scholarly journals Subacute combined degeneration of the spinal cord in functional vitamin B12 Deficiency states

2021 ◽  
Vol 20 (4) ◽  
pp. 21-23
Author(s):  
Christina Englezou ◽  
◽  
Di Liang ◽  
Keyword(s):  
Spinal Cord ◽  
Vitamin B12 ◽  
Cognitive Deficits ◽  
Metabolic Pathways ◽  
Case Series ◽  
Vitamin B12 Deficiency ◽  
Neurological Manifestations ◽  
Subacute Combined Degeneration ◽  
Ability To Act ◽  
B12 Deficiency

Vitamin B12 is an essential enzymatic cofactor in multiple cellular metabolic pathways. Deficiency states can arise as a result of both depletion of absolute systemic levels and pathological processes that block its ability to act as an enzymatic cofactor. The latter is also known as functional vitamin B12 deficiency. This can cause a variety of systemic, haematological, and neurological manifestations, some of which may be irreversible if not promptly treated. Neurological syndromes include subacute combined degeneration of the cord (SCDC), peripheral, optic, and autonomic neuropathies, and neuropsychiatric or cognitive deficits. This review presents a case series of vitamin B12 deficiencies leading to SCDC, and we include the clinical features, significant investigations, treatments, and prognoses.

Subacute Combined Degeneration of the Spinal Cord and Hydrocephalus Associated with Vitamin B12 Deficiency

2019 ◽  
Vol 128 ◽  
pp. 277-283 ◽  
Author(s):  
Wei Sun ◽  
Guangsheng Li ◽  
Zhaohui Lai ◽  
Zhijuan Lu ◽  
Ye Lin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Subacute Combined Degeneration ◽  
B12 Deficiency

scholarly journals Helicobacter pylori associated vitamin B12 deficiency, pernicious anaemia and subacute combined degeneration of the spinal cord

2013 ◽  
Vol 2013 (sep29 1) ◽  
pp. bcr2013200380-bcr2013200380 ◽  
Author(s):  
H. B. Gowdappa ◽  
M. Mahesh ◽  
K. V. K. S. N. Murthy ◽  
M. G. Narahari
Keyword(s):  
Spinal Cord ◽  
Helicobacter Pylori ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Pernicious Anaemia ◽  
Subacute Combined Degeneration ◽  
B12 Deficiency

scholarly journals Subacute Combined Degeneration of the Spinal Cord due to Different Etiologies and Improvement of MRI Findings

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Azize Esra Gürsoy ◽  
Mehmet Kolukısa ◽  
Gülsen Babacan-Yıldız ◽  
Arif Çelebi
Keyword(s):  
Spinal Cord ◽  
Nitrous Oxide ◽  
Vitamin B12 ◽  
Neurological Complication ◽  
Vitamin B12 Deficiency ◽  
Vegetarian Diet ◽  
Mri Findings ◽  
Subacute Combined Degeneration ◽  
B12 Deficiency ◽  
Reversible Condition

Subacute combined degeneration (SCD) is a rare neurological complication of vitamin B12 deficiency, characterized by demyelination of the dorsal and lateral spinal cord. Herein, we describe three cases, who presented with SCD, one related to reduced intake of vitamin B12 because of a vegetarian diet and two related to nitrous oxide exposure during surgery. MR images of our patients revealed symmetrical hyperintense signals in dorsal and lateral columns in T2 weighted series. After treatment with intramuscular B12 injections (1 mg daily for 2 weeks, once weekly thereafter for three months) all patients showed improvement of their symptoms. Abnormalities of the spinal cord on MRI resolved in three months. In conclusion, SCD either due to nitrous oxide exposure or due to reduced intake of vitamin B12 is a reversible condition, when detected and treated early.

scholarly journals Skin Hyperpigmentation as the Presenting Symptom of Subacute Combined Degeneration of the Spinal Cord

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Abdulhameed Alhazmi ◽  
Abdulrahman Almalki ◽  
Safieeldin Ghazala
Keyword(s):  
Spinal Cord ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Neurological Complications ◽  
Subacute Combined Degeneration ◽  
Skin Hyperpigmentation ◽  
B12 Deficiency

Vitamin B12 deficiency results in hematological, neurological, and rarely dermatological complications. Subacute combined degeneration of the cord is one of the neurological complications, and usually the presenting symptom is paresthesia. Herein, we report a case of a 46-year-old man with subacute combined degeneration presenting with knuckle hyperpigmentation.

SUBACUTE COMBINED DEGENERATION OF SPINAL CORD BY VITAMIN B12 DEFICIENCY IN A PATIENT WITH ATROPHIC GASTRITIS: CASE PRESENTATION

2020 ◽  
pp. 30-33
Author(s):  
Amanda Guariento Muniz Marques ◽  
Menandro Cardoso Abreu ◽  
Joao Batista Macedo Vianna ◽  
Lucas Porto Ferreira ◽  
Sarah Paranhos Campos ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Vitamin B12 ◽  
Atrophic Gastritis ◽  
Vitamin B12 Deficiency ◽  
Subacute Combined Degeneration ◽  
Case Presentation ◽  
B12 Deficiency
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