TarDict: RandomForestClassifier-based software predict Drug-Tartget interaction

Background: In this paper, a Convolutional Neural Network (CNN) to learn safe driving behavior and smooth steering manoeuvring, is proposed as an empowerment of autonomous driving technologies. The training data is collected from a front-facing camera and the steering commands issued by an experienced driver driving in traffic as well as urban roads. Methods: This data is then used to train the proposed CNN to facilitate what it is called “Behavioral Cloning”. The proposed Behavior Cloning CNN is named as “BCNet”, and its deep seventeen-layer architecture has been selected after extensive trials. The BCNet got trained using Adam’s optimization algorithm as a variant of the Stochastic Gradient Descent (SGD) technique. Results: The paper goes through the development and training process in details and shows the image processing pipeline harnessed in the development. Conclusion: The proposed approach proved successful in cloning the driving behavior embedded in the training data set after extensive simulations.

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Comparative Analysis of Machine Learning Techniques Using Predictive Modeling

Recent Advances in Computer Science and Communications ◽

10.2174/2666255813999200904164539 ◽

2020 ◽

Vol 13 ◽

Author(s):

Ritu Khandelwal ◽

Hemlata Goyal ◽

Rajveer Singh Shekhawat

Keyword(s):

Machine Learning ◽

Comparative Analysis ◽

Data Science ◽

Training Data ◽

Machine Learning Techniques ◽

Future Trends ◽

Data Set ◽

Learning Stage ◽

Learning Techniques ◽

Different Types

Introduction: Machine learning is an intelligent technology that works as a bridge between businesses and data science. With the involvement of data science, the business goal focuses on findings to get valuable insights on available data. The large part of Indian Cinema is Bollywood which is a multi-million dollar industry. This paper attempts to predict whether the upcoming Bollywood Movie would be Blockbuster, Superhit, Hit, Average or Flop. For this Machine Learning techniques (classification and prediction) will be applied. To make classifier or prediction model first step is the learning stage in which we need to give the training data set to train the model by applying some technique or algorithm and after that different rules are generated which helps to make a model and predict future trends in different types of organizations. Methods: All the techniques related to classification and Prediction such as Support Vector Machine(SVM), Random Forest, Decision Tree, Naïve Bayes, Logistic Regression, Adaboost, and KNN will be applied and try to find out efficient and effective results. All these functionalities can be applied with GUI Based workflows available with various categories such as data, Visualize, Model, and Evaluate. Result: To make classifier or prediction model first step is learning stage in which we need to give the training data set to train the model by applying some technique or algorithm and after that different rules are generated which helps to make a model and predict future trends in different types of organizations Conclusion: This paper focuses on Comparative Analysis that would be performed based on different parameters such as Accuracy, Confusion Matrix to identify the best possible model for predicting the movie Success. By using Advertisement Propaganda, they can plan for the best time to release the movie according to the predicted success rate to gain higher benefits. Discussion: Data Mining is the process of discovering different patterns from large data sets and from that various relationships are also discovered to solve various problems that come in business and helps to predict the forthcoming trends. This Prediction can help Production Houses for Advertisement Propaganda and also they can plan their costs and by assuring these factors they can make the movie more profitable.

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Building Damage Detection from Post-Event Aerial Imagery Using Single Shot Multibox Detector

Applied Sciences ◽

10.3390/app9061128 ◽

2019 ◽

Vol 9 (6) ◽

pp. 1128 ◽

Cited By ~ 12

Author(s):

Yundong Li ◽

Wei Hu ◽

Han Dong ◽

Xueyan Zhang

Keyword(s):

Machine Learning ◽

Data Augmentation ◽

Hurricane Sandy ◽

Training Data ◽

Aerial Images ◽

Detection Methods ◽

Single Shot ◽

Data Set ◽

Augmentation Strategies ◽

Post Disaster

Using aerial cameras, satellite remote sensing or unmanned aerial vehicles (UAV) equipped with cameras can facilitate search and rescue tasks after disasters. The traditional manual interpretation of huge aerial images is inefficient and could be replaced by machine learning-based methods combined with image processing techniques. Given the development of machine learning, researchers find that convolutional neural networks can effectively extract features from images. Some target detection methods based on deep learning, such as the single-shot multibox detector (SSD) algorithm, can achieve better results than traditional methods. However, the impressive performance of machine learning-based methods results from the numerous labeled samples. Given the complexity of post-disaster scenarios, obtaining many samples in the aftermath of disasters is difficult. To address this issue, a damaged building assessment method using SSD with pretraining and data augmentation is proposed in the current study and highlights the following aspects. (1) Objects can be detected and classified into undamaged buildings, damaged buildings, and ruins. (2) A convolution auto-encoder (CAE) that consists of VGG16 is constructed and trained using unlabeled post-disaster images. As a transfer learning strategy, the weights of the SSD model are initialized using the weights of the CAE counterpart. (3) Data augmentation strategies, such as image mirroring, rotation, Gaussian blur, and Gaussian noise processing, are utilized to augment the training data set. As a case study, aerial images of Hurricane Sandy in 2012 were maximized to validate the proposed method’s effectiveness. Experiments show that the pretraining strategy can improve of 10% in terms of overall accuracy compared with the SSD trained from scratch. These experiments also demonstrate that using data augmentation strategies can improve mAP and mF1 by 72% and 20%, respectively. Finally, the experiment is further verified by another dataset of Hurricane Irma, and it is concluded that the paper method is feasible.

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2D–3D reconstruction of distal forearm bone from actual X-ray images of the wrist using convolutional neural networks

Scientific Reports ◽

10.1038/s41598-021-94634-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Ryoya Shiode ◽

Mototaka Kabashima ◽

Yuta Hiasa ◽

Kunihiro Oka ◽

Tsuyoshi Murase ◽

...

Keyword(s):

Wrist Joint ◽

High Accuracy ◽

Training Data ◽

Small Data ◽

Data Set ◽

Accuracy Estimation ◽

X Ray ◽

Learning Network ◽

Forearm Bone ◽

Deep Learning Network

AbstractThe purpose of the study was to develop a deep learning network for estimating and constructing highly accurate 3D bone models directly from actual X-ray images and to verify its accuracy. The data used were 173 computed tomography (CT) images and 105 actual X-ray images of a healthy wrist joint. To compensate for the small size of the dataset, digitally reconstructed radiography (DRR) images generated from CT were used as training data instead of actual X-ray images. The DRR-like images were generated from actual X-ray images in the test and adapted to the network, and high-accuracy estimation of a 3D bone model from a small data set was possible. The 3D shape of the radius and ulna were estimated from actual X-ray images with accuracies of 1.05 ± 0.36 and 1.45 ± 0.41 mm, respectively.

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Optimal breeding-value prediction using a Sparse Selection Index

Genetics ◽

10.1093/genetics/iyab030 ◽

2021 ◽

Author(s):

Marco Lopez-Cruz ◽

Gustavo de los Campos

Keyword(s):

Sample Size ◽

Dna Sequences ◽

Genomic Prediction ◽

Prediction Accuracy ◽

Regularization Parameter ◽

Selection Index ◽

Prediction Method ◽

Training Data ◽

Breeding Value ◽

Data Set

Abstract Genomic prediction uses DNA sequences and phenotypes to predict genetic values. In homogeneous populations, theory indicates that the accuracy of genomic prediction increases with sample size. However, differences in allele frequencies and in linkage disequilibrium patterns can lead to heterogeneity in SNP effects. In this context, calibrating genomic predictions using a large, potentially heterogeneous, training data set may not lead to optimal prediction accuracy. Some studies tried to address this sample size/homogeneity trade-off using training set optimization algorithms; however, this approach assumes that a single training data set is optimum for all individuals in the prediction set. Here, we propose an approach that identifies, for each individual in the prediction set, a subset from the training data (i.e., a set of support points) from which predictions are derived. The methodology that we propose is a Sparse Selection Index (SSI) that integrates Selection Index methodology with sparsity-inducing techniques commonly used for high-dimensional regression. The sparsity of the resulting index is controlled by a regularization parameter (λ); the G-BLUP (the prediction method most commonly used in plant and animal breeding) appears as a special case which happens when λ = 0. In this study, we present the methodology and demonstrate (using two wheat data sets with phenotypes collected in ten different environments) that the SSI can achieve significant (anywhere between 5-10%) gains in prediction accuracy relative to the G-BLUP.

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A Data-Driven Surrogate Approach for the Temporal Stability Forecasting of Vegetation Covered Dikes

Water ◽

10.3390/w13010107 ◽

2021 ◽

Vol 13 (1) ◽

pp. 107

Author(s):

Elahe Jamalinia ◽

Faraz S. Tehrani ◽

Susan C. Steele-Dunne ◽

Philip J. Vardon

Keyword(s):

Numerical Simulation ◽

Water Flux ◽

Temporal Stability ◽

Synthetic Data ◽

Climatic Conditions ◽

Training Data ◽

Data Driven ◽

Data Set ◽

Surface Cracking ◽

Real Time Analysis

Climatic conditions and vegetation cover influence water flux in a dike, and potentially the dike stability. A comprehensive numerical simulation is computationally too expensive to be used for the near real-time analysis of a dike network. Therefore, this study investigates a random forest (RF) regressor to build a data-driven surrogate for a numerical model to forecast the temporal macro-stability of dikes. To that end, daily inputs and outputs of a ten-year coupled numerical simulation of an idealised dike (2009–2019) are used to create a synthetic data set, comprising features that can be observed from a dike surface, with the calculated factor of safety (FoS) as the target variable. The data set before 2018 is split into training and testing sets to build and train the RF. The predicted FoS is strongly correlated with the numerical FoS for data that belong to the test set (before 2018). However, the trained model shows lower performance for data in the evaluation set (after 2018) if further surface cracking occurs. This proof-of-concept shows that a data-driven surrogate can be used to determine dike stability for conditions similar to the training data, which could be used to identify vulnerable locations in a dike network for further examination.

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A machine learning case–control classifier for schizophrenia based on DNA methylation in blood

Translational Psychiatry ◽

10.1038/s41398-021-01496-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Chathura J. Gunasekara ◽

Eilis Hannon ◽

Harry MacKay ◽

Cristian Coarfa ◽

Andrew McQuillin ◽

...

Keyword(s):

Dna Methylation ◽

Population Based ◽

Case Control ◽

Training Data ◽

Polygenic Risk Score ◽

Reverse Causality ◽

Cell Type Specificity ◽

Data Set ◽

Human Genomic ◽

Genomic Regions

AbstractEpigenetic dysregulation is thought to contribute to the etiology of schizophrenia (SZ), but the cell type-specificity of DNA methylation makes population-based epigenetic studies of SZ challenging. To train an SZ case–control classifier based on DNA methylation in blood, therefore, we focused on human genomic regions of systemic interindividual epigenetic variation (CoRSIVs), a subset of which are represented on the Illumina Human Methylation 450K (HM450) array. HM450 DNA methylation data on whole blood of 414 SZ cases and 433 non-psychiatric controls were used as training data for a classification algorithm with built-in feature selection, sparse partial least squares discriminate analysis (SPLS-DA); application of SPLS-DA to HM450 data has not been previously reported. Using the first two SPLS-DA dimensions we calculated a “risk distance” to identify individuals with the highest probability of SZ. The model was then evaluated on an independent HM450 data set on 353 SZ cases and 322 non-psychiatric controls. Our CoRSIV-based model classified 303 individuals as cases with a positive predictive value (PPV) of 80%, far surpassing the performance of a model based on polygenic risk score (PRS). Importantly, risk distance (based on CoRSIV methylation) was not associated with medication use, arguing against reverse causality. Risk distance and PRS were positively correlated (Pearson r = 0.28, P = 1.28 × 10−12), and mediational analysis suggested that genetic effects on SZ are partially mediated by altered methylation at CoRSIVs. Our results indicate two innate dimensions of SZ risk: one based on genetic, and the other on systemic epigenetic variants.

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Information-Theoretic Generalization Bounds for Meta-Learning and Applications

Entropy ◽

10.3390/e23010126 ◽

2021 ◽

Vol 23 (1) ◽

pp. 126

Author(s):

Sharu Theresa Jose ◽

Osvaldo Simeone

Keyword(s):

Learning Algorithm ◽

Broad Class ◽

Performance Measure ◽

Training Data ◽

Learning To Learn ◽

Data Set ◽

Information Theoretic ◽

Meta Learning ◽

Task Training ◽

Test Sets

Meta-learning, or “learning to learn”, refers to techniques that infer an inductive bias from data corresponding to multiple related tasks with the goal of improving the sample efficiency for new, previously unobserved, tasks. A key performance measure for meta-learning is the meta-generalization gap, that is, the difference between the average loss measured on the meta-training data and on a new, randomly selected task. This paper presents novel information-theoretic upper bounds on the meta-generalization gap. Two broad classes of meta-learning algorithms are considered that use either separate within-task training and test sets, like model agnostic meta-learning (MAML), or joint within-task training and test sets, like reptile. Extending the existing work for conventional learning, an upper bound on the meta-generalization gap is derived for the former class that depends on the mutual information (MI) between the output of the meta-learning algorithm and its input meta-training data. For the latter, the derived bound includes an additional MI between the output of the per-task learning procedure and corresponding data set to capture within-task uncertainty. Tighter bounds are then developed for the two classes via novel individual task MI (ITMI) bounds. Applications of the derived bounds are finally discussed, including a broad class of noisy iterative algorithms for meta-learning.

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Localization of Scattering Objects Using Neural Networks

Sensors ◽

10.3390/s21010011 ◽

2020 ◽

Vol 21 (1) ◽

pp. 11

Author(s):

Domonkos Haffner ◽

Ferenc Izsák

Keyword(s):

Neural Networks ◽

Plane Waves ◽

Measurement Data ◽

Scattered Wave ◽

Training Data ◽

Data Set ◽

Main Compound ◽

Incident Plane ◽

The Neural Networks ◽

Simulation Package

The localization of multiple scattering objects is performed while using scattered waves. An up-to-date approach: neural networks are used to estimate the corresponding locations. In the scattering phenomenon under investigation, we assume known incident plane waves, fully reflecting balls with known diameters and measurement data of the scattered wave on one fixed segment. The training data are constructed while using the simulation package μ-diff in Matlab. The structure of the neural networks, which are widely used for similar purposes, is further developed. A complex locally connected layer is the main compound of the proposed setup. With this and an appropriate preprocessing of the training data set, the number of parameters can be kept at a relatively low level. As a result, using a relatively large training data set, the unknown locations of the objects can be estimated effectively.

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