scholarly journals A precision medicine approach to managing 2019 novel coronavirus pneumonia

2020 ◽  
Vol 3 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Minjin Wang ◽  
Yanbing Zhou ◽  
Zhiyong Zong ◽  
Zongan Liang ◽  
Yu Cao ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Disease Transmission ◽  
Respiratory Infections ◽  
Causal Organism ◽  
West China Hospital ◽  
West China ◽  
Genetic Sequence ◽  
Asymptomatic Patients ◽  
Novel Coronavirus ◽  
Strong Ability

Abstract In December 2019, several patients with pneumonia of an unknown cause were detected in Wuhan, China. On 7 January 2020, the causal organism was identified as a new coronavirus, later named as the 2019 novel coronavirus (2019-nCoV). Genome sequencing found the genetic sequence of 2019-nCoV homologous to that of severe acute respiratory syndrome-associated coronavirus. As of 29 January 2020, the virus had been diagnosed in more than 7000 patients in China and 77 patients in other countries. It is reported that both symptomatic and asymptomatic patients with 2019-nCoV can play a role in disease transmission via airborne and contact. This finding has caused a great concern about the prevention of illness spread. The clinical features of the infection are not specific and are often indistinguishable from those of other respiratory infections, making it difficult to diagnose. Given that the virus has a strong ability to spread between individuals, it is of top priority to identify potential or suspected patients as soon as possible—or the virus may cause a serious pandemic. Therefore, a precision medicine approach to managing this disease is urgently needed for detecting and controlling the spread of the virus. In this article, we present such an approach to managing 2019-nCoV-related pneumonia based on the unique traits of the virus recently revealed and on our experience with coronaviruses at West China Hospital in Chengdu, China.

scholarly journals Recommended psychological crisis intervention response to the 2019 novel coronavirus pneumonia outbreak in China: a model of West China Hospital

2020 ◽  
Vol 3 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Jun Zhang ◽  
Weili Wu ◽  
Xin Zhao ◽  
Wei Zhang
Keyword(s):  
Crisis Intervention ◽  
Psychological Intervention ◽  
Psychological Impact ◽  
Psychological Problems ◽  
Internet Technology ◽  
Social Psychological ◽  
West China Hospital ◽  
West China ◽  
Face To Face ◽  
Novel Coronavirus

Abstract The novel coronavirus pneumonia (COVID-19) epidemic has brought serious social psychological impact to the Chinese people, especially those quarantined and thus with limited access to face-to-face communication and traditional social psychological interventions. To better deal with the urgent psychological problems of people involved in the COVID-19 epidemic, we developed a new psychological crisis intervention model by utilizing internet technology. This new model, one of West China Hospital, integrates physicians, psychiatrists, psychologists and social workers into Internet platforms to carry out psychological intervention to patients, their families and medical staff. We hope this model will make a sound basis for developing a more comprehensive psychological crisis intervention response system that is applicable for urgent social and psychological problems.

scholarly journals Prevention and treatment system of novel coronavirus infection in medical and health institutions: experience in West China Hospital of Sichuan University

2020 ◽  
Vol 37 (10) ◽  
pp. 639-641
Author(s):  
Qiao Zhou ◽  
He Yu ◽  
Zong-An Liang ◽  
Rong Yao ◽  
Feng-Ming Luo ◽  
...  
Keyword(s):  
Treatment System ◽  
The Novel ◽  
West China Hospital ◽  
West China ◽  
Global Pandemic ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Health Institutions ◽  
Novel Coronavirus

The novel coronavirus infection broke out in Wuhan, China, in December 2019, and progressed to a global pandemic. We describe the measures taken by West China Hospital of Sichuan University to address the diagnosis, prevention and treatment of the infection.

scholarly journals Molecular epidemiology of SARS-CoV-2 clusters caused by asymptomatic cases in Anhui Province, China

2020 ◽  
Author(s):  
yuan yuan ◽  
Jun He ◽  
Lei Gong ◽  
Weiwei Li ◽  
Liangliang Jiang ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Close Contact ◽  
Control Strategies ◽  
Asymptomatic Infection ◽  
Droplet Spreading ◽  
Close Link ◽  
Spike Gene ◽  
Asymptomatic Patients ◽  
Asymptomatic Infections ◽  
Novel Coronavirus

Abstract Background: COVID-19 is a newly emerging disease caused by a novel coronavirus (SARS-CoV-2), which spread globally in early 2020. Asymptomatic carriers of the virus contribute to the propagation of this disease, and the existence of asymptomatic infection has caused widespread fear and concern in the control of this pandemic.Methods: In this study, we investigated the origin and transmission route of SARS-CoV-2 in Anhui’s two clusters, analyzed the role and infectiousness of asymptomatic patients in disease transmission, and characterized the complete spike gene sequences in the Anhui strains.Results: We conducted an epidemiological investigation of two clusters caused by asymptomatic infections sequenced the spike gene of viruses isolated from 12 patients. All cases of the two clusters we investigated had clear contact histories, both from Wuhan, Hubei province. The viruses isolated from two outbreaks in Anhui were found to show a genetically close link to the virus from Wuhan. In addition, new single nucleotide variations were discovered in the spike gene.Conclusions: Both clusters may have resulted from close contact and droplet-spreading and asymptomatic infections were identified as the initial cause. We also analyzed the infectiousness of asymptomatic cases and the challenges to the current epidemic to provided information for the development of control strategies.

scholarly journals HRCT imaging features in representative imported cases of 2019 novel coronavirus pneumonia

2020 ◽  
Vol 3 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Kaiyue Diao ◽  
Peilun Han ◽  
Tong Pang ◽  
Yuan Li ◽  
Zhigang Yang
Keyword(s):  
Ground Glass Opacity ◽  
Diagnostic Tools ◽  
Small Scale ◽  
Imaging Features ◽  
High Resolution Computed Tomography ◽  
West China Hospital ◽  
West China ◽  
Imported Cases ◽  
Novel Coronavirus

Abstract With the spread of novel coronavirus (2019-nCoV) pneumonia, chest high-resolution computed tomography (HRCT) has been one of the key diagnostic tools. To achieve early and accurate diagnostics, determining the radiological characteristics of the disease is of great importance. In this small scale research we retrospectively reviewed and selected six cases confirmed with 2019-nCoV infection in West China Hospital and investigated their initial and follow-up HRCT features, along with the clinical characteristics. The 2019-nCoV pneumonia basically showed a multifocal or unifocal involvement of ground-glass opacity (GGO), sometimes with consolidation and fibrosis. No pleural effusion or lymphadenopathy was identified in our presented cases. The follow-up CT generally demonstrated mild to moderate progression of the lesion, with only one case showing remission by the reducing extent and density of the airspace opacification.

scholarly journals Molecular epidemiology of SARS-CoV-2 clusters caused by asymptomatic cases in Anhui Province, China

2020 ◽  
Author(s):  
yuan yuan ◽  
Jun He ◽  
Lei Gong ◽  
Weiwei Li ◽  
Liangliang Jiang ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Close Contact ◽  
Control Strategies ◽  
Asymptomatic Infection ◽  
Droplet Spreading ◽  
Close Link ◽  
Spike Gene ◽  
Asymptomatic Patients ◽  
Asymptomatic Infections ◽  
Novel Coronavirus

Abstract Background: COVID-19 is a newly emerging disease caused by a novel coronavirus (SARS-CoV-2), which spread globally in early 2020. Asymptomatic carriers of the virus contribute to the propagation of this disease, and the existence of asymptomatic infection has caused widespread fear and concern in the control of this pandemic. Methods: In this study, we investigated the origin and transmission route of SARS-CoV-2 in Anhui’s two clusters, analyzed the role and infectiousness of asymptomatic patients in disease transmission, and characterized the complete spike gene sequences in the Anhui strains. Results: We conducted an epidemiological investigation of two clusters caused by asymptomatic infections sequenced the spike gene of viruses isolated from 12 patients. All cases of the two clusters we investigated had clear contact histories, both from Wuhan, Hubei province. The viruses isolated from two outbreaks in Anhui were found to show a genetically close link to the virus from Wuhan. In addition, new single nucleotide variations were discovered in the spike gene. Conclusions: Both clusters may have resulted from close contact and droplet-spreading and asymptomatic infections were identified as the initial cause. We also analyzed the infectiousness of asymptomatic cases and the challenges to the current epidemic to provided information for the development of control strategies.

scholarly journals A proposed two-stage quarantine containment scheme against spreading of novel coronavirus (SARS-CoV-2)

2020 ◽  
pp. 1420326X2096215
Author(s):  
W. K. Chow ◽  
C. L. Chow
Keyword(s):  
Disease Transmission ◽  
Safety Management ◽  
Cruise Ship ◽  
Two Stage ◽  
Second Stage ◽  
Global Pandemic ◽  
Asymptomatic Patients ◽  
Targeted Screening ◽  
The World ◽  
Novel Coronavirus

Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading rapidly all over the world with over 23 million infected near the end of August 2020. There are also asymptomatic patients (APs) who are difficult to identify, but they are infectious and believed to be one of the transmission sources. No specific medicine, no vaccine and even no reliable quick identification tests on SARS-CoV-2 are available yet. Workable safety management must be implemented to stop such global pandemic resulting from disease transmission, including those infected through APs. A two-stage containment scheme is proposed with quarantining people into units within blocks. The units inside a block is to be open after being closed for quarantine for an agreed period such as 14 days. The blocks would then be sealed for another period before opening. Argument of the proposal was supported by a simple mathematical approach with parameters deduced from observations on a cruise ship to estimate the infection constant. The proposed containment scheme is believed to be effective in controlling the spreading of SARS-CoV-2 and identifying APs by a more targeted screening test for the suspected group with a more acceptable environment at the second stage of containment.

scholarly journals Management measures implemented at the West China Hospital may help prevent and contain COVID-19 and similar outbreaks

2021 ◽  
pp. 1-17
Author(s):  
Sijia Liu ◽  
Chengqi He
Keyword(s):  
The West ◽  
West China Hospital ◽  
West China ◽  
Outbreak Management ◽  
Online Consultation ◽  
Management Measures ◽  
Management Processes ◽  
Hospital Resources ◽  
Novel Coronavirus ◽  
Command Systems

Abstract This article presents management processes for dealing with the novel coronavirus disease 2019 (COVID-19) outbreak at the West China Hospital of Sichuan University. From January to March 2020, the West China Hospital of Sichuan University established response structures and protocols, as well as integrated out-of-hospital resources, to deal with the COVID-19 outbreak. A total of 8,066 patients were screened and 345 COVID-19 patients were isolated for treatment. Hospital command systems, emergency management protocols, as well as process, space, and personnel management, and strengthening material reserves, and social responsibility strategies were implemented. Outbreak management aspects that required improvement included estimates of the anticipated number of cases, timely collection of patient information and feedback on the effect of outreach and online consultation methods.

scholarly journals Molecular Epidemiology of SARS-CoV-2 Clusters Caused by Asymptomatic Cases in Anhui Province, China

2020 ◽  
Author(s):  
yuan yuan ◽  
Jun He ◽  
Lei Gong ◽  
Weiwei Li ◽  
Liangliang Jiang ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Close Contact ◽  
Control Strategies ◽  
Asymptomatic Infection ◽  
Droplet Spreading ◽  
Close Link ◽  
Spike Gene ◽  
Asymptomatic Patients ◽  
Asymptomatic Infections ◽  
Novel Coronavirus

Abstract Background: COVID-19 is a newly emerging disease caused by a novel coronavirus (SARS-CoV-2), which spread globally in early 2020. Asymptomatic carriers of the virus contribute to the propagation of this disease, and the existence of asymptomatic infection has caused widespread fear and concern in the control of this pandemic. Methods: In this study, we investigated the origin and transmission route of SARS-CoV-2 in Anhui’s two clusters, analyzed the role and infectiousness of asymptomatic patients in disease transmission, and characterized the complete spike gene sequences in the Anhui strains. Results: We conducted an epidemiological investigation of two clusters caused by asymptomatic infections sequenced the spike gene of viruses isolated from 12 patients. All cases of the two clusters we investigated had clear contact histories, both from Wuhan, Hubei province. The viruses isolated from two outbreaks in Anhui were found to show a genetically close link to the virus from Wuhan. In addition, new single nucleotide variations were discovered in the spike gene. Conclusions: Both clusters may have resulted from close contact and droplet-spreading and asymptomatic infections were identified as the initial cause. We also analyzed the infectiousness of asymptomatic cases and the challenges to the current epidemic to provided information for the development of control strategies.

scholarly journals Molecular epidemiology of SARS-CoV-2 clusters caused by asymptomatic cases in Anhui Province, China

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuan Yuan ◽  
Jun He ◽  
Lei Gong ◽  
Weiwei Li ◽  
Liangliang Jiang ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Close Contact ◽  
Control Strategies ◽  
Asymptomatic Infection ◽  
Droplet Spreading ◽  
Close Link ◽  
Spike Gene ◽  
Asymptomatic Patients ◽  
Asymptomatic Infections ◽  
Novel Coronavirus

Abstract Background COVID-19 is a newly emerging disease caused by a novel coronavirus (SARS-CoV-2), which spread globally in early 2020. Asymptomatic carriers of the virus contribute to the propagation of this disease, and the existence of asymptomatic infection has caused widespread fear and concern in the control of this pandemic. Methods In this study, we investigated the origin and transmission route of SARS-CoV-2 in Anhui’s two clusters, analyzed the role and infectiousness of asymptomatic patients in disease transmission, and characterized the complete spike gene sequences in the Anhui strains. Results We conducted an epidemiological investigation of two clusters caused by asymptomatic infections sequenced the spike gene of viruses isolated from 12 patients. All cases of the two clusters we investigated had clear contact histories, both from Wuhan, Hubei province. The viruses isolated from two outbreaks in Anhui were found to show a genetically close link to the virus from Wuhan. In addition, new single nucleotide variations were discovered in the spike gene. Conclusions Both clusters may have resulted from close contact and droplet-spreading and asymptomatic infections were identified as the initial cause. We also analyzed the infectiousness of asymptomatic cases and the challenges to the current epidemic to provided information for the development of control strategies.

scholarly journals Molecular epidemiology of SARS-CoV-2 clusters caused by asymptomatic cases in Anhui Province, China

2020 ◽  
Author(s):  
yuan yuan ◽  
Jun He ◽  
Lei Gong ◽  
Weiwei Li ◽  
Liangliang Jiang ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Close Contact ◽  
Control Strategies ◽  
Asymptomatic Infection ◽  
Droplet Spreading ◽  
Close Link ◽  
Spike Gene ◽  
Asymptomatic Patients ◽  
Asymptomatic Infections ◽  
Novel Coronavirus

Abstract Background: COVID-19 is a newly emerging disease caused by a novel coronavirus (SARS-CoV-2), which spread globally in early 2020. Asymptomatic carriers of the virus contribute to the propagation of this disease, and the existence of asymptomatic infection has caused widespread fear and concern in the control of this pandemic. Methods: In this study, we investigated the origin and transmission route of SARS-CoV-2 in Anhui’s two clusters, analyzed the role and infectiousness of asymptomatic patients in disease transmission, and characterized the complete spike gene sequences in the Anhui strains. Results: We conducted an epidemiological investigation of two clusters caused by asymptomatic infections sequenced the spike gene of viruses isolated from 12 patients. All cases of the two clusters we investigated had clear contact histories, both from Wuhan, Hubei province. The viruses isolated from two outbreaks in Anhui were found to show a genetically close link to the virus from Wuhan. In addition, new single nucleotide variations were discovered in the spike gene. Conclusions: Both clusters may have resulted from close contact and droplet-spreading and asymptomatic infections were identified as the initial cause. We also analyzed the infectiousness of asymptomatic cases and the challenges to the current epidemic to provided information for the development of control strategies.

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