scholarly journals Investigating the genetic basis of altruism: the role of the COMT Val158Met polymorphism

2010 ◽  
Vol 6 (5) ◽  
pp. 662-668 ◽  
Author(s):  
Martin Reuter ◽  
Clemens Frenzel ◽  
Nora T. Walter ◽  
Sebastian Markett ◽  
Christian Montag
Keyword(s):  
Genetic Basis ◽  
Comt Val158met ◽  
Val158met Polymorphism

Examining The Link Between Harsh Parenting And Non-Suicidal Self-Injury In Adolescence: The Role of The COMT Val158Met Polymorphism And Depressive Symptoms

2021 ◽  
Author(s):  
Jinmeng Liu ◽  
Xia Liu ◽  
Hui Wang ◽  
Yemiao Gao
Keyword(s):  
High School Students ◽  
Depressive Symptoms ◽  
Junior High School ◽  
Longitudinal Design ◽  
Self Report ◽  
Harsh Parenting ◽  
Comt Val158met ◽  
Val158met Polymorphism ◽  
Self Injury

Abstract Background: Previous studies have suggested negative parenting environments, especially harsh parenting, is a specific risk factor for non-suicidal self-injury (NSSI). However, the potential mechanism between harsh parenting and NSSI has not been explored. Based on the experiential avoidance model and empirical researches, we aimed to examine if depressive symptoms are a mediator between harsh parenting and NSSI. Moreover, the catechol-O-methyltransferase (COMT) Val158Met polymorphism related to depressive symptoms may also exert a moderating effect on NSSI, thus, the interaction between harsh parenting and COMT were also considered in our study.Method：373 junior high school students were recruited for the study by using a longitudinal design. Adolescents answered self-report questionnaires and provided Saliva samples for DNA genotyping.Result：The results revealed that harsh parenting was positively associated with NSSI after 18 months, and this association was mediated by depressive symptoms. Moreover, the moderating role of COMT in the direct and indirect effect of harsh parenting on NSSI only among adolescents with two Val alleles. However, the relationship was not significant for Met carriers.Conclusion: Genetic variations of COMT Val158Met may be a critical candidate in understanding the development of depression and NSSI. We conclude that the Val homozygotes of the COMT Val158Met polymorphism play a susceptible role both in depressive symptoms and NSSI.

scholarly journals The role of the COMT val158met polymorphism in mediating aversive learning in visual cortex

NeuroImage ◽  
2016 ◽  
Vol 125 ◽  
pp. 633-642 ◽  
Author(s):  
L. Forest Gruss ◽  
Taimour Langaee ◽  
Andreas Keil
Keyword(s):  
Visual Cortex ◽  
Aversive Learning ◽  
Comt Val158met ◽  
Val158met Polymorphism

The role of the COMT Val158Met polymorphism in the phenotypic expression of obsessive-compulsive disorder

2009 ◽  
Vol 9999B ◽  
pp. n/a-n/a ◽  
Author(s):  
Hilga Katerberg ◽  
Danielle C. Cath ◽  
Damiaan A. J. P. Denys ◽  
Peter Heutink ◽  
Annemiek Polman ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Phenotypic Expression ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Comt Val158met ◽  
Val158met Polymorphism

Maternal rearing styles and loneliness: The moderating role of the COMT Val158Met polymorphism

2021 ◽  
Author(s):  
Wen Wei ◽  
Yudong Lin ◽  
Tiantian Hong ◽  
GeseDNA Research Team ◽  
Siyang Luo
Keyword(s):  
Comt Val158met ◽  
Val158met Polymorphism ◽  
Moderating Role

scholarly journals Role of COMT V158M Polymorphism in the Development of Dystonia after Administration of Antipsychotic Drugs

2021 ◽  
Vol 11 (10) ◽  
pp. 1293
Author(s):  
Antonio Gennaro Nicotera ◽  
Gabriella Di Rosa ◽  
Laura Turriziani ◽  
Maria Cristina Costanzo ◽  
Emanuela Stracuzzi ◽  
...  
Keyword(s):  
Psychiatric Patients ◽  
22Q11.2 Deletion Syndrome ◽  
Comt Gene ◽  
Extrapyramidal Symptoms ◽  
Deletion Syndrome ◽  
Drug Discontinuation ◽  
Comt Val158met ◽  
Val158met Polymorphism ◽  
Dopaminergic Dysfunction

Antipsychotics (APDs) represent the main pharmacological strategy in the treatment of schizophrenia; however, their administration often may result in severe adverse effects, such as extrapyramidal symptoms. Typically, dystonic movements are considered the result of impaired function and/or abnormalities of dopaminergic neurotransmission/signaling in the basal ganglia. The catechol O-methyltransferase (COMT) gene is located within the 22q11.2 region, and its product is an enzyme involved in transferring a methyl group from S-adenosylmethionine to catecholamines, including dopamine. Studies showed that COMT Val158Met polymorphism modifies enzymatic activity and, consequently, synaptic dopamine concentration in specific brain areas. We identified a patient with 22q11.2 deletion syndrome presenting with cervical and trunk dystonia after paliperidone administration, which persisted even after drug discontinuation. Given the patient’s genetic condition, we hypothesized that the dopaminergic dysfunction had been aggravated by COMT involvement, thus causing dystonia. In line with this hypothesis, we carried out a study on psychiatric patients in chronic treatment with APD to evaluate the distribution of the COMT Val158Met polymorphism and its role in the onset of adverse extrapyramidal symptoms. The study included four patients with dystonia after administration of APDs compared to 17 patients who never presented adverse drug reactions. Our data suggest that the Val/Val and Met/Met polymorphisms of the COMT gene are associated with a protective effect for the development of collateral extrapyramidal symptoms in patients treated with APDs, while the Val/Met genotype could be considered a risk factor for the development of dystonia after APDs administration.

The flexible mind is associated with the catechol-O-methyltransferase (COMT) Val158Met polymorphism: Evidence for a role of dopamine in the control of task-switching

2010 ◽  
Vol 48 (9) ◽  
pp. 2764-2768 ◽  
Author(s):  
Lorenza S. Colzato ◽  
Florian Waszak ◽  
Sander Nieuwenhuis ◽  
Danielle Posthuma ◽  
Bernhard Hommel
Keyword(s):  
Task Switching ◽  
Comt Val158met ◽  
Val158met Polymorphism

Anti-Myelin Oligodendrocyte Glycoprotein Encephalomyelitis and Extensive Longitudinal Transverse Myelitis Associated with Compound Heterozygous NLRP3 Missense Mutations in a Young Child

2020 ◽  
Author(s):  
Deirdre O'Sullivan ◽  
Michael Moore ◽  
Susan Byrne ◽  
Andreas O. Reiff ◽  
Susanna Felsenstein
Keyword(s):  
Young Child ◽  
Genetic Basis ◽  
Transverse Myelitis ◽  
Acute Disseminated Encephalomyelitis ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Compound Heterozygous ◽  
Missense Mutations ◽  
Childhood Onset

AbstractAcute disseminated encephalomyelitis in association with extensive longitudinal transverse myelitis is reported in a young child with positive anti-myelin oligodendrocyte glycoprotein (MOG) antibody with heterozygous NLRP3 missense mutations; p.(Arg488Lys) and p.(Ser159Ile). This case may well present an exceptional coincidence, but may describe a yet unrecognized feature of the spectrum of childhood onset cryopyrinopathies that contribute to the understanding of the genetic basis for anti-MOG antibody positive encephalomyelitis. Based on this observation, a larger scale study investigating the role of NLRP3 and other inflammasomes in this entity would provide important pathophysiological insights and potentially novel avenues for treatment.

Association between COMT Val158Met polymorphism and depression

2018 ◽  
Vol 26 (8) ◽  
pp. 1429
Author(s):  
Didi LIU ◽  
Meiping WANG ◽  
Pian CHEN ◽  
Wenxin ZHANG
Keyword(s):  
Comt Val158met ◽  
Val158met Polymorphism

scholarly journals Epistasis for Three Grain Yield Components in Rice (Oryxa sativa L.)

Genetics ◽  
1997 ◽  
Vol 145 (2) ◽  
pp. 453-465 ◽  
Author(s):  
Zhikang Li ◽  
Shannon R M Pinson ◽  
William D Park ◽  
Andrew H Paterson ◽  
James W Stansel
Keyword(s):  
Grain Yield ◽  
Complex Traits ◽  
Yield Components ◽  
Genetic Basis ◽  
Kernel Weight ◽  
Progeny Testing ◽  
Grain Yield Components ◽  
Main Effects ◽  
Grain Number Per Panicle

The genetic basis for three grain yield components of rice, 1000 kernel weight (KW), grain number per panicle (GN), and grain weight per panicle (GWP), was investigated using restriction fragment length polymorphism markers and F4 progeny testing from a cross between rice subspecies japonica (cultivar Lemont from USA) and indica (cv. Teqing from China). Following identification of 19 QTL affecting these traits, we investigated the role of epistasis in genetic control of these phenotypes. Among 63 markers distributed throughout the genome that appeared to be involved in 79 highly significant (P < 0.001) interactions, most (46 or 73%) did not appear to have “main” effects on the relevant traits, but influenced the trait(s) predominantly through interactions. These results indicate that epistasis is an important genetic basis for complex traits such as yield components, especially traits of low heritability such as GN and GWP. The identification of epistatic loci is an important step toward resolution of discrepancies between quantitative trait loci mapping and classical genetic dogma, contributes to better understanding of the persistence of quantitative genetic variation in populations, and impels reconsideration of optimal mapping methodology and marker-assisted breeding strategies for improvement of complex traits.

Sign in / Sign up

Export Citation Format

Share Document