scholarly journals Modulation of large-scale brain networks by transcranial direct current stimulation evidenced by resting-state functional MRI

2012 ◽  
Vol 5 (3) ◽  
pp. 252-263 ◽  
Author(s):  
Cleofé Peña-Gómez ◽  
Roser Sala-Lonch ◽  
Carme Junqué ◽  
Immaculada C. Clemente ◽  
Dídac Vidal ◽  
...  
Keyword(s):  
Functional Mri ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Resting State ◽  
Large Scale ◽  
Brain Networks ◽  
Direct Current Stimulation

scholarly journals Brain state and polarity dependent modulation of brain networks by transcranial direct current stimulation

2017 ◽  
Author(s):  
Lucia M. Li ◽  
Ines R. Violante ◽  
Rob Leech ◽  
Ewan Ross ◽  
Adam Hampshire ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Large Scale ◽  
Inferior Frontal Gyrus ◽  
Brain Networks ◽  
Cognitive Networks ◽  
Network Activity ◽  
Brain State ◽  
Direct Current Stimulation ◽  
Network Activation

AbstractTranscranial direct current stimulation (TDCS) has been widely used to improve cognitive function. However, current deficiencies in mechanistic understanding hinders wider applicability. To clarify its physiological effects, we acquired fMRI whilst simultaneously acquiring TDCS to the right inferior frontal gyrus (rIFG) of healthy human participants, a region involved in coordinating activity within brain networks. TDCS caused widespread modulation of network activity depending on brain state (‘rest’ or choice reaction time task) and polarity (anodal or cathodal). During task, TDCS increased salience network activation and default mode network deactivation, but had the opposite effect during ‘rest’. Furthermore, there was an interaction between brain state and TDCS polarity, with cathodal effects more pronounced during task performance and anodal effects more pronounced during ‘rest’. Overall, we show that rIFG TDCS produces brain state and polarity dependent effects within large-scale cognitive networks, in a manner that goes beyond predictions from the current literature.

scholarly journals Effects of transcranial direct current stimulation on brain networks related to creative thinking

2020 ◽  
Author(s):  
Koji Koizumi ◽  
Kazutaka Ueda ◽  
Ziyang Li ◽  
Masayuki Nakao
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Creative Thinking ◽  
Large Scale ◽  
Brain Networks ◽  
Temporal Cortex ◽  
Brain Network ◽  
Creative Performance ◽  
Direct Current Stimulation ◽  
Delta Band

AbstractHuman creative thinking is unique and capable of generating novel and valuable ideas. Recent research has clarified the contribution of different brain networks (default mode network, DN; executive control network; salience network) to creative thinking. However, the effects of brain stimulation on brain networks during creative thinking and on creative performance have not been clarified. The present study was designed to examine the changes in functional connectivity (FC) and effective connectivity (EC) of the large-scale brain network, and the ensuing changes in creative performance, induced by transcranial direct current stimulation (tDCS). Fourteen healthy male students underwent two tDCS sessions, one with actual stimulation and one with sham stimulation, on two separate days. Participants underwent tDCS (anode over the left dorsolateral prefrontal cortex, DLPFC; cathode over the right inferior parietal lobule, IPL) for 20 minutes. Before and after the tDCS session, electroencephalography signals were acquired from 32 electrodes over the whole head during the creative thinking task. On FC analysis, the delta band FC between the posterior cingulate cortex and IPL significantly increased only after real stimulation. We also found that the change of flexibility score was significantly correlated with the change in (i) delta band FC between mPFC and left lateral temporal cortex (LTC) and (ii) alpha band FC between IPL and right LTC. On EC analysis, decreased flow within the DN (from left LTC to right IPL) was observed. Our results reveal that tDCS could affect brain networks, particularly the DN, during creative thinking and modulate key FC in the generation of flexible creative ideas.

scholarly journals Bilateral Transcranial Direct Current Stimulation Reshapes Resting-State Brain Networks: A Magnetoencephalography Assessment

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Giovanni Pellegrino ◽  
Matteo Maran ◽  
Cristina Turco ◽  
Luca Weis ◽  
Giovanni Di Pino ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Resting State ◽  
Brain Plasticity ◽  
Brain Networks ◽  
Network Activity ◽  
Double Blind Study ◽  
Double Blind ◽  
Direct Current Stimulation ◽  
Alpha Beta

Transcranial direct current stimulation (tDCS) can noninvasively induce brain plasticity, and it is potentially useful to treat patients affected by neurological conditions. However, little is known about tDCS effects on resting-state brain networks, which are largely involved in brain physiological functions and in diseases. In this randomized, sham-controlled, double-blind study on healthy subjects, we have assessed the effect of bilateral tDCS applied over the sensorimotor cortices on brain and network activity using a whole-head magnetoencephalography system. Bilateral tDCS, with the cathode (−) centered over C4 and the anode (+) centered over C3, reshapes brain networks in a nonfocal fashion. Compared to sham stimulation, tDCS reduces left frontal alpha, beta, and gamma power and increases global connectivity, especially in delta, alpha, beta, and gamma frequencies. The increase of connectivity is consistent across bands and widespread. These results shed new light on the effects of tDCS and may be of help in personalizing treatments in neurological disorders.

The Effect of Prefrontal Transcranial Direct Current Stimulation on Resting State Functional Connectivity

2017 ◽  
Vol 41 (S1) ◽  
pp. S33-S34
Author(s):  
D. Keeser
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Motor Cortex ◽  
Functional Mri ◽  
Direct Current ◽  
Brain Stimulation ◽  
Transcranial Direct Current Stimulation ◽  
Resting State ◽  
State Dependency ◽  
Direct Current Stimulation

Transcranial direct current stimulation (tDCS) of the prefrontal cortex (PFC) is currently investigated as therapeutic non-invasive brain stimulation (NIBS) approach in major depressive (MDD) and other neuropsychiatric disorders. In both conditions, different sub regions of the PFC (e.g. the dorsolateral prefrontal cortex, the dorsomedial prefrontal cortex and others) are critically involved in their respective pathophysiology. Although the neurophysiological properties of tDCS have been extensively investigated at the motor cortex level, the action of PFC tDCS on resting state and functional MRI connectivity of neural networks is largely unexplored. Beyond motor cortex paradigms, we aim to establish a model for PFC tDCS modulating functional connectivity in different conditions to provide tailored tDCS protocols for clinical efficacy studies in major psychiatric disorders such as MDD and schizophrenia. One major obstacle in brain research is that patients represent themselves as individuals not as groups. Recent research has shown that the individual human brain functional MRI connectivity shows different within-variability than the variability found between subjects. Several neuroimaging methods may be useful to find a classifier that can be reliable used to predict NIBS effects. These neuroimaging methods include individual brain properties as well as the evaluation of state-dependency. Anatomical targeted analyses of rTMS and tDCS in neuropsychiatric patients and healthy subjects have found promising results.By combining neuroimaging and NIBS new functional models can be developed and compared in different health and pathology states, e.g. in the development of any given psychiatric disorder.Disclosure of interestSupported by the Federal Ministry of Research and Education (“Forschungsnetz für psychische Erkrankungen”, German Center for Brain Stimulation–GCBS–WP5).

Transcranial direct current stimulation increases resting state interhemispheric connectivity

2013 ◽  
Vol 539 ◽  
pp. 7-10 ◽  
Author(s):  
Chang-hyun Park ◽  
Won Hyuk Chang ◽  
Ji-Young Park ◽  
Yong-Il Shin ◽  
Sung Tae Kim ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Resting State ◽  
Direct Current Stimulation ◽  
Interhemispheric Connectivity
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