scholarly journals Binding Affinity Regression Models from Repeats Mutation in Polyglutamine Disease

2018 ◽  
Author(s):  
P R Asha ◽  
M S Vijaya
Keyword(s):  
Spinocerebellar Ataxia ◽  
Regression Models ◽  
Protein Complexes ◽  
Genetic Disorders ◽  
Research Work ◽  
Vital Role ◽  
Machine Learning Techniques ◽  
Learning Techniques ◽  
Regression Techniques ◽  
Framework Energy

AbstractDiagnosing and curing neurodegenarative disorder such as spinocerebellar ataxia is complicated when there is differences in formation of protein sequences and structures. Affinity prediction plays vital role to identify drugs for various genetic disorders. Spinocerebellar ataxia occurs but mainly it occurs due to polyglutamine repeats. This research work aims in predicting the affinity of spinocerebellar ataxia from the protein complexes by extracting the well-defined descriptors. Regression models are built to predict the affinity through machine learning techniques coded in python using the Scikit-Learn framework. Energy complexes and protein sequence descriptors are defined and extracted from the complex and sequences. Results show that the SVR is found to predict the affinity with high accuracy of 98% for spinocerebellar ataxia. This paper also deliberates the results of statistical learning carried out with the same set of complexes with various regression techniques.

scholarly journals Prediction of Confusion Attempting Algebra Homework in an Intelligent Tutoring System through Machine Learning Techniques for Educational Sustainable Development

2018 ◽  
Vol 11 (1) ◽  
pp. 105 ◽  
Author(s):  
Syed Abidi ◽  
Mushtaq Hussain ◽  
Yonglin Xu ◽  
Wu Zhang
Keyword(s):  
Machine Learning ◽  
Sustainable Development ◽  
Teaching And Learning ◽  
Performance Metrics ◽  
Intelligent Tutoring ◽  
Intelligent Tutoring System ◽  
Vital Role ◽  
Machine Learning Techniques ◽  
Tutoring System ◽  
Learning Techniques

Incorporating substantial, sustainable development issues into teaching and learning is the ultimate task of Education for Sustainable Development (ESD). The purpose of our study was to identify the confused students who had failed to master the skill(s) given by the tutors as homework using the Intelligent Tutoring System (ITS). We have focused ASSISTments, an ITS in this study, and scrutinized the skill-builder data using machine learning techniques and methods. We used seven candidate models including: Naïve Bayes (NB), Generalized Linear Model (GLM), Logistic Regression (LR), Deep Learning (DL), Decision Tree (DT), Random Forest (RF), and Gradient Boosted Trees (XGBoost). We trained, validated, and tested learning algorithms, performed stratified cross-validation, and measured the performance of the models through various performance metrics, i.e., ROC (Receiver Operating Characteristic), Accuracy, Precision, Recall, F-Measure, Sensitivity, and Specificity. We found RF, GLM, XGBoost, and DL were high accuracy-achieving classifiers. However, other perceptions such as detecting unexplored features that might be related to the forecasting of outputs can also boost the accuracy of the prediction model. Through machine learning methods, we identified the group of students that were confused when attempting the homework exercise, to help foster their knowledge and talent to play a vital role in environmental development.

scholarly journals Decision Tree: A Machine Learning for Intrusion Detection

2019 ◽  
Vol 8 (6S4) ◽  
pp. 1126-1130
Keyword(s):  
Machine Learning ◽  
Intrusion Detection ◽  
Detection System ◽  
Research Work ◽  
Machine Learning Techniques ◽  
Data Sets ◽  
Legitimate User ◽  
Learning Techniques ◽  
Three Stages

The Intrusion is a major threat to unauthorized data or legal network using the legitimate user identity or any of the back doors and vulnerabilities in the network. IDS mechanisms are developed to detect the intrusions at various levels. The objective of the research work is to improve the Intrusion Detection System performance by applying machine learning techniques based on decision trees for detection and classification of attacks. The methodology adapted will process the datasets in three stages. The experimentation is conducted on KDDCUP99 data sets based on number of features. The Bayesian three modes are analyzed for different sized data sets based upon total number of attacks. The time consumed by the classifier to build the model is analyzed and the accuracy is done.

scholarly journals An Advance Resource Reservation Approach in a Cloud Database Environment

2017 ◽  
Author(s):  
Vinicius Da S. Segalin ◽  
Carina F. Dorneles ◽  
Mario A. R. Dantas
Keyword(s):  
Machine Learning ◽  
Research Work ◽  
Resource Reservation ◽  
Machine Learning Techniques ◽  
Advance Reservation ◽  
Running Time ◽  
Knowing That ◽  
Learning Techniques ◽  
Proposed Model ◽  
Cloud Database

AA well-known challenge with long running time queries in database environments is how much time a query will take to execute. This prediction is relevant for several reasons. For instance, by knowing that a query will take longer to execute than desired, one resource reservation mechanism can be performed, which means reserving more resources in order to execute this query in a shorter time in a future request. In this research work, it is presented a proposal in which the use of an advance reservation mechanism in a cloud database environment, considering machine learning techniques, provides resource recommendation. The proposed model is presented, in addition to some experiments that evaluate benefits and the efficiency of this enhanced proposal.

Survey of Breast Cancer Detection Using Machine Learning Techniques in Big Data

2019 ◽  
Vol 21 (3) ◽  
pp. 80-92
Author(s):  
Madhuri Gupta ◽  
Bharat Gupta
Keyword(s):  
Breast Cancer ◽  
Machine Learning ◽  
Research Work ◽  
Cancer Recurrence ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Common Disease ◽  
Learning Techniques ◽  
Learning Frameworks ◽  
Processing Engine

Cancer is a disease in which cells in body grow and divide beyond the control. Breast cancer is the second most common disease after lung cancer in women. Incredible advances in health sciences and biotechnology have prompted a huge amount of gene expression and clinical data. Machine learning techniques are improving the prior detection of breast cancer from this data. The research work carried out focuses on the application of machine learning methods, data analytic techniques, tools, and frameworks in the field of breast cancer research with respect to cancer survivability, cancer recurrence, cancer prediction and detection. Some of the widely used machine learning techniques used for detection of breast cancer are support vector machine and artificial neural network. Apache Spark data processing engine is found to be compatible with most of the machine learning frameworks.

Automobile Gearbox Fault Diagnosis Using Naive Bayes and Decision Tree Algorithm

2015 ◽  
Vol 813-814 ◽  
pp. 943-948 ◽  
Author(s):  
P.G. Sreenath ◽  
Gopalakrishnan Praveen Kumare ◽  
Sundar Pravin ◽  
K.N. Vikram ◽  
M. Saimurugan
Keyword(s):  
Fault Diagnosis ◽  
Decision Tree ◽  
Vital Role ◽  
Condition Based Maintenance ◽  
Vibration Monitoring ◽  
Machine Learning Techniques ◽  
Decision Tree Algorithm ◽  
Vibration Signals ◽  
Learning Techniques ◽  
Technique Comparison

Gearbox plays a vital role in various fields in the industries. Failure of any component in the gearbox will lead to machine downtime. Vibration monitoring is the technique used for condition based maintenance of gearbox. This paper discusses the use of machine learning techniques for automating the fault diagnosis of automobile gearbox. Our experimental study monitors the vibration signals of actual automobile gearbox with simulated fault conditions in the gear and bearing. Statistical features are extracted and classified for identifying the faults using decision tree and Naïve bayes technique. Comparison of the techniques for determining the classification accuracy is discussed.

scholarly journals Computer-aided prediction and design of IL-6 inducing peptides: IL-6 plays a crucial role in COVID-19

2020 ◽  
Author(s):  
Anjali Dhall ◽  
Sumeet Patiyal ◽  
Neelam Sharma ◽  
Salman Sadullah Usmani ◽  
Gajendra P S Raghava
Keyword(s):  
Scientific Community ◽  
Prediction Models ◽  
Vital Role ◽  
Machine Learning Techniques ◽  
Validation Dataset ◽  
Independent Validation ◽  
Immune Epitope ◽  
Learning Techniques ◽  
Wide Range ◽  
Immune Epitope Database

Abstract Interleukin 6 (IL-6) is a pro-inflammatory cytokine that stimulates acute phase responses, hematopoiesis and specific immune reactions. Recently, it was found that the IL-6 plays a vital role in the progression of COVID-19, which is responsible for the high mortality rate. In order to facilitate the scientific community to fight against COVID-19, we have developed a method for predicting IL-6 inducing peptides/epitopes. The models were trained and tested on experimentally validated 365 IL-6 inducing and 2991 non-inducing peptides extracted from the immune epitope database. Initially, 9149 features of each peptide were computed using Pfeature, which were reduced to 186 features using the SVC-L1 technique. These features were ranked based on their classification ability, and the top 10 features were used for developing prediction models. A wide range of machine learning techniques has been deployed to develop models. Random Forest-based model achieves a maximum AUROC of 0.84 and 0.83 on training and independent validation dataset, respectively. We have also identified IL-6 inducing peptides in different proteins of SARS-CoV-2, using our best models to design vaccine against COVID-19. A web server named as IL-6Pred and a standalone package has been developed for predicting, designing and screening of IL-6 inducing peptides (https://webs.iiitd.edu.in/raghava/il6pred/).

scholarly journals Black-Box Marine Vehicle Identification with Regression Techniques for Random Manoeuvres

Electronics ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 492 ◽  
Author(s):  
Raul Moreno ◽  
David Moreno-Salinas ◽  
Joaquin Aranda
Keyword(s):  
System Identification ◽  
Symbolic Regression ◽  
Black Box ◽  
Machine Learning Techniques ◽  
Control Structures ◽  
Marine Vehicles ◽  
Building Models ◽  
Learning Techniques ◽  
Marine System ◽  
Regression Techniques

As a critical step to efficiently design control structures, system identification is concerned with building models of dynamical systems from observed input–output data. In this paper, a number of regression techniques are used for black-box marine system identification of a scale ship. Unlike other works that train the models using specific manoeuvres, in this work the data have been collected from several random manoeuvres and trajectories. Therefore, the aim is to develop general and robust mathematical models using real experimental data from random movements. The techniques used in this work are ridge, kernel ridge and symbolic regression, and the results show that machine learning techniques are robust approaches to model surface marine vehicles, even providing interpretable results in closed form equations using techniques such as symbolic regression.

scholarly journals Intersections of machine learning and epidemiological methods for health services research

2020 ◽  
Author(s):  
Sherri Rose
Keyword(s):  
Machine Learning ◽  
Health Care ◽  
Health Services Research ◽  
Health Services ◽  
Machine Learning Techniques ◽  
Epidemiological Methods ◽  
Learning Tools ◽  
Services Research ◽  
Learning Techniques ◽  
Regression Techniques

Abstract The field of health services research is broad and seeks to answer questions about the health care system. It is inherently interdisciplinary, and epidemiologists have made crucial contributions. Parametric regression techniques remain standard practice in health services research with machine learning techniques currently having low penetrance in comparison. However, studies in several prominent areas, including health care spending, outcomes and quality, have begun deploying machine learning tools for these applications. Nevertheless, major advances in epidemiological methods are also as yet underleveraged in health services research. This article summarizes the current state of machine learning in key areas of health services research, and discusses important future directions at the intersection of machine learning and epidemiological methods for health services research.

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