scholarly journals β β' β"-Triaminotriethylamine and its complex metallic compounds

1925 ◽  
Vol 109 (751) ◽  
pp. 444-458 ◽  
Keyword(s):  
General Type ◽  
Type I ◽  
Amino Group ◽  
Amino Groups ◽  
Basic Properties ◽  
Metallic Compounds ◽  
Primary Amino ◽  
Tertiary Amino ◽  
Trivalent Metals

We have recently shown (‘Roy. Soc. Proc.,’ A, 1924, vol. 107, p. 80) that 1:2:3-triaminopropane forms co-ordination compounds with certain trivalent metals, such as cobalt and rhodium; these compounds are of the general type of bis -propanetriamine cobaltic chloride, [Co 2(NH 2 .CH(CH 2 .NH 2 ) 2 )] Cl 3 , in accordance with Werner’s theory of co-ordination. In these compounds the triaminopropane behaves in a similar way to ethylenediamine, each amino-group taking part in the formation of the co-ordinated radicle. It is thus seen that the grouping, NH 2 .CH 2 .CH.NH 2 , which is present twice in the triamino- propane molecule, behaves for co-ordination purposes in the same way as the molecule of ethylenediamine, NH 2 .CH 2 .CH 2 .NH 2 . This analogy in behaviour appears worthy of further investigation, and we have therefore studied the manner in which β β' β"-triaminotriethylamine, N(CH 2 .CH 2 .NH 2 ) 3 , co-ordinates with the metals; in this substance the grouping, NH 2 .CH 2 .CH 2 .N:, occurs three times, but it would seem that the presence of the three primary amino-groups has greatly diminished the basic properties of the tertiary amino-radicle, since Ristenpart (‘Ber.,’ 1896, vol. 29, p. 2530) obtained only salts in which the substance acts as a tribasic amine. It might thus be anticipated that co-ordinated salts of the type I would be formed.

Anomalous phase behavior in blends of -SO3H terminated polystyrene with poly(n-butyl acrylate) containing a small amount of tertiary amino groups

e-Polymers ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Kenji Yamamoto ◽  
Ayumi Nanakno ◽  
Hiroyasu Masunaga ◽  
Isamu Akiba
Keyword(s):  
Butyl Acrylate ◽  
Stoichiometric Composition ◽  
Phase Region ◽  
Molar Ratio ◽  
Amino Group ◽  
Amino Groups ◽  
Two Phase ◽  
Dimethylaminoethyl Methacrylate ◽  
X Ray Scattering ◽  
Tertiary Amino

Abstract Phase behavior in the blend of -SO3H terminated polystyrene (PSS) with poly(n-butyl acrylate-co-N,N-dimethylaminoethyl methacrylate) containing 6.0 mol% N,N-dimethylaminoethyl methacrylate (P1) is investigated by optical microscopy and small-angle X-ray scattering (SAXS). Comparing the miscibility of polystyrene/P1 blend, it is confirmed that the miscibility of the PSS/P1 blend is drastically improved by the hydrogen bonds between -SO3H and tertiary amino group. In addition, two-phase region of the PSS/P1 blend is split into two regions around the stoichiometric composition, in which the molar ratio of -SO3H to tertiary amino group is 1:1 stoichiometry. SAXS result shows that the PSS/P1 blend at stoichiometric composition forms a block copolymer-like aggregate and it takes a disorder state.

scholarly journals Heterocycle-based bifunctional organocatalysts in asymmetric synthesis

2016 ◽  
Vol 88 (6) ◽  
pp. 561-578 ◽  
Author(s):  
Carmen Nájera ◽  
José Miguel Sansano ◽  
Enrique Gómez-Bengoa
Keyword(s):  
Michael Reaction ◽  
Amino Group ◽  
Benzylic Alcohols ◽  
Carbon Nucleophiles ◽  
Direct Aldol Reaction ◽  
Solvent Free Conditions ◽  
Different Types ◽  
Primary Amino ◽  
Tertiary Amino ◽  
The Michael Reaction

AbstractDifferent chiral bifunctional organocatalysts derived from trans-cyclohexane-1,2-diamine bearing different types of guanidine units able to form-hydrogen bonding activation have been designed. Conformational rigid 2-aminobenzimidazoles bearing a tertiary amino group have been used in enantioselective Michael type reactions of activated methylene compounds to nitroalkenes. The C2 symmetric bis(2-aminobenzimidazole) derivatives the appropriate organocatalyst for the conjugate addition of 1,3-dicarbonyl compounds to maleimides as well as for the SN1 reaction of benzylic alcohols with carbon nucleophiles. 2-Aminobenzimidazoles bearing a primary amino group have shown excellent catalytic activity in the Michael reaction of aldehydes to maleimides and nitroalkenes. Diastereomeric 2-aminopyrimidines bearing a prolinamide unit have been incorporated in the trans-cyclohexane-1,2-diamine scaffold and have been used for the inter- and intra-molecular direct aldol reaction under solvent-free conditions. For the Michael reaction of aldehydes with maleimides the primary amine 2-aminopyrimidine has shown excellent efficiency as organocatalyst. The bifunctional character of these organocatalysts has been demonstrated by means of DFT calculations.

New Method for the Determination of Free Amino Groups in Intact Pure Proteins: Relationship to Available Lysine

1976 ◽  
Vol 59 (6) ◽  
pp. 1251-1254
Author(s):  
James M Purcell ◽  
Daniel J Quimby ◽  
James R Cavanaugh
Keyword(s):  
Bovine Serum Albumin ◽  
Bovine Serum ◽  
Free Amino ◽  
Amino Group ◽  
Amino Groups ◽  
Primary Amino ◽  
Available Lysine ◽  
Β Lactoglobulin ◽  
Group Concentration

Abstract A new rapid method for the quantitative and routine determination of free amino groups in intact pure proteins has been developed. Primary amino groups are labeled with fluorescamine and the labeled groups are detected by absorption spectroscopy in the range 375–390 nm. The amino group concentration can be determined in a few minutes without hydrolyzing the labeled protein and extracting a lysine derivative. The method was tested with the following proteins: lysozyme, α-lactalbumin, β-lactoglobulin, bovine serum albumin, ribonuclease, ribonuclease-S-peptide, and αsl-rasciii B. Application of this method to the estimation of available lysine is discussed.

Impact of the Inter- and Intramolecular Tertiary Amino Group on the Primary Amino Group in the CO2 Absorption Process

2016 ◽  
Vol 55 (26) ◽  
pp. 7210-7217 ◽  
Author(s):  
Rui Zhang ◽  
Xiao Luo ◽  
Qi Yang ◽  
Fan Cao ◽  
Shupanxiang Chen ◽  
...  
Keyword(s):  
Co2 Absorption ◽  
Amino Group ◽  
Absorption Process ◽  
Primary Amino ◽  
Tertiary Amino

scholarly journals Selected Applications of Chitosan Composites

2021 ◽  
Vol 22 (20) ◽  
pp. 10968
Author(s):  
Kunal Pal ◽  
Deepti Bharti ◽  
Preetam Sarkar ◽  
Arfat Anis ◽  
Doman Kim ◽  
...  
Keyword(s):  
Food Packaging ◽  
Human Consumption ◽  
Packaging Materials ◽  
Amino Group ◽  
Amino Groups ◽  
Packaging Films ◽  
Biodegradable Packaging ◽  
Primary Amino ◽  
Antioxidant And Antimicrobial Activity ◽  
Preparation Techniques

Chitosan is one of the emerging materials for various applications. The most intensive studies have focused on its use as a biomaterial and for biomedical, cosmetic, and packaging systems. The research on biodegradable food packaging systems over conventional non-biodegradable packaging systems has gained much importance in the last decade. The deacetylation of chitin, a polysaccharide mainly obtained from crustaceans and shrimp shells, yields chitosan. The deacetylation process of chitin leads to the generation of primary amino groups. The functional activity of chitosan is generally owed to this amino group, which imparts inherent antioxidant and antimicrobial activity to the chitosan. Further, since chitosan is a naturally derived polymer, it is biodegradable and safe for human consumption. Food-focused researchers are exploiting the properties of chitosan to develop biodegradable food packaging systems. However, the properties of packaging systems using chitosan can be improved by adding different additives or blending chitosan with other polymers. In this review, we report on the different properties of chitosan that make it suitable for food packaging applications, various methods to develop chitosan-based packaging films, and finally, the applications of chitosan in developing multifunctional food packaging materials. Here we present a short overview of the chitosan-based nanocomposites, beginning with principal properties, selected preparation techniques, and finally, selected current research.

scholarly journals VALIDATION OF SODIUM NITROPRUSSIDE IN VISIBLE SPECTROPHOTOMETRIC DETERMINATION OF TRIPOLIDINE HYDROCHLORIDE

2020 ◽  
pp. 1-4
Author(s):  
ACHARYULU MN ◽  
MOHANA RAO PVSR ◽  
SIVA RAMA KOTI I
Keyword(s):  
Regression Analysis ◽  
Sodium Nitroprusside ◽  
Spectrophotometric Method ◽  
Correlation Coefficients ◽  
Molar Absorptivity ◽  
Amino Group ◽  
Amino Groups ◽  
Color Development ◽  
Tertiary Amino

Objective: A simple and sensitive extractive visible spectrophotometric method is developed for the assay of triprolidine hydrochloride using sodium nitroprusside. Methods: Based on color development with amino groups, presence, which is basic, may be due to the formation of inner complex replacing H2O by the tertiary amino group present in the drug. Results: The colored products exhibit absorption λmax at 447 nm. Regression analysis of Beer–Lambert plots showed good correlation in the concentration ranges (40–240) μg/ml and correlation coefficients are 0.994. The Sandell’s sensitivities 2.6373×10−2 (1 mole cm−1) and molar absorptivity value are 1.1938×104 (g cm−2). Recovery studies are found to be 99.708–99.786. Conclusion: The method can be applied successfully for the estimation of the drug in the presence of other ingredients that are usually present in formulations.

Aldehyde gold clusters for molecular labeling

1995 ◽  
Vol 53 ◽  
pp. 858-859
Author(s):  
James F. Hainfeld ◽  
Frederic R. Furuya
Keyword(s):  
Covalent Bond ◽  
Aldehyde Group ◽  
Gold Clusters ◽  
Side Reactions ◽  
Amino Groups ◽  
Sodium Cyanoborohydride ◽  
Schiff’S Base ◽  
Protein Molecules ◽  
Hydroxysuccinimide Esters ◽  
Primary Amino

Glutaraldehyde is a useful tissue and molecular fixing reagents. The aldehyde moiety reacts mainly with primary amino groups to form a Schiff's base, which is reversible but reasonably stable at pH 7; a stable covalent bond may be formed by reduction with, e.g., sodium cyanoborohydride (Fig. 1). The bifunctional glutaraldehyde, (CHO-(CH2)3-CHO), successfully stabilizes protein molecules due to generally plentiful amines on their surface; bovine serum albumin has 60; 59 lysines + 1 α-amino. With some enzymes, catalytic activity after fixing is preserved; with respect to antigens, glutaraldehyde treatment can compromise their recognition by antibodies in some cases. Complicating the chemistry somewhat are the reported side reactions, where glutaraldehyde reacts with other amino acid side chains, cysteine, histidine, and tyrosine. It has also been reported that glutaraldehyde can polymerize in aqueous solution. Newer crosslinkers have been found that are more specific for the amino group, such as the N-hydroxysuccinimide esters, and are commonly preferred for forming conjugates. However, most of these linkers hydrolyze in solution, so that the activity is lost over several hours, whereas the aldehyde group is stable in solution, and may have an advantage of overall efficiency.

Biphenyl-Derivatives Possessing Tertiary Amino Groups as β-Secretase (BACE1) Inhibitors

2010 ◽  
Vol 7 (7) ◽  
pp. 507-515
Author(s):  
Simone Bertini ◽  
Elisa Ghilardi ◽  
Valentina Asso ◽  
Carlotta Granchi ◽  
Filippo Minutolo ◽  
...  
Keyword(s):  
Amino Groups ◽  
Tertiary Amino

Purification of Penicillin Amidohydrolase, an Enzyme for Semisynthetic Procedures

1992 ◽  
Vol 57 (10) ◽  
pp. 2187-2191 ◽  
Author(s):  
Jiří Jiráček ◽  
Tomislav Barth ◽  
Jiří Velek ◽  
Ivo Bláha ◽  
Jan Pospíšek ◽  
...  
Keyword(s):  
Affinity Chromatography ◽  
Amino Groups ◽  
Primary Amino

Penicillin amidohydrolase (EC 3.5.1.11.) is one of the few enzymes used successfully for deprotection of primary amino groups of semisynthetic peptides. The available material is usually contamined by endo- and exopeptidases. We managed to prepare the enzyme devoid of trypsin- and chymotrypsin-like activities using affinity chromatography with specific ligands: Gly-D-Phe-Phe-Tyr-Thr-Pro-Lys-Thr (the fF peptide) and Leu-Gly-Val-D-Arg-Arg-Gly-Phe (the rR peptide). For further purification of the enzyme affinity chromatography with N-phenylacetyl-D-tert-Leu as a ligand was used.

Investigation of the effect of ring size on the product distribution for the Schiff base reaction of 2-acetylcycloalkanones with diamino alkanes

1995 ◽  
Vol 73 (1) ◽  
pp. 16-21 ◽  
Author(s):  
Raul G. Enriquez ◽  
Juan M. Fernandez-G ◽  
Ismael Leon ◽  
William F. Reynolds ◽  
Ji.-Ping Yang ◽  
...  
Keyword(s):  
Schiff Base ◽  
Condensation Reaction ◽  
2D Nmr ◽  
Product Distribution ◽  
Major Product ◽  
Ring Size ◽  
Amino Group ◽  
Amino Groups ◽  
Similar Product ◽  
Acetyl Group

The Schiff base condensation reaction of 1,2-diaminoethane with a series of 2-acetylcycloalkanones (from cyclopentanone to cyclooctanone) has been investigated and the products characterized by two-dimensional nuclear magnetic resonance. The site of attack of the amino groups, i.e., ring ketone or acetyl ketone, is determined primarily by ring size. 2-Acetylcyclohexanone yields two products in ca. 9:1 ratio, the major product where the two amino groups attack at the ring ketones of two different cyclohexanone molecules, and the minor product where one amino group attacks one ring carbonyl of one cyclohexanone while the second amino group attacks the acetyl group of another. 2-Acetylcyclopentanone yields all three possible products with the major product involving attack at the acetyl groups of two different cyclopentanones. The corresponding reactions for 2-acetylcycloheptanone and 2-acetylcyclooctanone each give a single product corresponding to attack at the acetyl groups of two different cycloalkanones. Similar product distributions are observed for the reactions of the different 2-acetylcycloalkanones with 1,4-diaminobutane. Keywords: Schiff base reactions, diketones, 2D NMR.

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