Beneficial effects of dietary omega‐3 polyunsaturated fatty acid on toxin‐induced neuronal degeneration in an animal model of Parkinson's disease

2007 ◽  
Vol 22 (4) ◽  
pp. 1213-1225 ◽  
Author(s):  
M. Bousquet ◽  
M. Saint‐Pierre ◽  
C. Julien ◽  
N. Salem ◽  
F. Cicchetti ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Neuronal Degeneration ◽  
Omega 3 ◽  
Beneficial Effects

Depression in Parkinson's disease: A double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation

2008 ◽  
Vol 111 (2-3) ◽  
pp. 351-359 ◽  
Author(s):  
Ticyana Moralez da Silva ◽  
Renato Puppi Munhoz ◽  
Cristiano Alvarez ◽  
Katya Naliwaiko ◽  
Ágata Kiss ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fatty Acid ◽  
Pilot Study ◽  
Omega 3 ◽  
Double Blind ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Omega 3 Fatty Acid

Protective effect of caffeine and/or taurine on the 6-hydroxydopamine-induced rat model of Parkinson’s disease: Behavioral and neurochemical evidence

2021 ◽  
pp. 1-9
Author(s):  
Amjad N. Abuirmeileh ◽  
Sawsan M. Abuhamdah ◽  
Asser Ashraf ◽  
Karem H. Alzoubi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Motor Behavior ◽  
Rat Striatum ◽  
Ipsilateral Side ◽  
Time Points ◽  
Beneficial Effects ◽  
Behavior Response ◽  
6 Hydroxydopamine

Background: Caffeine and taurine, which possess neuro-modulatory activity happen to be consumed together as part of the constituents of energy drinks, could have beneficial effects and prevent neuronal deterioration in Parkinson’s disease (PD). Objective: This study aimed to investigate behavioral and neurochemical effects of these two agents in an animal model of PD at two time points to evaluate possible neuro-protective or neuro- modulatory effects. Methods: Stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum was used to model PD-like behavior in animals. Motor behavior was assessed by a characteristic rotation behavior response to the apomorphine challenge and dopamine levels in the striatum were quantified using HPLC-ED. Results: A reduction in apomorphine induced rotations following administration of caffeine and/or taurine as compared to the untreated lesioned group (controls) was shown. Significant decreases in dopamine levels were also seen in the ipsilateral side of 6-OHDA group, this effect was not significantly reversed in caffeine and taurine treated groups. Treatments partially restored the content of DA levels in the lesioned striatum. Conclusions: Current results demonstrated beneficial effects for the combination of caffeine and taurine in PD animal model, suggesting that consumption of both agents could be a new added therapeutic target for Parkinson’s disease prevention and treatment.

scholarly journals Current Drugs and Potential Future Neuroprotective Compounds for Parkinson’s Disease

2019 ◽  
Vol 17 (3) ◽  
pp. 295-306 ◽  
Author(s):  
Iván Carrera ◽  
Ramón Cacabelos
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cholesterol Metabolism ◽  
Neuronal Degeneration ◽  
Research Progress ◽  
Protective Agent ◽  
In Vivo Models ◽  
Beneficial Effects

The research progress of understanding the etiology and pathogenesis of Parkinson's disease (PD) has yet lead to the development of some clinical approaches intended to treat cognitive and behavioral symptoms, such as memory and perception disorders. Despite the major advances in different genetic causes and risk factors for PD, which share common pathways to cell dysfunction and death, there is not yet a complete model of PD that can be used to accurately predict the effect of drugs on disease progression. Clinical trials are also important to test any novel neuro-protective agent, and recently there have been great advances in the use of anti-inflammatory drugs and plant flavonoid antioxidants to protect against specific neuronal degeneration and its interference with lipid and cholesterol metabolism. The increasing knowledge of the molecular events underlying the degenerative process of PD has stimulated research to identify natural compounds capable of halting or slowing the progress of neural deterioration. Polyphenols and flavonoids, which play a neuroprotective role in a wide array of in vitro and in vivo models of neurological disorders, emerged from among the multi-target bio-agents found mainly in plants and microorganisms. This review presents a detailed overview of the multimodal activities of neuroprotective bio-agents tested so far, emphasizing their neurorescue/neuroregenerative activity. The brain-penetrating property of bioagents may make these compounds an important class of natural drugs for the treatment of neurodegenerative diseases. Although there are numerous studies demonstrating beneficial effects in the laboratory by identifying critical molecular targets, the clinical efficacy of these neuroprotective treatments remains to be proven accurately.

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