scholarly journals Phenotypic characterization of Neisseria meningitidis strains isolated from invasive meningococcal disease in Brazil from 2002 to 2017

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Maria Cecília Gorla ◽  
Angela Pires Brandao ◽  
Juliana Maira Watanabe Pinhata ◽  
Camile de Moraes ◽  
Gabriela Pereira ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease ◽  
Phenotypic Characterization

scholarly journals Potential Capsule Switching from Serogroup Y to B: The Characterization of Three suchNeisseria meningitidisIsolates Causing Invasive Meningococcal Disease in Canada

2005 ◽  
Vol 16 (3) ◽  
pp. 171-174 ◽  
Author(s):  
Raymond SW Tsang ◽  
Dennis KS Law ◽  
Shaun D Tyler ◽  
Gwen S Stephens ◽  
Mark Bigham ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
Multilocus Sequence Typing ◽  
Housekeeping Gene ◽  
Sequence Type ◽  
Invasive Meningococcal Disease ◽  
Group B

Three group BNeisseria meningitidisisolates, recovered from meningococcal disease cases in Canada and typed as B:2c:P1.5, were characterized. Multilocus sequence typing showed that all three isolates were related because of an identical sequence type (ST) 573. Isolates typed as 2c:P1.5 are common in serogroup Y meningococci but rare in isolates from serogroups B or C. Although no serogroup Y isolates have been typed as ST-573, eight isolates showed five to six housekeeping gene alleles that were identical to that of ST-573. This suggested that the B:2c:P1.5 isolates may have originated from serogroup Y organisms, possibly by capsule switching.

scholarly journals Molecular characterization of Neisseria meningitidis isolates recovered from patients with invasive meningococcal disease in Colombia from 2013 to 2016

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0234475
Author(s):  
Jaime Moreno ◽  
Zonia Alarcon ◽  
Eliana Parra ◽  
Carolina Duarte ◽  
Olga Sanabria ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Molecular Characterization ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease

Prevalence and genetic diversity of two adhesion-related genes, pilE and nadA, in Neisseria meningitidis in China

2013 ◽  
Vol 141 (10) ◽  
pp. 2163-2172 ◽  
Author(s):  
X. SUN ◽  
H. ZHOU ◽  
L. XU ◽  
H. YANG ◽  
Y. GAO ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Neisseria Meningitidis ◽  
Adhesion Molecules ◽  
Meningococcal Disease ◽  
Class Ii ◽  
Type Iv Pili ◽  
Invasive Meningococcal Disease ◽  
Class I ◽  
Type Iv

SUMMARYThe main Neisseria meningitidis adhesion molecules, type IV pili (Tfp) and Neisseria adhesion A (NadA), play important roles in the pathogenesis of invasive meningococcal disease. PilE is the major Tfp subunit. In this study, the prevalence and genetic diversity of pilE and nadA were investigated in the prevalent serogroups and clonal complexes (CC) of N. meningitidis isolated in China. All serogroup A strains belonging to CC1 and CC5 and all CC11 serogroup W135 strains were clustered into class II PilE clades. All serogroup C and most of serogroup B isolates except CC8 and ST5642 were class I PilE clades. Class II pilE sequences were highly conserved. All isolates belonging to class I PilE isolates were nadA negative. However, nadA-positive strains were exclusively found in CC5 and CC11 isolates (class II PilE). This study showed that PilE and NadA may be related to epidemic or endemic meningococcal disease.

Genomic Characterization of Recent and Historic Meningococcal Serogroup E Invasive Disease in Australia: A Case Series

2019 ◽  
Vol 70 (8) ◽  
pp. 1761-1763 ◽  
Author(s):  
Dharshi Thangarajah ◽  
Christine J D Guglielmino ◽  
Stephen B Lambert ◽  
Gulam Khandaker ◽  
Bhakti R Vasant ◽  
...  
Keyword(s):  
Meningococcal Disease ◽  
Molecular Typing ◽  
Case Series ◽  
Invasive Disease ◽  
Invasive Meningococcal Disease ◽  
Recent Emergence ◽  
Genomic Characterization

Abstract We report the recent emergence of invasive meningococcal disease due to serogroup E in Queensland, Australia, in previously healthy patients. Molecular typing revealed the genotype of these strains to be E:P1.21-7,16:F5-36:ST-1157 (cc1157); when analyzed phylogenetically, compared with international cc1157 strains, they were relatively unrelated to each other.

scholarly journals An outbreak of severe invasive meningococcal disease due to a capsular switched Neisseria meningitidis hypervirulent strain B:cc11

2019 ◽  
Vol 25 (1) ◽  
pp. 111.e1-111.e4 ◽  
Author(s):  
P. Stefanelli ◽  
C. Fazio ◽  
P. Vacca ◽  
A. Palmieri ◽  
L. Ambrosio ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease
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