scholarly journals Social cognition, behaviour and therapy adherence in frontal lobe epilepsy: a study combining neuroeconomic and neuropsychological methods

2019 ◽  
Vol 6 (8) ◽  
pp. 180850 ◽  
Author(s):  
Andrija Javor ◽  
Carolina Ciumas ◽  
Danielle Ibarrola ◽  
Philippe Ryvlin ◽  
Sylvain Rheims
Keyword(s):  
Social Cognition ◽  
Frontal Lobe ◽  
Social Behaviour ◽  
Social Cognitive ◽  
Frontal Lobe Epilepsy ◽  
Therapy Adherence ◽  
Healthy Humans ◽  
Prisoners Dilemma ◽  
The Relationship ◽  
Neuropsychological Methods

Social behaviour of healthy humans and its neural correlates have been extensively studied in social neuroscience and neuroeconomics. Whereas it is well established that several types of epilepsies, such as frontal lobe epilepsy, lead to social cognitive impairments, experimental evidence on how these translate into behavioural symptoms is scarce. Furthermore, it is unclear whether social cognitive or behavioural disturbances have an impact on therapy adherence, which is critical for effective disease management, but generally low in these patients. In order to investigate the relationship between social cognition, social behaviour, and therapy adherence in patients with frontal lobe epilepsies (FLE), we designed a study combining conventional neuropsychological with behavioural economic and functional magnetic resonance imaging (fMRI) methodology. Fifteen patients and 15 healthy controls played a prisoners' dilemma game (an established game to operationalize social behaviour) while undergoing fMRI. Additionally, social cognitive, basic neuropsychological variables, and therapy adherence were assessed. Our results implicate that social behaviour is indeed affected and can be quantified using neuroeconomic methods in patients with FLE. Impaired social behaviour in these patients might be a consequence of altered brain activation in the medial prefrontal cortex and play a role in low therapy adherence. Finally, this study serves as an example of how to integrate neuroeconomic methods in neurology.

scholarly journals Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

2020 ◽  
Author(s):  
Rhideeta Jalal ◽  
Aarti Nair ◽  
Amy Lin ◽  
Ariel Eckfeld ◽  
Leila Kushan ◽  
...  
Keyword(s):  
Social Cognition ◽  
Social Behavior ◽  
Cognitive Abilities ◽  
Social Cognitive ◽  
22Q11.2 Deletion Syndrome ◽  
Neuropsychiatric Disorders ◽  
Intellectual Functioning ◽  
Deletion Syndrome ◽  
Neurocognitive Deficits ◽  
The Relationship

Abstract Background: 22q11.2 deletion syndrome (22q11DS) is a common recurrent neurogenetic condition associated with elevated risk for developmental neuropsychiatric disorders and intellectual disability. Children and adults with 22q11DS often exhibit marked social impairment as well as neurocognitive deficits, and have elevated rates of both autism spectrum disorder (ASD) and psychosis. However, the relationship between the basic processes of social cognition and cognitive ability has not been well studied in 22q11DS. Here, we examined differences in social cognition in 22q11DS, relative to multiple groups of idiopathic neuropsychiatric disorders, and typically developing healthy controls (HC). Additionally, we examined differences in intellectual functioning and its relationship to social cognitive abilities. Finally, we examined the relationship between social cognitive abilities and real-world social behavior. Methods: We examined social cognition and intellectual functioning in 273 participants (mean age = 17.74+/-5.18% female = 44.3%): 50 with 22q11DS, 49 youth with first episode psychosis (FEP), 48 at clinical high-risk (CHR) for psychosis, 24 participants with ASD, and 102 HC. Social cognition was assessed using The Awareness of Social Inference Test (TASIT), while reciprocal social behavior was assessed via parent/caregiver ratings on the Social Responsiveness Scale (SRS). Participants were also administered the Wechsler Abbreviated Scale of Intelligence, 2 nd edition (WASI-II) to assess intellectual functioning. Results: The 22q11DS group exhibited significantly lower social cognitive abilities compared to all other groups, even after controlling for intellectual functioning. Significant positive correlations were found between social cognition, as measured by the TASIT, and IQ across groups. In contrast, no significant relationships were found between TASIT and real-world social behavior (SRS) for any group. Conclusions: Our findings indicate social cognitive deficits are more prominent in 22q11DS than idiopathic neuropsychiatric conditions across the age range, even after adjusting for global intellectual function. These results contribute to our understanding of the intellectual and social vulnerabilities of 22q11DS in comparison to idiopathic neuropsychiatric disorders. Our findings of robust associations between intellectual ability and social cognition emphasizes the importance of accounting for neurocognitive deficits in social skills interventions and tailoring these existing treatment models for 22q11DS and other populations with intellectual impairment.

scholarly journals Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

2020 ◽  
Author(s):  
Rhideeta Jalal ◽  
Aarti Nair ◽  
Amy Lin ◽  
Ariel Eckfeld ◽  
Leila Kushan ◽  
...  
Keyword(s):  
Social Cognition ◽  
Social Behavior ◽  
Cognitive Abilities ◽  
Social Cognitive ◽  
22Q11.2 Deletion Syndrome ◽  
Neuropsychiatric Disorders ◽  
Intellectual Functioning ◽  
Deletion Syndrome ◽  
Neurocognitive Deficits ◽  
The Relationship

Abstract Background 22q11.2 deletion syndrome (22q11DS) is a common recurrent neurogenetic condition associated with elevated risk for developmental neuropsychiatric disorders and intellectual disability. Children and adults with 22q11DS often exhibit marked social impairment as well as neurocognitive deficits, and have elevated rates of both autism spectrum disorder (ASD) and psychosis. However, the relationship between the basic processes of social cognition and cognitive ability has not been well studied in 22q11DS. Here, we examined differences in social cognition in 22q11DS, relative to multiple groups of idiopathic neuropsychiatric disorders, and typically developing healthy controls (HC). Additionally, we examined differences in intellectual functioning and its relationship to social cognitive abilities. Finally, we examined the relationship between social cognitive abilities and real-world social behavior. Methods We examined social cognition and intellectual functioning in 306 participants (mean age = 16.63+/-4.59; % female = 44.8%): sixty-eight with 22q11DS, 49 youth with first episode psychosis (FEP), 48 at clinical high-risk (CHR) for psychosis, 24 participants with ASD, and 117 HC. Social cognition was assessed using The Awareness of Social Inference Test (TASIT), while reciprocal social behavior was assessed via parent/caregiver ratings on the Social Responsiveness Scale (SRS). Participants were also administered the Wechsler Abbreviated Scale of Intelligence, 2 nd edition (WASI-II) to assess intellectual functioning. Results The 22q11DS group exhibited significantly lower social cognitive abilities compared to all other groups, even after controlling for intellectual functioning. Significant positive correlations were found between social cognition, as measured by the TASIT, and IQ across groups. In contrast, no significant relationships were found between TASIT and real-world social behavior (SRS) for any group. Conclusions Our findings indicate social cognitive deficits are more prominent in 22q11DS than idiopathic neuropsychiatric conditions across the age range, even after adjusting for global intellectual function. These results contribute to our understanding of the intellectual and social vulnerabilities of 22q11DS in comparison to idiopathic neuropsychiatric disorders. Our findings of robust associations between intellectual ability and social cognition emphasizes the importance of accounting for neurocognitive deficits in social skills interventions and tailoring these existing treatment models for 22q11DS and other populations with intellectual impairment.

scholarly journals A study of the relationship between the seizure focus and 1H-MRS in temporal lobe epilepsy and frontal lobe epilepsy

2000 ◽  
Vol 54 (4) ◽  
pp. 455-459 ◽  
Author(s):  
Senichiro Kikuchi ◽  
Fumio Kubota ◽  
Takushiro Akata ◽  
Nobuyoshi Shibata ◽  
Suguru Hattori ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Frontal Lobe ◽  
Temporal Lobe ◽  
Frontal Lobe Epilepsy ◽  
1H Mrs ◽  
Seizure Focus ◽  
The Relationship

scholarly journals M67. UNDERSTANDING SOCIAL COGNITION IN SCHIZOPHRENIA THROUGH THE LENS OF SCHIZOTYPY

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S160-S161
Author(s):  
Sara-Ann Lee ◽  
Keane Lim ◽  
Max Lam ◽  
Jimmy Lee
Keyword(s):  
Social Cognition ◽  
Cognitive Performance ◽  
Cognitive Deficits ◽  
Social Cognitive ◽  
Healthy Controls ◽  
Cognitive Domains ◽  
The Social ◽  
Social Cognitive Deficits ◽  
The Relationship ◽  
Domain Scores

Abstract Background Social cognitive deficits are common, detectable across a wide range of tasks and appear to play a key role in influencing poor functioning in schizophrenia. Despite its importance as a treatment target, the factors that underlie social cognitive deficits in schizophrenia remains elusive. Schizotypy appears to be one such factor that can explain the variability in social cognitive deficits seen in schizophrenia. The study’s primary aim was to provide a more comprehensive understanding of social cognitive functioning and its relationship to schizotypy. Methods 108 patients and 70 healthy controls completed nine tasks across 4 social cognitive domains based on the SCOPE study. In addition, all participants completed the Schizotypal Personality Questionnaire. Clinical symptoms were also rated using the Brief Psychiatric Rating Scale. Results Theory of Mind, social perception, emotion processing and attribution bias were measured in patients with schizophrenia (n = 108) and healthy controls (n = 70). A social cognition composite score was calculated using principal components analysis. Cluster analysis on the derived factor scores revealed 3 clusters. Multiple univariate ANOVAS with Bonferroni correction were used to examine differences between the 3 clusters on each of the 4 social cognition domain scores, which indicated that higher social cognitive performance was related to lower schizotypy. In addition, results indicated that despite differences in the social cognitive performance among patients in the 3 clusters, they did not differ in clinical outcome measures. Discussion The primary aim of the study was to address gaps in the current literature by examining the relationship between social cognition and schizotypy. This study built upon past studies which had the tendency to focus on single, discrete domains by comparing the social cognitive performance of patients and controls using an extensive battery of tests, indexing four social cognitive domains. The significant differences on total SPQ score and the SPQ domain scores between the various clusters, coupled with the significant correlations between schizotypy and social cognition, reinforces the utility of schizotypy in refining our understanding of the variation in the degree of social cognitive deficits in schizophrenia. In conclusion, this study substantiates the importance of understanding the relationship between social cognition and schizotypy. This could support and pave the way for the development and implementation of targeted social cognitive interventions catered to the patients’ level of deficit.

scholarly journals Social cognition in 22q11.2 deletion syndrome and idiopathic developmental neuropsychiatric disorders

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Rhideeta Jalal ◽  
Aarti Nair ◽  
Amy Lin ◽  
Ariel Eckfeld ◽  
Leila Kushan ◽  
...  
Keyword(s):  
Social Cognition ◽  
Social Behavior ◽  
Cognitive Abilities ◽  
Social Cognitive ◽  
22Q11.2 Deletion Syndrome ◽  
Neuropsychiatric Disorders ◽  
Intellectual Functioning ◽  
Deletion Syndrome ◽  
Neurocognitive Deficits ◽  
The Relationship

Abstract Background 22q11.2 deletion syndrome (22q11DS) is a common recurrent neurogenetic condition associated with elevated risk for developmental neuropsychiatric disorders and intellectual disability. Children and adults with 22q11DS often exhibit marked social impairment as well as neurocognitive deficits, and have elevated rates of both autism spectrum disorder (ASD) and psychosis. However, the relationship between the basic processes of social cognition and cognitive ability has not been well studied in 22q11DS. Here, we examined differences in social cognition in 22q11DS, relative to multiple groups of idiopathic neuropsychiatric disorders, and typically developing healthy controls (HC). Additionally, we examined differences in intellectual functioning and its relationship to social cognitive abilities. Finally, we examined the relationship between social cognitive abilities and real-world social behavior. Methods We examined social cognition and intellectual functioning in 273 participants (mean age = 17.74 ± 5.18% female = 44.3%): 50 with 22q11DS, 49 youth with first episode psychosis (FEP), 48 at clinical high-risk (CHR) for psychosis, 24 participants with ASD, and 102 HC. Social cognition was assessed using The Awareness of Social Inference Test (TASIT), while reciprocal social behavior was assessed via parent/caregiver ratings on the Social Responsiveness Scale (SRS). Participants were also administered the Wechsler Abbreviated Scale of Intelligence, 2nd edition (WASI-II) to assess intellectual functioning. Results The 22q11DS group exhibited significantly lower social cognitive abilities compared to CHR, FEP, and HC groups after controlling for intellectual functioning, but not in comparison to the ASD group. Significant positive correlations were found between social cognition, as measured by the TASIT and IQ across groups. In contrast, no significant relationships were found between TASIT and real-world social behavior (SRS) for any group. Conclusions Our findings indicate social cognitive deficits are more prominent in 22q11DS than idiopathic neuropsychiatric conditions across the age range, even after adjusting for global intellectual function. These results contribute to our understanding of the intellectual and social vulnerabilities of 22q11DS in comparison to idiopathic neuropsychiatric disorders. Our findings of robust associations between intellectual ability and social cognition emphasizes the importance of accounting for neurocognitive deficits in social skills interventions and tailoring these existing treatment models for 22q11DS and other populations with intellectual impairment.

scholarly journals Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

2021 ◽  
Author(s):  
Rhideeta Jalal ◽  
Aarti Nair ◽  
Amy Lin ◽  
Ariel Eckfeld ◽  
Leila Kushan ◽  
...  
Keyword(s):  
Social Cognition ◽  
Social Behavior ◽  
Cognitive Abilities ◽  
Social Cognitive ◽  
22Q11.2 Deletion Syndrome ◽  
Neuropsychiatric Disorders ◽  
Intellectual Functioning ◽  
Deletion Syndrome ◽  
Neurocognitive Deficits ◽  
The Relationship

Abstract Background: 22q11.2 deletion syndrome (22q11DS) is a common recurrent neurogenetic condition associated with elevated risk for developmental neuropsychiatric disorders and intellectual disability. Children and adults with 22q11DS often exhibit marked social impairment as well as neurocognitive deficits, and have elevated rates of both autism spectrum disorder (ASD) and psychosis. However, the relationship between the basic processes of social cognition and cognitive ability has not been well studied in 22q11DS. Here, we examined differences in social cognition in 22q11DS, relative to multiple groups of idiopathic neuropsychiatric disorders, and typically developing healthy controls (HC). Additionally, we examined differences in intellectual functioning and its relationship to social cognitive abilities. Finally, we examined the relationship between social cognitive abilities and real-world social behavior.Methods: We examined social cognition and intellectual functioning in 273 participants (mean age = 17.74+/-5.18% female = 44.3%): 50 with 22q11DS, 49 youth with first episode psychosis (FEP), 48 at clinical high-risk (CHR) for psychosis, 24 participants with ASD, and 102 HC. Social cognition was assessed using The Awareness of Social Inference Test (TASIT), while reciprocal social behavior was assessed via parent/caregiver ratings on the Social Responsiveness Scale (SRS). Participants were also administered the Wechsler Abbreviated Scale of Intelligence, 2ndedition (WASI-II) to assess intellectual functioning. Results: The 22q11DS group exhibited significantly lower social cognitive abilities compared to CHR, FEP, and HC groups after controlling for intellectual functioning, but not in comparison to the ASD group. Significant positive correlations were found between social cognition, as measured by the TASIT, and IQ across groups. In contrast, no significant relationships were found between TASIT and real-world social behavior (SRS) for any group. Conclusions: Our findings indicate social cognitive deficits are more prominent in 22q11DS than idiopathic neuropsychiatric conditions across the age range, even after adjusting for global intellectual function. These results contribute to our understanding of the intellectual and social vulnerabilities of 22q11DS in comparison to idiopathic neuropsychiatric disorders. Our findings of robust associations between intellectual ability and social cognition emphasizes the importance of accounting for neurocognitive deficits in social skills interventions and tailoring these existing treatment models for 22q11DS and other populations with intellectual impairment.

scholarly journals Are Negative Symptoms Merely the “Real World” Consequences of Deficits in Social Cognition?

2019 ◽  
Vol 46 (2) ◽  
pp. 236-241 ◽  
Author(s):  
Andrea Pelletier-Baldelli ◽  
Daphne J Holt
Keyword(s):  
Social Cognition ◽  
Cognitive Deficits ◽  
Brain Function ◽  
Negative Symptoms ◽  
Social Cognitive ◽  
Downstream Effects ◽  
Social Cognitive Deficits ◽  
Long Term Prognosis ◽  
The Relationship

Abstract Many investigations have demonstrated that negative symptoms and social cognitive deficits in schizophrenia play a large role in determining functional outcomes and ultimately long-term prognosis. Given this, there is increasing interest in understanding the relationship between these two symptom domains, particularly since studies have consistently found moderate to large associations between them. This shared variance raises a key question: to what degree do these two categories of symptoms arise from overlapping or identical changes in brain function? In other words, do some or all negative symptoms represent merely the downstream effects of social cognition deficits on daily functioning? In this commentary, the evidence for and against this possibility, limitations of currently validated empirical measurements of these symptoms, and directions for further investigation of this hypothesis are discussed. Understanding the shared and distinct mechanisms of these disabling deficits will have important implications for the design of novel, personalized treatments for psychotic illness.

Self-Referential Processing Predicts Social Cognitive Ability

2020 ◽  
Vol 12 (1) ◽  
pp. 99-107
Author(s):  
Stejara Dinulescu ◽  
Talha Alvi ◽  
David Rosenfield ◽  
Cecile S. Sunahara ◽  
Junghee Lee ◽  
...  
Keyword(s):  
Social Cognition ◽  
Cognitive Ability ◽  
Social Cognitive ◽  
Empathic Accuracy ◽  
Depression Symptoms ◽  
Making Sense ◽  
Referential Processing ◽  
Behavioral Assessments ◽  
Behavioral Evidence ◽  
The Relationship

Self-referential processing is critical for making sense of others. However, there remains surprisingly little research examining associations between behavioral assessments of self-referential processing and social cognition (i.e., tasks assessing one’s understanding of others’ thoughts and emotions). This study ( n = 396) examined this link by associating accuracy in a self-referential processing task with two assessments of social cognition (i.e., theory of mind and empathic accuracy). Exploratory analyses included an examination of the relationship between self-referential processing and autism-related traits, as well as depression symptoms, both of which have been previously associated with decreased social cognitive ability. Self-referential processing was positively related to performance in both social cognition tasks, and these relationships were not valence-specific or moderated by gender. Moreover, no associations were found between self-referential processing and autism-related traits or depressive symptoms. Our findings provide behavioral evidence for a relation between self-referential processing and social cognition.

scholarly journals Relationship between Basic Neurological Cognition and Social Cognition among Allen Cognitive Disability Levels of Acquired Brain Injury

Healthcare ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 412
Author(s):  
Myoung-Ok Park ◽  
Sang-Heon Lee
Keyword(s):  
Social Cognition ◽  
Brain Injury ◽  
Cognitive Function ◽  
Linear Correlation ◽  
Social Cognitive ◽  
Acquired Brain Injury ◽  
Cognitive Disability ◽  
Cognitive Level ◽  
Significant Difference ◽  
The Relationship

(1) Background: There are various cognitive, perceptual, and social problems associated with acquired brain injury (ABI). The Allen cognitive impairment level indicates the degree of cognitive function required for everyday activities. Until recently, there have been no studies on the relationship between basic neurological cognition and social cognitive function according to the Allen cognitive level (ACL). The aim of this study is to identify the relationship between basic neurological and social cognition among Allen cognitive disability levels of ABI. (2) Methods: Thirty-four patients with ABI were identified. Cartoon Intention Inference Task (CIIT), Social Behavior Sequence Task (SBST), Korean version Mimi-Mental Status Examination (K-MMSE), and Lowenstein Occupational Therapy Cognitive Assessment (LOTCA)-tests were administered to examine the differences in neurological and social cognitive functions according to each participant’s Allen Cognitive Level Screening (ACLS). (3) Results: There were significant differences between K-MMSE, LOTCA, CIIT and SBST results among Allen cognitive levels (p < 0.05). There was a linear correlation between K-MMSE (r = 0.778, p < 0.01), LOTCA-total score (r = 0.627, p < 0.01), LOTCA-orientation (r = 0.470, p = 0.01), LOTCA-thinking operation (r = 0.341, p < 0.05), CIIT (r = 0.817, p < 0.05), and SBST (r = 0.376, p < 0.05) and ACL. Stepwise multivariate regression showed that the subscales affecting the ACLS score were SBST (β = 0.239, p = 0.000) and K-MMSE (β = 0.068, p = 0.001). The explanatory power of this regression equation, R2, was 0.767. (4) Conclusions: A significant difference was found in neurological and social cognitive function according to the ACL level of the ABI patient. In addition, there was a linear correlation between the ACLS scores of the ABI patients and the underlying neurological cognitive function and social cognition. The higher the overall functional cognitive level (i.e., the group with higher ACLS scores), and the lower the degree of help required in daily life, the higher both the neurological cognition level and social cognitive level were determined to be.

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