scholarly journals Effect of Temperature During the Incubation Period on Tibial Growth Plate Chondrocyte Differentiation and the Incidence of Tibial Dyschondroplasia

2007 ◽  
Vol 86 (8) ◽  
pp. 1772-1783 ◽  
Author(s):  
S. Yalçin ◽  
H.B. Molayoglu ◽  
M. Baka ◽  
O. Genin ◽  
M. Pines
Keyword(s):  
Incubation Period ◽  
Growth Plate ◽  
Effect Of Temperature ◽  
Chondrocyte Differentiation ◽  
Tibial Dyschondroplasia ◽  
Growth Plate Chondrocyte ◽  
Tibial Growth Plate

scholarly journals Effect of Anacardic Acid against Thiram Induced Tibial Dyschondroplasia in Chickens via Regulation of Wnt4 Expression

Animals ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 82 ◽  
Author(s):  
Xiong Jiang ◽  
Hui Zhang ◽  
Khalid Mehmood ◽  
Kun Li ◽  
Lihong Zhang ◽  
...  
Keyword(s):  
Growth Plate ◽  
Conversion Ratio ◽  
Anacardic Acid ◽  
Feed Conversion ◽  
Bone Parameters ◽  
Tibial Dyschondroplasia ◽  
Tibia Bone ◽  
Poultry Birds ◽  
Antioxidant Parameters ◽  
Tibial Growth Plate

Tibial dyschondroplasia (TD) is a tibia bone problem in broilers. Anacardic acid (AA) is a traditional Chinese medicine, which is commonly used to treat arthritis in human. The purpose of the present study is to investigate the effect of AA against TD. A total of 300 day-old poultry birds were equally divided and distributed into three different groups: Control, TD and AA groups. The results showed that the feed conversion ratio was significantly lower in the TD group than control chickens. The tibia bone parameters including weight, length and width were of low quality in TD chickens, while the width of the tibial growth plate was enlarged remarkably. Whereas, in the AA treatment group, the tibia bone parameters showed improvement and tend to return to normal. The antioxidant parameters level of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), total and antioxidant capacity (T-AOC) was significantly decreased, while malondialdehyde (MDA) level was increased significantly in TD affected chickens. AA administration restored the antioxidant parameters significantly. The gene expression revealed a decrease in Wnt4 expression in TD chickens as compared to control chickens, while AA treatment up-regulated the Wnt4 expression. The present study demonstrates that the AA plays an important role to prevent the lameness and restore the size of tibial growth plate of chickens by regulating the expression of Wnt4.

scholarly journals ALTERATION IN FIBRONECTIN SYNTHESIS DURING RAT GROWTH PLATE CHONDROCYTE DIFFERENTIATION IN CULTURE

1996 ◽  
Vol 17 (4) ◽  
pp. 297-303
Author(s):  
TADASHI YASUDA ◽  
KATSUJI SHIMIZU ◽  
HIROSHI ISHIKAWA ◽  
TAKASHI NAKAMURA
Keyword(s):  
Growth Plate ◽  
Chondrocyte Differentiation ◽  
Growth Plate Chondrocyte ◽  
Rat Growth

Microtubules are potential regulators of growth-plate chondrocyte differentiation and hypertrophy

Bone ◽  
1999 ◽  
Vol 25 (4) ◽  
pp. 405-412 ◽  
Author(s):  
C Farquharson ◽  
D Lester ◽  
E Seawright ◽  
D Jefferies ◽  
B Houston
Keyword(s):  
Growth Plate ◽  
Chondrocyte Differentiation ◽  
Growth Plate Chondrocyte

Effect of Temperature on ADP-Induced Platelet Aggregation

1973 ◽  
Vol 29 (01) ◽  
pp. 183-189
Author(s):  
C. A Praga ◽  
E. M Pogliani
Keyword(s):  
Platelet Aggregation ◽  
Incubation Period ◽  
Room Temperature ◽  
Important Variable ◽  
Practical Significance ◽  
Effect Of Temperature ◽  
Induce Platelet Aggregation ◽  
Cuvette Holder ◽  
Exact Temperature

SummaryTemperature represents a very important variable in ADP-induced platelet aggregation.When low doses of ADP ( < 1 (μM) are used to induce platelet aggregation, the length of the incubation period of PRP in the cuvette holder of the aggregometer, thermostatted at 37° C, is very critical. Samples of the same PRP previously kept at room temperature, were incubated for increasing periods of time in the cuvette of the aggregometer before adding ADP, and a significant decrease of aggregation, proportional to the length of incubation, was observed. Stirring of the PRP during the incubation period made these changes more evident.To measure the exact temperature of the PRP during incubation in the aggre- gometer, a thermocouple device was used. While the temperature of the cuvette holder was stable at 37° C, the PRP temperature itself increased exponentially, taking about ten minutes from the beginning of the incubation to reach the value of 37° C. The above results have a practical significance in the reproducibility of the platelet aggregation test in vitro and acquire particular value when the effect of inhibitors of ADP induced platelet aggregation is studied.Experiments carried out with three anti-aggregating agents (acetyl salicyclic acid, dipyridamole and metergoline) have shown that the incubation conditions which influence both the effect of the drugs on platelets and the ADP breakdown in plasma must be strictly controlled.

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