Proton NMR studies of brain metabolism

1990 ◽  
Vol 333 (1632) ◽  
pp. 561-570 ◽  
Keyword(s):  
Brain Tumours ◽  
Brain Metabolism ◽  
Glycolytic Metabolism ◽  
Nmr Studies ◽  
Non Invasive ◽  
The Past ◽  
Technical Developments ◽  
Wide Range ◽  
The Brain ◽  
Very High

As a result of several technical developments that have taken place over the past few years, it is now possible to obtain 1 H spectra of very high quality from localized regions of the human brain. 1 H spectroscopy provides scope for detecting a wide range of metabolites, and offers spatial resolution that is superior to that available with other nuclei. The animal and clinical studies that have so far been reported indicate that abnormal 1 H spectra are associated with a variety of disorders of the brain. Among the metabolites of interest are lactate and N -acetylaspartate. The signal from lactate can provide information about abnormal glycolytic metabolism, for example in brain tumours and cerebrovascular disease. N -Acetylaspartate is believed to be located primarily in neurons, and its signal could prove to be particularly useful as a non-invasive marker for neurons.

Minds and brains: angels, humans, and brutes

1982 ◽  
Vol 57 (3) ◽  
pp. 309-315
Author(s):  
Mortimer J. Adler
Keyword(s):  
Nervous System ◽  
Animal Behavior ◽  
Personal Experience ◽  
Human Beings ◽  
Content Type ◽  
The Past ◽  
Wide Range ◽  
Conceptual Thought ◽  
The Brain ◽  
Fine Print

✓ In his 1982 Cushing oration, a distinguished philosopher, author, and discerning critic presents a distillate of his phenomenally wide range of personal experience and his familiarity with the great books and teachers of the present and the past. He explores the differences and relationships between human beings, brute animals, and machines. Knowledge of the brain and nervous system contribute to the explanation of all aspects of animal behavior, intelligence, and mentality, but cannot completely explain human conceptual thought.

Magnetic resonance spectroscopy in anxiety disorders

2008 ◽  
Vol 20 (2) ◽  
pp. 56-71 ◽  
Author(s):  
Clarissa Trzesniak ◽  
David Araújo ◽  
José Alexandre S. Crippa
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Anxiety Disorders ◽  
Resonance Spectroscopy ◽  
Neuronal Viability ◽  
Non Invasive ◽  
Wide Range ◽  
Brain Changes ◽  
The Brain

Objective:Magnetic resonance spectroscopy (MRS) is a non-invasive in vivo method used to quantify metabolites that are relevant to a wide range of brain processes. This paper briefly describes neuroimaging using MRS and provides a systematic review of its application to anxiety disorders.Method:A literature review was performed in the PubMed, Lilacs and Scielo databases using the keywords spectroscopy and anxiety disorder. References of selected articles were also hand-searched for additional citations.Results:Recent studies have shown that there are significant metabolic differences between patients with anxiety disorders and healthy controls in various regions of the brain. Changes were mainly found in N-acetylaspartate, which is associated with neuronal viability, but some of them were also seen in creatine, a substance that is thought to be relatively constant among individuals with different pathological conditions.Conclusions:MRS is a sophisticated neuroimaging technique that has provided useful insights into the biochemical and neurobiological basis of many anxiety disorders. Nevertheless, its utilization in some anxiety disorders is still modest, particularly social phobia and generalised anxiety. Although it is an extremely useful advance in neuroimaging, further research in other brain areas and patient populations is highly advisable.

Nutrient control of brain neurotransmitter synthesis and function

1983 ◽  
Vol 61 (4) ◽  
pp. 271-281 ◽  
Author(s):  
G. Harvey Anderson ◽  
Janice L. Johnston
Keyword(s):  
Brain Function ◽  
Brain Metabolism ◽  
Nutrient Content ◽  
Feedback Systems ◽  
The Past ◽  
Brain Neurotransmitter ◽  
And Function ◽  
Neurotransmitter Precursors ◽  
To Receive ◽  
The Brain

The significance of normal variations in dietary and plasma nutrient content to brain metabolism and function began to receive examination in the past decade. It is now clear that the brain is much more sensitive to variations in nutrient supply than previously thought. Indeed, it seems likely that the diet-induced plasma fluctuations in nutrients, either as a result of their cofactor roles or as neurotransmitter precursors, are important components of feedback systems assisting the brain in controlling many of its functions. This discovery has suggested new approaches to understanding mechanisms controlling brain function and to treatment of diseases of the brain.

scholarly journals Electromagnetic Torso Scanning: A Review of Devices, Algorithms, and Systems

Biosensors ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 135
Author(s):  
Sasan Ahdi Ahdi Rezaeieh ◽  
Amin Darvazehban ◽  
Azin S. Janani ◽  
Amin M. Abbosh
Keyword(s):  
Fatty Liver Disease ◽  
Advantages And Disadvantages ◽  
Non Invasive ◽  
Disruptive Technologies ◽  
The Past ◽  
Thoracic Diseases ◽  
Wide Range ◽  
Diagnostic Modalities ◽  
Imaging Algorithms ◽  
Scanning Systems

The past decade has witnessed a surge into research on disruptive technologies that either challenge or complement conventional thoracic diagnostic modalities. The non-ionizing, non-invasive, compact, and low power requirements of electromagnetic (EM) techniques make them among the top contenders with varieties of proposed scanning systems, which can be used to detect wide range of thoracic illnesses. Different configurations, antenna topologies and detection or imaging algorithms are utilized in these systems. Hence, to appreciate their progress and assess their potential, a critical review of EM thoracic scanning systems is presented. Considering the numerous thoracic diseases, such as fatty liver disease, lung cancer, respiratory and heart related complications, this paper will exclusively focus on torso scanning systems, tracing the early foundation of research that studied the possibility of using EM waves to detect thoracic diseases besides exploring recent progresses. The advantages and disadvantages of proposed systems and future possibilities are thoroughly discussed.

Optical Properties of HVEM Accelerators

1975 ◽  
Vol 33 ◽  
pp. 180-181
Author(s):  
A. Strojnik ◽  
J.W. Scholl ◽  
V. Bevc
Keyword(s):  
Optical Properties ◽  
Electron Accelerator ◽  
Systematic Investigation ◽  
Electron Source ◽  
High Brightness ◽  
The Past ◽  
Wide Range ◽  
Optical Behavior

The electron accelerator, as inserted between the electron source (injector) and the imaging column of the HVEM, is usually a strong lens and should be optimized in order to ensure high brightness over a wide range of accelerating voltages and illuminating conditions. This is especially true in the case of the STEM where the brightness directly determines the highest resolution attainable. In the past, the optical behavior of accelerators was usually determined for a particular configuration. During the development of the accelerator for the Arizona 1 MEV STEM, systematic investigation was made of the major optical properties for a variety of electrode configurations, number of stages N, accelerating voltages, 1 and 10 MEV, and a range of injection voltages ϕ0 = 1, 3, 10, 30, 100, 300 kV).

TEM study of boron additions to cobalt aluminide

1988 ◽  
Vol 46 ◽  
pp. 546-547
Author(s):  
Gerald B. Feldewerth
Keyword(s):  
High Temperature ◽  
Turbine Engines ◽  
Major Drawback ◽  
University Of Missouri ◽  
Specific Strength ◽  
Aerospace Applications ◽  
Wide Range ◽  
Ordered Alloys ◽  
The University ◽  
Very High

In recent years an increasing emphasis has been placed on the study of high temperature intermetallic compounds for possible aerospace applications. One group of interest is the B2 aiuminides. This group of intermetaliics has a very high melting temperature, good high temperature, and excellent specific strength. These qualities make it a candidate for applications such as turbine engines. The B2 aiuminides exist over a wide range of compositions and also have a large solubility for third element substitutional additions, which may allow alloying additions to overcome their major drawback, their brittle nature.One B2 aluminide currently being studied is cobalt aluminide. Optical microscopy of CoAl alloys produced at the University of Missouri-Rolla showed a dramatic decrease in the grain size which affects the yield strength and flow stress of long range ordered alloys, and a change in the grain shape with the addition of 0.5 % boron.

Pursuit of the Abscopal Effect

2020 ◽  
Vol 04 (04) ◽  
pp. 369-372
Author(s):  
Paul B. Romesser ◽  
Christopher H. Crane
Keyword(s):  
Tumor Immunology ◽  
Antitumor Immunity ◽  
Clinical Success ◽  
Immune Recognition ◽  
Immune Modulators ◽  
Cancer Subtypes ◽  
The Past ◽  
Tumor Irradiation ◽  
Wide Range ◽  
Tumor Recognition

AbstractEvasion of immune recognition is a hallmark of cancer that facilitates tumorigenesis, maintenance, and progression. Systemic immune activation can incite tumor recognition and stimulate potent antitumor responses. While the concept of antitumor immunity is not new, there is renewed interest in tumor immunology given the clinical success of immune modulators in a wide range of cancer subtypes over the past decade. One particularly interesting, yet exceedingly rare phenomenon, is the abscopal response, characterized by a potent systemic antitumor response following localized tumor irradiation presumably attributed to reactivation of antitumor immunity.

Features of the Christian values ​​system

2004 ◽  
pp. 21-29
Author(s):  
G.V. Pyrog
Keyword(s):  
Public Opinion ◽  
Religious Beliefs ◽  
Religious Values ◽  
Direct Influence ◽  
Moral Norms ◽  
Value System ◽  
Christian Religion ◽  
Mass Consciousness ◽  
Wide Range ◽  
Very High

In domestic scientific and public opinion, interest in religion as a new worldview paradigm is very high. Today's attention to the Christian religion in our society is connected, in our opinion, with the specificity of its value system, which distinguishes it from other forms of consciousness: the idea of ​​God, the absolute, the eternity of moral norms. That is why its historical forms do not receive accurate characteristics and do not matter in the mass consciousness. Modern religious beliefs do not always arise as a result of the direct influence of church preaching. The emerging religious values ​​are absorbed in a wide range of philosophical, artistic, ethical ideas, acting as a compensation for what is generally defined as spirituality. At the same time, the appeal to Christian values ​​became very popular.

The Many Pasts of Detective Fiction

2020 ◽  
Vol 1 (2) ◽  
pp. 157-172
Author(s):  
Thomas Leitch
Keyword(s):  
Detective Fiction ◽  
Golden Age ◽  
Public History ◽  
Detective Novel ◽  
Sherlock Holmes ◽  
Detective Story ◽  
The Past ◽  
Wide Range ◽  
Detective Novels ◽  
The Many

Building on Tzvetan Todorov's observation that the detective novel ‘contains not one but two stories: the story of the crime and the story of the investigation’, this essay argues that detective novels display a remarkably wide range of attitudes toward the several pasts they represent: the pasts of the crime, the community, the criminal, the detective, and public history. It traces a series of defining shifts in these attitudes through the evolution of five distinct subgenres of detective fiction: exploits of a Great Detective like Sherlock Holmes, Golden Age whodunits that pose as intellectual puzzles to be solved, hardboiled stories that invoke a distant past that the present both breaks with and echoes, police procedurals that unfold in an indefinitely extended present, and historical mysteries that nostalgically fetishize the past. It concludes with a brief consideration of genre readers’ own ambivalent phenomenological investment in the past, present, and future each detective story projects.

Nine Centuries of Man

2017 ◽  
Keyword(s):  
Twentieth Century ◽  
Diverse Range ◽  
Gender Expectations ◽  
Court Records ◽  
The Past ◽  
Wide Range ◽  
Police Reports ◽  
Late Twentieth ◽  
Scottish History ◽  
Late Twentieth Century

What did it mean to be a man in Scotland over the past nine centuries? Scotland, with its stereotypes of the kilted warrior and the industrial ‘hard man’, has long been characterised in masculine terms, but there has been little historical exploration of masculinity in a wider context. This interdisciplinary collection examines a diverse range of the multiple and changing forms of masculinities from the late eleventh to the late twentieth century, exploring the ways in which Scottish society through the ages defined expectations for men and their behaviour. How men reacted to those expectations is examined through sources such as documentary materials, medieval seals, romances, poetry, begging letters, police reports and court records, charity records, oral histories and personal correspondence. Focusing upon the wide range of activities and roles undertaken by men – work, fatherhood and play, violence and war, sex and commerce – the book also illustrates the range of masculinities that affected or were internalised by men. Together, the chapters illustrate some of the ways Scotland’s gender expectations have changed over the centuries and how, more generally, masculinities have informed the path of Scottish history

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