scholarly journals Biochemical Impedance on Intracellular Functions of Vitamin B12 in Chronic Toxigenic Mold Exposures

2007 ◽  
Vol 7 ◽  
pp. 1649-1657 ◽  
Author(s):  
Ebere C. Anyanwu ◽  
Ijeoma Kanu
Keyword(s):  
Vitamin B12 ◽  
Neurological Disorders ◽  
Vitamin B12 Deficiency ◽  
Methionine Synthase ◽  
Neurological Manifestations ◽  
Biochemical Processes ◽  
B12 Deficiency ◽  
Spinal Degeneration ◽  
One Carbon Metabolism ◽  
And Function

A majority of patients with neurological disorders with chronic exposures to toxigenic molds and mycotoxins has vitamin B12 deficiency that is unrelated to dietary insufficiency. Vitamin B12 is a source of coenzymes, and participates in intracellular recycling of methionine, and in methionine synthase reactions. The biochemical processes that lead to B12 depletion and deficiency are not fully understood. This paper examines and assesses various most likely biochemical reasons that could impede upon the normal intracellular functions of vitamin B12 that lead to neurological manifestations. By biochemical implications and derivations, it is most likely that mycotoxins interrupt the structure and function of vitamin B12 through reactive interference with the normal One-Carbon metabolism leading to the observed clinical neurological manifestations such as nerve damage and, demyelination, degeneration of PNS leading to paralysis, progressive peripheral neuropathy, and spinal degeneration.

scholarly journals Vitamin B12 deficiency: metabolic effects, clinical evaluation, and treatment

2019 ◽  
Vol 59 (2) ◽  
pp. 40 ◽  
Author(s):  
Synara Cavalcante Lopes ◽  
Daniel Duarte Gadelha ◽  
Manuela Dias de Carvalho ◽  
Virgínia Oliveira Fernandes ◽  
Renan Magalhães Montenegro Junior
Keyword(s):  
Insulin Resistance ◽  
Vitamin B12 ◽  
Neurological Disorders ◽  
Vitamin B12 Deficiency ◽  
The Body ◽  
Water Soluble ◽  
Metabolic Effects ◽  
Pharmacological Treatments ◽  
B12 Deficiency ◽  
Composition Changes

Vitamin B12 is a water-soluble essential micronutrient, required by all the body cells. Its deficiency has been implicated not only in hematological and neurological disorders, but also in many metabolic processes, such as insulin resistance and body composition changes, which have aroused particular interest in recent years. This study reviews the physiology of vitamin B12 from its digestion and absorption to its distribution in tissues, metabolic effects and controversies regarding the diagnosis of deficiency, and to dietary and pharmacological treatments.

scholarly journals Genetic Bases of VitaminB12 Deficiency: Impact of MTHFR, TCN-II and GIF Polymorphisms on Vitamin B12 Level

2022 ◽  
Vol 19 ◽  
pp. 10-13
Author(s):  
Mazhar Salim Al Zoubi
Keyword(s):  
Vitamin B12 ◽  
Neurological Disorders ◽  
Molecular Basis ◽  
Vitamin B12 Deficiency ◽  
Mthfr Gene ◽  
Control Group ◽  
Mthfr Polymorphisms ◽  
Jordanian Population ◽  
B12 Deficiency ◽  
The Impact

Vitamin B12 deficiency is associated with serious health problems such as neurological disorders. In Jordan, few studies have evaluated the level of vitamin B21 in the Jordanian population with different prevalence. Genetic predisposition, lifestyle, environment, socioeconomic status, and geographic have been linked to vitamin B12 deficiency. Polymorphisms in the GIF, MTHFR, and Transcobalamins, have been proposed to be associated with the level of vitamin B12. The aim of the current study was to evaluate the impact of certain polymorphisms in MTHFR, TCN-II and GIF genes on the level of vitamin B12 in the Jordanian population. Polymorphic sites of the MTHFR (c.677 C>T, rs1801133 and c.1286A>C, rs1801131), TCN2-776C>G (Arg259Pro) (rs1801198) and GIF-68 A>G (Q5R) genes were analyzed by RFLP and DNA sequencing in a group of vitamin B12 deficient individuals (n = 100). The control group included 100 matching individuals with a normal level of vitamin B12 (>200 ng/mL). Our results showed a significant association between the homologous variant of the TCN2 gene (G776G) and MTHFR c.677C>T genes and vitamin B12 deficiency. On the other hand, The MTHFR c.1286A>C variant and GIF variants did not show significant association with vitamin B12 deficiency. This study expounds the association of TCN2 and MTHFR polymorphisms with cobalamin levels in a Jordanian population and highlights the necessity of further studies to elucidate the molecular basis and impact of TCN2, GIF, and MTHFR gene polymorphisms on vitamin B12 deficiency and associated disorders.

scholarly journals Manifestações neurológicas em decorrência da carência de cianocobalamina (Vitamina B12): Um relato de caso / Neurological manifestations due to cyanocobalamin (Vitamin B12) deficiency: a case report

2021 ◽  
Vol 4 (5) ◽  
pp. 18562-18564
Author(s):  
Gianott Oliveira Celeste ◽  
Marina Pinheiro Bezerra Justo ◽  
Maria Eduarda Cabral Crispim ◽  
Clara Campêlo Lucena Vieira ◽  
Lara Beatriz Viana Freitas Costa
Keyword(s):  
Case Report ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Neurological Manifestations ◽  
B12 Deficiency

scholarly journals VITAMIN DEFICIENCY AND FOOD SUPPLEMENTS

2021 ◽  
Vol 9 (12) ◽  
pp. 540-552
Author(s):  
Saad Fahad Aldaihani
Keyword(s):  
Vitamin B12 ◽  
Human Body ◽  
Vitamin B12 Deficiency ◽  
Vitamin Deficiency ◽  
Megaloblastic Anaemia ◽  
Water Soluble ◽  
Vitamin B ◽  
B12 Deficiency ◽  
And Function ◽  
Harmful Effects

Vitamins are a heterogeneous group of organic compounds that help ensure the human bodys wellbeing and function. This paper introduces the importance of all vitamins, both water-soluble and fat-soluble, as well as problems deriving from their deficiency. Additionally, vitamin supplements as part of treating vitamin deficiency, and possible harmful effects on the human body areshowcased. The main focus of the paper is on the vitamin B complex, and vitamin B12 specifically. The benefits of vitamin B12, as well as its action in the human body and the noxious effects of any lack of vitamin B12 in the human body, are also discussed. Some of the health conditionsan individual may need to face when they have vitamin B12 deficiency include neural tube defects, Alzheimers disease, depression, and megaloblastic anaemia, which are also introduced and further discussed, in terms of symptomatology, causes and suggested treatment. The toxicity of vitamin B12 is also introduced, and possible causes for vitamin B12 deficiency are showcased.

Neurological disorders due to vitamin B12 deficiency

2021 ◽  
Vol 429 ◽  
pp. 119370
Author(s):  
Nadia Bouattour ◽  
Sameh Triki ◽  
Salma Sakka ◽  
Nouha Farhat ◽  
Olfa Hdiji ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Neurological Disorders ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

scholarly journals VITAMIN B12 DEFICIENCY; FREQUENCY OF NEUROLOGICAL MANIFESTATIONS IN QUETTA

2017 ◽  
Vol 24 (06) ◽  
pp. 878-887
Author(s):  
IRFANA HASSAN ◽  
BHAGWAN DAS ◽  
SANTOSH KUMAR ◽  
GHULAM HAIDER KHALID ◽  
ABDUL MANAN JUNEJO ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Neurological Manifestations ◽  
B12 Deficiency

scholarly journals Subacute combined degeneration of the spinal cord in functional vitamin B12 Deficiency states

2021 ◽  
Vol 20 (4) ◽  
pp. 21-23
Author(s):  
Christina Englezou ◽  
◽  
Di Liang ◽  
Keyword(s):  
Spinal Cord ◽  
Vitamin B12 ◽  
Cognitive Deficits ◽  
Metabolic Pathways ◽  
Case Series ◽  
Vitamin B12 Deficiency ◽  
Neurological Manifestations ◽  
Subacute Combined Degeneration ◽  
Ability To Act ◽  
B12 Deficiency

Vitamin B12 is an essential enzymatic cofactor in multiple cellular metabolic pathways. Deficiency states can arise as a result of both depletion of absolute systemic levels and pathological processes that block its ability to act as an enzymatic cofactor. The latter is also known as functional vitamin B12 deficiency. This can cause a variety of systemic, haematological, and neurological manifestations, some of which may be irreversible if not promptly treated. Neurological syndromes include subacute combined degeneration of the cord (SCDC), peripheral, optic, and autonomic neuropathies, and neuropsychiatric or cognitive deficits. This review presents a case series of vitamin B12 deficiencies leading to SCDC, and we include the clinical features, significant investigations, treatments, and prognoses.

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