Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C‐dependent NADPH oxidase activation: effect on platelet recruitment

2006 ◽  
Vol 20 (8) ◽  
pp. 1082-1089 ◽  
Author(s):  
P. Pignatelli ◽  
S. Di Santo ◽  
B. Buchetti ◽  
V. Sanguigni ◽  
A. Brunelli ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Activation Effect ◽  
Kinase C ◽  
Inhibiting Protein ◽  
Nadph Oxidase Activation

Protein kinase C-α and -δ are required for NADPH oxidase activation in WKYMVm-stimulated IMR90 human fibroblasts

2007 ◽  
Vol 459 (2) ◽  
pp. 288-294 ◽  
Author(s):  
Annalisa Iaccio ◽  
Claudio Collinet ◽  
Nicola Montesano Gesualdi ◽  
Rosario Ammendola
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Human Fibroblasts ◽  
Kinase C ◽  
Nadph Oxidase Activation

scholarly journals Protein kinase C-β contributes to NADPH oxidase activation in neutrophils

2000 ◽  
Vol 347 (1) ◽  
pp. 285-289 ◽  
Author(s):  
Lodewijk V. DEKKER ◽  
Michael LEITGES ◽  
Gabriel ALTSCHULER ◽  
Nishil MISTRY ◽  
Aileen MCDERMOTT ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Specific Inhibitor ◽  
Human Neutrophils ◽  
Cell Fractionation ◽  
Coated Particles ◽  
Kinase C ◽  
Pkc Β ◽  
Nadph Oxidase Activation

We have analysed the involvement of the β isotype of the protein kinase C (PKC) family in the activation of NADPH oxidase in primary neutrophils. Using immunofluorescence and cell fractionation, PKC-β is shown to be recruited to the plasma membrane upon stimulation with phorbol ester and to the phagosomal membrane upon phagocytosis of IgG-coated particles (Fcγ-receptor stimulus). The time course of recruitment is similar to that of NADPH oxidase activation by these stimuli. The PKC-β specific inhibitor 379196 inhibits the response to PMA as well as to IgG-coated bacteria. Partial inhibition occurs between 10 and 100 nM of inhibitor, the concentration at which PKC-β, but not other PKC isotypes, is targeted. Neutrophils isolated from a mouse that lacks PKC-β also showed an inhibition of NADPH oxidase activation by PMA and IgG-coated particles. The level of inhibition is comparable to that achieved with 379196 in human neutrophils. Thus the PKC-β isotype mediates activation of NADPH oxidase by PMA and by stimulation of Fcγ receptors in neutrophils.

scholarly journals Protein kinase C-β contributes to NADPH oxidase activation in neutrophils

2000 ◽  
Vol 347 (1) ◽  
pp. 285 ◽  
Author(s):  
Lodewijk V. DEKKER ◽  
Michael LEITGES ◽  
Gabriel ALTSCHULER ◽  
Nishil MISTRY ◽  
Aileen MCDERMOTT ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Kinase C ◽  
Nadph Oxidase Activation

scholarly journals Losartan Metabolite EXP3179 Blocks NADPH Oxidase-Mediated Superoxide Production by Inhibiting Protein Kinase C

Hypertension ◽  
2009 ◽  
Vol 54 (4) ◽  
pp. 744-750 ◽  
Author(s):  
Ana Fortuño ◽  
Julen Bidegain ◽  
Pablo A. Robador ◽  
José Hermida ◽  
Jacinto López-Sagaseta ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Superoxide Production ◽  
Kinase C ◽  
Inhibiting Protein

NADPH-oxidase activation by protein kinase C-isotypes

1991 ◽  
Vol 177 (3) ◽  
pp. 1033-1040 ◽  
Author(s):  
P. Sharma ◽  
A.T. Evans ◽  
P.J. Parker ◽  
F.J. Evans
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Kinase C ◽  
Nadph Oxidase Activation

Indication of a Protein Kinase C-Independent Pathway for NADPH Oxidase Activation in Human Neutrophils

1998 ◽  
Vol 349 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Naoko Kawakami ◽  
Hiroaki Takemasa ◽  
Teruhide Yamaguchi ◽  
Takao Hayakawa ◽  
Shun Shimohama ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Human Neutrophils ◽  
Kinase C ◽  
Nadph Oxidase Activation
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