Promoting healthy lifestyle behaviours in youth: Findings from a novel intervention for children at risk of cardiovascular disease

2021 ◽  
Author(s):  
Marina Ybarra ◽  
Prince Kevin Danieles ◽  
Tracie A Barnett ◽  
Marie-Ève Mathieu ◽  
Andraea Van Hulst ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
At Risk ◽  
Physical Fitness ◽  
Lipid Profile ◽  
Lifestyle Intervention ◽  
Physical Capacity ◽  
Children At Risk ◽  
Mixed Effect ◽  
Z Scores

Abstract Objectives Obesity is the most prevalent risk factor for cardiovascular disease (CVD) in children. We developed a 2-year lifestyle intervention for youth at risk of CVD. We assessed changes in body mass index z-scores (zBMI) and key cardiometabolic risk factors, physical fitness, and capacity among those who completed the program. Methods The CIRCUIT program is a multidisciplinary lifestyle intervention for children aged 4 to 18 years at risk of CVD, based on a personalized plan to improve cardiometabolic outcomes by increasing physical activity and reducing sedentary behaviours. Both at baseline and 2-year follow-up, we measured zBMI, blood pressure z-scores (zBP), adiposity (%body and %trunk fat), fasting blood glucose and lipid profile, aerobic (VO2max) and anaerobic (5×5 m shuttle run test) fitness, and physical capacity indicators. Differences between baseline and follow-up were examined using paired t-tests (for age-sex standardized outcomes) and multivariable mixed effect models, adjusted for age and sex (for other outcomes). Results Among the 106 participants (53 males) who completed the 2-year program, mean age at baseline was 10.9 years (SD=3.2). After 2 years, zBMI and diastolic zBP decreased by 0.30SD (95% CI: −0.44; −0.16) and 0.43SD (95% CI: −0.65; −0.23), respectively. Participants improved %body and %trunk fat, lipid profile, aerobic and anaerobic fitness levels, and physical capacity (p<0.02). No changes in systolic zBP nor in fasting plasma glucose were observed. Conclusion Our findings showed improved zBMI, cardiometabolic outcomes, physical fitness, and capacity among children at risk of CVD, suggesting that CIRCUIT is a promising intervention.

Children at risk for delinquency: A follow-up comparison of aggressive children and children who steal

1979 ◽  
Vol 7 (3) ◽  
pp. 345-355 ◽  
Author(s):  
Dennis R. Moore ◽  
Patricia Chamberlain ◽  
Leona H. Mukai
Keyword(s):  
At Risk ◽  
Children At Risk ◽  
Aggressive Children

scholarly journals The Effects of a Preconception Lifestyle Intervention on Childhood Cardiometabolic Health—Follow-Up of a Randomized Controlled Trial

Cells ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 41
Author(s):  
Stijn Mintjens ◽  
Mireille N. M. van Poppel ◽  
Henk Groen ◽  
Annemieke Hoek ◽  
Ben Willem Mol ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Lifestyle Intervention ◽  
Maternal Obesity ◽  
Controlled Trial ◽  
Cardiometabolic Health ◽  
Control Group ◽  
Z Score ◽  
Infertile Women ◽  
Z Scores

Maternal obesity is associated with adverse metabolic outcomes in her offspring, from the earliest stages of development leading to obesity and poorer cardiometabolic health in her offspring. We investigated whether an effective preconception lifestyle intervention in obese women affected cardiometabolic health of their offspring. We randomly allocated 577 infertile women with obesity to a 6-month lifestyle intervention, or to prompt infertility management. Of the 305 eligible children, despite intensive efforts, 17 in the intervention and 29 in the control group were available for follow-up at age 3–6 years. We compared the child’s Body Mass Index (BMI) Z score, waist and hip circumference, body-fat percentage, blood pressure Z scores, pulse wave velocity and serum lipids, glucose and insulin concentrations. Between the intervention and control groups, the mean (±SD) offspring BMI Z score (0.69 (±1.17) vs. 0.62 (±1.04)) and systolic and diastolic blood pressure Z scores (0.45 (±0.65) vs. 0.54 (±0.57); 0.91 (±0.66) vs. 0.96 (±0.57)) were similar, although elevated compared to the norm population. We also did not detect any differences between the groups in the other outcomes. In this study, we could not detect effects of a preconception lifestyle intervention in obese infertile women on the cardiometabolic health of their offspring. Low follow-up rates, perhaps due to the children’s age or the subject matter, combined with selection bias abating contrast in periconceptional weight between participating mothers, hampered the detection of potential effects. Future studies that account for these factors are needed to confirm whether a preconception lifestyle intervention may improve the cardiometabolic health of children of obese mothers.

scholarly journals A Follow-up Study on BMI-SDS and Insulin Resistance in Overweight and Obese Children at Risk for Type 2 Diabetes Mellitus

2015 ◽  
Vol 2 ◽  
pp. 2333794X1456845 ◽  
Author(s):  
Soulmaz Fazeli Farsani ◽  
Marloes P. van der Aa ◽  
Catherijne A. J. Knibbe ◽  
Anthonius de Boer ◽  
Marja M. J. van der Vorst
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
At Risk ◽  
Type 2 Diabetes Mellitus ◽  
Model Assessment ◽  
Children At Risk ◽  
The Mean

Objectives. To evaluate body mass index standard deviation score (BMI-SDS), insulin sensitivity, and progression to type 2 diabetes mellitus (T2DM) in children at risk for T2DM approximately 3 years after being diagnosed with overweight/obesity and insulin resistance (measured by Homeostasis Model Assessment of Insulin Resistance [HOMA-IR]). Methods. Out of 86 invited children, 44 (mean age 15.4 ± 3.6 years) participated. Medical history, physical examination, and laboratory workup were performed. Results. While the mean BMI-SDS significantly increased from 2.9 to 3.4, the mean HOMA-IR significantly decreased from 5.5 to 4.6 (baseline vs follow-up visit). Change in HOMA-IR was only due to a decrease in mean fasting plasma insulin (24.1 vs 21.1, P = .073). Conclusions. Although increase in BMI-SDS in these children is worrisome, the American Diabetes Association recommended screening interval of 3 years for children at risk for T2DM is not too long based on the fact that none of our study participants developed T2DM.

Normal Children at Risk for Suicidal Behavior: A Two-Year Follow-up Study

1988 ◽  
Vol 27 (1) ◽  
pp. 34-41 ◽  
Author(s):  
CYNTHIA R. PFEFFER ◽  
ROBERT LIPKINS ◽  
ROBERT PLUTCHIK ◽  
MARK MIZRUCHI
Keyword(s):  
At Risk ◽  
Suicidal Behavior ◽  
Children At Risk ◽  
Normal Children ◽  
Follow Up Study

scholarly journals Navy Bean and Rice Bran Intake Alters the Plasma Metabolome of Children at Risk for Cardiovascular Disease

2018 ◽  
Vol 4 ◽  
Author(s):  
Katherine J. Li ◽  
Erica C. Borresen ◽  
NaNet Jenkins-Puccetti ◽  
Gary Luckasen ◽  
Elizabeth P. Ryan
Keyword(s):  
Cardiovascular Disease ◽  
At Risk ◽  
Rice Bran ◽  
Children At Risk ◽  
Navy Bean ◽  
Plasma Metabolome
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