scholarly journals Mycobacterium tuberculosis H37Rv has a single nucleotide polymorphism in PhoR which affects cell wall hydrophobicity and gene expression

Microbiology ◽  
2015 ◽  
Vol 161 (4) ◽  
pp. 765-773 ◽  
Author(s):  
L. J. Schreuder ◽  
P. Carroll ◽  
J. Muwanguzi-Karugaba ◽  
Rachel Kokoczka ◽  
Amanda C. Brown ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Wall ◽  
Single Nucleotide Polymorphism ◽  
Mycobacterium Tuberculosis ◽  
Tuberculosis H37rv ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Mycobacterium Tuberculosis H37rv

A snapshot of the predominant single nucleotide polymorphism cluster groups of Mycobacterium tuberculosis clinical isolates in Delhi, India

Tuberculosis ◽  
2016 ◽  
Vol 100 ◽  
pp. 72-81 ◽  
Author(s):  
Mandira Varma-Basil ◽  
Anshika Narang ◽  
Soumitesh Chakravorty ◽  
Kushal Garima ◽  
Shraddha Gupta ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Mycobacterium Tuberculosis ◽  
Clinical Isolates ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals Transcriptomics and functional genetic polymorphisms as biomarkers of micronutrient function: focus on selenium as an exemplar

2011 ◽  
Vol 70 (3) ◽  
pp. 365-373 ◽  
Author(s):  
John Hesketh ◽  
Catherine Méplan
Keyword(s):  
Gene Expression ◽  
Single Nucleotide Polymorphism ◽  
Stress Response ◽  
Association Studies ◽  
Disease Association ◽  
Genomic Research ◽  
Polymorphism Analysis ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Selenoprotein S

Micronutrients are essential for optimal human health. However, in some cases, raising intake by supplementation has not proven to be beneficial and there is even some evidence that supplementation may increase disease risk, highlighting the importance of assessing the functional status of micronutrients. Techniques such as gene microarrays and single-nucleotide polymorphism analysis have the potential to examine effects of micronutrient intake on patterns of gene expression and inter-individual variation in micronutrient metabolism. Recent genomic research related to selenium (Se) provides examples illustrating how studies of functional single-nucleotide polymorphism and gene expression patterns can reveal novel biomarkers of micronutrient function. Both in vitro and in vivo experiments show that there are functionally relevant polymorphisms in genes encoding glutathione peroxidases 1, 3 and 4, selenoprotein P, selenoprotein S and the 15 kDa selenoprotein. Disease association studies investigating these gene variants have so far been relatively small but an association of a polymorphism in the selenoprotein S gene with colorectal cancer risk has been replicated in two distinct populations. Future disease association studies should examine effects of multiple variants in combination with nutritional status. Gene microarray studies indicate that changes in Se intake alter expression of components of inflammatory, stress response and translation pathways. Our hypothesis is that Se intake and genetic factors have linked effects on stress response, inflammation and apoptotic pathways. Combining such data in a systems biology approach has the potential to identify both biomarkers of micronutrients status and sub-group populations at particular risk.

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