A simulation of warfarin maintenance dose requirement using a pharmacogenetic algorithm in an ethnically diverse cohort

2010 ◽  
Vol 7 (3) ◽  
pp. 319-325 ◽  
Author(s):  
Patrick Gladding ◽  
John Mackay ◽  
Irene Zeng ◽  
Ralph Stewart ◽  
Rishi Prabkahar ◽  
...  
Keyword(s):  
Maintenance Dose ◽  
Ethnically Diverse ◽  
Dose Requirement ◽  
Pharmacogenetic Algorithm ◽  
Warfarin Maintenance Dose

scholarly journals Effects of VKORC1 Genetic Polymorphisms on Warfarin Maintenance Dose Requirement in a Chinese Han Population

2015 ◽  
Vol 21 ◽  
pp. 3577-3584 ◽  
Author(s):  
Xiaojuan Yan ◽  
Feng Yang ◽  
Hanyun Zhou ◽  
Hongshen Zhang ◽  
Jianfei Liu ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Maintenance Dose ◽  
Chinese Han Population ◽  
Dose Requirement ◽  
Chinese Han ◽  
Han Population ◽  
Warfarin Maintenance Dose

Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy

1995 ◽  
Vol 5 (6) ◽  
pp. 389-392 ◽  
Author(s):  
Hirokazu Furuya ◽  
Pedro Fernandez-Salguero ◽  
Wendy Gregory ◽  
Heather Taber ◽  
Annette Steward ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Maintenance Dose ◽  
Anticoagulation Therapy ◽  
Dose Requirement ◽  
Warfarin Maintenance Dose

Ethnic differences in warfarin maintenance dose requirement and its relationship with genetics

2008 ◽  
Vol 9 (9) ◽  
pp. 1331-1346 ◽  
Author(s):  
Hedi Schelleman ◽  
Nita A Limdi ◽  
Stephen E Kimmel
Keyword(s):  
Ethnic Differences ◽  
Maintenance Dose ◽  
Dose Requirement ◽  
Warfarin Maintenance Dose

scholarly journals Influence of NQO1 Polymorphisms on Warfarin Maintenance Dose: A Systematic Review and Meta-Analysis (rs1800566 and rs10517)

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Lihong Tian ◽  
Pingping Xiao ◽  
Bingrong Zhou ◽  
Yishan Chen ◽  
Lijuan Kang ◽  
...  
Keyword(s):  
Maintenance Dose ◽  
Meta Analysis ◽  
Warfarin Dose ◽  
Maintenance Dosage ◽  
Sensitivity Analyses ◽  
Cochrane Library ◽  
The Cochrane Library ◽  
The Relationship ◽  
Review Manager ◽  
Warfarin Maintenance Dose

This meta-analysis was conducted to analyze the effect of NQO1 polymorphism on the warfarin maintenance dosage. Using strict inclusion and exclusion criteria, we searched PubMed, EMBASE, and the Cochrane Library for eligible studies published prior to July 7, 2021. The required data were extracted, and experts were consulted when necessary. Review Manager Version 5.4 software was used to analyze the relationship between NQO1 polymorphisms and the warfarin maintenance dosage. Four articles involving 757 patients were included in the meta-analysis. Patients who were NQO1 rs10517 G carriers (AG carriers or GG carriers) required a 48% higher warfarin maintenance dose than those who were AA carriers. Patients with NQO1 rs1800566 CT carriers required a 13% higher warfarin dose than those who were CC carriers, with no associations observed with the other comparisons of the NQO1 rs1800566 genotypes. However, the results obtained by comparing the NQO1 rs1800566 genotypes require confirmation, as significant changes in the results were found in sensitivity analyses. Our meta-analysis suggests that the NQO1 rs10517and NQO1 rs1800566 variant statuses affect the required warfarin maintenance dose.

The effect of the plasma levels of proteins C and S on the prediction of warfarin maintenance dose requirements

1992 ◽  
Vol 52 (1) ◽  
pp. 42-49 ◽  
Author(s):  
Aharon Lubetsky ◽  
Uri Seligsohn ◽  
David Ezra ◽  
Hillel Halkin
Keyword(s):  
Plasma Levels ◽  
Maintenance Dose ◽  
Warfarin Maintenance Dose
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