scholarly journals Distinct sources of deterministic and stochastic components of action timing decisions in rodent frontal cortex

2016 ◽  
Author(s):  
Masayoshi Murakami ◽  
Hanan Shteingart ◽  
Yonatan Loewenstein ◽  
Zachary F. Mainen
Keyword(s):  
Frontal Cortex ◽  
Neural Circuits ◽  
Internal State ◽  
Theoretical Models ◽  
Neural Dynamics ◽  
Stochastic Choice ◽  
Electrophysiological Recordings ◽  
Timing Decisions ◽  
Action Timing ◽  
Differential Coding

SUMMARYThe selection and timing of actions are subject to determinate influences such as sensory cues and internal state as well as to effectively stochastic variability. Although stochastic choice mechanisms are assumed by many theoretical models, their origin and mechanisms remain poorly understood. Here we investigated this issue by studying how neural circuits in the frontal cortex determine action timing in rats performing a waiting task. Electrophysiological recordings from two regions necessary for this behavior, medial prefrontal cortex (mPFC) and secondary motor cortex (M2), revealed an unexpected functional dissociation. Both areas encoded deterministic biases in action timing, but only M2 neurons reflected stochastic trial-by-trial fluctuations. This differential coding was reflected in distinct timescales of neural dynamics in the two frontal cortical areas. These results suggest a two-stage model in which stochastic components of action timing decisions are injected by circuits downstream of those carrying deterministic bias signals.

scholarly journals Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex

Neuron ◽  
2017 ◽  
Vol 94 (4) ◽  
pp. 908-919.e7 ◽  
Author(s):  
Masayoshi Murakami ◽  
Hanan Shteingart ◽  
Yonatan Loewenstein ◽  
Zachary F. Mainen
Keyword(s):  
Frontal Cortex ◽  
Timing Decisions ◽  
Action Timing

scholarly journals Cortical processing of chemosensory and hedonic features of taste in active licking mice

2020 ◽  
Author(s):  
Cecilia Bouaichi ◽  
Roberto Vincis
Keyword(s):  
Fixed Ratio ◽  
Stereotyped Behavior ◽  
Neural Dynamics ◽  
Ratio Schedule ◽  
Neural Processing ◽  
Fixed Ratio Schedule ◽  
Gustatory Cortex ◽  
Electrophysiological Recordings ◽  
Taste Processing ◽  
To Receive

ABSTRACTIn the last two decades, a considerable amount of work has been devoted to investigating the neural processing and dynamics of the primary taste cortex of rats. Surprisingly, much less information is available on cortical taste electrophysiology in awake mice, an animal model that is taking a more prominent role in taste research. Here we present electrophysiological evidence demonstrating how the gustatory cortex (GC) encodes information pertaining the basic taste qualities (sweet, salty, sour, and bitter) when stimuli are actively sampled through licking, the stereotyped behavior by which mice control the access of fluids in the mouth. Mice were trained to receive each stimulus on a fixed ratio schedule in which they had to lick a dry spout six times to receive a tastant on the seventh lick. Electrophysiological recordings confirmed that GC neurons encode both chemosensory and hedonic aspects of actively sampled tastants. In addition, our data revealed two other main findings; GC neurons encoded information about taste identity in as little as 120 ms. Consistent with the ability of GC neurons to rapidly encode taste information, nearly half of the recorded neurons exhibited spiking activity that was entrained to licking at rates up to 8 Hz. Overall, our results highlight how the GC of mice processes tastants when they are actively sensed through licking, reaffirming and expanding our knowledge on cortical taste processing.NEW & NOTEWORTHYRelatively little information is available on the neural dynamics of taste processing in the mouse gustatory cortex (GC). In this study we investigate how the GC encodes information of the qualities and hedonics of a broad panel of gustatory stimuli when tastants are actively sampled through licking. Our results show that the GC neurons broadly encode taste qualities but also process taste hedonics and licking information in a temporally dynamic manner.

scholarly journals Genetic variation in dispersal plasticity in an aquatic host-parasite model system

2020 ◽  
Author(s):  
Giacomo Zilio ◽  
Louise Solveig Noergaard ◽  
Giovanni Petrucci ◽  
Nathalie Zeballos ◽  
Claire Gougat-Barbera ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Internal State ◽  
Theoretical Models ◽  
Infection Prevalence ◽  
Main Role ◽  
Dependent Plasticity ◽  
Evolutionary Forces ◽  
State Dependent ◽  
Context Dependent ◽  
Host Parasite

Dispersal plays a main role in determining spatial dynamics, and both theory and empirical evidence indicate that evolutionary optima exist for constitutive or plastic dispersal behaviour. Plasticity in dispersal can be influenced by factors both internal (state-dependent) or external (context-dependent) to individuals. Parasitism is interesting in this context, as it can influence both types of host dispersal plasticity: individuals can disperse in response to internal infection status but might also respond to the presence of infected individuals around them. We still know little about the driving evolutionary forces of host dispersal plasticity, but a first requirement is the presence of a genetic basis on which natural selection can act. In this study, we used microcosm dispersal mazes to investigate plastic dispersal of 20 strains of the freshwater protist Paramecium caudatum in response to the bacterial parasite Holospora undulata. We additionally quantified the genetic component of the plastic responses, i.e. the heritability of state- and context-depended dispersal. We found that infection by the parasite can either increase or decrease dispersal of individual strains relative to the uninfected (state-dependent plasticity), and this to be heritable. We also found strain-specific change of dispersal of uninfected Paramecium when exposed to variable infection prevalence (context-dependent plasticity) with very low level of heritability. To our knowledge, this is the first explicit empirical demonstration and quantification of genetic variation of plastic dispersal in a host-parasite system, which could have important implications for meta-population and epidemiological dynamics. We discuss some of the underlying mechanisms of this variation and link our results to the existing theoretical models.

scholarly journals Behavioural adjustment of fish to temporal variation in fishing pressure affects catchability: an experiment with angled trout

2020 ◽  
Vol 77 (1) ◽  
pp. 188-193 ◽  
Author(s):  
Barbara Koeck ◽  
Magnus Lovén Wallerius ◽  
Robert Arlinghaus ◽  
Jörgen I. Johnsson
Keyword(s):  
Temporal Variation ◽  
Internal State ◽  
Empirical Support ◽  
Population Level ◽  
Theoretical Models ◽  
Fishing Effort ◽  
Threat Perception ◽  
Fishing Pressure ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Catch Rates

In passive fisheries, such as angling, the fishing success depends on the ultimate decision of a fish to ingest the bait, based on an individual’s internal state, previous experience, and threat perception. Fish surviving capture by anglers are known to be less vulnerable, and catch rates usually quickly decline with increasing fishing effort. Previous theoretical models have thus suggested fishing closures as a means to recover responsiveness of fish to angling gear and maintain catch rates, yet empirical support remains limited. In a controlled replicated pond experiment, we evaluated the effects of temporal variation in fishing pressure on catch rates of rainbow trout (Oncorhynchus mykiss) by simulating short-term fishing closures. Fishing closures increased catch rates and population-level catchability by reducing threat perception at the population level and allowing released individuals to return to a vulnerable state. Our experimental results show that periodic fishing closures benefit catch rates but at the risk of aggravating the likelihood of overharvesting.

scholarly journals Hierarchical reasoning by neural circuits in the frontal cortex

Science ◽  
2019 ◽  
Vol 364 (6441) ◽  
pp. eaav8911 ◽  
Author(s):  
Morteza Sarafyazd ◽  
Mehrdad Jazayeri
Keyword(s):  
Frontal Cortex ◽  
Neural Circuits ◽  
Anterior Cingulate ◽  
Cortical Circuits ◽  
Neural Basis ◽  
Stimulus Response ◽  
Response Contingency ◽  
Dorsomedial Frontal Cortex ◽  
Reasoning Strategy ◽  
Additional Perturbation

Humans process information hierarchically. In the presence of hierarchies, sources of failures are ambiguous. Humans resolve this ambiguity by assessing their confidence after one or more attempts. To understand the neural basis of this reasoning strategy, we recorded from dorsomedial frontal cortex (DMFC) and anterior cingulate cortex (ACC) of monkeys in a task in which negative outcomes were caused either by misjudging the stimulus or by a covert switch between two stimulus-response contingency rules. We found that both areas harbored a representation of evidence supporting a rule switch. Additional perturbation experiments revealed that ACC functioned downstream of DMFC and was directly and specifically involved in inferring covert rule switches. These results‏ reveal the computational principles of hierarchical reasoning, as implemented by cortical circuits.

scholarly journals Neural Circuits Underlying Behavioral Flexibility: Insights From Drosophila

2022 ◽  
Vol 15 ◽  
Author(s):  
Anita V. Devineni ◽  
Kristin M. Scaplen
Keyword(s):  
Drosophila Melanogaster ◽  
Neural Circuits ◽  
Neural Circuit ◽  
Internal State ◽  
Behavioral Responses ◽  
Behavioral Flexibility ◽  
Environmental Context ◽  
Behavioral State ◽  
Insight Into

Behavioral flexibility is critical to survival. Animals must adapt their behavioral responses based on changes in the environmental context, internal state, or experience. Studies in Drosophila melanogaster have provided insight into the neural circuit mechanisms underlying behavioral flexibility. Here we discuss how Drosophila behavior is modulated by internal and behavioral state, environmental context, and learning. We describe general principles of neural circuit organization and modulation that underlie behavioral flexibility, principles that are likely to extend to other species.

scholarly journals Imaging Voltage with Microbial Rhodopsins

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiao Min Zhang ◽  
Tatsushi Yokoyama ◽  
Masayuki Sakamoto
Keyword(s):  
Membrane Potential ◽  
Brain Function ◽  
Critical Parameter ◽  
Neural Circuits ◽  
Superior Performance ◽  
Neuronal Dynamics ◽  
Spatiotemporal Resolution ◽  
Invasive Approach ◽  
Electrophysiological Recordings ◽  
Genetic Specificity

Membrane potential is the critical parameter that reflects the excitability of a neuron, and it is usually measured by electrophysiological recordings with electrodes. However, this is an invasive approach that is constrained by the problems of lacking spatial resolution and genetic specificity. Recently, the development of a variety of fluorescent probes has made it possible to measure the activity of individual cells with high spatiotemporal resolution. The adaptation of this technique to image electrical activity in neurons has become an informative method to study neural circuits. Genetically encoded voltage indicators (GEVIs) can be used with superior performance to accurately target specific genetic populations and reveal neuronal dynamics on a millisecond scale. Microbial rhodopsins are commonly used as optogenetic actuators to manipulate neuronal activities and to explore the circuit mechanisms of brain function, but they also can be used as fluorescent voltage indicators. In this review, we summarize recent advances in the design and the application of rhodopsin-based GEVIs.

Intersubjectivity and Embodied Communication Systems

2012 ◽  
Vol 4 (1) ◽  
pp. 125-138
Author(s):  
Maurizio Gentilucci ◽  
Claudia Gianelli ◽  
Giovanna Cristina Campione
Keyword(s):  
Frontal Cortex ◽  
Cognitive Processes ◽  
Communication Systems ◽  
Neural Circuits ◽  
Neural Correlates ◽  
Spoken Language ◽  
Present Review ◽  
Embodied Communication ◽  
Symbolic Gestures ◽  
Transitive Actions

Abstract Both intersubjectivity and embodied cognitive processes are based on mechanisms for sharing actions, common to the species. The evolution of spoken language and of communication systems in general are good examples of this. In the present review, we propose that, by a process of observation and imitation, the sharing of object-directed actions (i.e., transitive arm/hand actions) and their pantomimes could have been used to progressively construct communication systems capable of representing action meaning (i.e., their goals). Starting from this process of observation and imitation, humans may have constructed progressively more complex communication systems based on iconic and symbolic arm gestures. These communication systems may have gradually been translated into more specific, buccal, gesture-based systems that gave rise to spoken language. In support of these hypotheses, we report evidence showing that the execution and observation of transitive actions and their pantomimes affects the production of phonological units. We describe the effects of the production and observation of symbolic gestures on word pronunciation. Finally, we report evidence that these systems relating gesture to speech have neural correlates in neural circuits located in the frontal cortex, understood to be involved in spoken language..

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