scholarly journals HRCT imaging features in representative imported cases of 2019 novel coronavirus pneumonia

2020 ◽  
Vol 3 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Kaiyue Diao ◽  
Peilun Han ◽  
Tong Pang ◽  
Yuan Li ◽  
Zhigang Yang
Keyword(s):  
Ground Glass Opacity ◽  
Diagnostic Tools ◽  
Small Scale ◽  
Imaging Features ◽  
High Resolution Computed Tomography ◽  
West China Hospital ◽  
West China ◽  
Imported Cases ◽  
Novel Coronavirus

Abstract With the spread of novel coronavirus (2019-nCoV) pneumonia, chest high-resolution computed tomography (HRCT) has been one of the key diagnostic tools. To achieve early and accurate diagnostics, determining the radiological characteristics of the disease is of great importance. In this small scale research we retrospectively reviewed and selected six cases confirmed with 2019-nCoV infection in West China Hospital and investigated their initial and follow-up HRCT features, along with the clinical characteristics. The 2019-nCoV pneumonia basically showed a multifocal or unifocal involvement of ground-glass opacity (GGO), sometimes with consolidation and fibrosis. No pleural effusion or lymphadenopathy was identified in our presented cases. The follow-up CT generally demonstrated mild to moderate progression of the lesion, with only one case showing remission by the reducing extent and density of the airspace opacification.

scholarly journals Lung nodules and IgG4 related disease: a single-center based experience

2020 ◽  
Author(s):  
Yan Xie ◽  
Anji Xiong ◽  
Tony Marion ◽  
Yi Liu
Keyword(s):  
Lung Diseases ◽  
Immunosuppressive Agents ◽  
Ground Glass Opacity ◽  
Lung Nodules ◽  
Bronchial Wall ◽  
West China Hospital ◽  
West China ◽  
Related Disease ◽  
Igg4 Related Disease

Abstract Background and objective: This study was undertaken in an attempt to characterize the frequency and clinical features of lung nodules in IgG4 related disease (IgG4-RD) patients as an insight for help with the diagnosis of lung nodules.Methods: A retrospective study was carried out in West China Hospital, Sichuan University from January 2012 to December 2018, 89 patients with definite IgG4-RD were enrolled.Results: Fifty of 89 patients with definite IgG4-RD had radiologically confirmed lung nodules, 6 of whom were diagnosed with definite IgG4 related lung disease. Lung nodules detected in more than 40 patients were small and solid, always with regular margins. Multiple (41/50) and bilateral (34/50) distributions was also a major characteristic of these lung nodules. Lobulation and speculation were simultaneously detected in 3 patients, including 2 patients combined with pleural indentation. Calcification of nodules was detected in only one patient. Thirty-seven patients also had additional radiological abnormalities of lungs, including ground-glass opacity (21/50), thickening of pleura (9/50), thickening of interlobular septa (4/50), thickening of bronchial wall (3/50), pleural effusion (4/50), mass (3/50), interstitial changes (5/50), and mediastinal or hilar lymphadenopathy (32/50). Most patients (44/50) were treated with glucocorticoids alone or combined with immunosuppressive agents. Sixteen patients received a re-examination by chest computed tomography (CT) scan after treatment, 10 of whom showed a decrease in the size and/or the number of nodules.Conclusions: The incidence of lung nodules in IgG4-RD patients can be high. For an IgG4-RD patient with lung nodules, the possibility that the lung nodules related to IgG4-RLD is high. It is hard to differentiate IgG4 related lung nodules from other lung diseases, in particular, lung cancer. Radiological characteristics and positive responses to glucocorticoids and immunosuppressive agents can help with the differential diagnosis. For these patients, regular follow-up is also important.

scholarly journals CT Imaging Features During Disease Progression of 2019 Novel Coronavirus (COVID-19) Pneumonia

2020 ◽  
Vol 17 (4) ◽  
Author(s):  
Nan Yu ◽  
Yong Yu ◽  
Shubo Cai ◽  
Cong Shen ◽  
Youmin Guo
Keyword(s):  
Disease Progression ◽  
Symptom Onset ◽  
Early Stage ◽  
Ground Glass Opacity ◽  
Ct Imaging ◽  
Imaging Features ◽  
Imaging Characteristics ◽  
Novel Coronavirus ◽  
Stage 1

Objectives: To describe the characteristics of computed tomography (CT) in patients with 2019 novel coronavirus (COVID-19) pneumonia and their changes during disease progression. Patients and Methods: A total of 96 chest CT scans of 61 pneumonia patients associated with COVID-19 were reviewed to identify CT features associated with the time of symptom onset and the evolution of disease. Results: The initial CTs of 61 patients were obtained during 1 to 11 days after the onset. The main CT pattern of initial CT obtained during 1 - 3 days after the symptom onset was single (7/23, 35%) or multiple ground-glass opacity (GGO, 8/23, 35%). At 4 - 7 days after the symptom onset, the main imaging features were crazy paving GGO mixed with partial consolidation pattern (15/32, 47%). At 8 - 11 days after the symptom onset, the CT images showed consolidation pattern (3/6, 50%). A total of 35 follow up CTs were collected. The mean interval time between each follow up CT was 3 ± 2 days. The CT patterns also changed with the evolution of the disease: the features of GGO manifested at the early stage (1 - 3d). The crazy paving GGO pattern, consolidation pattern and mixed with partial consolidation pattern were found 4 to 14 days after the onset. In the absorption stage (15 - 24d), both density and extent of lesions were reduced. Conclusion: The CT imaging features are associated with the time of symptom onset and evolution of disease. Understanding the imaging characteristics of each stage is very helpful for understanding the development of disease.

scholarly journals Lung nodules and IgG4 related disease: a single-center based experience

2020 ◽  
Author(s):  
Yan Xie ◽  
Anji Xiong ◽  
Tony Marion ◽  
Yi Liu
Keyword(s):  
Lung Diseases ◽  
Immunosuppressive Agents ◽  
Ground Glass Opacity ◽  
Lung Nodules ◽  
Bronchial Wall ◽  
West China Hospital ◽  
West China ◽  
Related Disease ◽  
Igg4 Related Disease

Abstract Background: This study was undertaken in an attempt to characterize the frequency and clinical features of lung nodules in IgG4 related disease (IgG4-RD) patients as an insight for help with the diagnosis of lung nodules.Methods: A retrospective study was carried out in West China Hospital, Sichuan University from January 2012 to December 2018, 89 patients with definite IgG4-RD were enrolled.Results: Fifty of 89 patients with definite IgG4-RD had radiologically confirmed lung nodules, 6 of whom were diagnosed with definite IgG4 related lung disease. Lung nodules detected in more than 40 patients were small and solid, always with regular margins. Multiple (41/50) and bilateral (34/50) distributions was also a major characteristic of these lung nodules. Lobulation and speculation were simultaneously detected in 3 patients, including 2 patients combined with pleural indentation. Calcification of nodules was detected in only one patient. Thirty-seven patients also had additional radiological abnormalities of lungs, including ground-glass opacity (21/50), thickening of pleura (9/50), thickening of interlobular septa (4/50), thickening of bronchial wall (3/50), pleural effusion (4/50), mass (3/50), interstitial changes (5/50), and mediastinal or hilar lymphadenopathy (32/50). Most patients (44/50) were treated with glucocorticoids alone or combined with immunosuppressive agents. Sixteen patients received a re-examination by chest computed tomography (CT) scan after treatment, 10 of whom showed a decrease in the size and/or the number of nodules.Conclusions: The incidence of lung nodules in IgG4-RD patients can be high. For an IgG4-RD patient with lung nodules, the possibility that the lung nodules related to IgG4-RLD is high. It is hard to differentiate IgG4 related lung nodules from other lung diseases, in particular, lung cancer. Radiological characteristics and positive responses to glucocorticoids and immunosuppressive agents can help with the differential diagnosis. For these patients, regular follow-up is also important.

scholarly journals Lung nodules and IgG4 related disease: a single-center based experience

2020 ◽  
Author(s):  
Yan Xie ◽  
Anji Xiong ◽  
Tony Marion ◽  
Yi Liu
Keyword(s):  
Lung Diseases ◽  
Immunosuppressive Agents ◽  
Ground Glass Opacity ◽  
Lung Nodules ◽  
Bronchial Wall ◽  
West China Hospital ◽  
West China ◽  
Related Disease ◽  
Igg4 Related Disease

Abstract Background: This study was undertaken in an attempt to characterize the frequency and clinical features of lung nodules in IgG4 related disease (IgG4-RD) patients as an insight for help with the diagnosis of lung nodules.Methods: A retrospective study was carried out in West China Hospital, Sichuan University from January 2012 to December 2018, 89 patients with definite IgG4-RD were enrolled.Results: Fifty of 89 patients with definite IgG4-RD had radiologically confirmed lung nodules, 6 of whom were diagnosed with definite IgG4 related lung disease. Lung nodules detected in more than 40 patients were small and solid, always with regular margins. Multiple (41/50) and bilateral (34/50) distributions was also a major characteristic of these lung nodules. Lobulation and speculation were simultaneously detected in 3 patients, including 2 patients combined with pleural indentation. Calcification of nodules was detected in only one patient. Thirty-seven patients also had additional radiological abnormalities of lungs, including ground-glass opacity (21/50), thickening of pleura (9/50), thickening of interlobular septa (4/50), thickening of bronchial wall (3/50), pleural effusion (4/50), mass (3/50), interstitial changes (5/50), and mediastinal or hilar lymphadenopathy (32/50). Most patients (44/50) were treated with glucocorticoids alone or combined with immunosuppressive agents. Sixteen patients received a re-examination by chest computed tomography (CT) scan after treatment, 10 of whom showed a decrease in the size and/or the number of nodules.Conclusions: The incidence of lung nodules in IgG4-RD patients can be high. For an IgG4-RD patient with lung nodules, the possibility that the lung nodules related to IgG4-RLD is high. It is hard to differentiate IgG4 related lung nodules from other lung diseases, in particular, lung cancer. Radiological characteristics and positive responses to glucocorticoids and immunosuppressive agents can help with the differential diagnosis. For these patients, regular follow-up is also important.

scholarly journals CT features and artificial intelligence quantitative analysis of recovered COVID-19 patients with negative RT-PCR and clinical symptoms

2020 ◽  
Author(s):  
Siyao Du ◽  
Si Gao ◽  
Guoliang Huang ◽  
Shu Li ◽  
Wei Chong ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Quantitative Analysis ◽  
Clinical Symptoms ◽  
Lower Lobe ◽  
Ground Glass Opacity ◽  
Imaging Features ◽  
Rt Pcr ◽  
Ct Value ◽  
Novel Coronavirus

Abstract Objectives: To evaluate imaging features and performed quantitative analysis for mild novel coronavirus pneumonia (COVID-19) cases ready for discharge.Methods: CT images of 125 patients (16-67 years, 63 males) recovering from COVID-19 were examined. We defined the double-negative period (DNp) as the period between the sampling days of two consecutive negative RT-PCR and three days thereafter. Lesion demonstrations and distributions on CT in DNp (CTDN) were evaluated by radiologists and artificial intelligence (AI) software. Major lesion transformations and the involvement range for patients with follow-up CT were analyzed.Results: Twenty (16.0%) patients exhibited normal CTDN; abnormal CTDN for 105 indicated ground-glass opacity (GGO) (99/125, 79.2%) and fibrosis (56/125, 44.8%) as the most frequent CT findings. Bilateral-lung involvement with mixed or random distribution was most common for GGO on CTDN. Fibrous lesions often affected both lungs, tending to distribute on the subpleura. Follow-up CT showed lesion improvement manifesting as GGO thinning (40/40, 100%), fibrosis reduction (17/26, 65.4%), and consolidation fading (9/11, 81.8%), with or without range reduction. AI analysis showed the highest proportions for right lower lobe involvement (volume, 12.01±35.87cm3; percentage; 1.45±4.58%) and CT-value ranging –570 to –470 HU (volume, 2.93±7.04cm3; percentage, 5.28±6.47%). Among cases with follow-up CT, most of lung lobes and CT-value ranges displayed a significant reduction after DNp.Conclusions: The main CT imaging manifestations were GGO and fibrosis in DNp, which weakened with or without volume reduction. AI analysis results were consistent with imaging features and changes, possibly serving as an objective indicator for disease monitoring and discharge.

scholarly journals Recommended psychological crisis intervention response to the 2019 novel coronavirus pneumonia outbreak in China: a model of West China Hospital

2020 ◽  
Vol 3 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Jun Zhang ◽  
Weili Wu ◽  
Xin Zhao ◽  
Wei Zhang
Keyword(s):  
Crisis Intervention ◽  
Psychological Intervention ◽  
Psychological Impact ◽  
Psychological Problems ◽  
Internet Technology ◽  
Social Psychological ◽  
West China Hospital ◽  
West China ◽  
Face To Face ◽  
Novel Coronavirus

Abstract The novel coronavirus pneumonia (COVID-19) epidemic has brought serious social psychological impact to the Chinese people, especially those quarantined and thus with limited access to face-to-face communication and traditional social psychological interventions. To better deal with the urgent psychological problems of people involved in the COVID-19 epidemic, we developed a new psychological crisis intervention model by utilizing internet technology. This new model, one of West China Hospital, integrates physicians, psychiatrists, psychologists and social workers into Internet platforms to carry out psychological intervention to patients, their families and medical staff. We hope this model will make a sound basis for developing a more comprehensive psychological crisis intervention response system that is applicable for urgent social and psychological problems.

scholarly journals Prevention and treatment system of novel coronavirus infection in medical and health institutions: experience in West China Hospital of Sichuan University

2020 ◽  
Vol 37 (10) ◽  
pp. 639-641
Author(s):  
Qiao Zhou ◽  
He Yu ◽  
Zong-An Liang ◽  
Rong Yao ◽  
Feng-Ming Luo ◽  
...  
Keyword(s):  
Treatment System ◽  
The Novel ◽  
West China Hospital ◽  
West China ◽  
Global Pandemic ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Health Institutions ◽  
Novel Coronavirus

The novel coronavirus infection broke out in Wuhan, China, in December 2019, and progressed to a global pandemic. We describe the measures taken by West China Hospital of Sichuan University to address the diagnosis, prevention and treatment of the infection.

Brainstem gangliogliomas: a retrospective series

2013 ◽  
Vol 118 (4) ◽  
pp. 884-888 ◽  
Author(s):  
Si Zhang ◽  
Xiang Wang ◽  
Xuesong Liu ◽  
Yan Ju ◽  
Xuhui Hui
Keyword(s):  
Subtotal Resection ◽  
Who Grade ◽  
Duration Of Symptoms ◽  
West China Hospital ◽  
West China ◽  
Clinical Presentations ◽  
Close Observation ◽  
The Mean ◽  
Residual Lesions

Object The authors retrospectively analyzed data on brainstem gangliogliomas treated in their department and reviewed the pertinent literature to foster understanding of the preoperative characteristics, management, and clinical outcomes of this disease. Methods In 2006, the authors established a database of treated lesions of the posterior fossa. The epidemiology findings, clinical presentations, radiological investigations, pathological diagnoses, management, and prognosis for brainstem gangliogliomas were retrospectively analyzed. Results Between 2006 and 2012, 7 patients suffering from brainstem ganglioglioma were treated at the West China Hospital of Sichuan University. The mean age of the patients, mean duration of symptoms prior to diagnosis, and mean duration of follow-up were 28.6 years, 19.4 months, and 38.1 months, respectively. The main presentations were progressive cranial nerve deficits and cerebellar signs. Subtotal resection was achieved in 2 patients, and partial resection in 5. All tumors were pathologically diagnosed as WHO Grade I or II ganglioglioma. Radiotherapy and adjuvant chemotherapy were not administered. After 21–69 months of follow-up, patient symptoms were resolved or stable without aggravation, and MRI showed that the size of residual lesions was unchanged without progression or recurrence. Conclusions The diagnosis of brainstem ganglioglioma is of great importance given its favorable prognosis. The authors recommend the maximal safe resection followed by close observation without adjuvant therapy as the optimal treatment for this disease.

scholarly journals The multicenter study of Chest HRCT imaging characteristics of 2019 Novel Coronavirus (COVID-19) Pneumonia

2020 ◽  
Author(s):  
Zhehao Lyu ◽  
Meiji Ren ◽  
Lian-Ming Wu ◽  
Yuxin Yang ◽  
Yi-Bo Lu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Acute Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Chest Ct ◽  
Imaging Features ◽  
Wholesale Market ◽  
High Resolution Computed Tomography ◽  
Imaging Characteristics ◽  
History Of ◽  
Novel Coronavirus

Abstract Background: In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A novel coronavirus was detected, capable of infecting humans, on 6 January 2020 and termed COVID-19. By 16 February 2020, there were 51857 confirmed cases with 2019-nCoV (COVID-19) pneumonia in 25 countries. COVID-19 can also lead to acute respiratory distress syndrome (ARDS).Methods: 149 patients with 2019 Novel Coronavirus (COVID-19)pneumonia(68 males, 81 females, ages 1-89)from 6 research centers in China were diagnosed with positive 2019 Novel Coronavirus(COVID-19)nucleic acids antibodies. And their high-resolution computed tomography(HRCT) imaging datas were evaluated.Results: 136/149(91.3%)patients had a clear history of exposure to Wuhan. Fever (122/149, 81.9%)and cough(83/149, 55.7%)were the most common symptoms. The main imaging characteristics within 4 days of onset included 30(20.13%) cases of pure ground glass opacities (P<0.05), 38(25.50%) cases of GGO with reticulation(P<0.01), 12(8.05%) cases of consolidation(P<0.01). In the 5-8 days group, the main imaging features included 71(47.65%) cases of pGGO(P<0.05), 69(46.31%) cases of GGO with reticulation(P<0.01). In the 9-12 days group, the main feature was 85(57.04%) cases with GGO with reticulation(P<0.01). In the group of 13-16 days group, the main imaging characteristics included 48(32.21%) cases of GGO with reticulation(P < 0.01), 34(22.82%) cases of consolidation(P<0.01).Conclusion: Patients infected with COVID-19 pneumonia show more chest CT characteristics within 5-8 days after the onset of disease. The main manifestations included pGGO, GGO with reticulation, consolidation and GGO with consolidation.

Investigation of HRCT Chest Severity in Patients with COVID-19: A Study of Tertiary Care Hospital in Pakistan

2021 ◽  
Vol 15 (5) ◽  
pp. 1084-1089
Author(s):  
Saulat Sarfraz ◽  
Kh. Bilal Waheed ◽  
Masood Akhtar ◽  
Sarfraz Latif ◽  
Muhammad Asif ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Lower Lobe ◽  
Ground Glass Opacity ◽  
Pulmonary Involvement ◽  
Clinical Severity ◽  
Ground Glass ◽  
Care Hospital ◽  
Imaging Features ◽  
High Resolution Computed Tomography ◽  
Cross Sectional

Background: High-resolution computed tomography (HRCT) chest has a key role in diagnosis COVID-19, as it provides specific imaging features, i.e., bilateral, peripheral and sub-pleural, ground-glass opacity (GGO), consolidation and many associated findings. Aim: To provide the detailed chest HRCT findings along with clinical information in patients with COVID-19. Methods: A cross-sectional study was conducted in the Department of Radiology SZPGMI, Lahore. Information on clinical data, chest radiography appearance and comorbidities were recorded ona designed proforma. HRCT chest findings were recorded in terms of pattern, distribution, laterality, and other findings. HRCT chest severity was calculated using a 25 point CT severity score. Kendall’s Tau test applied to investigate the correlation between the severity of HRCT chest with clinical severity levels of COVID-19. Results: Fever (74%) was the most reported presenting symptom, followed by dry cough (70%). The majority of patients had abnormal chest X-ray (57%) as well as abnormal HRCT chest (90%). The majority of patients were in mild clinical scoring levels of disease (61%) and mild category (49%) of HRCT chest severity. In majority of the patients (46%), all five pulmonary lobes were involved, whereas the right lower lobe was most frequently affected. The pattern of ground-glass opacity (GGO) was found in 82% of patients. Most common distribution was ‘peripheral’, reported in 90% patients. Multiple lobe involvement was found in 82% of patients. The unilateral pulmonary involvement was observed in 12% of patients, whereas, bilateral was found in 78% of patients. Reticulations were reported in 22% followed by atelectasis in 18% patients. Conclusion: COVID-19 patients usually present with abnormal HRCT chest, mostly with a benign course. Multiple pulmonary lobes are commonly involved, especially basal lobes with ground glass opacities. Clinical severity of the disease is reflected in HRCT findings. Keywords: COVID-19 Pandemic, HRCT Chest Findings, Ground Glass Opacity (GGO), Consolidation

Sign in / Sign up

Export Citation Format

Share Document