scholarly journals The effect of emotion regulation on risk-taking and decision-related activity in prefrontal cortex

2019 ◽  
Vol 14 (10) ◽  
pp. 1109-1118 ◽  
Author(s):  
Carmen Morawetz ◽  
Peter N C Mohr ◽  
Hauke R Heekeren ◽  
Stefan Bode
Keyword(s):  
Decision Making ◽  
Emotion Regulation ◽  
Prefrontal Cortex ◽  
Risk Taking ◽  
Control Strategies ◽  
Emotional Responses ◽  
Brain Regions ◽  
Risky Decision ◽  
Subsequent Choice ◽  
Risky Decisions

Abstract Emotion regulation impacts the expected emotional responses to the outcomes of risky decisions via activation of cognitive control strategies. However, whether the regulation of emotional responses to preceding, incidental stimuli also impacts risk-taking in subsequent decisions is still poorly understood. In this study, we investigated the interplay between the regulation of incidentally induced emotional responses and subsequent choice behavior using a risky decision-making task in two independent samples (behavioral and functional magnetic resonance imaging experiment). We found that overall, emotion regulation was followed by less risky decisions, which was further reflected in an increase in activation in brain regions in dorsolateral and ventrolateral prefrontal cortex and cingulate cortex. These findings suggest that altering incidental emotions using reappraisal strategies impacts on subsequent risk-taking in decision-making.

scholarly journals Hippocampal regenerative medicine: neurogenic implications for addiction and mental disorders

2021 ◽  
Author(s):  
Lee Peyton ◽  
Alfredo Oliveros ◽  
Doo-Sup Choi ◽  
Mi-Hyeon Jang
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Executive Function ◽  
General Population ◽  
Mental Disorders ◽  
Psychiatric Illness ◽  
Neural Circuitry ◽  
Brain Regions ◽  
Neuropsychiatric Disease ◽  
Motivated Behavior

AbstractPsychiatric illness is a prevalent and highly debilitating disorder, and more than 50% of the general population in both middle- and high-income countries experience at least one psychiatric disorder at some point in their lives. As we continue to learn how pervasive psychiatric episodes are in society, we must acknowledge that psychiatric disorders are not solely relegated to a small group of predisposed individuals but rather occur in significant portions of all societal groups. Several distinct brain regions have been implicated in neuropsychiatric disease. These brain regions include corticolimbic structures, which regulate executive function and decision making (e.g., the prefrontal cortex), as well as striatal subregions known to control motivated behavior under normal and stressful conditions. Importantly, the corticolimbic neural circuitry includes the hippocampus, a critical brain structure that sends projections to both the cortex and striatum to coordinate learning, memory, and mood. In this review, we will discuss past and recent discoveries of how neurobiological processes in the hippocampus and corticolimbic structures work in concert to control executive function, memory, and mood in the context of mental disorders.

scholarly journals Uncovering the spatio-temporal dynamics of value-based decision-making in the human brain: a combined fMRI–EEG study

2014 ◽  
Vol 369 (1655) ◽  
pp. 20130473 ◽  
Author(s):  
Tobias Larsen ◽  
John P. O'Doherty
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Temporal Dynamics ◽  
Brain Regions ◽  
Choice Task ◽  
Binary Choice ◽  
Intraparietal Sulcus ◽  
Trial Onset ◽  
Eeg Data ◽  
Spatio Temporal

While there is a growing body of functional magnetic resonance imaging (fMRI) evidence implicating a corpus of brain regions in value-based decision-making in humans, the limited temporal resolution of fMRI cannot address the relative temporal precedence of different brain regions in decision-making. To address this question, we adopted a computational model-based approach to electroencephalography (EEG) data acquired during a simple binary choice task. fMRI data were also acquired from the same participants for source localization. Post-decision value signals emerged 200 ms post-stimulus in a predominantly posterior source in the vicinity of the intraparietal sulcus and posterior temporal lobe cortex, alongside a weaker anterior locus. The signal then shifted to a predominantly anterior locus 850 ms following the trial onset, localized to the ventromedial prefrontal cortex and lateral prefrontal cortex. Comparison signals between unchosen and chosen options emerged late in the trial at 1050 ms in dorsomedial prefrontal cortex, suggesting that such comparison signals may not be directly associated with the decision itself but rather may play a role in post-decision action selection. Taken together, these results provide us new insights into the temporal dynamics of decision-making in the brain, suggesting that for a simple binary choice task, decisions may be encoded predominantly in posterior areas such as intraparietal sulcus, before shifting anteriorly.

scholarly journals Neuroanatomical Correlates of Impulsive Choices and Risky Decision Making in Young Chronic Tobacco Smokers: A Voxel-Based Morphometry Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Aldo Alberto Conti ◽  
Alexander Mario Baldacchino
Keyword(s):  
Decision Making ◽  
Smoking Behavior ◽  
Smoking Initiation ◽  
Brain Regions ◽  
Anterior Cingulate ◽  
Risky Decision Making ◽  
Voxel Based Morphometry ◽  
Tobacco Exposure ◽  
Risky Decision ◽  
Cognitive Impulsivity

Introduction: Impairments in the multifaceted neuropsychological construct of cognitive impulsivity are a main feature of chronic tobacco smokers. According to the literature, these cognitive impairments are relevant for the initiation and maintenance of the smoking behavior. However, the neuroanatomical correlates of cognitive impulsivity in chronic smokers remain under-investigated.Methods: A sample of 28 chronic smokers (mean age = 28 years) not affected by polysubstance dependence and 24 matched non-smoker controls was recruited. Voxel Based Morphometry (VBM) was employed to assess Gray Matter (GM) volume differences between smokers and non-smokers. The relationships between GM volume and behavioral manifestations of impulsive choices (5 trial adjusting delay discounting task, ADT-5) and risky decision making (Cambridge Gambling Task, CGT) were also investigated.Results: VBM results revealed GM volume reductions in cortical and striatal brain regions of chronic smokers compared to non-smokers. Additionally, smokers showed heightened impulsive choices (p < 0.01, Cohen's f = 0.50) and a riskier decision- making process (p < 0.01, Cohen's f = 0.40) compared to non-smokers. GM volume reductions in the left Anterior Cingulate Cortex (ACC) correlated with impaired impulsive and risky choices, while GM volume reductions in the left Ventrolateral Prefrontal Cortex (VLPFC) and Caudate correlated with heightened impulsive choices. Reduced GM volume in the left VLPFC correlated with younger age at smoking initiation (mean = 16 years).Conclusion: Smokers displayed significant GM volume reductions and related cognitive impulsivity impairments compared to non-smoker individuals. Longitudinal studies would be required to assess whether these impairments underline neurocognitive endophenotypes or if they are a consequence of tobacco exposure on the adolescent brain.

scholarly journals Novel Inferences in a Multidimensional Social Network Use a Grid-like Code

2020 ◽  
Author(s):  
Seongmin A. Park ◽  
Douglas S. Miller ◽  
Erie D. Boorman
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Entorhinal Cortex ◽  
Brain Regions ◽  
Cognitive Map ◽  
General Mechanism ◽  
Temporoparietal Junction ◽  
Flexible Behavior ◽  
Discrete Problems

ABSTRACTGeneralizing experiences to guide decision making in novel situations is a hallmark of flexible behavior. It has been hypothesized such flexibility depends on a cognitive map of an environment or task, but directly linking the two has proven elusive. Here, we find that discretely sampled abstract relationships between entities in an unseen two-dimensional (2-D) social hierarchy are reconstructed into a unitary 2-D cognitive map in the hippocampus and entorhinal cortex. We further show that humans utilize a grid-like code in several brain regions, including entorhinal cortex and medial prefrontal cortex, for inferred direct trajectories between entities in the reconstructed abstract space during discrete decisions. Moreover, these neural grid-like codes in the entorhinal cortex predict neural decision value computations in the medial prefrontal cortex and temporoparietal junction area during choice. Collectively, these findings show that grid-like codes are used by the human brain to infer novel solutions, even in abstract and discrete problems, and suggest a general mechanism underpinning flexible decision making and generalization.

Modeling the Effects of Sleep Deprivation on Real-Time Risky Decision-Making

1998 ◽  
Vol 42 (3) ◽  
pp. 330-334
Author(s):  
Joshua B. Hurwitz
Keyword(s):  
Decision Making ◽  
Risk Perception ◽  
Real Time ◽  
Risk Taking ◽  
Time Of Day ◽  
Risky Decision Making ◽  
Risky Decision ◽  
Distance Information ◽  
Driving Task ◽  
Response Choices

Increased real-time risk-taking under sleep loss could be marked by changes in risk perception or acceptance. Risk-perception processes are those involved in estimating real-time parameters such as the speeds and distances of hazardous objects. Risk-acceptance processes relate to response choices given risk estimates. Risk-taking under fatigue was studied using a simulated intersection-crossing driving task in which subjects decided when it was safe to cross an intersection as an oncoming car approached from the cross street. The subjects performed this task at 3-hour intervals over a 36-hour period without sleep. Results were modeled using a model of real-time risky decision making that has perceptual components that process speed, time and distance information, and a decisional component for accepting risk. Results showed that varying a parameter for the decisional component across sessions best accounted for variations in performance relating to time of day.

scholarly journals Modernizing Conceptions of Valuation and Cognitive-Control Deployment in Adolescent Risk Taking

2019 ◽  
Vol 29 (1) ◽  
pp. 102-109 ◽  
Author(s):  
Kathy T. Do ◽  
Paul B. Sharp ◽  
Eva H. Telzer
Keyword(s):  
Decision Making ◽  
Control System ◽  
Cognitive Control ◽  
Computational Model ◽  
Risk Taking ◽  
Expected Value ◽  
Risky Decision Making ◽  
Risky Decision ◽  
Adolescent Risk ◽  
Risk Taking Behavior

Heightened risk taking in adolescence has long been attributed to valuation systems overwhelming the deployment of cognitive control. However, this explanation of why adolescents engage in risk taking is insufficient given increasing evidence that risk-taking behavior can be strategic and involve elevated cognitive control. We argue that applying the expected-value-of-control computational model to adolescent risk taking can clarify under what conditions control is elevated or diminished during risky decision-making. Through this lens, we review research examining when adolescent risk taking might be due to—rather than a failure of—effective cognitive control and suggest compelling ways to test such hypotheses. This effort can resolve when risk taking arises from an immaturity of the control system itself, as opposed to arising from differences in what adolescents value relative to adults. It can also identify promising avenues for channeling cognitive control toward adaptive outcomes in adolescence.

scholarly journals Heightened Adolescent Risk-Taking? Insights From Lab Studies on Age Differences in Decision-Making

2019 ◽  
Vol 6 (1) ◽  
pp. 56-63 ◽  
Author(s):  
Ivy N. Defoe ◽  
Judith Semon Dubas ◽  
Daniel Romer
Keyword(s):  
Decision Making ◽  
Age Differences ◽  
Risk Taking ◽  
Real World ◽  
Meta Analysis ◽  
Risky Decision Making ◽  
Risky Decision ◽  
Neuropsychological Development ◽  
Integrative Framework ◽  
Adolescent Risk

Surveys concur that adolescents disproportionately engage in many real-world risk behaviors, compared with children and adults. Recently researchers have employed laboratory risky decision-making tasks to replicate this apparent heightened adolescent risk-taking. This review builds on the main findings of the first meta-analysis of such age differences in risky decision-making in the laboratory. Overall, although adolescents engage in more risky decision-making than adults, adolescents engage in risky decision-making equal to children. However, adolescents take fewer risks than children on tasks that allow the option of opting out of taking a risk. To reconcile findings on age differences in risk-taking in the real-world versus the laboratory, an integrative framework merges theories on neuropsychological development with ecological models that emphasize the importance of risk exposure in explaining age differences in risk-taking. Policy insights and recent developments are discussed.

scholarly journals Chimpanzees (Pan troglodytes) Are More Averse to Social Than Nonsocial Risk

2018 ◽  
Vol 30 (1) ◽  
pp. 105-115 ◽  
Author(s):  
Sarah E. Calcutt ◽  
Darby Proctor ◽  
Sarah M. Berman ◽  
Frans B. M. de Waal
Keyword(s):  
Decision Making ◽  
Pan Troglodytes ◽  
Risk Taking ◽  
Trust Game ◽  
Risk Attitudes ◽  
Social Risk ◽  
Risky Decision ◽  
Emotional Factors ◽  
Economic Decision Making ◽  
Tit For Tat

Social risk is a domain of risk in which the costs, benefits, and uncertainty of an action depend on the behavior of another individual. Humans overvalue the costs of a socially risky decision when compared with that of purely economic risk. Here, we played a trust game with 8 female captive chimpanzees ( Pan troglodytes) to determine whether this bias exists in one of our closest living relatives. A correlation between an individual’s social- and nonsocial-risk attitudes indicated stable individual variation, yet the chimpanzees were more averse to social than nonsocial risk. This indicates differences between social and economic decision making and emotional factors in social risk taking. In another experiment using the same paradigm, subjects played with several partners with whom they had varying relationships. Preexisting relationships did not impact the subjects’ choices. Instead, the apes used a tit-for-tat strategy and were influenced by the outcome of early interactions with a partner.

scholarly journals Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making

Brain ◽  
2008 ◽  
Vol 131 (5) ◽  
pp. 1311-1322 ◽  
Author(s):  
L. Clark ◽  
A. Bechara ◽  
H. Damasio ◽  
M. R. F. Aitken ◽  
B. J. Sahakian ◽  
...  
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Ventromedial Prefrontal Cortex ◽  
Risky Decision Making ◽  
Risky Decision ◽  
Differential Effects
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