scholarly journals Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making

Brain ◽  
2008 ◽  
Vol 131 (5) ◽  
pp. 1311-1322 ◽  
Author(s):  
L. Clark ◽  
A. Bechara ◽  
H. Damasio ◽  
M. R. F. Aitken ◽  
B. J. Sahakian ◽  
...  
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Ventromedial Prefrontal Cortex ◽  
Risky Decision Making ◽  
Risky Decision ◽  
Differential Effects

scholarly journals Risky Decision Making, Prefrontal Cortex, and Mesocorticolimbic Functional Connectivity in Methamphetamine Dependence

2014 ◽  
Vol 71 (7) ◽  
pp. 812 ◽  
Author(s):  
Milky Kohno ◽  
Angelica M. Morales ◽  
Dara G. Ghahremani ◽  
Gerhard Hellemann ◽  
Edythe D. London
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Risky Decision Making ◽  
Risky Decision ◽  
Methamphetamine Dependence

scholarly journals Dissociation between Private and Social Counterfactual Value Signals Following Ventromedial Prefrontal Cortex Damage

2019 ◽  
Vol 31 (5) ◽  
pp. 639-656 ◽  
Author(s):  
Nadège Bault ◽  
Giuseppe di Pellegrino ◽  
Martina Puppi ◽  
Gaëlle Opolczynski ◽  
Alessia Monti ◽  
...  
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Ventromedial Prefrontal Cortex ◽  
The Other ◽  
Healthy Controls ◽  
Risky Decision ◽  
Brain Areas ◽  
Social Settings ◽  
Neuropsychological Study

Individuals learn by comparing the outcome of chosen and unchosen actions. A negative counterfactual value signal is generated when this comparison is unfavorable. This can happen in private as well as in social settings—where the foregone outcome results from the choice of another person. We hypothesized that, despite sharing similar features such as supporting learning, these two counterfactual signals might implicate distinct brain networks. We conducted a neuropsychological study on the role of private and social counterfactual value signals in risky decision-making. Patients with lesions in the ventromedial prefrontal cortex (vmPFC), lesion controls, and healthy controls repeatedly chose between lotteries. In private trials, participants could observe the outcomes of their choices and the outcomes of the unselected lotteries. In social trials, participants could also see the other player's choices and outcome. At the time of outcome, vmPFC patients were insensitive to private counterfactual value signals, whereas their responses to social comparison were similar to those of control participants. At the time of choice, intact vmPFC was necessary to integrate counterfactual signals in decisions, although amelioration was observed during the course of the task, possibly driven by social trials. We conclude that if the vmPFC is critical in processing private counterfactual signals and in integrating those signals in decision-making, then distinct brain areas might support the processing of social counterfactual signals.

Sign in / Sign up

Export Citation Format

Share Document