scholarly journals A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Jianmin Yang ◽  
Yufeng Huang ◽  
Jiajia Dai ◽  
Xianai Shi ◽  
Yunquan Zheng
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Wound Dressing ◽  
Sandwich Structure ◽  
Porcine Model ◽  
The Body ◽  
Nanoporous Structure ◽  
Severe Burn ◽  
Burn Wound ◽  
Burn Wound Healing

Abstract Wounds may remain open for a few weeks in severe burns, which provide an entry point for pathogens and microorganisms invading. Thus, wound dressings with long-term antimicrobial activity are crucial for severe burn wound healing. Here, a sandwich structure composite wound dressing anchored with silver nanoparticles (AgNPs) was developed for severe burn wound healing. AgNPs were in situ synthesized on the fibers of chitosan nonwoven fabric (CSNWF) as the interlayer of wound dressing for sustained release of silver ion. The firmly anchored AgNPs could prevent its entry into the body, thereby eliminating the toxicity of nanomaterials. The outer layer was a polyurethane membrane, which has a nanoporous structure that could maintain free transmission of water vapor. Chitosan/collagen sponge was selected as the inner layer because of its excellent biocompatibility and biodegradability. The presence of AgNPs in the CSNWF was fully characterized, and the high antibacterial activity of CSNWF/AgNPs was confirmed by against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The superior wound healing effect on deep dermal burns of presented composite wound dressing was demonstrated in a porcine model. Our finding suggested that the prepared AgNPs doped sandwich structure composite wound dressing has great potential application in severe wound care.

scholarly journals Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model

2015 ◽  
Vol 135 (10) ◽  
pp. 2519-2529 ◽  
Author(s):  
Yu-I Shen ◽  
Hyun-Ho G. Song ◽  
Arianne E. Papa ◽  
Jacqueline A. Burke ◽  
Susan W. Volk ◽  
...  
Keyword(s):  
Wound Healing ◽  
Porcine Model ◽  
Burn Wound ◽  
Burn Wound Healing

scholarly journals 3D bioprinting of integral ADSCs-NO hydrogel scaffolds to promote severe burn wound healing

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Yu Wu ◽  
Tangzhao Liang ◽  
Ying Hu ◽  
Shihai Jiang ◽  
Yuansen Luo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Umbilical Vein ◽  
3D Bioprinting ◽  
Severe Burn ◽  
Burn Wound ◽  
Hydrogel Scaffold ◽  
Hydrogel Scaffolds ◽  
Burn Wound Healing ◽  
Severe Burns

Abstract Severe burns are challenging to heal and result in significant death throughout the world. Adipose-derived mesenchymal stem cells (ADSCs) have emerged as a promising treatment for full-thickness burn healing but are impeded by their low viability and efficiency after grafting in vivo. Nitric oxide (NO) is beneficial in promoting stem cell bioactivity, but whether it can function effectively in vivo is still largely unknown. In this study, we bioprinted an efficient biological scaffold loaded with ADSCs and NO (3D-ADSCs/NO) to evaluate its biological efficacy in promoting severe burn wound healing. The integral 3D-ADSCs/NO hydrogel scaffolds were constructed via 3D bioprinting. Our results shown that 3D-ADSCs/NO can enhance the migration and angiogenesis of Human Umbilical Vein Endothelial Cells (HUVECs). Burn wound healing experiments in mice revealed that 3D-ADSCs/NO accelerated the wound healing by promoting faster epithelialization and collagen deposition. Notably, immunohistochemistry of CD31 suggested an increase in neovascularization, supported by the upregulation of vascular endothelial growth factor (VEGF) mRNA in ADSCs in the 3D biosystem. These findings indicated that 3D-ADSC/NO hydrogel scaffold can promote severe burn wound healing through increased neovascularization via the VEGF signalling pathway. This scaffold may be considered a promising strategy for healing severe burns.

Effects of Silver Nanoparticles on Burn Wound Healing in a Mouse Model

2019 ◽  
Vol 193 (2) ◽  
pp. 456-465 ◽  
Author(s):  
Lamiaa G. Wasef ◽  
Hazem M. Shaheen ◽  
Yasser S. El-Sayed ◽  
Thanaa I. A. Shalaby ◽  
Dalia H. Samak ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Mouse Model ◽  
Burn Wound ◽  
Burn Wound Healing

scholarly journals Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4037
Author(s):  
Xushan Chen ◽  
Huimin Zhang ◽  
Xin Yang ◽  
Wuhong Zhang ◽  
Ming Jiang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Wound Dressing ◽  
Healing Process ◽  
Antibacterial Activities ◽  
Burn Wound ◽  
Burn Wounds ◽  
Oxidized Dextran ◽  
Quaternized Chitosan ◽  
Burn Wound Healing ◽  
Fast Healing

Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The Ag@ODex/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection.

Bacterial cellulose matrix with in situ impregnation of silver nanoparticles via catecholic redox chemistry for third degree burn wound healing

2020 ◽  
Vol 245 ◽  
pp. 116573 ◽  
Author(s):  
Swaminathan Jiji ◽  
Sivalingam Udhayakumar ◽  
Kannan Maharajan ◽  
Chellan Rose ◽  
Chellappa Muralidharan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Bacterial Cellulose ◽  
Redox Chemistry ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Cellulose Matrix ◽  
Degree Burn

scholarly journals Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aaron Martínez-Higuera ◽  
César Rodríguez-Beas ◽  
Jesús Mauro Adolfo Villalobos-Noriega ◽  
Abraham Arizmendi-Grijalva ◽  
Carlos Ochoa-Sánchez ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Photoelectron Spectroscopy ◽  
Burn Injury ◽  
Histopathological Analysis ◽  
Burn Wound ◽  
X Ray ◽  
Burn Wound Healing ◽  
Mimosa Tenuiflora ◽  
Second Degree

AbstractIn this work we use Mimosa tenuiflora (MtE) extracts as reducing agents to synthesize silver nanoparticles (AgMt NPs) which were characterized by DPPH and Total Polyphenols Assays, UV–visible, X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and Thermogravimetric analysis (TGA). AgMt NPs possess average sizes of 21 nm and fcc crystalline structure, it was also confirmed that the MtE is present in the AgMt NPs even after the cleaning protocol applied. Subsequently, carbopol hydrogels were made and the MtE and the synthesized AgMt NPs were dispersed in different gels (MtE-G and AgMt NPs-G, respectively) at 100 µg/g concentration. The gels were characterized by UV–Vis, IR, and rheology. Antimicrobial tests were performed using Staphylococcus aureus and Escherichia coli. Burn wound healing was evaluated in a second-degree burn injury on a Wistar rats model for 14 days and additional skin biopsies were examined with histopathological analysis. Gel with commercial silver nanoparticles (Ag NPs) was prepared and employed as a control on the biological assays. Hydrogel system containing silver nanoparticles synthesized with Mimosa tenuiflora (AgMt NPs-G) is a promising therapeutic strategy for burn wound healing, this due to bactericidal and anti-inflammatory effects, which promotes a more effective recovery (in percentage terms) by damaged area.

Morphological Study of Burn Wound Healing with the Use of Collagen-Chitosan Wound Dressing

2013 ◽  
Vol 154 (5) ◽  
pp. 692-696 ◽  
Author(s):  
A. K. Kirichenko ◽  
I. N. Bolshakov ◽  
A. E. Ali-Rizal ◽  
A. A. Vlasov
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Morphological Study ◽  
Burn Wound ◽  
Burn Wound Healing

An Overview of the Most Important Medicinal Plants Native to Iran by Property of Burn Wound Healing: A Systematic Review

2017 ◽  
Vol 8 (02) ◽  
Author(s):  
Mehrdad Karimi ◽  
Mahnaz Mardani ◽  
Leila Mahmoodnia
Keyword(s):  
Wound Healing ◽  
Medicinal Plants ◽  
Cinnamic Acid ◽  
Healing Process ◽  
Review Article ◽  
The Body ◽  
Wound Healing Process ◽  
Burn Wound ◽  
Burn Wounds ◽  
Burn Wound Healing

Burn is an injury where the skin is destroyedby various factors such as heat, cold, electricity, etc.When skin injuryoccurs, pathogens can invade the body and burn wounds get infected shortly after the damage. The wound healing process is a process done by the coordination of tissues, cells and various factors. In the acute phase, inflammatory mechanism of burns has negative effects due to capillary leak. On the other hand, in the later stages of burn,inflammation is necessary for wound healing. Silver nitrate, silver sulfadiazine, and Mafenide acetate are also used for wound care. These compounds cause delayed wound healing and have cytotoxic effects. Iran is among the countries that have rich traditional medicine and herbal treatment of burn wounds in history. Therefore, in this review article, we tried to report the medicinal plants native to Iran which are effective for burn wounds. In this review article, by searching databases such as Scopus, Google Scholar, Spy DVD, mag Iran and… the articles were searched by searching keywords including burn wounds, herbs, extracts, essences and Iran. After finally searching, it was determined that medicinal plants below are the most important medicinal plants native to Iran that affect burn wounds. 11 Medicinal herbs 11 Abukhalsa plant, chamomile, oak, hungry for love, green tea, purslane, cinnamon, Hypericum, and Commiphora are the most important Medicinal Plants which are effective for burn wound healing in Iran. Alkanin, Naphthoquinone and Shikonin, tannins, pectin, alkaloids, saponins and tannins fixed, resin and vitamin C, flavonoids rutin, aucubin and catalpolCatechin, Epicatechin, EpicatechinGallate, Epigallocatechin and Epigallocatechin-gallate, oxalic acid, Cinnamic acid, caffeic acid , maleic acid, Citric acid, coumarin, flavonoids, alanine, tannins, alpha-linolenic acid, cinnamic acid, phenolic compounds such as eugenol, and safrolephellandrene, terpene compounds such as limonene and linalool, trans-cinnamaldehyde (MDA), tannins, coumarin, resin, Cinema-hydroxy phenyl propane compounds such as formaldehyde and mannitol, curcumin, terpenoids, steroids, Flavonoids, lignans are active compounds of plant bioactive substances that are effective on burn wound healing.

scholarly journals Delayed application of silver nanoparticles reveals the role of early inflammation in burn wound healing

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kangjun Zhang ◽  
Vincent C. H. Lui ◽  
Yan Chen ◽  
Chun Nam Lok ◽  
Kenneth K. Y. Wong
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Burn Wound ◽  
Burn Wound Healing
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