scholarly journals Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community

2020 ◽  
Author(s):  
Ayesha Appa ◽  
Saki Takahashi ◽  
Isabel Rodriguez-Barraquer ◽  
Gabriel Chamie ◽  
Aenor Sawyer ◽  
...  
Keyword(s):  
Rural Community ◽  
Antibody Testing ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Rural Town ◽  
Combining Data ◽  
Low Prevalence ◽  
Prior Infection ◽  
Abbott Architect

Background: The absence of systematic surveillance for SARS-CoV-2 has curtailed accurate appraisal of transmission intensity. Our objective was to perform case detection of an entire rural community to quantify SARS-CoV-2 transmission using PCR and antibody testing. Methods: We conducted a cross-sectional survey of the prevalence and cumulative incidence of SARS-CoV-2 infection in the rural town of Bolinas, California (population 1,620), four weeks following shelter-in-place orders. Residents and county essential workers were tested between April 20th-24th, 2020. Prevalence by PCR and seroprevalence combining data from two forms of antibody testing were performed in parallel (Abbott ARCHITECT IgG to nucleocapsid protein and in-house IgG ELISA to the receptor binding domain). Results: Of 1,891 participants, 1,312 were confirmed Bolinas residents (>80% community ascertainment). Zero participants were PCR positive. Assuming 80% sensitivity, it would have been unlikely to observe these results (p<0.05) if there were >3 active infections in the community. Based on antibody results, estimated prevalence of prior infection was 0.16% (95% CrI: 0.02%, 0.46%). Seroprevalence estimates using only one of the two tests would have been higher, with greater uncertainty. The positive predictive value (PPV) of a positive result on both tests was 99.11% (95% CrI: 95.75%, 99.94%), compared to PPV 44.19%-63.32% (95% CrI range 3.25%-98.64%) if only one test was utilized. Conclusions: Four weeks following shelter-in-place, active and prior SARS-CoV-2 infection in a rural Northern California community was extremely rare. In this low prevalence setting, use of two antibody tests increased the PPV and precision of seroprevalence estimates.

scholarly journals Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community

2020 ◽  
Author(s):  
Ayesha Appa ◽  
Saki Takahashi ◽  
Isabel Rodriguez-Barraquer ◽  
Gabriel Chamie ◽  
Aenor Sawyer ◽  
...  
Keyword(s):  
Rural Community ◽  
The United States ◽  
Rural Setting ◽  
Antibody Testing ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Rural Town ◽  
Low Prevalence ◽  
Prior Infection ◽  
Estimate Precision

Abstract Background Limited systematic surveillance for SARS-CoV-2 in the early months of the United States epidemic curtailed accurate appraisal of transmission intensity. Our objective was to perform case detection of an entire rural community to quantify SARS-CoV-2 transmission using PCR and antibody testing. Methods We conducted a cross-sectional survey of SARS-CoV-2 infection in the rural town of Bolinas, California (population 1,620), four weeks following shelter-in-place orders. Participants were tested between April 20 th – 24 th, 2020. Prevalence by PCR and seroprevalence from two forms of antibody testing were performed in parallel (Abbott ARCHITECT IgG and in-house IgG ELISA). Results Of 1,891 participants, 1,312 were confirmed Bolinas residents (&gt;80% community ascertainment). Zero participants were PCR positive. Assuming 80% sensitivity, it would have been unlikely to observe these results (p&lt;0.05) if there were &gt;3 active infections in the community. Based on antibody results, estimated prevalence of prior infection was 0.16% (95% CrI: 0.02%, 0.46%). The positive predictive value (PPV) of a positive result on both tests was 99.11% (95% CrI: 95.75%, 99.94%), compared to PPV 44.19%-63.32% (95% CrI range 3.25%-98.64%) if one test was utilized. Conclusions Four weeks following shelter-in-place, SARS-CoV-2 infection in a rural Northern California community was extremely rare. In this low prevalence setting, use of two antibody tests increased seroprevalence estimate precision. This was one of the first community-wide studies to successfully implement synchronous PCR and antibody testing, particularly in a rural setting. Widespread testing remains an underpinning of effective disease control in conjunction with consistent uptake of public health measures.

scholarly journals Internet Use among Community-Based Rehabilitation Workers in Bosnia and Herzegovina: A Cross-Sectional Survey

2011 ◽  
Vol 63 (4) ◽  
pp. 445-452 ◽  
Author(s):  
Euson Yeung ◽  
Robert Balogh ◽  
Donald Cole ◽  
Djenana Jalovcic ◽  
Michel D. Landry
Keyword(s):  
Bosnia And Herzegovina ◽  
Internet Use ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Community Based Rehabilitation

Dengue vaccine acceptance and associated factors in Indonesia: A community-based cross-sectional survey in Aceh

Vaccine ◽  
2016 ◽  
Vol 34 (32) ◽  
pp. 3670-3675 ◽  
Author(s):  
Harapan Harapan ◽  
Samsul Anwar ◽  
Abdul Malik Setiawan ◽  
R. Tedjo Sasmono
Keyword(s):  
Associated Factors ◽  
Dengue Vaccine ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Vaccine Acceptance

scholarly journals Over-the-Counter Drugs and Complementary Medications Use among Children in Southern Italy

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Claudia Pileggi ◽  
Valentina Mascaro ◽  
Aida Bianco ◽  
Maria Pavia
Keyword(s):  
Positive Attitude ◽  
Southern Italy ◽  
Sole Source ◽  
Structured Interviews ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Over The Counter ◽  
Source Of Information

The use of nonprescription medicines (NPDs) for children illnesses without a doctor’s suggestion can lead to unnecessary medication use and is not free of risks. The aim of our study was to examine attitudes and practice of parents towards NPDs use for their children. We also investigated the conditions that may predict NPDs use. A cross-sectional survey was conducted on parents of children attending Community Based Pediatrician (CBP) consultation and data were collected through structured interviews. Positive attitude on NPDs use was reported by 71.4% of parents, and 61.5% of them had administered NPDs in the previous 6 months. Antipyretic drugs were the most frequently used medication class without the supervision of the CBP. A positive attitude towards NPDs was significantly more frequent in parents who did not use the CBP as the sole source of information about drugs. The study demonstrated a widespread use of NPDs in children in our context, supported by a substantial positive attitude towards their safety. However, considering potential harms related to some NPDs and the finding that most parents rely on CBP advice, role of CBP on appropriate use of NPDs by parents should be emphasized.

scholarly journals Fathering Agency Staff Members’ Perspectives on Domestic Violence Perpetration

2010 ◽  
Vol 5 (1) ◽  
pp. 47-56
Author(s):  
Peter F. Cronholm ◽  
Willie Ellison ◽  
Silvana Mazzella ◽  
Marcy Witherspoon ◽  
Joy Bowman Lim ◽  
...  
Keyword(s):  
Domestic Violence ◽  
Odds Ratio ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Agency Staff ◽  
Staff Members ◽  
Training Interventions ◽  
Violence Perpetration ◽  
Low Prevalence ◽  
Routine Inquiry

Purpose: To describe the perspectives of fathering staff regarding domestic violence (DV) perpetration. Materials and methods: A cross-sectional survey of 85 fathering staff members was conducted to identify behaviors and barriers regarding inquiry about DV perpetration. Results: Almost half (47.1%) of the surveyed staff reported never having identified DV perpetration. Routine inquiry was less likely if staff perceived low prevalence rates among their clients (odds ratio [OR] = 0.11, p = .001), did not have standard ways of asking (OR = 0.11, p < .001), or if they had never identified family violence before (OR = 0.07, p < .001). Increased years as a provider (OR = 6.62, p = .001) and DV training (OR = 7.29, p = .003) increased rates of DV perpetration inquiry. Conclusions: Staff of fathering agencies do not routinely screen for DV perpetration likely due to the interplay between individual and agency-level barriers. Appropriate training interventions can address identified barriers.

scholarly journals Seroprevalence of hepatitis B and hepatitis C markers in adolescents in Southern Brazil

2011 ◽  
Vol 27 (4) ◽  
pp. 753-758 ◽  
Author(s):  
Natália Gazzoni Scaraveli ◽  
Ana Maria Passos ◽  
Andréia Royer Voigt ◽  
Andréa do Livramento ◽  
Gabriela Tonial ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Health Campaigns ◽  
Cross Sectional Survey ◽  
School Students ◽  
Cross Sectional ◽  
Immunosorbant Assay ◽  
B Virus ◽  
Low Prevalence ◽  
The City

This study was carried out to determine the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) markers among adolescents aged between 10 and 16 years old, who are elementary school students in the city of Chapecó, Santa Catarina State, Brazil. The study involved a cross-sectional survey that included 418 volunteers, from March to July, 2008. Serology comprised HBsAg, anti-HBc, anti-HBs and anti-HCV. Tests were performed using automated Microparticle Enzyme Immunosorbant Assay (Abbott, AxSYM System, Wiesbaden, Germany). The prevalence of HBsAg was found to be 0.2% (95%CI: 0.0-1.3), and the prevalence of anti-HBc was found to be 1.4% (95%CI: 0.5-3.1). Regarding anti-HBs, 48.6% had titers greater than 10UI/L. None of the volunteers presented reactive results for anti-HCV. This study showed a low prevalence of HBV and HCV markers of infection and a great number of volunteers immunized against HBV. Finally this study shows the importance of proper health campaigns and policies in reducing those prevalences.

scholarly journals Prevalence of eczema among older persons: A population-based cross-sectional study

2021 ◽  
Vol 0 ◽  
pp. 1-5
Author(s):  
Vijayan Neena ◽  
Neelakandhan Asokan ◽  
Rajany Jose ◽  
A. Sarin
Keyword(s):  
Older Persons ◽  
Health Workers ◽  
Age Groups ◽  
Medical Knowledge ◽  
Population Based ◽  
Cross Sectional Survey ◽  
Community Based Interventions ◽  
Community Based ◽  
Cross Sectional ◽  
Lichen Simplex Chronicus

Background: There are very few population-based studies on the prevalence of eczema among older persons Aims: To estimate the prevalence and types of eczema in those aged 65 years or more in the community and to evaluate the effectiveness of community-based interventions for case finding. Methods: In the first stage of this cross-sectional survey, trained health workers of a non-governmental organization surveyed the eligible population and identified persons likely to have eczema. In the second stage, dermatologists examined such persons to ascertain the diagnosis. Statistical analysis was done using Epi Info software version 7. Prevalence of eczema was expressed in percentages. Chi-square test was used for comparing the difference in prevalence of eczema in various age groups and sex. Results: Health workers identified 98 persons as possible cases of eczema after interviewing 385 older persons in the community. Among them 95 persons were examined by dermatologists and 44 were confirmed to have eczema (diagnostic accuracy of health workers = 46.3%).Point prevalence of eczema was 11.4% (44/385). Prevalence was similar in males and females. It was greater (18.2 %) among persons aged 81 years or more. Asteatotic eczema, gravitational eczema and lichen simplex chronicus were the more common types of eczema. Limitations: Possible underestimation of the prevalence rates due to limited medical knowledge of health workers; limited facilities for examination and investigations at the medical camps and home visits. Conclusion: There appears to be a considerable burden of eczema among older persons in the community. A community-based approach involving non-governmental organizations has the potential to identify cases and offer care close to their homes.

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