scholarly journals Spinal nerve ligation decreases γ-aminobutyric acidB receptors on specific populations of immunohistochemically identified neurons in L5 dorsal root ganglion of the rat

2012 ◽  
Vol 520 (8) ◽  
pp. 1663-1677 ◽  
Author(s):  
Mitchell P. Engle ◽  
Michelle A. Merrill ◽  
Blanca Marquez De Prado ◽  
Donna L. Hammond
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation ◽  
Identified Neurons

Effects of selective spinal nerve ligation on acetic acid-induced nociceptive responses and ASIC3 immunoreactivity in the rat dorsal root ganglion

2008 ◽  
Vol 1219 ◽  
pp. 26-31 ◽  
Author(s):  
Megumi Omori ◽  
Masataka Yokoyama ◽  
Yoshikazu Matsuoka ◽  
Hiroyuki Kobayashi ◽  
Satoshi Mizobuchi ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation ◽  
Nociceptive Responses

Differential expression of alpha1-adrenoceptor subtype mRNAs in the dorsal root ganglion after spinal nerve ligation

2001 ◽  
Vol 93 (2) ◽  
pp. 164-172 ◽  
Author(s):  
Jiangang Xie ◽  
Young Ho Lee ◽  
Chen Wang ◽  
Jin Mo Chung ◽  
Kyungsoon Chung
Keyword(s):  
Dorsal Root Ganglion ◽  
Differential Expression ◽  
Dorsal Root ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation

Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation

Pain ◽  
2012 ◽  
Vol 153 (1) ◽  
pp. 68-79 ◽  
Author(s):  
Tetsuo Fukuoka ◽  
Hiroki Yamanaka ◽  
Kimiko Kobayashi ◽  
Masamichi Okubo ◽  
Kan Miyoshi ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation ◽  
Dorsal Root Ganglion Neurons ◽  
Phenotypic Changes ◽  
Ganglion Neurons

Distinct Membrane Effects of Spinal Nerve Ligation on Injured and Adjacent Dorsal Root Ganglion Neurons in Rats

2005 ◽  
Vol 103 (2) ◽  
pp. 360-376 ◽  
Author(s):  
Damir Sapunar ◽  
Marko Ljubkovic ◽  
Philipp Lirk ◽  
J Bruce McCallum ◽  
Quinn H. Hogan
Keyword(s):  
Membrane Potential ◽  
Dorsal Root Ganglion ◽  
Action Potential ◽  
Action Potential Duration ◽  
Dorsal Root ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation ◽  
Dorsal Root Ganglion Neurons ◽  
Resting Membrane Potential ◽  
Ganglion Neurons

Background Painful peripheral nerve injury results in disordered sensory neuron function that contributes to the pathogenesis of neuropathic pain. However, the relative roles of neurons with transected axons versus intact adjacent neurons have not been resolved. An essential first step is identification of electrophysiologic changes in these two neuronal populations after partial nerve damage. Methods Twenty days after spinal nerve ligation (SNL), intracellular recordings were obtained from axotomized fifth lumbar (L5) dorsal root ganglion neurons and adjacent, intact L4 neurons, as well as from control neurons and others subjected to sham-SNL surgery. Results Pronounced electrophysiologic changes were seen only in L5 neurons after SNL. Both Aalpha/beta and Adelta neuron types showed increased action potential duration, decreased afterhyperpolarization amplitude and duration, and decreased current threshold for action potential initiation. Aalpha/beta neurons showed resting membrane potential depolarization, and increased repetitive firing during sustained depolarization developed in Adelta neurons. The afterhyperpolarization duration in neurons with C fibers shortened after axotomy. In contrast to the axotomized L5 neurons, neighboring L4 neurons showed no changes in action potential duration, afterhyperpolarization dimensions, or excitability after SNL. Depolarization rate (dV/dt) increased after SNL in L4 Aalpha/beta and Adelta neurons but decreased in L5 neurons. Time-dependent rectification during hyperpolarizing current injection (sag) was greater after SNL in Aalpha/beta L4 neurons compared with L5. Sham-SNL surgery produced only a decreased input resistance in Aalpha/beta neurons and a decreased conduction velocity in medium-sized cells. In the L5 ganglion after axotomy, a novel set of neurons, consisting of 24% of the myelinated population, exhibited long action potential durations despite myelinated neuron conduction velocities, particularly depolarized resting membrane potential, low depolarization rate, and absence of sag. Conclusions These findings indicate that nerve injury-induced electrical instability is restricted to axotomized neurons and is absent in adjacent intact neurons.

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