scholarly journals Single Nucleotide Polymorphism in Ag85 Genes of Mycobacterium Tuberculosis Complex: Analysis of 178 Clinical Isolates from China and 13 BCG strains

2015 ◽  
Vol 12 (2) ◽  
pp. 126-134 ◽  
Author(s):  
Yi Jiang ◽  
Haican Liu ◽  
Machao Li ◽  
Guilian Li ◽  
Hui Pang ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Mycobacterium Tuberculosis ◽  
Complex Analysis ◽  
Mycobacterium Tuberculosis Complex ◽  
Clinical Isolates ◽  
Nucleotide Polymorphism ◽  
Tuberculosis Complex ◽  
Single Nucleotide

A snapshot of the predominant single nucleotide polymorphism cluster groups of Mycobacterium tuberculosis clinical isolates in Delhi, India

Tuberculosis ◽  
2016 ◽  
Vol 100 ◽  
pp. 72-81 ◽  
Author(s):  
Mandira Varma-Basil ◽  
Anshika Narang ◽  
Soumitesh Chakravorty ◽  
Kushal Garima ◽  
Shraddha Gupta ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Mycobacterium Tuberculosis ◽  
Clinical Isolates ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals Diversity of Mycobacterium tuberculosis Complex Lineages Associated with Pulmonary Tuberculosis in Southwestern, Uganda

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Lisa Nkatha Micheni ◽  
Kennedy Kassaza ◽  
Hellen Kinyi ◽  
Ibrahim Ntulume ◽  
Joel Bazira
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Mycobacterium Tuberculosis Complex ◽  
Genotypic Diversity ◽  
Hiv Incidence ◽  
Nucleotide Polymorphism ◽  
Tuberculosis Complex ◽  
Single Nucleotide ◽  
The World ◽  
Southwestern Uganda

Uganda is among the 22 countries in the world with a high burden of tuberculosis. The southwestern region of the country has consistently registered a high TB/HIV incidence rate. This study is aimed at characterizing the Mycobacterium tuberculosis complex (MTBC) genotypic diversity in southwestern Uganda. A total of 283 sputum samples from patients with pulmonary tuberculosis were genotyped using specific single nucleotide polymorphism markers for lineages 3 and 4. Most of the patients were males with a mean age of 34. The lineage 4 Ugandan family was found to be the most dominant strains accounting for 59.7% of all cases followed by lineage 3 at 15.2%. The lineage 4 non-Ugandan family accounted for 14.5% of all cases while 4.2% showed amplification for both lineage 4 and lineage 3. Eighteen samples (6.4%) of the strains remained unclassified since they could not be matched to any lineage based on the genotyping technique used. This study demonstrates that a wide diversity of strains is causing pulmonary tuberculosis in this region with those belonging to the lineage 4 Ugandan family being more predominant. However, to confirm this, further studies using more discriminative genotyping methods are necessary.

scholarly journals Diversified lineages and drug-resistance profiles of clinical isolates of Mycobacterium tuberculosis complex in Malaysia

2019 ◽  
Vol 8 (4) ◽  
pp. 320
Author(s):  
MohdSalleh Zaki ◽  
MohdNur Noorizhab Fakhruzzaman ◽  
NorzulianaZainal Abidin ◽  
ZirwatulAdilah Aziz ◽  
WaiFeng Lim ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Mycobacterium Tuberculosis Complex ◽  
Clinical Isolates ◽  
Tuberculosis Complex
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