Protein kinase C-independent pathway for NADPH oxidase activation in guinea pig peritoneal polymorphonuclear leukocytes by cytochalasin D

2005 ◽  
Vol 438 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Naoki Imagawa ◽  
Kazuki Nagasawa ◽  
Katsuhito Nagai ◽  
Naoko Kawakami-Honda ◽  
Sadaki Fujimoto
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Guinea Pig ◽  
Nadph Oxidase ◽  
Polymorphonuclear Leukocytes ◽  
Cytochalasin D ◽  
Kinase C ◽  
Nadph Oxidase Activation

Protein kinase C-α and -δ are required for NADPH oxidase activation in WKYMVm-stimulated IMR90 human fibroblasts

2007 ◽  
Vol 459 (2) ◽  
pp. 288-294 ◽  
Author(s):  
Annalisa Iaccio ◽  
Claudio Collinet ◽  
Nicola Montesano Gesualdi ◽  
Rosario Ammendola
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Human Fibroblasts ◽  
Kinase C ◽  
Nadph Oxidase Activation

scholarly journals Protein kinase C-β contributes to NADPH oxidase activation in neutrophils

2000 ◽  
Vol 347 (1) ◽  
pp. 285-289 ◽  
Author(s):  
Lodewijk V. DEKKER ◽  
Michael LEITGES ◽  
Gabriel ALTSCHULER ◽  
Nishil MISTRY ◽  
Aileen MCDERMOTT ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Specific Inhibitor ◽  
Human Neutrophils ◽  
Cell Fractionation ◽  
Coated Particles ◽  
Kinase C ◽  
Pkc Β ◽  
Nadph Oxidase Activation

We have analysed the involvement of the β isotype of the protein kinase C (PKC) family in the activation of NADPH oxidase in primary neutrophils. Using immunofluorescence and cell fractionation, PKC-β is shown to be recruited to the plasma membrane upon stimulation with phorbol ester and to the phagosomal membrane upon phagocytosis of IgG-coated particles (Fcγ-receptor stimulus). The time course of recruitment is similar to that of NADPH oxidase activation by these stimuli. The PKC-β specific inhibitor 379196 inhibits the response to PMA as well as to IgG-coated bacteria. Partial inhibition occurs between 10 and 100 nM of inhibitor, the concentration at which PKC-β, but not other PKC isotypes, is targeted. Neutrophils isolated from a mouse that lacks PKC-β also showed an inhibition of NADPH oxidase activation by PMA and IgG-coated particles. The level of inhibition is comparable to that achieved with 379196 in human neutrophils. Thus the PKC-β isotype mediates activation of NADPH oxidase by PMA and by stimulation of Fcγ receptors in neutrophils.

scholarly journals Protein kinase C-β contributes to NADPH oxidase activation in neutrophils

2000 ◽  
Vol 347 (1) ◽  
pp. 285 ◽  
Author(s):  
Lodewijk V. DEKKER ◽  
Michael LEITGES ◽  
Gabriel ALTSCHULER ◽  
Nishil MISTRY ◽  
Aileen MCDERMOTT ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Kinase C ◽  
Nadph Oxidase Activation

Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C‐dependent NADPH oxidase activation: effect on platelet recruitment

2006 ◽  
Vol 20 (8) ◽  
pp. 1082-1089 ◽  
Author(s):  
P. Pignatelli ◽  
S. Di Santo ◽  
B. Buchetti ◽  
V. Sanguigni ◽  
A. Brunelli ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Activation Effect ◽  
Kinase C ◽  
Inhibiting Protein ◽  
Nadph Oxidase Activation

NADPH-oxidase activation by protein kinase C-isotypes

1991 ◽  
Vol 177 (3) ◽  
pp. 1033-1040 ◽  
Author(s):  
P. Sharma ◽  
A.T. Evans ◽  
P.J. Parker ◽  
F.J. Evans
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Kinase C ◽  
Nadph Oxidase Activation
Sign in / Sign up

Export Citation Format

Share Document