scholarly journals Acute heat stress stimulates mitochondrial superoxide production in broiler skeletal muscle, possibly via downregulation of uncoupling protein content

2006 ◽  
Vol 85 (7) ◽  
pp. 1259-1265 ◽  
Author(s):  
A. Mujahid ◽  
K. Sato ◽  
Y. Akiba ◽  
M. Toyomizu
Keyword(s):  
Skeletal Muscle ◽  
Heat Stress ◽  
Protein Content ◽  
Uncoupling Protein ◽  
Superoxide Production ◽  
Mitochondrial Superoxide ◽  
Acute Heat Stress

scholarly journals Mitochondrial Oxidative Damage in Chicken Skeletal Muscle Induced by Acute Heat Stress

2007 ◽  
Vol 44 (4) ◽  
pp. 439-445 ◽  
Author(s):  
Ahmad Mujahid ◽  
Neil R. Pumford ◽  
Walter Bottje ◽  
Kiyotaka Nakagawa ◽  
Teruo Miyazawa ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Stress ◽  
Oxidative Damage ◽  
Acute Heat Stress ◽  
Mitochondrial Oxidative Damage ◽  
Chicken Skeletal Muscle

scholarly journals Superoxide radical production in chicken skeletal muscle induced by acute heat stress

2005 ◽  
Vol 84 (2) ◽  
pp. 307-314 ◽  
Author(s):  
A. Mujahid ◽  
Y. Yoshiki ◽  
Y. Akiba ◽  
M. Toyomizu
Keyword(s):  
Skeletal Muscle ◽  
Heat Stress ◽  
Superoxide Radical ◽  
Radical Production ◽  
Acute Heat Stress ◽  
Chicken Skeletal Muscle

scholarly journals Acute heat stress prior to downhill running may enhance skeletal muscle remodeling

2012 ◽  
Vol 17 (6) ◽  
pp. 693-705 ◽  
Author(s):  
Chad D. Touchberry ◽  
Anisha A. Gupte ◽  
Gregory L. Bomhoff ◽  
Zachary A. Graham ◽  
Paige C. Geiger ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Stress ◽  
Downhill Running ◽  
Acute Heat Stress ◽  
Muscle Remodeling

scholarly journals Asymmetric superoxide release inside and outside the mitochondria in skeletal muscle under conditions of aging and disuse

2010 ◽  
Vol 109 (4) ◽  
pp. 1133-1139 ◽  
Author(s):  
Xin Xu ◽  
Chiao-nan (Joyce) Chen ◽  
Edgar A. Arriaga ◽  
LaDora V. Thompson
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Oxidative Damage ◽  
Superoxide Production ◽  
Type I ◽  
Electrophoretic Method ◽  
Specific Product ◽  
Mitochondrial Superoxide ◽  
The Matrix ◽  
Superoxide Release

Superoxide released from mitochondria forms reactive oxygen species that can cause severe oxidative damage and have been associated with aging- and disuse-induced muscle dysfunction. Superoxide is released to both the exterior and the matrix of mitochondria, where oxidative damage is not necessarily the same. This complicates determining the role of mitochondrial superoxide in eliciting oxidative stress in skeletal muscle. A newly developed capillary electrophoretic method analyzes hydroxytriphenylphosphonium ethidium, a superoxide-specific product of triphenylphosphonium hydroethidine, released to outside the mitochondria (supernatant) and retained in the matrix (pellet). In this study, we investigated the mitochondrial superoxide production of soleus (type I) and semimembranosus (type II) muscles of Fischer 344 rats affected by aging (13 vs. 26 mo) and disuse (hindlimb unloading). In agreement with previous studies, overall superoxide production increased with aging and disuse. On the other hand, the new experimental method revealed that superoxide production outside the mitochondria of the soleus does not show a significant age-related increase. Another observation was that the superoxide production increase in the matrix occurs earlier (7 days of disuse) compared with the outside mitochondria (14 days of disuse) in both muscle types. These findings indicate that superoxide release is complex as it occurs asymmetrically at both sides of the mitochondrial inner membrane, and that such release has muscle type and temporal specificity. These findings are important to refine current concepts on oxidative stress associated with muscle aging and disuse.

scholarly journals Altered Mitochondrial Superoxide Production in Skeletal Muscle of an ALS Mouse Model during the Disease Progression

2014 ◽  
Vol 106 (2) ◽  
pp. 184a
Author(s):  
Chehade Karam ◽  
Jianxun Yi ◽  
Jiajie Xu ◽  
Carlo Manno ◽  
Kaitao Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Disease Progression ◽  
Superoxide Production ◽  
Mitochondrial Superoxide
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