scholarly journals Perfluorocarboxylic Acids Induce Cytochrome P450 Enzymes in Mouse Liver through Activation of PPAR-α and CAR Transcription Factors

2008 ◽  
Vol 106 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Xingguo Cheng ◽  
Curtis D. Klaassen
Keyword(s):  
Cytochrome P450 ◽  
Transcription Factors ◽  
Mouse Liver ◽  
Cytochrome P450 Enzymes ◽  
Perfluorocarboxylic Acids

scholarly journals Acetaminophen-Induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-Dependent Manner in Mouse Liver

2020 ◽  
Vol 48 (5) ◽  
pp. 326-336 ◽  
Author(s):  
Yifan Bao ◽  
Pei Wang ◽  
Xueyan Shao ◽  
Junjie Zhu ◽  
Jingcheng Xiao ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Liver Injury ◽  
Mouse Liver ◽  
Dependent Manner ◽  
Cytochrome P450 Enzymes ◽  
Age Dependent

scholarly journals Diverse roles of MAX1 homologues in rice

2020 ◽  
Author(s):  
Marek Marzec ◽  
Apriadi Situmorang ◽  
Philip B. Brewer ◽  
Agnieszka Brąszewska-Zalewska
Keyword(s):  
Heavy Metals ◽  
Cytochrome P450 ◽  
Oryza Sativa ◽  
Transcription Factors ◽  
Flower Development ◽  
Expression Profiles ◽  
Structural Diversity ◽  
Cytochrome P450 Enzymes ◽  
Wide Range ◽  
Wax Synthesis

AbstractCytochrome P450 enzymes encoded by MORE AXILLARY GROWTH1 (MAX1)-like genes produce most of the structural diversity of strigolactones during the final steps of strigolactone biosynthesis. The diverse copies of MAX1 in Oryza sativa provide a resource to investigate why plants produce such a wide range of strigolactones. Here we performed in silico analyses of transcription factors and microRNAs that may regulate each rice MAX1, and compared the results with available data about MAX1 expression profiles and genes co-expressed with MAX1 genes. Data suggest that distinct mechanisms regulate the expression of each MAX1. Moreover, there may be novel functions for MAX1 homologues, such as the regulation of flower development or responses to heavy metals. In addition, individual MAX1s could be involved in specific functions, such as the regulation of seed development or wax synthesis in rice. Our analysis reveals potential new avenues of strigolactone research that may otherwise not be obvious.

Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes

Life Sciences ◽  
2005 ◽  
Vol 77 (7) ◽  
pp. 735-745 ◽  
Author(s):  
Yueh-Ching Chou ◽  
Yune-Fang Ueng ◽  
Chia-Yu Chou ◽  
Jung-Hsiung Tien
Keyword(s):  
Cytochrome P450 ◽  
Mouse Liver ◽  
Cytochrome P450 Enzymes ◽  
Microsomal Cytochrome ◽  
Microsomal Cytochrome P450

Inoculation of Human Tumor Cells Alters the Basal Expression but Not the Inducibility of Cytochrome P450 Enzymes in Tumor-Bearing Mouse Liver

2009 ◽  
Vol 37 (11) ◽  
pp. 2244-2254 ◽  
Author(s):  
Michiko Sugawara ◽  
Kiyoshi Okamoto ◽  
Tadashi Kadowaki ◽  
Kazutomi Kusano ◽  
Akiyoshi Fukamizu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Tumor Cells ◽  
Mouse Liver ◽  
Human Tumor ◽  
Tumor Bearing Mouse ◽  
Cytochrome P450 Enzymes ◽  
Human Tumor Cells ◽  
Tumor Bearing ◽  
Basal Expression

β-Catenin as a multilayer modulator of zonal cytochrome P450 expression in mouse liver

2010 ◽  
Vol 391 (2/3) ◽  
Author(s):  
Albert Braeuning ◽  
Michael Schwarz
Keyword(s):  
Cytochrome P450 ◽  
Mouse Liver ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Central Vein ◽  
Cytochrome P450 Enzymes ◽  
Metabolizing Enzymes ◽  
Major Organ ◽  
Exogenous Compounds ◽  
Review Current

Abstract The liver is the major organ for metabolism of drugs and other xenobiotics. Expression of many drug-metabolizing enzymes is not equally distributed throughout the liver: under normal conditions, many of them, including the most relevant members of the cytochrome P450 superfamily, are exclusively expressed in a hepatocyte subpopulation located near branches of the efferent central vein. Activation of different ligand-dependent transcription factors by exogenous compounds stimulates high expression of certain cytochrome P450 isoforms. This process also occurs preferentially in perivenous hepatocytes. The mechanisms, however, which determine the zone-specificity of basal and xenobiotic-induced expression of cytochrome P450 enzymes, have remained largely unknown for decades. Very recently, signaling through the Wnt/β-catenin pathway has been implicated in the regulation of zonal gene expression in mouse liver. In this review, current knowledge of cytochrome P450 regulation by β-catenin-dependent transcription is summarized and underlying molecular mechanisms are discussed.

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