scholarly journals Brain state and polarity dependent modulation of brain networks by transcranial direct current stimulation

2017 ◽  
Author(s):  
Lucia M. Li ◽  
Ines R. Violante ◽  
Rob Leech ◽  
Ewan Ross ◽  
Adam Hampshire ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Large Scale ◽  
Inferior Frontal Gyrus ◽  
Brain Networks ◽  
Cognitive Networks ◽  
Network Activity ◽  
Brain State ◽  
Direct Current Stimulation ◽  
Network Activation

AbstractTranscranial direct current stimulation (TDCS) has been widely used to improve cognitive function. However, current deficiencies in mechanistic understanding hinders wider applicability. To clarify its physiological effects, we acquired fMRI whilst simultaneously acquiring TDCS to the right inferior frontal gyrus (rIFG) of healthy human participants, a region involved in coordinating activity within brain networks. TDCS caused widespread modulation of network activity depending on brain state (‘rest’ or choice reaction time task) and polarity (anodal or cathodal). During task, TDCS increased salience network activation and default mode network deactivation, but had the opposite effect during ‘rest’. Furthermore, there was an interaction between brain state and TDCS polarity, with cathodal effects more pronounced during task performance and anodal effects more pronounced during ‘rest’. Overall, we show that rIFG TDCS produces brain state and polarity dependent effects within large-scale cognitive networks, in a manner that goes beyond predictions from the current literature.

scholarly journals Effects of transcranial direct current stimulation on brain networks related to creative thinking

2020 ◽  
Author(s):  
Koji Koizumi ◽  
Kazutaka Ueda ◽  
Ziyang Li ◽  
Masayuki Nakao
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Creative Thinking ◽  
Large Scale ◽  
Brain Networks ◽  
Temporal Cortex ◽  
Brain Network ◽  
Creative Performance ◽  
Direct Current Stimulation ◽  
Delta Band

AbstractHuman creative thinking is unique and capable of generating novel and valuable ideas. Recent research has clarified the contribution of different brain networks (default mode network, DN; executive control network; salience network) to creative thinking. However, the effects of brain stimulation on brain networks during creative thinking and on creative performance have not been clarified. The present study was designed to examine the changes in functional connectivity (FC) and effective connectivity (EC) of the large-scale brain network, and the ensuing changes in creative performance, induced by transcranial direct current stimulation (tDCS). Fourteen healthy male students underwent two tDCS sessions, one with actual stimulation and one with sham stimulation, on two separate days. Participants underwent tDCS (anode over the left dorsolateral prefrontal cortex, DLPFC; cathode over the right inferior parietal lobule, IPL) for 20 minutes. Before and after the tDCS session, electroencephalography signals were acquired from 32 electrodes over the whole head during the creative thinking task. On FC analysis, the delta band FC between the posterior cingulate cortex and IPL significantly increased only after real stimulation. We also found that the change of flexibility score was significantly correlated with the change in (i) delta band FC between mPFC and left lateral temporal cortex (LTC) and (ii) alpha band FC between IPL and right LTC. On EC analysis, decreased flow within the DN (from left LTC to right IPL) was observed. Our results reveal that tDCS could affect brain networks, particularly the DN, during creative thinking and modulate key FC in the generation of flexible creative ideas.

scholarly journals Bilateral Transcranial Direct Current Stimulation Reshapes Resting-State Brain Networks: A Magnetoencephalography Assessment

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Giovanni Pellegrino ◽  
Matteo Maran ◽  
Cristina Turco ◽  
Luca Weis ◽  
Giovanni Di Pino ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Resting State ◽  
Brain Plasticity ◽  
Brain Networks ◽  
Network Activity ◽  
Double Blind Study ◽  
Double Blind ◽  
Direct Current Stimulation ◽  
Alpha Beta

Transcranial direct current stimulation (tDCS) can noninvasively induce brain plasticity, and it is potentially useful to treat patients affected by neurological conditions. However, little is known about tDCS effects on resting-state brain networks, which are largely involved in brain physiological functions and in diseases. In this randomized, sham-controlled, double-blind study on healthy subjects, we have assessed the effect of bilateral tDCS applied over the sensorimotor cortices on brain and network activity using a whole-head magnetoencephalography system. Bilateral tDCS, with the cathode (−) centered over C4 and the anode (+) centered over C3, reshapes brain networks in a nonfocal fashion. Compared to sham stimulation, tDCS reduces left frontal alpha, beta, and gamma power and increases global connectivity, especially in delta, alpha, beta, and gamma frequencies. The increase of connectivity is consistent across bands and widespread. These results shed new light on the effects of tDCS and may be of help in personalizing treatments in neurological disorders.

scholarly journals Brain state and polarity dependent modulation of brain networks by transcranial direct current stimulation

2018 ◽  
Vol 40 (3) ◽  
pp. 904-915 ◽  
Author(s):  
Lucia M. Li ◽  
Ines R. Violante ◽  
Rob Leech ◽  
Ewan Ross ◽  
Adam Hampshire ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Brain Networks ◽  
Brain State ◽  
Direct Current Stimulation

scholarly journals Modulation of large-scale brain networks by transcranial direct current stimulation evidenced by resting-state functional MRI

2012 ◽  
Vol 5 (3) ◽  
pp. 252-263 ◽  
Author(s):  
Cleofé Peña-Gómez ◽  
Roser Sala-Lonch ◽  
Carme Junqué ◽  
Immaculada C. Clemente ◽  
Dídac Vidal ◽  
...  
Keyword(s):  
Functional Mri ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Resting State ◽  
Large Scale ◽  
Brain Networks ◽  
Direct Current Stimulation

Effects of Anodal Transcranial Direct Current Stimulation (atDCS) on Sentence Comprehension

2019 ◽  
Vol 25 (3) ◽  
pp. 331-335
Author(s):  
Jarrad A. G. Lum ◽  
Gillian M. Clark ◽  
Caitlyn M. Rogers ◽  
James D. Skalkos ◽  
Ian Fuelscher ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Sentence Comprehension ◽  
Inferior Frontal Gyrus ◽  
Reaction Times ◽  
Healthy Adults ◽  
Word Comprehension ◽  
Sham Stimulation ◽  
Direct Current Stimulation ◽  
Comprehension Task

AbstractObjectives: This study examined the effects of anodal transcranial direct current stimulation (a-tDCS) on sentence and word comprehension in healthy adults. Methods: Healthy adult participants, aged between 19 and 30 years, received either a-tDCS over the left inferior frontal gyrus (n=18) or sham stimulation (n=18). Participants completed sentence comprehension and word comprehension tasks before and during stimulation. Accuracy and reaction times (RTs) were recorded as participants completed both tasks. Results: a-tDCS was found to significantly decrease RT on the sentence comprehension task compared to baseline. There was no change in RT following sham stimulation. a-tDCS was not found to have a significant effect on accuracy. Also, a-tDCS did not affect accuracy or RTs on the word comprehension task. Conclusions: The study provides evidence that non-invasive anodal electrical stimulation can modulate sentence comprehension in healthy adults, at least compared to their baseline performance. (JINS, 2019, 25, 331–335)

Anodal transcranial direct current stimulation over left inferior frontal gyrus enhances sentence comprehension

2018 ◽  
Vol 176 ◽  
pp. 36-41 ◽  
Author(s):  
Beatrice Giustolisi ◽  
Alessandra Vergallito ◽  
Carlo Cecchetto ◽  
Erica Varoli ◽  
Leonor J. Romero Lauro
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Sentence Comprehension ◽  
Inferior Frontal Gyrus ◽  
Left Inferior Frontal Gyrus ◽  
Direct Current Stimulation

scholarly journals Transcranial direct current stimulation over the left inferior frontal gyrus improves sentence comprehension

2020 ◽  
Author(s):  
Eleni Peristeri ◽  
Zeyi Wang ◽  
Olivia Herrmann ◽  
Brian Caffo ◽  
Constantine Frangakis ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Sentence Comprehension ◽  
Inferior Frontal Gyrus ◽  
Post Treatment ◽  
Lexical Retrieval ◽  
Transfer Effects ◽  
Far Transfer ◽  
Left Inferior Frontal Gyrus ◽  
Direct Current Stimulation

Background. The left inferior frontal gyrus (IFG) has been shown to be involved in sentence comprehension in many studies through its involvement in both semantic and syntactic computations. However, causal evidence for its involvement in sentence comprehension is scarce. We used transcranial direct current stimulation (tDCS) to test the causal involvement of the left IFG in sentence comprehension in a group of individuals with primary progressive aphasia (PPA). These individuals participated in a tDCS study targeting lexical retrieval only, not sentence comprehension, therefore in the present study we report on far-transfer effects of tDCS in sentence comprehension. Objective. We sought to determine whether tDCS over the left inferior frontal gyrus (IFG) coupled with lexical retrieval treatment may improve sentence comprehension in PPA. Method. Within a sham-controlled, double-blind design, we tested whether 15 daily sessions of anodal tDCS over the left IFG may improve sentence comprehension in 27 people with PPA, and whether the tDCS effects were sustained up to two months post-treatment. Results. We found that immediately post-treatment, and up to 2-months post-treatment, there was significantly larger improvement of sentence comprehension in the tDCS condition compared to sham. There were, however, differential effects of tDCS in each PPA variant and sentence-type. Importantly, participants with the epicenter of atrophy over the stimulated area (non-fluent PPA) benefited most from tDCS. Conclusion. TDCS over the left IFG induces far-transfer effects and may improve sentence comprehension in PPA. We provide causal evidence that left IFG is a critical area for sentence comprehension.

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