scholarly journals Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model

2015 ◽  
Vol 135 (10) ◽  
pp. 2519-2529 ◽  
Author(s):  
Yu-I Shen ◽  
Hyun-Ho G. Song ◽  
Arianne E. Papa ◽  
Jacqueline A. Burke ◽  
Susan W. Volk ◽  
...  
Keyword(s):  
Wound Healing ◽  
Porcine Model ◽  
Burn Wound ◽  
Burn Wound Healing

scholarly journals A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Jianmin Yang ◽  
Yufeng Huang ◽  
Jiajia Dai ◽  
Xianai Shi ◽  
Yunquan Zheng
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Wound Dressing ◽  
Sandwich Structure ◽  
Porcine Model ◽  
The Body ◽  
Nanoporous Structure ◽  
Severe Burn ◽  
Burn Wound ◽  
Burn Wound Healing

Abstract Wounds may remain open for a few weeks in severe burns, which provide an entry point for pathogens and microorganisms invading. Thus, wound dressings with long-term antimicrobial activity are crucial for severe burn wound healing. Here, a sandwich structure composite wound dressing anchored with silver nanoparticles (AgNPs) was developed for severe burn wound healing. AgNPs were in situ synthesized on the fibers of chitosan nonwoven fabric (CSNWF) as the interlayer of wound dressing for sustained release of silver ion. The firmly anchored AgNPs could prevent its entry into the body, thereby eliminating the toxicity of nanomaterials. The outer layer was a polyurethane membrane, which has a nanoporous structure that could maintain free transmission of water vapor. Chitosan/collagen sponge was selected as the inner layer because of its excellent biocompatibility and biodegradability. The presence of AgNPs in the CSNWF was fully characterized, and the high antibacterial activity of CSNWF/AgNPs was confirmed by against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The superior wound healing effect on deep dermal burns of presented composite wound dressing was demonstrated in a porcine model. Our finding suggested that the prepared AgNPs doped sandwich structure composite wound dressing has great potential application in severe wound care.

The Safety and Efficacy of Mupirocin Topical Spray for Burn Wound Healing in A Rat Model

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Sritharadol Rutthapol ◽  
Chunhachaichana Charisopon ◽  
Kumlungmak Sukanjana ◽  
Buatong Wilaiporn ◽  
Dechraksa Janwit ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Rat Model ◽  
Transforming Growth Factor ◽  
Immunohistochemical Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Burn Wound ◽  
Safety And Efficacy ◽  
Burn Wound Healing ◽  
Tgf Β1

ABSTRACT This study evaluated the effect of mupirocin topical spray on burn wound healing in a rat model. Fifteen male Sprague Dawley rats were used to create full-thickness burns on the rat dorsum using a cylindrical stainless steel rod. The rats were topically treated with normal saline solution (NSS), mupirocin spray, ointment, and solution. The wound size and morphological evaluation were investigated by photographs and clinical criterions for wound healing. The histology was observed by hematoxylin and eosin (HandE) staining assay. The immunohistochemical study was evaluated by detection of transforming growth factor-beta 1 (TGF-β1), and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of matrix metalloproteinase-1 (MMP-9/TIMP-1) was quantified using the enzyme-linked immunosorbent assay (ELISA) assay. A complete healing was observed at 28 days in all treatments. Mupirocin formulations accelerated the wound healing faster than NSS in size. However, the clinical criteria indicated a desirable skin appearance in the mupirocin spray and ointment treated groups. The histological evaluations showed no differences between the treatments while the immunohistochemical study revealed that all treatments reduced the level of TGF-β1 over time, particularly on day 28 in the mupirocin spray and ointment treated groups. The MMP-9/TIMP-1 ratio was significantly lower in the mupirocin spray and ointment treated groups than in the NSS and mupirocin solution groups. This study shows the safety and efficacy in the use of mupirocin topical spray. The topical mupirocin spray is an alternative suitable for development as a human topical anti-infective and wound protection spray.

scholarly journals Validity of thermography for measuring burn wound healing potential

2019 ◽  
Vol 28 (3) ◽  
pp. 347-354 ◽  
Author(s):  
Michelle E. Carrière ◽  
Louise E. M. Haas ◽  
Anouk Pijpe ◽  
Annebeth Meij‐de Vries ◽  
Kim L. M. Gardien ◽  
...  
Keyword(s):  
Wound Healing ◽  
Burn Wound ◽  
Burn Wound Healing

556 The Use of a Concentrated Surfactant Based Gel to Promote Burn Wound Healing

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S126-S127
Author(s):  
Rebecca Coffey ◽  
Rachel Penny
Keyword(s):  
Wound Healing ◽  
New Product ◽  
Ease Of Use ◽  
Burn Injuries ◽  
Full Thickness ◽  
Burn Wound ◽  
Burn Wounds ◽  
Burn Care ◽  
Product Trial ◽  
Burn Wound Healing

Abstract Introduction Strategies to remove necrotic tissue from burn wounds include excisional and non-excisional debridement. Alternative treatments could promote burn wound healing while minimizing patient discomfort and the need for surgery. We evaluated the usage of a concentrated surfactant gel (CSG) to promote burn wound healing in those with indeterminate depth and full thickness burn injuries. Methods An IRB approved retrospective study was conducted during a 10-patient new product trial period with enrollment between September and October 2019. Patients included in this study had indeterminate or full thickness burn wounds and were treated with a concentrated surfactant-based gel. Patients with non-burn diagnoses were excluded. Data collected included demographic information, injury descriptors, and additional burn wound characteristics. Results A total of 10 patients were included in this study as part of a new product trial. The subjects were 80% male with an average TBSA of 7.5%. 40% had indeterminate and 60% had full thickness burn wounds. Prior to initiation of the CSG, the burn wounds had been open for an average of 41 days. There were no infections or complications with usage of the CSG. 90% of patients reported less pain than the standard of care topical agents for burns. Average duration of treatment with the CSG until healing was 28 days. After usage of the CSG, no patients required surgery. Conclusions Our findings support the usage of a concentrated surfactant-based gel in patients with burn wounds. Patients reported decreased pain during dressing changes and ease of use compared to the standard topical agent in burn care. It also prevented surgical debridement in those with indeterminate and full thickness burn injuries.

Fat Grafting and Adipose-Derived Regenerative Cells in Burn Wound Healing and Scarring

2016 ◽  
Vol 137 (1) ◽  
pp. 302-312 ◽  
Author(s):  
Alexandra Condé-Green ◽  
Andrew A. Marano ◽  
Edward S. Lee ◽  
Tom Reisler ◽  
Leigh Ann Price ◽  
...  
Keyword(s):  
Wound Healing ◽  
Fat Grafting ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Regenerative Cells

Recent developments and advanced strategies for promoting burn wound healing

2022 ◽  
pp. 103092
Author(s):  
Zahid Hussain ◽  
Hnin Ei Thu ◽  
Mutasem Rawas-Qalaji ◽  
Mahnoor Naseem ◽  
Shahzeb Khan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Recent Developments
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