scholarly journals Field synopsis and systematic meta-analyses of genetic association studies in isolated dystonia

2018 ◽  
Author(s):  
Olena Ohlei ◽  
Valerija Dobricic ◽  
Katja Lohmann ◽  
Christine Klein ◽  
Christina Lill ◽  
...  
Keyword(s):  
Genetic Association ◽  
Large Scale ◽  
Complex Disease ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Sufficient Information ◽  
Genetic Associations ◽  
Pubmed Database ◽  
The Status ◽  
Meta Analyses

AbstractBackground and objectivesDystonia is a genetically complex disease with both monogenic and polygenic causes. For the latter, numerous genetic associations studies have been performed with largely inconsistent results. The aim of this study was to perform a field synopsis including systematic meta-analyses of genetic association studies in isolated dystoniaMethodsFor the field synopsis we systematically screened and scrutinized the published literature using NCBI’s PubMed database. For genetic variants with sufficient information in at least two independent datasets, random-effects meta-analyses were performed, including meta-analyses stratified by ethnic descent and dystonia subtypes.ResultsA total of 3,575 articles were identified and scrutinized resulting in the inclusion of 42 independent publications allowing 134 meta-analyses on 45 variants across 17 genes. While our meta-analyses pinpointed several significant association signals with variants in TOR1A, DRD1, and ARSG, no single variant displayed compelling association with dystonia in the available data.ConclusionsOur study provides an up-to-date summary of the status of dystonia genetic association studies. Additional large-scale studies are needed to better understand the genetic causes of isolated dystonia.

scholarly journals Assessing the Probability that a Finding Is Genuine for Large-Scale Genetic Association Studies

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0124107 ◽  
Author(s):  
Chia-Ling Kuo ◽  
Olga A. Vsevolozhskaya ◽  
Dmitri V. Zaykin
Keyword(s):  
Genetic Association ◽  
Large Scale ◽  
Association Studies ◽  
Genetic Association Studies

scholarly journals Carotid Artery Atherosclerosis: A Review on Heritability and Genetics

2018 ◽  
Vol 21 (5) ◽  
pp. 333-346 ◽  
Author(s):  
Bianka Forgo ◽  
Emanuela Medda ◽  
Anita Hernyes ◽  
Laszlo Szalontai ◽  
David Laszlo Tarnoki ◽  
...  
Keyword(s):  
Association Studies ◽  
Genetic Association Studies ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Phenotypic Variance ◽  
Genome Wide Association Studies ◽  
Genetic Associations ◽  
Carotid Artery Atherosclerosis ◽  
Meta Analyses

Carotid atherosclerosis (CAS) is associated with increased cardiovascular risk, and therefore, assessing the genetic versus environmental background of CAS traits is of key importance. Carotid intima-media-thickness and plaque characteristics seem to be moderately heritable, with remarkable differences in both heritability and presence or severity of these traits among ethnicities. Although the considerable role of additive genetic effects is obvious, based on the results so far, there is an important emphasis on non-shared environmental factors as well. We aimed to collect and summarize the papers that investigate twin and family studies assessing the phenotypic variance attributable to genetic associations with CAS. Genes in relation to CAS markers were overviewed with a focus on genetic association studies and genome-wide association studies. Although the role of certain genes is confirmed by studies conducted on large populations and meta-analyses, many of them show conflicting results. A great focus should be on future studies elucidating the exact pathomechanism of these genes in CAS in order to imply them as novel therapeutic targets.

scholarly journals Microarray genotyping resource to determine population stratification in genetic association studies of complex disease

BioTechniques ◽  
2004 ◽  
Vol 37 (6) ◽  
pp. 977-985 ◽  
Author(s):  
Scott J. Tebbutt ◽  
Jian-Qing He ◽  
Kelly M. Burkett ◽  
Jian Ruan ◽  
Igor V. Opushnyev ◽  
...  
Keyword(s):  
Genetic Association ◽  
Population Stratification ◽  
Complex Disease ◽  
Association Studies ◽  
Genetic Association Studies

scholarly journals Comprehensive Field Synopsis and Systematic Meta-analyses of Genetic Association Studies in Cutaneous Melanoma

2011 ◽  
Vol 103 (16) ◽  
pp. 1227-1235 ◽  
Author(s):  
F. Chatzinasiou ◽  
C. M. Lill ◽  
K. Kypreou ◽  
I. Stefanaki ◽  
V. Nicolaou ◽  
...  
Keyword(s):  
Genetic Association ◽  
Cutaneous Melanoma ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Meta Analyses

scholarly journals A systematic review evaluating the methodological aspects of meta-analyses of genetic association studies in cancer research

2010 ◽  
Vol 25 (11) ◽  
pp. 765-775 ◽  
Author(s):  
Stefania Boccia ◽  
Emma De Feo ◽  
Paola Gallì ◽  
Francesco Gianfagna ◽  
Rosarita Amore ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Research ◽  
Genetic Association ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Meta Analyses ◽  
Methodological Aspects

scholarly journals Systematic Meta-Analyses and Field Synopsis of Genetic Association Studies in Colorectal Cancer

2012 ◽  
Vol 104 (19) ◽  
pp. 1433-1457 ◽  
Author(s):  
E. Theodoratou ◽  
Z. Montazeri ◽  
S. Hawken ◽  
G. C. Allum ◽  
J. Gong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Genetic Association ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Meta Analyses

scholarly journals A fast multilocus test with adaptive SNP selection for large-scale genetic-association studies

2013 ◽  
Vol 22 (5) ◽  
pp. 696-702 ◽  
Author(s):  
Han Zhang ◽  
Jianxin Shi ◽  
Faming Liang ◽  
William Wheeler ◽  
Rachael Stolzenberg-Solomon ◽  
...  
Keyword(s):  
Genetic Association ◽  
Large Scale ◽  
Association Studies ◽  
Genetic Association Studies ◽  
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