scholarly journals The impact of sarcopenia and acute muscle mass loss on long‐term outcomes in critically ill patients with intra‐abdominal sepsis

2021 ◽  
Author(s):  
Michael C. Cox ◽  
Matthew Booth ◽  
Gabriela Ghita ◽  
Zhongkai Wang ◽  
Anna Gardner ◽  
...  
Keyword(s):  
Mass Loss ◽  
Critically Ill ◽  
Muscle Mass ◽  
Critically Ill Patients ◽  
Abdominal Sepsis ◽  
Long Term Outcomes ◽  
Muscle Mass Loss ◽  
The Impact

Long-term outcomes and quality of life in critically ill patients with hematological or solid malignancies: a single center study

2012 ◽  
Vol 39 (5) ◽  
pp. 889-898 ◽  
Author(s):  
S. G. Oeyen ◽  
D. D. Benoit ◽  
L. Annemans ◽  
P. O. Depuydt ◽  
S. J. Van Belle ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Single Center ◽  
Long Term Outcomes ◽  
Solid Malignancies ◽  
Single Center Study ◽  
Center Study

scholarly journals Muscle Wasting and Resistance of Muscle Anabolism: The “Anabolic Threshold Concept” for Adapted Nutritional Strategies during Sarcopenia

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Dominique Dardevet ◽  
Didier Rémond ◽  
Marie-Agnès Peyron ◽  
Isabelle Papet ◽  
Isabelle Savary-Auzeloux ◽  
...  
Keyword(s):  
Mass Loss ◽  
Muscle Mass ◽  
Muscle Protein ◽  
Anabolic Resistance ◽  
Negative Results ◽  
Skeletal Muscle Loss ◽  
Muscle Mass Loss ◽  
Nutritional Strategies

Skeletal muscle loss is observed in several physiopathological situations. Strategies to prevent, slow down, or increase recovery of muscle have already been tested. Besides exercise, nutrition, and more particularly protein nutrition based on increased amino acid, leucine or the quality of protein intake has generated positive acute postprandial effect on muscle protein anabolism. However, on the long term, these nutritional strategies have often failed in improving muscle mass even if given for long periods of time in both humans and rodent models. Muscle mass loss situations have been often correlated to a resistance of muscle protein anabolism to food intake which may be explained by an increase of the anabolic threshold toward the stimulatory effect of amino acids. In this paper, we will emphasize how this anabolic resistance may affect the intensity and the duration of the muscle anabolic response at the postprandial state and how it may explain the negative results obtained on the long term in the prevention of muscle mass. Sarcopenia, the muscle mass loss observed during aging, has been chosen to illustrate this concept but it may be kept in mind that it could be extended to any other catabolic states or recovery situations.

Short- and Long-term Outcomes of Critically Ill Patients With Cancer and Prolonged ICU Length of Stay

CHEST Journal ◽  
2008 ◽  
Vol 134 (3) ◽  
pp. 520-526 ◽  
Author(s):  
Márcio Soares ◽  
Jorge I.F. Salluh ◽  
Viviane B.L. Torres ◽  
Juliana V.R. Leal ◽  
Nelson Spector
Keyword(s):  
Length Of Stay ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Long Term Outcomes ◽  
Patients With Cancer ◽  
Icu Length Of Stay ◽  
Short And Long Term

Rapid Muscle Loss Negatively Impacts Survival in Critically Ill Patients With Cirrhosis

2018 ◽  
Vol 35 (7) ◽  
pp. 663-671 ◽  
Author(s):  
Sunmi Ju ◽  
Sun Mi Choi ◽  
Young Sik Park ◽  
Chang-Hoon Lee ◽  
Sang-Min Lee ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Critically Ill ◽  
Muscle Mass ◽  
Critically Ill Patients ◽  
Mass Change ◽  
Apache Ii Score ◽  
Muscle Loss ◽  
Icu Mortality ◽  
Skeletal Muscle Index ◽  
The Impact

Purpose: To assess the impact of rapid muscle loss before admission to intensive care unit (ICU) in critically ill patients with cirrhosis. Materials and Methods: Patients with cirrhosis who had undergone 2 or more recent computed tomography scans before admission to the medical ICU were included. Muscle cross-sectional area at the level of the third lumbar vertebra was quantified using OsiriX software. The rate of muscle mass change and skeletal muscle index (SMI) were also calculated. Multivariable Cox proportional hazards regression was used to evaluate the association between muscle loss and mortality. Results: Among 125 patients, 113 (90.4%) patients were classified as having sarcopenia. The mean body mass index was 22.6 (3.9) kg/m2. Thirty-nine (31.2%) patients were within the normal range for muscle mass change, while 86 (68.8%) patients demonstrated rapid decline in muscle mass before admission to the ICU. Patients with rapid muscle loss showed high ICU mortality (59.3%) and in-hospital mortality (77.9%). Multivariate Cox analysis showed that ICU mortality and in-hospital mortality were independently associated with malignancy, Acute Physiology and Chronic Health Evaluation (APACHE) II score, SMI, and rapid muscle loss. Conclusion: Rapid muscle decline is correlated with increased ICU mortality and in-hospital mortality in critically ill patients with cirrhosis.

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