Wang ◽  
Ting-Ting Zhao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Tumor Stage ◽  
Nodal Status ◽  
Human Gastric Cancer ◽  
Advanced Tumor Stage ◽  
Cancer Cell Growth ◽  
Advanced Tumor

scholarly journals High plasma levels of COL10A1 are associated with advanced tumor stage in gastric cancer patients

2020 ◽  
Vol 26 (22) ◽  
pp. 3024-3033 ◽  
Author(s):  
Laura Necula ◽  
Lilia Matei ◽  
Denisa Dragu ◽  
Ioana Pitica ◽  
Ana Iulia Neagu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Plasma Levels ◽  
Tumor Stage ◽  
High Plasma ◽  
Advanced Tumor Stage ◽  
Advanced Tumor ◽  
Gastric Cancer Patients

scholarly journals miR-632 promotes gastric cancer progression by accelerating angiogenesis in a TFF1-dependent manner

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ying Shi ◽  
Xiaoxiao Huang ◽  
Guobin Chen ◽  
Ying Wang ◽  
Yuansheng Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Dependent Manner ◽  
Gastric Cancer Progression

scholarly journals Integrated Bioinformatic Analysis of the Expression and Prognosis of Caveolae-Related Genes in Human Breast Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Yao Tian ◽  
Xiaofeng Liu ◽  
Jing Hu ◽  
Huan Zhang ◽  
Baichuan Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Enrichment Analysis ◽  
Bioinformatic Analysis ◽  
Tumor Stage ◽  
Gene Set Enrichment Analysis ◽  
Advanced Tumor Stage ◽  
Surface Receptors ◽  
Kegg Pathway Database ◽  
Advanced Tumor

Caveolae-related genes, including CAVs that encodes caveolins and CAVINs that encodes caveolae-associated proteins cavins, have been identified for playing significant roles in a variety of biological processes including cholesterol transport and signal transduction, but evidences related to tumorigenesis and cancer progression are not abundant to correlate with clinical characteristics and prognosis of patients with cancer. In this study, we investigated the expression of these genes at transcriptional and translational levels in patients with breast cancer using Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), cBioPortal databases, and immunohistochemistry of the patients in our hospital. Prognosis of patients with breast cancer based on the expressions of CAVs and CAVINs was summarized using Kaplan-Meier Plotter with their correlation to different subtyping. The relevant molecular pathways of these genes were further analyzed using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database and Gene Set Enrichment Analysis (GSEA). Results elucidated that expression levels of CAV1, CAV2, CAVIN1, CAVIN2, and CAVIN3 were significantly lower in breast cancer tissues than in normal samples, while the expression level of CAVIN2 was correlated with advanced tumor stage. Furthermore, investigations on survival of patients with breast cancer indicated outstanding associations between prognosis and CAVIN2 levels, especially for the patients with estrogen receptor positive (ER+) breast cancer. In conclusion, our investigation indicated CAVIN2 is a potential therapeutic target for patients with ER+ breast cancer, which may relate to functions of cancer cell surface receptors and adhesion molecules.

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