scholarly journals Transcriptome analysis of a Pseudomonas aeruginosa sn-glycerol-3-phosphate dehydrogenase mutant reveals a disruption in bioenergetics

Microbiology ◽  
2018 ◽  
Vol 164 (4) ◽  
pp. 551-562 ◽  
Author(s):  
Jon Shuman ◽  
Tyler Xavier Giles ◽  
Leslie Carroll ◽  
Kenji Tabata ◽  
Austin Powers ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Transcriptome Analysis ◽  
Glycerol 3 Phosphate Dehydrogenase

Impact of glycerol-3-phosphate dehydrogenase on virulence factor production byPseudomonas aeruginosa

2014 ◽  
Vol 60 (12) ◽  
pp. 857-863 ◽  
Author(s):  
Jonathan B. Daniels ◽  
Jessica Scoffield ◽  
Jessica L. Woolnough ◽  
Laura Silo-Suh
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Metabolic Pathways ◽  
Lung Surfactant ◽  
Carbon Sources ◽  
Chronic Infections ◽  
Available Nutrients ◽  
Therapeutic Benefits ◽  
Glycerol Utilization ◽  
Glycerol 3 Phosphate Dehydrogenase ◽  
Virulence Factor Production

Pseudomonas aeruginosa establishes life-long chronic infections in the cystic fibrosis (CF) lung by utilizing various adaptation strategies. Some of these strategies include altering metabolic pathways to utilize readily available nutrients present in the host environment. The airway sputum contains various host-derived nutrients that can be utilized by P. aeruginosa, including phosphatidylcholine, a major component of lung surfactant. Pseudomonas aeruginosa can degrade phosphatidylcholine to glycerol and fatty acids to increase the availability of usable carbon sources in the CF lung. In this study, we show that some CF-adapted P. aeruginosa isolates utilize glycerol more efficiently as a carbon source than nonadapted isolates. Furthermore, a mutation in a gene required for glycerol utilization impacts the production of several virulence factors in both acute and chronic isolates of P. aeruginosa. Taken together, the results suggest that interference with this metabolic pathway may have potential therapeutic benefits.

scholarly journals Transcriptome Analysis Reveals the Resistance Mechanism of Pseudomonas aeruginosa to Tachyplesin I

2020 ◽  
Vol Volume 13 ◽  
pp. 155-169
Author(s):  
Jun Hong ◽  
Honghao Jiang ◽  
Jianye Hu ◽  
Lianzhe Wang ◽  
Ruifang Liu
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Transcriptome Analysis ◽  
Resistance Mechanism ◽  
Tachyplesin I

scholarly journals Human transcriptome analysis reveals a potential role for active transport in the metabolism of Pseudomonas aeruginosa autoinducers

2010 ◽  
Vol 12 (12-13) ◽  
pp. 1042-1050 ◽  
Author(s):  
Amanda Bryan ◽  
Chase Watters ◽  
Lars Koenig ◽  
Eunseog Youn ◽  
Aaron Olmos ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Active Transport ◽  
Transcriptome Analysis ◽  
Potential Role ◽  
Human Transcriptome

scholarly journals Differential expression of GPD1L in cancer of the vulva.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Disease Progression ◽  
Differential Expression ◽  
Microarray Data ◽  
Transcriptome Analysis ◽  
Vulvar Cancer ◽  
Vulvar Carcinoma ◽  
Tissue Of Origin ◽  
Glycerol 3 Phosphate Dehydrogenase

In these brief notes we document work using published microarray data (1, 2) to pioneer integrative transcriptome analysis comparing vulvar carcinoma to its tissue of origin, the vulva. We report the differential expression of glycerol-3-phosphate dehydrogenase 1-like, encoded by GPD1L, in cancer of the vulva. GPD1L may be of pertinence to understanding transformation and disease progression in vulvar cancer (3).

scholarly journals Transcriptome Analysis of the Response of Pseudomonas aeruginosa to Hydrogen Peroxide

2004 ◽  
Vol 186 (1) ◽  
pp. 248-252 ◽  
Author(s):  
Marco Palma ◽  
Darrow DeLuca ◽  
Stefan Worgall ◽  
Luis E. N. Quadri
Keyword(s):  
Hydrogen Peroxide ◽  
Pseudomonas Aeruginosa ◽  
Transcriptome Analysis ◽  
Transcriptome Profiling ◽  
Early Response ◽  
Primary Metabolism ◽  
High Concentration ◽  
Protective Mechanisms ◽  
Human Host

ABSTRACT Pseudomonas aeruginosa must often overcome a high concentration of oxidants to successfully infect the human host. We report here the results of a transcriptome profiling comparing cells treated with H2O2 and untreated controls. The data indicate that the early response of P. aeruginosa to H2O2 consists of an upregulation of protective mechanisms and a downregulation of primary metabolism.

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