scholarly journals Pitch discrimination performance of ferrets and humans on a go/no-go task

2017 ◽  
Author(s):  
Kerry MM Walker ◽  
Amelia Davies ◽  
Jennifer K Bizley ◽  
Jan WH Schnupp ◽  
Andrew J King
Keyword(s):  
Discrimination Performance ◽  
Forced Choice ◽  
Pitch Discrimination ◽  
List Type ◽  
Human Species ◽  
Detection Thresholds ◽  
Pitch Processing ◽  
Pitch Change ◽  
2Afc Task ◽  
Neurophysiological Basis

ABSTRACTAnimal models are widely used to examine the neurophysiological basis of human pitch perception, and it is therefore important to understand the similarities and differences in pitch processing across species. Pitch discrimination performance is usually measured using two-alternative forced choice (2AFC) procedures in humans and go/no-go tasks in animals, potentially confounding human-to-animal comparisons. We have previously shown that pitch discrimination thresholds of ferrets on a 2AFC task are markedly poorer than those reported for go/no-go tasks in other non-human species (Walker et al., 2009). To better compare the pitch discrimination performance of ferret with other species, here we measure pitch change detection thresholds of ferrets and humans on a common, appetitive go/no-go task design. We found that ferrets’ pitch thresholds were ~10 times larger than that of humans on the go/no-go task, and were within the range of thresholds reported in other non-human species. Interestingly, ferrets’ thresholds were 100 times larger than human thresholds on a 2AFC pitch discrimination task using the same stimuli. These results emphasize that sensory discrimination thresholds can differ across tasks, particularly for non-human animals. Performance on our go/no-go task is likely to reflect different neurobiological processes than that on our 2AFC task, as the former required the subjects only to detect a pitch change while the latter required them to label the direction of the pitch change.ABBREVIATIONS2AFC2-Alternative Forced ChoiceF0Fundamental FrequencyHIGHLIGHTSPitch discrimination thresholds of ferrets were 10 times larger than those of humans on a go/no-go taskFerrets’ pitch thresholds are similar to those reported for a range of other mammalsPitch thresholds of ferrets, but not humans, were drastically better on the go/no-go task than a 2AFC task using the same stimuli

SPECIAL PROBLEMS IN TOXICITY TESTING OF LONG ACTING DEPOT CONTRACEPTIVES

1974 ◽  
Vol 77 (1_Suppla) ◽  
pp. S315-S354 ◽  
Author(s):  
F. Neumann ◽  
R. von Berswordt-Wallrabe ◽  
W. Elger ◽  
K.-J. Gräf ◽  
S. H. Hasan ◽  
...  
Keyword(s):  
Biological Effects ◽  
Histological Finding ◽  
Toxicity Testing ◽  
Prolactin Secretion ◽  
List Type ◽  
Human Species ◽  
Prolactin Plasma Level ◽  
Human Use ◽  
Long Acting ◽  
Reproductive Processes

ABSTRACT Two types of so-called "depot contraceptives", long-acting steroids which are of interest for human use, were studied in animals. Norethisterone oenanthate, mainly gestagenic in the human and other species, turned out to be predominantly oestrogenic in rats. This oestrogenicity caused indirectly, via an enhanced hypophysial prolactin secretion, the well-known hypophysial and mammary tumours in rats. Another synthetic gestagen, 4,6-dichloro- 17- acetoxy- 16α-methyl-4,6-pregnadiene-3,20-dione, which might be considered in its biological actions similar to preparations containing chlormadinone acetate or medroxy-progesterone acetate, induced no signs of oestrogenicity in dogs. It is surmised that its gestagenic influence indirectly, and probaby, via an enhanced hypophysial prolactin secretion caused "mammary nodules" in this "non-rodent" species. These studies have born out mainly two facts: A synthetic steroid, norethisterone oenanthate, exerted different biological effects in different species: it was a gestagen in the rabbit, whereas in rats, its predominant influence was oestrogenic. The hypophysial prolactin secretion was enhanced in various species by different mechanisms: in rats, the oestrogenicity caused an increased prolactin plasma level, whereas in dogs, a gestagen with obviously no inherent oestrogenicity, 4,6-dichloro-17-acetoxy-16α-methyl-4,6-pregnadiene-3,20-dione, converted the histological appearance of the anterior pituitary into a condition with a greatly increased number of eosinophils. This histological finding was interpreted as an indicator for a hypersecretion of prolactin. Hence, animal work with "gestagens" has only limited predictive value with respect to their possible effects in the human species. Therefore, inflexible recommendations are not helpful in solving the safety problem of long-acting steroids which affect primarily reproductive processes.

The Influence of the Psychophysical Assessment Paradigm on Pitch Discrimination for Adults (and a Pilot Sample of Children)

2021 ◽  
pp. 003151252110440
Author(s):  
Ashley G. Flagge ◽  
Lucile Puranen ◽  
Madhuri S. Mulekar
Keyword(s):  
Discrimination Performance ◽  
Assessment Method ◽  
Pitch Discrimination ◽  
Adult Women ◽  
Language And Literacy ◽  
Discrimination Accuracy ◽  
Discrimination Ability ◽  
Research Paradigms ◽  
Pilot Sample ◽  
Pattern Of Performance

Pitch discrimination ability has been of research interest due to its potential relationship to language and literacy. However, assessment protocols for pitch discrimination have varied widely. Prior studies with both children and adults have produced conflicting performance findings across different pitch discrimination research paradigms, though they have consistently shown that discrimination accuracy is based on the psychophysical assessment method applied. In the present study, we examined pitch discrimination performance among convenience samples of 19 adult women and ten female children across six different adaptive psychophysical measurement conditions. We found pitch discrimination performance in both groups to be impacted by the measurement paradigm such that, while adults exhibited significantly better discrimination thresholds than did children, the pattern of performance across the six conditions was similar for both the adults and the children.

scholarly journals Meta-analytic evidence for the non-modularity of pitch processing in congenital amusia

2020 ◽  
Author(s):  
Dominique T Vuvan ◽  
Marília Nunes-Silva ◽  
Isabelle Peretz
Keyword(s):  
Meta Analysis ◽  
Pitch Perception ◽  
Developmental Trajectory ◽  
Pitch Discrimination ◽  
Major Theme ◽  
Performance Gap ◽  
Pitch Processing ◽  
Congenital Amusia ◽  
Musical Pitch ◽  
Using Data

A major theme driving research in congenital amusia is related to the modularity of this musical disorder, with two possible sources of the amusic pitch perception deficit. The first possibility is that the amusic deficit is due to a broad disorder of acoustic pitch processing that has the effect of disrupting downstream musical pitch processing, and the second is that amusia is specific to a musical pitch processing module. To interrogate these hypotheses, we performed a meta-analysis on two types of effect sizes contained within 42 studies in the amusia literature: the performance gap between amusics and controls on tasks of pitch discrimination, broadly defined, and the correlation between specifically acoustic pitch perception and musical pitch perception. To augment the correlation database, we also calculated this correlation using data from 106 participants tested by our own research group. We found strong evidence for the acoustic account of amusia. The magnitude of the performance gap was moderated by the size of pitch change, but not by whether the stimuli were composed of tones or speech. Furthermore, there was a significant correlation between an individual's acoustic and musical pitch perception. However, individual cases show a double dissociation between acoustic and musical processing, which suggests that although most amusic cases are probably explainable by an acoustic deficit, there is heterogeneity within the disorder. Finally, we found that tonal language fluency does not influence the performance gap between amusics and controls, and that there was no evidence that amusics fare worse with pitch direction tasks than pitch discrimination tasks. These results constitute a quantitative review of the current literature of congenital amusia, and suggest several new directions for research, including the experimental induction of amusic behaviour through transcranial magnetic stimulation (TMS) and the systematic exploration of the developmental trajectory of this disorder.

Estimating discrimination performance in two-alternative forced choice tasks: Routines for MATLAB and R

2012 ◽  
Vol 44 (4) ◽  
pp. 1157-1174 ◽  
Author(s):  
Karin M. Bausenhart ◽  
Oliver Dyjas ◽  
Dirk Vorberg ◽  
Rolf Ulrich
Keyword(s):  
Discrimination Performance ◽  
Forced Choice ◽  
Forced Choice Tasks ◽  
Choice Tasks

Global and Local Contributions to the Optical Specification of Time to Contact: Observer Sensitivity to Composite Tau

Perception ◽  
10.1068/p3230 ◽  
2002 ◽  
Vol 31 (8) ◽  
pp. 901-924 ◽  
Author(s):  
Reinoud J Bootsma ◽  
Cathy M Craig
Keyword(s):  
Discrimination Performance ◽  
Forced Choice ◽  
Object Motion ◽  
Time To Contact ◽  
Local Expansion ◽  
First Order ◽  
Optical Distance ◽  
Observer Motion ◽  
Environmental Element ◽  
Global And Local

First-order time remaining until a moving observer will pass an environmental element is optically specified in two different ways. The specification provided by global tau (based on the pattern of change of angular bearing) requires that the element is stationary and that the direction of motion is accurately detected, whereas the specification provided by composite tau (based on the patterns of change of optical size and optical distance) does not require either of these. We obtained converging evidence for our hypothesis that observers are sensitive to composite tau in four experiments involving relative judgments of time to passage with forced-choice methodology. Discrimination performance was enhanced in the presence of a local expansion component, while being unaffected when the detection of the direction of heading was impaired. Observers relied on the information carried in composite tau rather than on the information carried in its constituent components. Finally, performance was similar under conditions of observer motion and conditions of object motion. Because composite tau specifies first-order time remaining for a large number of situations, the different ways in which it may be detected are discussed.

Tonal Expectations Influence Early Pitch Processing

2011 ◽  
Vol 23 (10) ◽  
pp. 3095-3104 ◽  
Author(s):  
Frédéric Marmel ◽  
Fabien Perrin ◽  
Barbara Tillmann
Keyword(s):  
Discrimination Task ◽  
Pitch Perception ◽  
Attentional Selection ◽  
Pitch Discrimination ◽  
Musical Note ◽  
Pitch Processing ◽  
Selection Of

The present study investigated the ERP correlates of the influence of tonal expectations on pitch processing. Participants performed a pitch discrimination task between penultimate and final tones of melodies. These last two tones were a repetition of the same musical note, but penultimate tones were always in tune whereas final tones were slightly out of tune in half of the trials. The pitch discrimination task allowed us to investigate the influence of tonal expectations in attentive listening and, for penultimate tones, without being confounded by decisional processes (occurring on final tones). Tonal expectations were manipulated by a tone change in the first half of the melodies that changed their tonality, hence changing the tonal expectedness of penultimate and final tones without modifying them acoustically. Manipulating tonal expectations with minimal acoustic changes allowed us to focus on the cognitive expectations based on listeners' knowledge of tonal structures. For penultimate tones, tonal expectations modulated processing within the first 100 msec after onset resulting in an Nb/P1 complex that differed in amplitude between tonally related and less related conditions. For final tones, out-of-tune tones elicited an N2/P3 complex and, on in-tune tones only, tonal manipulation elicited an ERAN/RATN-like negativity overlapping with the N2. Our results suggest that cognitive tonal expectations can influence pitch perception at several steps of processing, starting with early attentional selection of pitch.

scholarly journals A sliding two-alternative forced-choice paradigm for pitch discrimination

2017 ◽  
Vol 142 (1) ◽  
pp. 167-172 ◽  
Author(s):  
Dorothée Arzounian ◽  
Mathilde de Kerangal ◽  
Alain de Cheveigné
Keyword(s):  
Forced Choice ◽  
Pitch Discrimination

scholarly journals Midfrontal theta and pupil dilation parametrically track subjective conflict (but also surprise) during intertemporal choice

2017 ◽  
Author(s):  
Hause Lin ◽  
Blair Saunders ◽  
Cendri A Hutcherson ◽  
Michael Inzlicht
Keyword(s):  
Intertemporal Choice ◽  
Economic Modeling ◽  
Pupil Dilation ◽  
Self Control ◽  
Neural Systems ◽  
List Type ◽  
Costs And Benefits ◽  
Eeg Data ◽  
Adaptive Shifts ◽  
Neurophysiological Basis

AbstractMany everyday choices are based on personal, subjective preferences. When choosing between two options, we often feel conflicted, especially when trading off costs and benefits occurring at different times (e.g., saving for later versus spending now). Although previous work has investigated the neurophysiological basis of conflict during inhibitory control tasks, less is known about subjective conflict resulting from competing subjective preferences. In this pre-registered study, we investigated subjective conflict during intertemporal choice, whereby participants chose between smaller immediate versus larger delayed rewards (e.g., $15 today vs. $22 in 30 days). We used economic modeling to parametrically vary eleven different levels of conflict, and recorded EEG data and pupil dilation. Midfrontal theta power, derived from EEG, correlated with pupil responses, and our results suggest that these signals track different gradations of subjective conflict. Unexpectedly, both signals were also maximally enhanced when decisions were surprisingly easy. Therefore, these signals may track events requiring increased attention and adaptive shifts in behavioral responses, with subjective conflict being only one type of such event. Our results suggest that the neural systems underlying midfrontal theta and pupil responses interact when weighing costs and benefits during intertemporal choice. Thus, understanding these interactions might elucidate how individuals resolve self-control conflicts.HighlightsModeled conflict during intertemporal choice and measured EEG and pupil responses.Midfrontal theta and pupil responses parametrically tracked subjective conflict.But theta and pupil responses were also large when decisions were surprisingly easy.These signals may implement adaptive control during value-guided choice.

Sign in / Sign up

Export Citation Format

Share Document