scholarly journals Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

2015 ◽  
Author(s):  
Elise B Robinson ◽  
Beate St Pourcain ◽  
Verneri Anttila ◽  
Jack Kosmicki ◽  
Brendan Bulik-Sullivan ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
General Population ◽  
Genetic Risk ◽  
Adaptive Functioning ◽  
De Novo ◽  
Neuropsychiatric Symptoms ◽  
Population Based ◽  
Autism Spectrum ◽  
Spectrum Disorders ◽  
Almost All

Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of that risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortia and population based resources, we find genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both inherited and de novo variation, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in an ASD or other neuropsychiatric disorder diagnosis. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology.

Homogeneous Combinations of ASD–ADHD Traits and Their Cognitive and Behavioral Correlates in a Population-Based Sample

2014 ◽  
Vol 21 (9) ◽  
pp. 753-763 ◽  
Author(s):  
Jolanda M. J. van der Meer ◽  
Martijn G. A. Lappenschaar ◽  
Catharina A. Hartman ◽  
Corina U. Greven ◽  
Jan K. Buitelaar ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
General Population ◽  
Cognitive Functioning ◽  
Latent Class ◽  
Population Based ◽  
Autism Spectrum ◽  
Behavioral Correlates ◽  
Visual Spatial ◽  
Latent Class Analyses ◽  
Spectrum Disorders

Objective: Autism Spectrum Disorders (ASD) and ADHD are assumed to be the extreme manifestations of continuous heterogeneous traits that frequently co-occur. This study aims to identify subgroups of children with distinct ASD–ADHD trait profiles in the general population, using measures sensitive across both trait continua, and show how these subgroups differ in cognitive functioning. Method: We examined 378 children (6-13 years) from a population-based sample. Results: Latent class analyses (LCA) detected three concordant classes with low (10.1%), medium (54.2%), or high (13.2%) scores on both traits, and two discordant classes with more ADHD than ASD characteristics (ADHD > ASD, 18.3%) and vice versa (ASD > ADHD, 4.2%). Findings suggest that ASD and ADHD traits usually are strongly related in the unaffected population, and that a minority of children displays atypical discordant trait profiles characterized by differential visual-spatial functioning. Conclusion: This dissociation suggests that heterogeneity in ASD and ADHD is rooted in heterogeneity in the lower unaffected end of the distribution.

scholarly journals Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

2016 ◽  
Vol 48 (5) ◽  
pp. 552-555 ◽  
Author(s):  
Elise B Robinson ◽  
◽  
Beate St Pourcain ◽  
Verneri Anttila ◽  
Jack A Kosmicki ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
General Population ◽  
Genetic Risk ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals Early Adaptive Functioning Trajectories in Preschoolers With Autism Spectrum Disorders

2018 ◽  
Vol 43 (7) ◽  
pp. 800-813 ◽  
Author(s):  
Martina Franchini ◽  
Daniela Zöller ◽  
Edouard Gentaz ◽  
Bronwyn Glaser ◽  
Hilary Wood de Wilde ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Adaptive Functioning ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals Autism Spectrum Disorders and Race, Ethnicity, and Nativity: A Population-Based Study

PEDIATRICS ◽  
2014 ◽  
Vol 134 (1) ◽  
pp. e63-e71 ◽  
Author(s):  
T. A. Becerra ◽  
O. S. von Ehrenstein ◽  
J. E. Heck ◽  
J. Olsen ◽  
O. A. Arah ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Population Based ◽  
Autism Spectrum ◽  
Population Based Study ◽  
Race Ethnicity ◽  
Spectrum Disorders

scholarly journals CACNA1D De Novo Mutations in Autism Spectrum Disorders Activate Cav1.3 L-Type Calcium Channels

2015 ◽  
Vol 77 (9) ◽  
pp. 816-822 ◽  
Author(s):  
Alexandra Pinggera ◽  
Andreas Lieb ◽  
Bruno Benedetti ◽  
Michaela Lampert ◽  
Stefania Monteleone ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Calcium Channels ◽  
De Novo ◽  
Autism Spectrum ◽  
De Novo Mutations ◽  
Spectrum Disorders

scholarly journals Early screening and diagnosis of autism spectrum disorders in Vietnam: A population-based cross-sectional survey

2021 ◽  
Author(s):  
Le Thi Vui ◽  
Duong Minh Duc ◽  
Nguyen Thuy Quynh ◽  
Nguyen Thi Huong Giang ◽  
Vu Thi Thanh Mai ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Early Detection ◽  
Public Health Problem ◽  
Population Based ◽  
Autism Spectrum ◽  
Urban Setting ◽  
Cross Sectional ◽  
Middle Income ◽  
Middle Income Countries ◽  
Spectrum Disorders

Background: Early detection of autism spectrum disorders (ASDs) is essential given the under-reported cases in low- and middle-income countries. This first national representative survey was conducted to explore the prevalence of ASDs amongst 18 and 30 months in seven provinces in Vietnam.Design and Method: During 2017- 2018, a national cross-sectional and population-based survey for autism spectrum disorder (ASD) amongst 40,243 children aged 18 to 30 months was conducted in 7 provinces representing the socio-economic regions of Vietnam. M-CHAT was used to screen children and then confirmed by diagnostic assessment using DSM-IV criteria.Results: The prevalence of ASDs amongst children aged 18 and 30 months in Vietnam was high (0.758% or 1 in 132 children). Urban setting, male gender, and hereditable genes were associated with ASD prevalence.Conclusion: ASDs amongst children aged 18 and 30 months in Vietnam tend to be increasing and are similar to this rate in other middle-income countries but lower than that in Western countries. This under-recognized public health problem amongst children should be addressed by early detection and intervention for families with affected children.

scholarly journals Possible Endophenotypes in the Search for Genetic Risk Factors in Autism Spectrum Disorders

10.5772/60039 ◽  
2015 ◽  
Author(s):  
Adriana Díaz-Anzaldúa ◽  
Rigoberto Rosendo Gutiérrez ◽  
Alejandro Díaz-Anzaldúa ◽  
José Octavio Hernández Lagunas
Keyword(s):  
Risk Factors ◽  
Autism Spectrum Disorders ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals Prenatal antibiotics exposure and the risk of autism spectrum disorders: A population-based cohort study

PLoS ONE ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. e0221921 ◽  
Author(s):  
Amani F. Hamad ◽  
Silvia Alessi-Severini ◽  
Salaheddin M. Mahmud ◽  
Marni Brownell ◽  
I fan Kuo
Keyword(s):  
Cohort Study ◽  
Autism Spectrum Disorders ◽  
Population Based ◽  
Autism Spectrum ◽  
Spectrum Disorders
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