scholarly journals Enhanced RAGE Expression in the Dorsal Root Ganglion May Contribute to Neuropathic Pain Induced by Spinal Nerve Ligation in Rats

Pain Medicine ◽  
2015 ◽  
pp. pnv035 ◽  
Author(s):  
Xiangnan Li ◽  
Haiqin Yang ◽  
Qing Ouyang ◽  
Fangting Liu ◽  
Jian Li ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation ◽  
Rage Expression

scholarly journals Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain

2019 ◽  
Vol 20 (4) ◽  
pp. 811 ◽  
Author(s):  
Mei Kwan ◽  
Anthony Choo ◽  
Taleen Hanania ◽  
Afshin Ghavami ◽  
Jose Beltran ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Root Ganglion ◽  
Rat Model ◽  
Dorsal Root ◽  
Mechanical Allodynia ◽  
Caspase 3 ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation ◽  
Oral Dosing ◽  
Protein Levels

There is an unmet medical need for the development of non-addicting pain therapeutics with enhanced efficacy and tolerability. The current study examined the effects of AQU-118, an orally active inhibitor of metalloproteinase-2 (MMP-2) and MMP-9, in the spinal nerve ligation (SNL) rat model of neuropathic pain. Mechanical allodynia and the levels of various biomarkers were examined within the dorsal root ganglion (DRG) before and after oral dosing with AQU-118. The rats that received the SNL surgery exhibited significant mechanical allodynia as compared to sham controls. Animals received either vehicle, positive control (gabapentin), or AQU-118. After SNL surgery, the dorsal root ganglion (DRG) of those rats dosed with vehicle had elevated messenger RNA (mRNA) expression levels for MMP-2, IL1-β & IL-6 and elevated protein levels for caspase-3 while exhibiting decreased protein levels for myelin basic protein (MBP) & active IL-β as compared to sham controls. Rats orally dosed with AQU-118 exhibited significantly reduced mechanical allodynia and decreased levels of caspase-3 in the DRG as compared to vehicle controls. Results demonstrate that oral dosing with the dual active, MMP-2/-9 inhibitor, AQU-118, attenuated mechanical allodynia while at the same time significantly reduced the levels of caspase-3 in the DRG.

Effects of selective spinal nerve ligation on acetic acid-induced nociceptive responses and ASIC3 immunoreactivity in the rat dorsal root ganglion

2008 ◽  
Vol 1219 ◽  
pp. 26-31 ◽  
Author(s):  
Megumi Omori ◽  
Masataka Yokoyama ◽  
Yoshikazu Matsuoka ◽  
Hiroyuki Kobayashi ◽  
Satoshi Mizobuchi ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation ◽  
Nociceptive Responses

Differential expression of alpha1-adrenoceptor subtype mRNAs in the dorsal root ganglion after spinal nerve ligation

2001 ◽  
Vol 93 (2) ◽  
pp. 164-172 ◽  
Author(s):  
Jiangang Xie ◽  
Young Ho Lee ◽  
Chen Wang ◽  
Jin Mo Chung ◽  
Kyungsoon Chung
Keyword(s):  
Dorsal Root Ganglion ◽  
Differential Expression ◽  
Dorsal Root ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation

Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation

Pain ◽  
2012 ◽  
Vol 153 (1) ◽  
pp. 68-79 ◽  
Author(s):  
Tetsuo Fukuoka ◽  
Hiroki Yamanaka ◽  
Kimiko Kobayashi ◽  
Masamichi Okubo ◽  
Kan Miyoshi ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation ◽  
Dorsal Root Ganglion Neurons ◽  
Phenotypic Changes ◽  
Ganglion Neurons
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