scholarly journals Does Social Exclusion Alter Sensory and Pain Thresholds in Children and Adolescents with Functional Abdominal Pain? – Results from a Preliminary Study

Pain Medicine ◽  
2018 ◽  
Vol 20 (8) ◽  
pp. 1472-1478
Author(s):  
Marco Daniel Gulewitsch ◽  
Aiste Jusyte ◽  
Katja Weimer ◽  
Michael Schönenberg
Keyword(s):  
Abdominal Pain ◽  
Social Exclusion ◽  
Experimental Studies ◽  
Control Group ◽  
Childhood And Adolescence ◽  
Sensory Threshold ◽  
Functional Abdominal Pain ◽  
Pain Thresholds ◽  
Before And After ◽  
Underlying Mechanisms

Abstract Objective Functional abdominal pain (AP) is a prevalent issue in childhood and adolescence. The contribution of psychosocial factors in the development and maintenance of this health problem is rather unclear, and experimental studies about underlying mechanisms are lacking. This study investigates whether experimentally induced social exclusion decreases sensory and pain thresholds in children suffering from AP. Subjects Twenty children/adolescents with AP and 22 healthy controls. Methods Children/adolescents participated in the Cyberball paradigm, which affects an experience of social exclusion. Thermal sensory and pain thresholds were measured before and after Cyberball. Results Children/adolescents with AP showed a divergent reaction regarding their sensory threshold after social exclusion: The control group exhibited a tendency toward a decreased sensory threshold whereas the AP group remained stable. Concerning the pain threshold, no effect of social exclusion could be identified. The increase of both thresholds (“numbing”) after Cyberball was positively correlated with symptoms of mental health issues. Conclusions This is the first study to investigate changes in sensory and pain thresholds following painful social interactions in a sample of children/adolescents with a chronic pain condition. Results suggest that AP and control children differ in their reaction of sensory thresholds, which might indicate an altered processing of social exclusion. Replication and further methodological improvements are needed.

scholarly journals Higher Prevalence of Obesity among Children with Functional Abdominal Pain Disorders

2020 ◽  
Author(s):  
Tut Galai ◽  
Hadar Moran-Lev ◽  
Shlomi Cohen ◽  
Amir Ben-Tov ◽  
Dina Levy ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Normal Weight ◽  
Control Group ◽  
Obese Children ◽  
Functional Abdominal Pain ◽  
Future Studies ◽  
Prevalence Of Obesity ◽  
Healthy Control ◽  
Irritable Bowel ◽  
Gastroenterology Unit

Abstract Background Functional abdominal pain (FAP) disorders are one of the most common gastrointestinal disorders in children. We aimed to define the association between obesity and functional abdominal pain (FAP) disorders and to assess differences between overweight/obese children and normal weight children with FAP disorders.Methods We conducted a retrospective study of children (2-18 years old) with a clinical diagnosis of FAP who were followed-up in our pediatric gastroenterology unit between 1/2016-10/2018. FAP disorders were defined according to the ROME IV criteria. Body mass index (BMI) percentiles were defined by CDC standards. Patients with BMIs ≥85% were designated as being overweight/obese. A healthy control group was obtained from the 2015-2016 Israel national health survey.Results Data from 173 children with FAP disorders (median age 11.5 years, 114 females) were included. Seventy-one children (41%) were classified as having abdominal pain-NOS, 67 (38.7%) as having irritable bowel syndrome (IBS), and 35 (20.2%) has having functional dyspepsia. Fifty-three children (30.6%) were classified as being overweight/obese. Adolescents with FAP disorders had a significantly higher prevalence of overweight/obesity compared to controls (39.5% vs. 30%, respectively, p = 0.04). Overweight FAP children were older [12.4 (range 9.8-15.3) vs. 10.8 (7.4-14.1) years, p = 0.04] and had more hospitalizations due to FAP (20.8% vs. 7.6%, p = 0.01) compared to normal weight FAP children.Conclusions Children with FAP had higher prevalence of overweight/obesity compared to healthy controls. Future studies are warranted to raise awareness of weight issues in FAP and determine the effect of weight loss on FAP.

scholarly journals Pain Neuroscience Education for Children with Functional Abdominal Pain Disorders: A Randomized Comparative Pilot Study

2020 ◽  
Vol 9 (6) ◽  
pp. 1797 ◽  
Author(s):  
Roselien Pas ◽  
Emma Rheel ◽  
Sophie Van Oosterwijck ◽  
Anthe Foubert ◽  
Robby De Pauw ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Functional Disability ◽  
Pain Catastrophizing ◽  
Pain Modulation ◽  
Therapy Session ◽  
Control Group ◽  
Functional Abdominal Pain ◽  
Local Pressure ◽  
Neuroscience Education

This article explores the effectiveness of a newly developed Pain Neuroscience Education program for children (PNE4Kids) with functional abdominal pain disorder (FAPD). Children (6–12 years) with FAPD were randomly assigned to 1) the experimental group (n = 14), participating in one hypnotherapy session (i.e., usual care) and one additional PNE4Kids session, or 2) the control group (n = 14), participating in two hypnotherapy sessions. Parental pain catastrophizing, the child’s functional disability (parental-proxy), pain-related fear (parent-proxy) and pain intensity, were assessed at baseline and one and three weeks after each therapy session. Pressure algometry and a conditioned pain modulation paradigm were performed at baseline and three weeks after completion of the last therapy session. Parents from both the experimental as well as the control group showed significantly less parental pain catastrophizing (p < 0.01). Children showed significantly less functional disability (p < 0.05), pain-related fear (p < 0.01) and local pressure pain sensitivity (p < 0.05) at short-term follow-up (three weeks after last intervention) in both groups. No significant (p > 0.05) between-group differences were found. Hypnotherapy combined with PNE4Kids did not result in better clinical outcomes compared to hypnotherapy alone. Study limitations include the application of one single PNE4Kids session and the short follow-up time.

scholarly journals Functional abdominal pain in childhood and adolescence increases risk for chronic pain in adulthood

Pain ◽  
2010 ◽  
Vol 150 (3) ◽  
pp. 568-572 ◽  
Author(s):  
Lynn S. Walker ◽  
Christine M. Dengler-Crish ◽  
Sara Rippel ◽  
Stephen Bruehl
Keyword(s):  
Chronic Pain ◽  
Abdominal Pain ◽  
Childhood And Adolescence ◽  
Functional Abdominal Pain

scholarly journals Attentional bias to pain and social threat in pediatric patients with functional abdominal pain and pain-free youth before and after performance evaluation

Pain ◽  
2011 ◽  
Vol 152 (5) ◽  
pp. 1061-1067 ◽  
Author(s):  
Joy E. Beck ◽  
Tricia A. Lipani ◽  
Kari F. Baber ◽  
Lynette Dufton ◽  
Judy Garber ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Performance Evaluation ◽  
Attentional Bias ◽  
Pediatric Patients ◽  
Social Threat ◽  
Functional Abdominal Pain ◽  
Before And After

scholarly journals Effect of Danshen Polyphenate Combined with Pelectin on Diabetic Pe- ripheral Neuropathy and Its Effects on Serum IGF-1, FFA and MBP

1970 ◽  
Vol 1 (1) ◽  
Author(s):  
Bai Xiaogang
Keyword(s):  
Peripheral Neuropathy ◽  
Conduction Velocity ◽  
Diabetic Peripheral Neuropathy ◽  
Salvia Miltiorrhiza ◽  
Ankle Brachial Index ◽  
Control Group ◽  
Sensory Threshold ◽  
Observation Group ◽  
Before And After ◽  
And Control

Objective: To observe the therapeutic effect of salvia miltiorrhiza phenylephrine combined with puerarin sodium on diabetic peripheral neuropathy (DPN) and the effect of serum insulin-like growth factor 1 (IGF-1), free fatty acid (FFA) and human myelin Protein (MBP). Methods: A total of 116 patients with diabetic peripheral neuropathy were randomly divided into observation group (58 cases) and control group (58 cases). The control group was treated with sodium prostaglandin sodium. The observation group was treated with Danshephenolic acid Treatment, treatment for 8 weeks. The changes of total symptom score system (TSS), vibration sensory threshold (VPT), ankle brachial index (ABI) and peripheral nerve conduction velocity (NCV), serum IGF-1, FFA and MBP were observed before and after treatment. Results: The levels of numbness, tingling, burning, paresthesia and total score were significantly decreased in both groups after treatment, VPT, ABI and NCV were improved (P < 0.05), and the above indexes (P < 0.05). The levels of serum IGF-1 were increased and the levels of FFA and MBP were lower in the two groups. The improvement of the above indexes was better than that of the control group (P < 0.05). Conclusion: Salvia miltiorrhiza polyphenate combined with puerarin sodium can significantly improve the vibration sensory threshold and ankle-brachial index, enhance the nerve conduction velocity and relieve clinical symptoms in patients with diabetic peripheral neuropathy. The mechanism may be related to the regulation of serum IGF-1,FFA, The level of MBP is relevant.

scholarly journals Nutrition of children and gastrointestinal microflora in the insult of diagnostic parameters

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Małgorzata Frajberg ◽  
Katarzyna Eufemia Przybyłowicz ◽  
Lucyna Kłe˛bukowska
Keyword(s):  
Abdominal Pain ◽  
Intestinal Microflora ◽  
Dietary Intervention ◽  
Intestinal Bacteria ◽  
Food Allergies ◽  
Functional Abdominal Pain ◽  
Double Blind ◽  
Blind Test ◽  
Before And After ◽  
Fodmap Diet

AbstractDoes dietary intervention affect the change of the intestinal microflora, causes the unsealing of the intestinal mucosa. After four weeks of dietary intervention with FODMAP diets and a diet based on NICE recommendations in children with functional abdominal pain, the intestinal microflora will change and the level of zonulin will decrease.Bacterial intestine, intestinal bacteria is a set of microorganisms, the main bacteria that form a complex ecosystem in the digestive tract. Scientific research indicates that some bacteria may contribute to the formation of certain disease entities.Children with functional abdominal pain participated in the research.The study was a randomized intervention and a double-blind test. 32 children were examined, patients of gastroenterological counseling center of the Provincial Specialist Children's Hospital in Olsztyn. Children were 4–12 years old, functional abdominal pain was diagnosed on the basis of Roman criteria, a positive decision of the gastroenterologist regarding the inclusion of the patient, conscious and voluntary consent of the child's guardian to participate in the study. Exclusion criteria include irritable bowel syndrome, abdominal migraine, diagnosed food allergies or food intolerance, the coexistence of chronic diseases or antibiotic therapy in the last 8 weeks.The dietary intervention lasted 4 weeks, meals were prepared on the basis of a menu developed by a dietician.Diagnostic tests were carried out before and after dietary intervention. One group of children with functional abdominal pain received the Fodmap diet, the second group, a diet based on NICE recommendations.The intestinal microflora, the level of zonulin in the stool were tested and the organic acids in the urine were determined by capillary gas chromatography/mass spectrometers (GC/MS).A preliminary analysis of test conditions prior to dietary intervention was found.Dysbiosis occurred in all 26 children (4 children did not perform the test). An increased number of Bacteroides spp. Was observed in the majority of children in stool tests, studies have reported that the growth of this bacterium in the intestinal microflora occurs in IBD intestinal inflammatory syndrome. Preliminary researches show that this bacterium was dominant in the examined children. In the test, an intermediate urine dysbiosis test of 24 out of 26 children was tested had at least one parameter elevated. After the dietary intervention, the diet had an effect on changing the intestinal microflora, changing the parameters of dysbiosis and the parameter of zonulin, although more research is needed on a larger population.

scholarly journals Evaluating an Educational Intervention Designed to Foster Environmental Citizenship among Undergraduate University Students

2021 ◽  
Vol 13 (15) ◽  
pp. 8219
Author(s):  
Audronė Telešienė ◽  
Jelle Boeve-de Pauw ◽  
Daphne Goldman ◽  
Ralph Hansmann
Keyword(s):  
Undergraduate Students ◽  
Educational Intervention ◽  
Survey Methodology ◽  
Survey Design ◽  
Control Group ◽  
Childhood And Adolescence ◽  
Environmental Citizenship ◽  
Before And After ◽  
Quasi Experimental ◽  
And Gender

Taking its primary interest in active environmental citizenship, this paper aims at evaluating a case of an educational intervention designed to foster environmental citizenship among undergraduate students at a technological university. The study employs a survey methodology implementing a recently validated environmental citizenship questionnaire. A randomized pre-group –post-group quasi-experimental survey design explores students’ environmental citizenship attributes before and after the intervention course, ‘Sustainable Development’, in comparison to students who participated in a general elective course, ‘Media Philosophy’. The results show that the participation in the intervention course induced positive change in students’ environmental citizenship in comparison to the control group. Additional analysis indicates that environmental citizenship is significantly related to environmental attitudes, nature experiences during childhood and adolescence, and gender. The article provides a timely contribution shedding light on how specific pedagogical approaches in higher education can foster environmental citizenship.

scholarly journals Higher Prevalence of Obesity among Children with Functional Abdominal Pain Disorders

2020 ◽  
Author(s):  
Tut Galai ◽  
Hadar Moran-Lev ◽  
Shlomi Cohen ◽  
Amir Ben-Tov ◽  
Dina Levy ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Population Control ◽  
National Health Survey ◽  
Normal Weight ◽  
Control Group ◽  
Functional Abdominal Pain ◽  
Prevalence Of Obesity ◽  
Survey Results ◽  
Irritable Bowel ◽  
Population Control Group

Abstract Background Functional abdominal pain (FAP) disorders are one of the most common gastrointestinal disorders in children. We aimed to define the association between obesity and functional abdominal pain (FAP) disorders and to assess differences between overweight/obese children and normal weight children with FAP disorders. Methods We conducted a retrospective study of children (2-18 years old) with a clinical diagnosis of FAP who were followed-up in our pediatric gastroenterology unit between 1/2016-10/2018. FAP disorders were defined according to the ROME IV criteria. Body mass index (BMI) percentiles were defined by CDC standards. Patients with BMIs ≥85th percentile were designated as being overweight/obese. A population control group was obtained from the 2015-2016 Israel national health survey. Results Data from 173 children with FAP disorders (median age 11.5 years, 114 females) were included. Seventy-one children (41%) were classified as having functional abdominal pain-NOS, 67 (38.7%) as having irritable bowel syndrome (IBS), and 35 (20.2%) has having functional dyspepsia. Fifty-three children (30.6%) were classified as being overweight/obese. Adolescents with FAP disorders had a significantly higher prevalence of overweight/obesity compared to controls (39.5% vs. 30%, respectively, p = 0.04). Children with FAP and overweight were older [12.4 (range 9.8-15.3) vs. 10.8 (7.4-14.1) years, p = 0.04] and had more hospitalizations due to FAP (20.8% vs. 7.6%, p = 0.01) compared to Children with FAP and normal weight. Conclusions Adolescents with FAP had higher prevalence of overweight/obesity compared to controls. Future studies are warranted to raise awareness of weight issues in FAP and determine the effect of weight loss on FAP.

scholarly journals The Gut Microbiome Alterations in Pediatric Patients with Functional Abdominal Pain Disorders

2021 ◽  
Vol 9 (11) ◽  
pp. 2354
Author(s):  
Bassam Abomoelak ◽  
Veronica Pemberton ◽  
Chirajyoti Deb ◽  
Stephani Campion ◽  
Michelle Vinson ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Gut Microbiome ◽  
Beta Diversity ◽  
Pediatric Patients ◽  
Control Group ◽  
Functional Abdominal Pain ◽  
Prospective Longitudinal Study ◽  
Linear Discriminant ◽  
Alpha And Beta Diversity ◽  
Prospective Longitudinal

In this prospective longitudinal study, we enrolled 54 healthy pediatric controls and 28 functional abdominal pain disorders (FAPDs) pediatric patients (mean age was 11 ± 2.58 years old). Fecal samples and symptom questionnaires were obtained from all participants over the course of the year. Clinical data assessment showed that FAPDs patients were more symptomatic than the control group. Microbiome analysis revealed that Phylum Bacteroidetes was higher in FAPDs compared to the control group (p < 0.05), while phylum Firmicutes was lower in FAPDs (p < 0.05). In addition, Verrucomicrobiota was higher in the control group than the FAPDs (p < 0.05). At the genus level the relative abundance of 72 bacterial taxa showed statistically significant differences between the two groups and at the school term levels. In the control group, Shannon diversity, Observed_species, and Simpson were higher than the FAPDs (p < 0.05), and beta diversity showed differences between the two groups (PERMANOVA = 2.38; p = 0.002) as well. Using linear discriminant analysis effect size (LEfSe), Enterobacteriaceae family and Megaspherae showed increased abundances in vacation term (LDA score > 2.0, LEfSe, p < 0.05). In the FAPDs group, the severity of symptoms (T-scores) correlated with 11 different taxa bacterial relative abundances using Pearson′s correlation and linear regression analyses. Our data showed that gut microbiome is altered in FAPDs compared to the control. Differences in other metrics such as alpha- and beta diversity were also reported between the two groups. Correlation of the severity of the disease (T-scores) correlated with gut microbiome. Finally, our findings support the use of Faecalibacterium/Bacteroides ratio as a potential diagnostic biomarker for FAPDs.

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