scholarly journals Muscle Wasting and Resistance of Muscle Anabolism: The “Anabolic Threshold Concept” for Adapted Nutritional Strategies during Sarcopenia

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Dominique Dardevet ◽  
Didier Rémond ◽  
Marie-Agnès Peyron ◽  
Isabelle Papet ◽  
Isabelle Savary-Auzeloux ◽  
...  
Keyword(s):  
Mass Loss ◽  
Muscle Mass ◽  
Muscle Protein ◽  
Anabolic Resistance ◽  
Negative Results ◽  
Skeletal Muscle Loss ◽  
Muscle Mass Loss ◽  
Nutritional Strategies

Skeletal muscle loss is observed in several physiopathological situations. Strategies to prevent, slow down, or increase recovery of muscle have already been tested. Besides exercise, nutrition, and more particularly protein nutrition based on increased amino acid, leucine or the quality of protein intake has generated positive acute postprandial effect on muscle protein anabolism. However, on the long term, these nutritional strategies have often failed in improving muscle mass even if given for long periods of time in both humans and rodent models. Muscle mass loss situations have been often correlated to a resistance of muscle protein anabolism to food intake which may be explained by an increase of the anabolic threshold toward the stimulatory effect of amino acids. In this paper, we will emphasize how this anabolic resistance may affect the intensity and the duration of the muscle anabolic response at the postprandial state and how it may explain the negative results obtained on the long term in the prevention of muscle mass. Sarcopenia, the muscle mass loss observed during aging, has been chosen to illustrate this concept but it may be kept in mind that it could be extended to any other catabolic states or recovery situations.

scholarly journals Nutritional strategies to counteract muscle atrophy caused by disuse and to improve recovery

2013 ◽  
Vol 26 (2) ◽  
pp. 149-165 ◽  
Author(s):  
Hugues Magne ◽  
Isabelle Savary-Auzeloux ◽  
Didier Rémond ◽  
Dominique Dardevet
Keyword(s):  
Mass Loss ◽  
Muscle Mass ◽  
Muscle Atrophy ◽  
Whey Proteins ◽  
Leucine Supplementation ◽  
Positive Effects ◽  
Muscle Disuse ◽  
Muscle Mass Loss ◽  
Nutritional Strategies ◽  
Mass Recovery

Periods of immobilisation are often associated with pathologies and/or ageing. These periods of muscle disuse induce muscle atrophy which could worsen the pathology or elderly frailty. If muscle mass loss has positive effects in the short term, a sustained/uncontrolled muscle mass loss is deleterious for health. Muscle mass recovery following immobilisation-induced atrophy could be critical, particularly when it is uncompleted as observed during ageing. Exercise, the best way to recover muscle mass, is not always applicable. So, other approaches such as nutritional strategies are needed to limit muscle wasting and to improve muscle mass recovery in such situations. The present review discusses mechanisms involved in muscle atrophy following disuse and during recovery and emphasises the effect of age in these mechanisms. In addition, the efficiency of nutritional strategies proposed to limit muscle mass loss during disuse and to improve protein gain during recovery (leucine supplementation, whey proteins, antioxidants and anti-inflammatory compounds, energy intake) is also discussed.

MON-P082: Muscle Mass Loss (MML) Assessed by Abdominal CT Affects Long-Term Survival after Liver Resection for Intra Hepatic Cholangiocarcinoma (ICC)

2017 ◽  
Vol 36 ◽  
pp. S209-S210
Author(s):  
L. Lacaze ◽  
D. Bergeat ◽  
E. Bardou-Jacquet ◽  
A. Merdrignac ◽  
P. Meurice ◽  
...  
Keyword(s):  
Liver Resection ◽  
Mass Loss ◽  
Muscle Mass ◽  
Abdominal Ct ◽  
Term Survival ◽  
Long Term Survival ◽  
Muscle Mass Loss

Jiangnan Dietary Pattern Actively Prevents Muscle Mass Loss: Based on a Cohort Study

2021 ◽  
Author(s):  
Zhengyuan Wang ◽  
Xinyi Dong ◽  
Qi Song ◽  
Xueying Cui ◽  
Zehuan Shi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Mass Loss ◽  
Muscle Mass ◽  
Dietary Pattern ◽  
Muscle Mass Loss

scholarly journals Racial Differences in Relative Skeletal Muscle Mass Loss During Diet-Induced Weight Loss in Women

Obesity ◽  
2018 ◽  
Vol 26 (8) ◽  
pp. 1255-1260 ◽  
Author(s):  
Gary R. Hunter ◽  
David R. Bryan ◽  
Juliano H. Borges ◽  
M. David Diggs ◽  
Stephen J. Carter
Keyword(s):  
Skeletal Muscle ◽  
Weight Loss ◽  
Mass Loss ◽  
Racial Differences ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Muscle Mass Loss

scholarly journals Renal Rehabilitation: Exercise Intervention and Nutritional Support in Dialysis Patients

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1444
Author(s):  
Junichi Hoshino
Keyword(s):  
Nutritional Support ◽  
Exercise Intervention ◽  
Muscle Protein ◽  
Dialysis Patients ◽  
Dialysis Treatment ◽  
Beneficial Effects ◽  
Multidisciplinary Program ◽  
Nutrition Programs ◽  
Skeletal Muscle Loss

With the growing number of dialysis patients with frailty, the concept of renal rehabilitation, including exercise intervention and nutrition programs for patients with chronic kidney disease (CKD), has become popular recently. Renal rehabilitation is a comprehensive multidisciplinary program for CKD patients that is led by doctors, rehabilitation therapists, diet nutritionists, nursing specialists, social workers, pharmacists, and therapists. Many observational studies have observed better outcomes in CKD patients with more physical activity. Furthermore, recent systematic reviews have shown the beneficial effects of exercise intervention on exercise tolerance, physical ability, and quality of life in dialysis patients, though the beneficial effect on overall mortality remains unclear. Nutritional support is also fundamental to renal rehabilitation. There are various causes of skeletal muscle loss in CKD patients. To prevent muscle protein catabolism, in addition to exercise, a sufficient supply of energy, including carbohydrates, protein, iron, and vitamins, is needed. Because of decreased digestive function and energy loss due to dialysis treatment, dialysis patients are recommended to ingest 1.2-fold more protein than the regular population. Motivating patients to join in activities is also an important part of renal rehabilitation. It is essential for us to recognize the importance of renal rehabilitation to maximize patient satisfaction.

Application of transcutaneous ultrasonography for the diagnosis of muscle mass loss in patients with liver cirrhosis

2017 ◽  
Vol 53 (5) ◽  
pp. 652-659 ◽  
Author(s):  
Kazufumi Kobayashi ◽  
Hitoshi Maruyama ◽  
Soichiro Kiyono ◽  
Sadahisa Ogasawara ◽  
Eiichiro Suzuki ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Mass Loss ◽  
Muscle Mass ◽  
Muscle Mass Loss
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