scholarly journals Challenges of Analysing Gene-Environment Interactions in Mouse Models of Schizophrenia

2011 ◽  
Vol 11 ◽  
pp. 1411-1420 ◽  
Author(s):  
Peter L. Oliver
Keyword(s):  
Comparative Analysis ◽  
Prenatal Stress ◽  
Pathogenic Mutation ◽  
New Approach ◽  
Neuropsychiatric Disease ◽  
Environmental Manipulation ◽  
Gene Environment ◽  
New Models ◽  
Stress Models ◽  
The Relationship

The modelling of neuropsychiatric disease using the mouse has provided a wealth of information regarding the relationship between specific genetic lesions and behavioural endophenotypes. However, it is becoming increasingly apparent that synergy between genetic and nongenetic factors is a key feature of these disorders that must also be taken into account. With the inherent limitations of retrospective human studies, experiments in mice have begun to tackle this complex association, combining well-established behavioural paradigms and quantitative neuropathology with a range of environmental insults. The conclusions from this work have been varied, due in part to a lack of standardised methodology, although most have illustrated that phenotypes related to disorders such as schizophrenia are consistently modified. Far fewer studies, however, have attempted to generate a “two-hit” model, whereby the consequences of a pathogenic mutation are analysed in combination with environmental manipulation such as prenatal stress. This significant, yet relatively new, approach is beginning to produce valuable new models of neuropsychiatric disease. Focussing on prenatal and perinatal stress models of schizophrenia, this review discusses the current progress in this field, and highlights important issues regarding the interpretation and comparative analysis of such complex behavioural data.

Colonialism and the Highland Clearances

2017 ◽  
Vol 8 (1) ◽  
pp. 22-48 ◽  
Author(s):  
Iain Mackinnon
Keyword(s):  
Industrial Development ◽  
Comparative Approach ◽  
Indigenous Research ◽  
Internal Colonialism ◽  
New Approach ◽  
A Site ◽  
Relationship Of ◽  
The Relationship ◽  
Imperial State ◽  
Late Modern

This article employs a new approach to studying internal colonialism in northern Scotland during the 18th and 19th centuries. A common approach to examining internal colonial situations within modern state territories is to compare characteristics of the internal colonial situation with attested attributes of external colonial relations. Although this article does not reject the comparative approach, it seeks to avoid criticisms that this approach can be misleading by demonstrating that promoters and managers of projects involving land use change, territorial dispossession and industrial development in the late modern Gàidhealtachd consistently conceived of their work as projects of colonization. It further argues that the new social, cultural and political structures these projects imposed on the area's indigenous population correspond to those found in other colonial situations, and that racist and racialist attitudes towards Gaels of the time are typical of those in colonial situations during the period. The article concludes that the late modern Gàidhealtachd has been a site of internal colonization where the relationship of domination between colonizer and colonized is complex, longstanding and occurring within the imperial state. In doing so it demonstrates that the history and present of the Gaels of Scotland belongs within the ambit of an emerging indigenous research paradigm.

The number of employed as a macroeconomic indicator of working time dynamics

2020 ◽  
Vol 16 (5) ◽  
pp. 935-945
Author(s):  
I.A. Zaikova
Keyword(s):  
Comparative Analysis ◽  
Manufacturing Sector ◽  
Working Hours ◽  
Working Time ◽  
Labor Costs ◽  
Factors Affecting ◽  
Time Dynamics ◽  
Developed Economies ◽  
The Relationship ◽  
Macroeconomic Indicator

Subject. The working time of workers at any stage of economic development is a value reflecting the level of labor productivity. Any progress in productivity contributes to changes in the volume of labor costs and the number of employed. Depending on the relationship between the total volume of labor costs and the number of employed, the duration of working time per one worker may change (it may increase, decrease, or remain unchanged). Objectives. The study aims to confirm the importance of such a macroeconomic indicator as the number of employed in varying working hours. Methods. The study rests on the comparative analysis of countries with developed economies based on some indicators like dynamics of the working time fund, dynamics of the number of employed, average number of hours worked during the year per employee, etc. The analyzed timespan is 25 years (from 1991 to 2016). Results. The comparative analysis revealed that in the non-production sphere and the economy as a whole the macroeconomic determinants correlate so that the length of working time per worker reduces. When considering the analysis results for the manufacturing sector, no single trend was identified. Conclusions. One of the key factors affecting the change in working hours is the number of employed. The relationship between the working time fund and the number of employed directly determines the dynamics of working time per worker.

ON COMPARATIVE ANALYSIS OF PERFORMANCE OPTIMIZATION METHODS OF MULTI-PUMP UNITS

2020 ◽  
pp. 23-28
Author(s):  
A.I. Glushchenko ◽  
M.Yu. Serov
Keyword(s):  
Energy Efficiency ◽  
Control System ◽  
Comparative Analysis ◽  
Performance Optimization ◽  
Optimization Methods ◽  
Online Optimization ◽  
New Approach ◽  
Advantages And Disadvantages ◽  
Analysis Of Performance

В статье рассматривается вопрос совершенствования системы управления параллельно-работающими насосными агрегатами с целью повышения энергоэффективности их работы. Проведено сравнение и выявление недостатков существующих методов решения рассматриваемой проблемы. Предложена идея нового подхода на базе онлайн оптимизации. The problem under consideration is improvement of the energy efficiency of a control system of parallel-running pump units. Known methods used to solve this problem are considered. Their advantages and disadvantages are shown. Finally, the idea of a new approach, which is based on online optimization, is proposed.

scholarly journals Modeling the Radial Stem Growth of the Pine (Pinus sylvestris L.) Forests Using the Satellite-Derived NDVI and LST (MODIS/AQUA) Data

Atmosphere ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 12
Author(s):  
Yulia Ivanova ◽  
Anton Kovalev ◽  
Vlad Soukhovolsky
Keyword(s):  
Land Surface ◽  
Vegetation Index ◽  
Normalized Difference Vegetation Index ◽  
Principal Component ◽  
Stem Growth ◽  
Forest Growth ◽  
Parabolic Approximation ◽  
New Approach ◽  
The Relationship ◽  
Tree Increment

The paper considers a new approach to modeling the relationship between the increase in woody phytomass in the pine forest and satellite-derived Normalized Difference Vegetation Index (NDVI) and Land Surface Temperature (LST) (MODIS/AQUA) data. The developed model combines the phenological and forest growth processes. For the analysis, NDVI and LST (MODIS) satellite data were used together with the measurements of tree-ring widths (TRW). NDVI data contain features of each growing season. The models include parameters of parabolic approximation of NDVI and LST time series transformed using principal component analysis. The study shows that the current rate of TRW is determined by the total values of principal components of the satellite indices over the season and the rate of tree increment in the preceding year.

A new approach to the bienergy and biangle of a moving particle lying in a surface of lorentzian space

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Talat Körpınar ◽  
Yasin Ünlütürk
Keyword(s):  
Vector Fields ◽  
Elastic Surface ◽  
Geometrical Characterization ◽  
Lorentzian Space ◽  
New Approach ◽  
Darboux Vector ◽  
Moving Particle ◽  
The Relationship ◽  
Surface Curve

AbstractIn this research, we study bienergy and biangles of moving particles lying on the surface of Lorentzian 3-space by using their energy and angle values. We present the geometrical characterization of bienergy of the particle in Darboux vector fields depending on surface. We also give the relationship between bienergy of the surface curve and bienergy of the elastic surface curve. We conclude the paper by providing bienergy-curve graphics for different cases.

scholarly journals Research on the Relationship between Shared Leadership and Individual Creativity-Qualitative Comparative Analysis on the Basis of Clear Set

2021 ◽  
Vol 13 (10) ◽  
pp. 5445
Author(s):  
Muyun Sun ◽  
Jigan Wang ◽  
Ting Wen
Keyword(s):  
Comparative Analysis ◽  
Environmental Factors ◽  
Shared Leadership ◽  
Management Practices ◽  
Qualitative Comparative Analysis ◽  
Necessary Condition ◽  
The Individual ◽  
The Impact ◽  
The Relationship ◽  
Sufficient And Necessary Condition

Creativity is the key to obtaining and maintaining competitiveness of modern organizations, and it has attracted much attention from academic circles and management practices. Shared leadership is believed to effectively influence team output. However, research on the impact of individual creativity is still in its infancy. This study adopts the qualitative comparative analysis method, taking 1584 individuals as the research objects, underpinned by a questionnaire-based survey. It investigates the influence of the team’s shared leadership network elements and organizational environmental factors on the individual creativity. We have found that there are six combination of conditions of shared leadership and organizational environmental factors constituting sufficient combination of conditions to increase or decrease individual creativity. Moreover, we have noticed that the low network density of shared leadership is a sufficient and necessary condition of reducing individual creativity. Our results also provide management suggestions for practical activities during the team management.

scholarly journals What Do Those Cohabiting Believe about Relationship Social Support and Premarital Counseling? A Comparative Analysis

2021 ◽  
Vol 10 (5) ◽  
pp. 183
Author(s):  
Jennifer McGhee ◽  
Brandon Burr ◽  
Allison Vanrosendale ◽  
Deisy Figueroa
Keyword(s):  
Social Support ◽  
Comparative Analysis ◽  
Relationship Satisfaction ◽  
Human Ecology ◽  
Premarital Counseling ◽  
Relationship Status ◽  
Family Practitioners ◽  
Study Results ◽  
Relationship Success ◽  
The Relationship

Relationship researchers have long studied factors that boost or detract from relationship success. Social support and premarital counseling are factors that have been shown to boost relationship satisfaction and relationship success. However, little is known about how relationship status may influence attitudes toward social support and premarital counseling. Using a human ecology lens, this study explores the relationship between relationship status and attitudes toward social support and premarital counseling from a sample of 385 individuals. Implications for family practitioners and future researchers are provided based on study results.

Innovation and Corporate Social Responsibility in SMEs

2015 ◽  
Vol 808 ◽  
pp. 359-363
Author(s):  
Cristina Feniser ◽  
Florin Lungu
Keyword(s):  
Corporate Social Responsibility ◽  
Life Cycle ◽  
Open Innovation ◽  
Social Goals ◽  
New Approach ◽  
Rational Management ◽  
Corporate Social ◽  
Qualitative Exploration ◽  
Whole Life Cycle ◽  
The Relationship

So far little attention has been given the differences or the compatibilities between CSR and innovation. Few works treats CSR in combination with innovation. What exactly is the relationship between CSR and innovation? Recent phenomena such as open innovation is based on the concept that the stakeholder's dialogue that overlaps with some dimensions of CSR. Being innovative means to bring organizational and technical improvements which will translate into a better position in the market. These improvements don't just aim the product, but the process by which it is obtained and its whole life-cycle. We're talking about a new approach to innovation, namely its orientation towards sustainability. Although SMEs have many features which facilitate implementation of CSR, activities of this type in such organizations are still limited. SMEs managers often make choices that are related to rational management. This leads to divergence between economical and social goals. Through a qualitative exploration of the concepts of CSR and innovation, we wanted to find out from some managers whether there is a link between innovation and CSR in SMEs and whether the activities corresponding to the two concepts overlap in a certain measure.

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