Prediction of stable acenocoumarol dose by a pharmacogenetic algorithm

2014 ◽  
Vol 24 (10) ◽  
pp. 501-513 ◽  
Author(s):  
Enrique Jiménez-Varo ◽  
Marisa Cañadas-Garre ◽  
María J. Gutiérrez-Pimentel ◽  
Miguel Á. Calleja-Hernández
Keyword(s):  
Pharmacogenetic Algorithm

Pharmacogenetic algorithm for predicting daily dose of warfarin in Caucasian patients of Czech origin

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Aleš Tomek ◽  
Tereza Růžičková ◽  
Vojtěch Kaplan ◽  
Zuzana Lacinová ◽  
Simona Kumstýřová ◽  
...  
Keyword(s):  
Validation Cohort ◽  
Warfarin Dose ◽  
Therapeutic Index ◽  
Coefficient Of Determination ◽  
Dose Prediction ◽  
Pharmacogenetic Algorithm ◽  
Daily Dose ◽  
Caucasian Patients ◽  
Variant Alleles ◽  
Initiation Of Therapy

Abstract Objectives Warfarin use is limited by a low therapeutic index and significant interindividual variability of the daily dose. The most important factor predicting daily warfarin dose is individual genotype, polymorphisms of genes CYP2C9 (warfarin metabolism) and VKORC1 (sensitivity for warfarin). Algorithms using clinical and genetic variables could predict the daily dose before the initiation of therapy. The aim of this study was to develop and validate an algorithm for the prediction of warfarin daily dose in Czech patients. Methods Detailed clinical data of patients with known and stable warfarin daily dose were collected. All patients were genotyped for polymorphisms in genes CYP2C9 and VKORC1. Results Included patients were divided into derivation (n=175) and validation (n=223) cohorts. The final algorithm includes the following variables: Age, height, weight, treatment with amiodarone and presence of variant alleles of genes CYP2C9 and VKORC1. The adjusted coefficient of determination is 72.4% in the derivation and 62.3% in the validation cohort (p<0.001). Conclusions Our validated algorithm for warfarin daily dose prediction in our Czech cohort had higher precision than other currently published algorithms. Pharmacogenetics of warfarin has the potential in the clinical practice in specialized centers.

scholarly journals A published pharmacogenetic algorithm was poorly predictive of tacrolimus clearance in an independent cohort of renal transplant recipients

2013 ◽  
Vol 76 (3) ◽  
pp. 425-431 ◽  
Author(s):  
Oliver Boughton ◽  
Gabor Borgulya ◽  
Maurizio Cecconi ◽  
Salim Fredericks ◽  
Michelle Moreton-Clack ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Pharmacogenetic Algorithm ◽  
Independent Cohort

Clinical benefits of pharmacogenetic algorithm-based warfarin dosing: Meta-analysis of randomized controlled trials: Comment

2015 ◽  
Vol 136 (1) ◽  
pp. 180-181 ◽  
Author(s):  
Emilie P. Belley-Côté ◽  
Richard P. Whitlock ◽  
Benjamin French ◽  
Nathan Evaniew ◽  
Stephen E. Kimmel
Keyword(s):  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Pharmacogenetic Algorithm ◽  
Clinical Benefits ◽  
Warfarin Dosing

scholarly journals Evaluation of Pharmacogenetic Algorithm for Warfarin Dose Requirements in Japanese Patients

2010 ◽  
Vol 74 (5) ◽  
pp. 977-982 ◽  
Author(s):  
Fumihiko Takeuchi ◽  
Mitsuo Kashida ◽  
Osamu Okazaki ◽  
Yuriko Tanaka ◽  
Shoji Fukuda ◽  
...  
Keyword(s):  
Warfarin Dose ◽  
Japanese Patients ◽  
Pharmacogenetic Algorithm

scholarly journals TheCYP3A4*22allele affects the predictive value of a pharmacogenetic algorithm predicting tacrolimus predose concentrations

2013 ◽  
Vol 75 (6) ◽  
pp. 1545-1547 ◽  
Author(s):  
Laure Elens ◽  
Dennis A. Hesselink ◽  
Ron H. N. van Schaik ◽  
Teun van Gelder
Keyword(s):  
Predictive Value ◽  
Pharmacogenetic Algorithm

A simulation of warfarin maintenance dose requirement using a pharmacogenetic algorithm in an ethnically diverse cohort

2010 ◽  
Vol 7 (3) ◽  
pp. 319-325 ◽  
Author(s):  
Patrick Gladding ◽  
John Mackay ◽  
Irene Zeng ◽  
Ralph Stewart ◽  
Rishi Prabkahar ◽  
...  
Keyword(s):  
Maintenance Dose ◽  
Ethnically Diverse ◽  
Dose Requirement ◽  
Pharmacogenetic Algorithm ◽  
Warfarin Maintenance Dose

scholarly journals Acenocoumarol Pharmacogenetic Dosing Algorithm versus Usual Care in Patients with Venous Thromboembolism: A Randomised Clinical Trial

2021 ◽  
Vol 10 (13) ◽  
pp. 2949
Author(s):  
Hoi Tong ◽  
Alberto Borobia ◽  
Manuel Quintana-Díaz ◽  
Sara Fabra ◽  
Manuel González-Viñolis ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Venous Thromboembolism ◽  
Therapeutic Range ◽  
Dose Adjustment ◽  
Standard Of Care ◽  
Randomised Clinical Trial ◽  
Control Group ◽  
Pharmacogenetic Algorithm ◽  
Dosing Algorithm

Patients with venous thromboembolism (VTE) require immediate treatment with anticoagulants such as acenocoumarol. This multicentre randomised clinical trial evaluated the effectiveness of a dosing pharmacogenetic algorithm versus a standard-of-care dose adjustment at the beginning of acenocoumarol treatment. We included 144 patients with VTE. On the day of recruitment, a blood sample was obtained for genotyping (CYP2C9*2, CYP2C9*3, VKORC1, CYP4F2, APOE). Dose adjustment was performed on day 3 or 4 after the start of treatment according to the assigned group and the follow-up was at 12 weeks. The principal variable was the percentage of patients with an international normalised ratio (INR) within the therapeutic range on day 7. Thirty-four (47.2%) patients had an INR within the therapeutic range at day 7 after the start of treatment in the genotype-guided group compared with 14 (21.9%) in the control group (p = 0.0023). There were no significant differences in the time to achieve a stable INR, the number of INRs within the range in the first 6 weeks and at the end of study. Our results suggest the use of a pharmacogenetic algorithm for patients with VTE could be useful in achieving target INR control in the first days of treatment.

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