scholarly journals Supercritical carbon dioxide: putting the fizz into biomaterials

2005 ◽  
Vol 364 (1838) ◽  
pp. 249-261 ◽  
Author(s):  
John J.A Barry ◽  
Marta M.C.G Silva ◽  
Vladimir K Popov ◽  
Kevin M Shakesheff ◽  
Steven M Howdle
Keyword(s):  
Tissue Engineering ◽  
Supercritical Fluids ◽  
Recent Progress ◽  
Cartilage Tissue Engineering ◽  
Three Dimensional ◽  
Cartilage Tissue ◽  
Sintering Process ◽  
Tissue Engineering Scaffolds ◽  
Biodegradable Polyesters ◽  
Made In

This paper describes recent progress made in the use of high pressure or supercritical fluids to process polymers into three-dimensional tissue engineering scaffolds. Three current examples are highlighted: foaming of acrylates for use in cartilage tissue engineering; plasticization and encapsulation of bioactive species into biodegradable polyesters for bone tissue engineering; and a novel laser sintering process used to fabricate three-dimensional biodegradable polyester structures from particles prepared via a supercritical route.

Three-Dimensional Porous Scaffolds with Biomimetic Microarchitecture and Bioactivity for Cartilage Tissue Engineering

2019 ◽  
Vol 11 (40) ◽  
pp. 36359-36370 ◽  
Author(s):  
Yaqiang Li ◽  
Yanqun Liu ◽  
Xiaowei Xun ◽  
Wei Zhang ◽  
Yong Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Three Dimensional ◽  
Cartilage Tissue ◽  
Porous Scaffolds

scholarly journals Mechanical loading inhibits hypertrophy in chondrogenically differentiating hMSCs within a biomimetic hydrogel

2016 ◽  
Vol 4 (20) ◽  
pp. 3562-3574 ◽  
Author(s):  
E. A. Aisenbrey ◽  
S. J. Bryant
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Mechanical Loading ◽  
Cartilage Tissue Engineering ◽  
Three Dimensional ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Cartilage Tissue

Three dimensional hydrogels are a promising vehicle for delivery of adult human bone-marrow derived mesenchymal stem cells (hMSCs) for cartilage tissue engineering.

scholarly journals Three-Dimensional Printing Strategies for Irregularly Shaped Cartilage Tissue Engineering: Current State and Challenges

2022 ◽  
Vol 9 ◽  
Author(s):  
Hui Wang ◽  
Zhonghan Wang ◽  
He Liu ◽  
Jiaqi Liu ◽  
Ronghang Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Cartilage Tissue Engineering ◽  
Three Dimensional ◽  
Cartilage Tissue ◽  
Future Research ◽  
Engineering Construction ◽  
Three Dimensional Printing ◽  
Current State ◽  
Dimensional Printing

Although there have been remarkable advances in cartilage tissue engineering, construction of irregularly shaped cartilage, including auricular, nasal, tracheal, and meniscus cartilages, remains challenging because of the difficulty in reproducing its precise structure and specific function. Among the advanced fabrication methods, three-dimensional (3D) printing technology offers great potential for achieving shape imitation and bionic performance in cartilage tissue engineering. This review discusses requirements for 3D printing of various irregularly shaped cartilage tissues, as well as selection of appropriate printing materials and seed cells. Current advances in 3D printing of irregularly shaped cartilage are also highlighted. Finally, developments in various types of cartilage tissue are described. This review is intended to provide guidance for future research in tissue engineering of irregularly shaped cartilage.

Collagen-alginate as bioink for three-dimensional (3D) cell printing based cartilage tissue engineering

2018 ◽  
Vol 83 ◽  
pp. 195-201 ◽  
Author(s):  
Xingchen Yang ◽  
Zhenhui Lu ◽  
Huayu Wu ◽  
Wei Li ◽  
Li Zheng ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Three Dimensional ◽  
Cartilage Tissue ◽  
Cell Printing

scholarly journals Chondrocyte Spheroids Laden in GelMA/HAMA Hybrid Hydrogel for Tissue-Engineered Cartilage with Enhanced Proliferation, Better Phenotype Maintenance, and Natural Morphological Structure

Gels ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 247
Author(s):  
Guanhuier Wang ◽  
Yang An ◽  
Xinling Zhang ◽  
Pengbing Ding ◽  
Hongsen Bi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Proliferation ◽  
Cartilage Tissue Engineering ◽  
Three Dimensional ◽  
Morphological Structure ◽  
Research Direction ◽  
Cartilage Tissue ◽  
Hybrid Hydrogel

Three-dimensional cell-laden tissue engineering has become an extensive research direction. This study aimed to evaluate whether chondrocyte spheroids (chondro-spheroids) prepared using the hanging-drop method could develop better cell proliferation and morphology maintenance characteristics, and be optimized as a micro unit for cartilage tissue engineering. Chondro-spheroids were loaded into a cross-linkable hybrid hydrogel of gelatin methacrylate (GelMA) and hyaluronic acid methacrylate (HAMA) in vivo and in vitro. Cell proliferation, aggregation, cell morphology maintenance as well as cartilage-related gene expression and matrix secretion in vitro and in vivo were evaluated. The results indicated that compared with chondrocyte-laden hydrogel, chondro-spheroid-laden hydrogel enhanced proliferation, had better phenotype maintenance, and a more natural morphological structure, which made it appropriate for use as a micro unit in cartilage tissue engineering.

New strategies for cartilage regeneration exploiting selected glycosaminoglycans to enhance cell fate determination

2014 ◽  
Vol 42 (3) ◽  
pp. 703-709 ◽  
Author(s):  
Bethanie I. Ayerst ◽  
Anthony J. Day ◽  
Victor Nurcombe ◽  
Simon M. Cool ◽  
Catherine L.R. Merry
Keyword(s):  
Tissue Engineering ◽  
Cell Fate ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
Stem Cell Differentiation ◽  
Biologically Active ◽  
Cartilage Tissue ◽  
Research Strategies ◽  
Tissue Engineering Scaffolds ◽  
Ecm Extracellular Matrix

Most research strategies for cartilage tissue engineering use extended culture with complex media loaded with costly GFs (growth factors) to drive tissue assembly and yet they result in the production of cartilage with inferior mechanical and structural properties compared with the natural tissue. Recent evidence suggests that GAGs (glycosaminoglycans) incorporated into tissue engineering scaffolds can sequester and/or activate GFs and thereby more effectively mimic the natural ECM (extracellular matrix). Such approaches may have potential for the improvement of cartilage engineering. However, natural GAGs are structurally complex and heterogeneous, making structure–function relationships hard to determine and clinical translation difficult. Importantly, subfractions of GAGs with specific chain lengths and sulfation patterns have been shown to activate key signalling processes during stem cell differentiation. In addition, recently, GAGs have been bound to synthetic biomaterials, such as electrospun scaffolds and hydrogels, in biologically active conformations, and methods to purify and select affinity-matched GAGs for specific GFs have also been developed. The identification and use of specific GAG moieties to promote chondrogenesis is therefore an exciting new avenue of research. Combining these with synthetic biomaterials may allow a more effective mimicry of the natural ECM, reduction in the need for expensive GFs, and perhaps the deposition of an articular cartilage-like matrix in a clinically relevant manner.

Chondrogenesis from Human Placenta-Derived Mesenchymal Stem Cells in Three-Dimensional Scaffolds for Cartilage Tissue Engineering

2011 ◽  
Vol 17 (11-12) ◽  
pp. 1549-1560 ◽  
Author(s):  
Shan-hui Hsu ◽  
Tsung-Bin Huang ◽  
Shun-Jung Cheng ◽  
Su-Ying Weng ◽  
Ching-Lin Tsai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Placenta ◽  
Cartilage Tissue Engineering ◽  
Three Dimensional ◽  
Cartilage Tissue
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