scholarly journals 10 Year Epidemiologic data of Parkinson’s Disease: A Nationwide Population-based Retrospective Cohort of South Korea

2018 ◽  
Author(s):  
Hyoung Seop Kim ◽  
Joon-Byum Kwon ◽  
Hyun-Sun Lim ◽  
Jiook Cha ◽  
Hye Won Kim
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Health Insurance ◽  
South Korea ◽  
National Sample ◽  
Population Based ◽  
Hazard Ratio ◽  
Conflicts Of Interests ◽  
Medical Facilities ◽  
Epidemiological Information

AbstractObjectivesThe aims of this study were to determine the prevalence, incidence, and P/I ratio of Parkinson’s disease (PD) in South Korea and to present basic epidemiological information on PD patients for making effective health policies.MethodsWe used National Health Insurance Service-National Sample Cohort (KNHIS-NSC) data to analyze the prevalence, incidence, and P/I ratio of PD from 2003 to 2013 and then followed up using the NHID in 2008 to obtain the hazard ratio (HR) of death in PD itself and other comorbidities from 2008 to 2013.ResultsThe prevalence and incidence of PD increased rapidly from 72.9 and 32.8 in 2003 to 213.4 and 58.0 in 2013, and the P/I ratio increased from 2.22 in 2003 to 3.62 in 2013. The prevalence, incidence, and P/I ratio of PD were all higher in women than in men. The hazard ratio for death was significantly higher in PD patients (15.36) compared to subjects without the disease. Stroke was the most frequent cause of death in the PD patient population followed by cancer and pneumonia.ConclusionThe prevalence, incidence, and P/I ratio of PD rapidly increased as the years progressed. This indirectly proves that the health insurance system in Korea is efficient and has allowed patients with PD to access medical facilities more easily. However, a newer public healthy strategy should be established for patients with PD because PD itself has a high HR for death, and patients with PD have a high mortality rate when stroke and pneumonia are also involved.DisclosureAll authors have reported no biomedical interests and potential conflicts of interests.

scholarly journals Rehabilitation Therapy Utilization in Patients with Parkinson’s Disease in Korea

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Han Gil Seo ◽  
Sang Jun Park ◽  
Jiah Seo ◽  
Seong Jun Byun ◽  
Byung-Mo Oh
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Health Insurance ◽  
Clinical Practice ◽  
Patient Characteristics ◽  
National Sample ◽  
Present Evidence ◽  
Rehabilitation Therapy ◽  
Swallowing Therapy ◽  
Over Time

Objective. Although evidence and guidelines recommend appropriate rehabilitation from the beginning of diagnosis in patients with Parkinson’s disease (PD), there is a lack of data addressing the utilization of rehabilitation therapies for these patients in practice. The aim of this study is to investigate the rate of rehabilitation therapy utilization over time in patients with PD using a nationwide cohort in Korea. Methods. Patients were identified using the registration code for PD in the program for rare, intractable disease from the National Health Insurance Service-National Sample Cohort database, which consists of 979,390 Korean residents. Data were divided into four periods: 2004–2006, 2007–2009, 2010–2012, and 2013–2015. We assessed the utilization of rehabilitation therapies and the associated patient characteristics. Results. The numbers of patients with PD were 384 in 2004, 855 in 2007, 1,023 in 2010, and 1,222 in 2013. The numbers of physiatrist visits per person were 0.58, 0.96, 1.97, and 2.91, in the respective periods. Among the patients, 35–40% had claims for physical therapy, 16–19% for occupational therapy, and 4–6% for swallowing therapy. There were no remarkable differences between these rates between the study periods. Sex, age, income, disability, and levodopa-equivalent dose were significantly associated with the utilization of rehabilitation therapy. Conclusion. This study demonstrated that the rate of rehabilitation therapy utilization did not change remarkably in patients with PD from 2004 to 2015 in Korea although the number of physiatrist visits increased dramatically. The present evidence and guidelines may have not been adequately integrated into clinical practice during the period of study. Additional efforts may be warranted to provide adequate rehabilitation therapies in clinical practice for patients with PD.

Cancer risk in patients with Parkinson’s disease in South Korea: A nationwide, population-based cohort study

2019 ◽  
Vol 117 ◽  
pp. 5-13 ◽  
Author(s):  
Joo-Hyun Park ◽  
Do-Hoon Kim ◽  
Yong-Gyu Park ◽  
Do-Young Kwon ◽  
Moonyoung Choi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cohort Study ◽  
Cancer Risk ◽  
South Korea ◽  
Population Based

The mortality rate of Parkinson’s disease and related comorbidities: a nationwide population-based matched cohort study in Korea

2020 ◽  
Author(s):  
Seo Yeon Yoon ◽  
Jaeyong Shin ◽  
Yong Wook Kim ◽  
Jee Suk Chang ◽  
Hye Won Kim
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cohort Study ◽  
Mortality Rate ◽  
Mortality Risk ◽  
Haemorrhagic Stroke ◽  
National Sample ◽  
Population Based ◽  
Chronic Obstructive ◽  
Matched Cohort

Abstract Background previous studies on mortality of Parkinson’s disease (PD) enrolled a relatively small number of participants and were conducted in western countries. The objective of this study was to evaluate mortality rate of PD using a large nationwide cohort in Korea and to evaluate effects comorbidities have on mortality in PD. Methods the nationwide population-based cohort study was conducted using the Korean National Health Insurance Service—National Sample Cohort data. Patients with a primary diagnosis of PD were selected from the database. A matched cohort without PD was enrolled through randomly matching patients by sex, age, year of diagnosis, residential area and income level to the PD group with a ratio of 1:9. The Cox proportional hazard model was used to assess mortality risk between the two cohorts. A logistic regression analysis was used to identify mortality risk factors in PD cohort. Results in total, 25,620 patients were enrolled. The Cox proportional regression model had an adjusted hazard ratio of 2.479 [95% confidence interval (CI), 2.272-2.704] for mortality in PD cohort. Comorbidities, such as ischaemic stroke [odds ratios (OR) = 2.314, 95% CI, 1.895-2.824], haemorrhagic stroke (OR = 2.281, 95% CI, 1.466-3.550) and chronic obstructive pulmonary disease (OR = 1.307, 95% CI, 1.048-1.630) were associated with increased mortality, whereas dyslipidemia (OR = 0.285, 95% CI, 0.227-0.358) was negatively correlated with mortality. Conclusion over the 10 year follow-up period, the PD cohort’s mortality rate was 2.5 times higher than the comparison cohort. Understanding the effects that comorbidities have on morality in PD would be useful for predicting mortality in patients with PD.

scholarly journals Traditional Chinese Medicine Might Reduce Risk of Dementia in Patients with Parkinson’s disease: A Population-based Nested Case-control Study

2020 ◽  
Author(s):  
Yun-Tzu Liang ◽  
Chia-Yang Lin ◽  
Yu-Hsun Wang ◽  
Hsi-Hsien Chou ◽  
James Cheng-Chung Wei
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Health Insurance ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
National Health Insurance ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study

Abstract Background Patients who have Parkinson’s disease (PD) comorbid with dementia is common. With the prolonged life expectancy, dementia is gradually becoming prevalent and affects most patients’ life qualities. However, the efficacy of current treatments in dementia of Parkinson’s disease is limited. Previous studies indicated the potential roles of Traditional Chinese Medicine (TCM) in treating dementia, yet its effects in preventing dementia from Parkinson’s patients are unknown.Methods This case–control study was nested within a national health insurance database of patients over 50 years old with newly diagnosed Parkinson’s disease from year 2000 to 2010. Among these PD patients, dementia and non-dementia groups were discussed respectively in terms of the duration of taking TCM (≥ 90 days versus < 90 days), age (50–64 versus ≥ 65) and gender.Results The risk of dementia in patients with Parkinson's disease is decreased by using TCM for < 90 days and ≥ 90 days, especially in the group who took TCM for more than 90 days. The use of TCM significantly reduces the risk of dementia in the subgroups of age ≥ 65 years, female patients using TCM for both < 90 days and ≥ 90 days, and male patients using TCM for < 90 days. Overall, we can see the protection tendency among all of the target population under TCM use.Conclusions The results showed that there is a significant reduction of nearly 38% in the risk of dementia for patients with Parkinson’s disease after the usage of Traditional Chinese Medicine. The beneficial effects for using TCM ≥ 90 days in women age ≥ 65 years are most prominent.Trial registration The study data were acquired from the Taiwan’s National Health Insurance (NHI) Research Database. The NHI-claimed data provide clinical information for population-based epidemiologic research. This study was approved by the Institutional Review Board of Chung Shan Medical University Hospital.

Public Awareness and Knowledge about Parkinson's Disease: A National Population Based Survey in South Korea

2016 ◽  
Vol 47 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Jinyoung Youn ◽  
Eungseok Oh ◽  
Jinse Park ◽  
Suyeon Park ◽  
Ji Sun Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
South Korea ◽  
Low Socioeconomic Status ◽  
Public Awareness ◽  
Multivariate Logistic Regression Analysis ◽  
Population Based ◽  
Education Level ◽  
Educational Strategies ◽  
Optimal Care

Background: Considering the increasing prevalence of Parkinson's disease (PD), the lack of awareness and knowledge regarding PD may be barriers to the early diagnosis and the provision of optimal care to affected patients. This study aimed to investigate the awareness and knowledge about PD among the general population in South Korea and to identify the factors that are associated with these parameters. Methods: We developed a structured, 22-item questionnaire that consisted of both open-ended and close-ended questions. A total of 1,000 people from the general public were randomly sampled in proportion to the country's population density and were questioned by well-trained interviewers. Multivariate logistic regression analysis was applied to identify the factors associated with awareness and knowledge of PD. Results: Age, household income and education level were independently associated with awareness of PD. Subjects between 40 and 59 years of age and those who had completed more than 12 years of education showed more awareness of PD. Regarding knowledge about PD, younger subjects exhibited the least knowledge compared to respondents between 40 and 59 years of age and those above 60 years of age. Low socioeconomic status tended to be associated with poor knowledge of PD. Conclusions: Awareness and knowledge of PD showed hierarchical gradients with respect to age, income and education level. Pertinent educational strategies and approaches targeting specific subgroups are necessary to improve public awareness and knowledge about PD.

scholarly journals Evaluation of the association between periodontitis and risk of Parkinson’s disease: a nationwide retrospective cohort study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eunkyung Jeong ◽  
Jun-Beom Park ◽  
Yong-Gyu Park
Keyword(s):  
Parkinson’S Disease ◽  
Metabolic Syndrome ◽  
Parkinson's Disease ◽  
South Korea ◽  
Large Scale ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Population Based ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model

AbstractThe objective of this study was to examine the association between periodontitis and risk of incident Parkinson’s disease using large-scale cohort data on the entire population of South Korea. Health checkup data from 6,856,180 participants aged 40 and older were provided by the National Health Insurance Service of South Korea between January 1, 2009, and December 31, 2009, and the data were followed until December 31, 2017. The hazard ratio (HR) of Parkinson’s disease and 95% confidence interval (CI) were estimated using a Cox proportional hazards model adjusted for potential confounders. The incidence probability of Parkinson’s disease was positively correlated with the presence of periodontitis. The HR of Parkinson’s disease for the participants without the need of further dentist visits was 0.96 (95% CI 0.921–1.002); the HR of Parkinson’s disease increased to 1.142 (95% CI 1.094–1.193) for the individuals who needed further dentist visits. Compared to individuals without periodontitis and without metabolic syndrome, the HR of incident Parkinson’s disease gradually increased for individuals with periodontitis, with metabolic syndrome, and with both periodontitis and metabolic syndrome. People with periodontitis and metabolic syndrome had the highest HR of incident Parkinson’s disease, at 1.167 (95% CI 1.118–1.219). In conclusion, a weak association between periodontitis and Parkinson’s disease was suggested after adjusting for confounding factors from the population-based large-scale cohort of the entire South Korean population.

Falls Predict Acute Hospitalization in Parkinson’s Disease

2021 ◽  
pp. 1-20
Author(s):  
Diego Santos García ◽  
Teresa de Deus Fonticoba ◽  
Carlos Cores ◽  
Ester Suárez Castro ◽  
Jorge Hernández Vara ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cox Regression ◽  
Independent Predictor ◽  
Hazard Ratio ◽  
Acute Hospitalization ◽  
Baseline Visit ◽  
Kaplan Meier ◽  
Non Motor Symptoms

Background: There is a need for identifying risk factors for hospitalization in Parkinson’s disease (PD) and also interventions to reduce acute hospital admission. Objective: To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort. Methods: PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit. Results: Thirty-five out of 605 (5.8%) PD patients (62.5±8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065–5.678; p = 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319–6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757–8.470; p = 0.001), and dysphagia (HR 2.356; 95% CI 1.124–4.941; p = 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080–8.322; p = 0.035) was an independent predictor of AH. Conclusion: Falls is an independent predictor of AH in PD patients.

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