scholarly journals Correction of Linezolid-Induced Myelotoxicity After Switch to Tedizolid in a Patient Requiring Suppressive Antimicrobial Therapy for Multidrug-Resistant Staphylococcus epidermidis Prosthetic-Joint Infection

2018 ◽  
Vol 5 (10) ◽  
Author(s):  
Tristan Ferry ◽  
Cécile Batailler ◽  
Anne Conrad ◽  
Claire Triffault-Fillit ◽  
Frédéric Laurent ◽  
...  
Keyword(s):  
Antimicrobial Therapy ◽  
Prosthetic Joint Infection ◽  
Staphylococcus Epidermidis ◽  
Joint Infection ◽  
Multidrug Resistant ◽  
Prosthetic Joint

scholarly journals Successful Treatment of Staphylococcus aureus Prosthetic Joint Infection with Bacteriophage Therapy

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1182
Author(s):  
Claudia Ramirez-Sanchez ◽  
Francis Gonzales ◽  
Maureen Buckley ◽  
Biswajit Biswas ◽  
Matthew Henry ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Multidrug Resistant ◽  
Successful Outcome ◽  
Prolonged Treatment ◽  
Lytic Phage ◽  
Bacteriophage Therapy ◽  
Prosthetic Joint ◽  
Knee Joint Infection

Successful joint replacement is a life-enhancing procedure with significant growth in the past decade. Prosthetic joint infection occurs rarely; it is a biofilm-based infection that is poorly responsive to antibiotic alone. Recent interest in bacteriophage therapy has made it possible to treat some biofilm-based infections, as well as those caused by multidrug-resistant pathogens, successfully when conventional antibiotic therapy has failed. Here, we describe the case of a 61-year-old woman who was successfully treated after a second cycle of bacteriophage therapy administered at the time of a two-stage exchange procedure for a persistent methicillin-sensitive Staphylococcus aureus (MSSA) prosthetic knee-joint infection. We highlight the safety and efficacy of both intravenous and intra-articular infusions of bacteriophage therapy, a successful outcome with a single lytic phage, and the development of serum neutralization with prolonged treatment.

scholarly journals 400. Comparison of Tolerance and Microbiological Efficacy of Cefepime and Piperacillin/Tazobactam in Combination with Vancomycin as Empirical Antimicrobial Therapy of Prosthetic Joint Infection: A Propensity-Matched Cohort Study

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S204-S205
Author(s):  
Claire Triffault-Fillit ◽  
Eugenie Mabrut ◽  
Karine Corbin ◽  
Agathe Becker ◽  
Evelyne Braun ◽  
...  
Keyword(s):  
Renal Function ◽  
Antimicrobial Therapy ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Fisher Exact Test ◽  
In Vitro Susceptibility ◽  
Empirical Antimicrobial Therapy ◽  
Prosthetic Joint ◽  
Increased Risk ◽  
Baseline Renal Function

Abstract Background The use of piperacillin/tazobactam with vancomycin as empirical antimicrobial therapy (EAT) for prosthetic joint infection (PJI) has been associated with an increased risk of acute kidney injury (AKI), leading to propose cefepime as an alternative since 2017 in our reference center. The present study compared microbiological efficacy and tolerance of these two EAT strategies. Methods All adult patients with PJI empirically treated by vancomycin-cefepime (n = 89) were enrolled in a prospective observational study, and matched with vancomycin-piperacillin/tazobactam-treated historical controls (n = 89) according to a propensity score including age, baseline renal function and concomitant use of other nephrotoxics. The two groups were compared using Kaplan–Meier curve analysis and non-parametric tests (Fisher exact test and Mann–Whitney U-test) regarding: (i) the proportion efficacious empirical regimen (i.e., at least one of the two molecules active against the identified organism(s) based on in vitro susceptibility testing); and (ii) the incidence of empirical therapy-related adverse events (AE), classified according to the Common terminology criteria for AE (CTCAE). Results Among the 146 (82.0%) documented infections, the EAT was considered as efficacious in 77 (98.7%) and 65 (98.5%) of the piperacillin–tazobactam and cefepim-treated patients, respectively (P = 1.000). The rate of AE, and in particular AKI, was significantly higher in the vancomycin–piperacillin/tazobactam (n = 27 [30.3%] and 23 [25.8%%]) compared with the vancomycin-cefepim (n = 13 [14.6%] and 6 [6.7%]) group (P = 0.019 and <0.001, respectively; figure), leading to a premature EAT discontinuation in 20 (22.5%) and 5 (5.6%) patients (P = 0.002). Of note, no significant differences were observed between the two groups regarding sex (91 males; 51.1%), median age (68-year-old; IQR, 59.3–75), main comorbidities including baseline renal function and proportion of patients receiving other nephrotoxics, and vancomycin plasmatic overload. Conclusion The empirical use of vancomycin-cefepim in PJI was as efficient as vancomycin–piperacillin/tazobactam, and was associated with a significantly lower incidence of AKI. Disclosures All authors: No reported disclosures.

scholarly journals Molecular Characterization of an Early Invasive Staphylococcus epidermidis Prosthetic Joint Infection

2011 ◽  
Vol 17 (3) ◽  
pp. 345-350 ◽  
Author(s):  
Marnie E. Rosenthal ◽  
LISA L. Dever ◽  
Calin S. Moucha ◽  
Kalyan D. Chavda ◽  
Michael Otto ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Prosthetic Joint Infection ◽  
Staphylococcus Epidermidis ◽  
Joint Infection ◽  
Prosthetic Joint

scholarly journals Gonococcal Prosthetic Joint Infection

2017 ◽  
Vol 2 (3) ◽  
pp. 160-162 ◽  
Author(s):  
Ian Gassiep ◽  
Bradley Gilpin ◽  
Joel Douglas ◽  
David Siebert
Keyword(s):  
Septic Arthritis ◽  
Antimicrobial Therapy ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Age Groups ◽  
Gonococcal Infection ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Neisseria Gonorrhoea ◽  
Prosthetic Joint

Abstract. Neisseria gonorrhoea is a common sexually transmitted infection worldwide. Disseminated gonococcal infection is an infrequent presentation and rarely can be associated with septic arthritis. Incidence of this infection is rising, both internationally and in older age groups. We present the first documented case of N. gonorrhoea prosthetic joint infection which was successfully treated with laparoscopic debridement and antimicrobial therapy.

scholarly journals Draft Genome Sequence of a Multidrug-Resistant Klebsiella pneumoniae Isolate from a Prosthetic Joint Infection

2021 ◽  
Vol 10 (13) ◽  
Author(s):  
Hosoon Choi ◽  
Chetan Jinadatha ◽  
Piyali Chatterjee ◽  
Munok Hwang ◽  
Dhammika H. Navarathna
Keyword(s):  
Klebsiella Pneumoniae ◽  
Genome Sequence ◽  
Prosthetic Joint Infection ◽  
Antibiotic Susceptibility ◽  
Joint Infection ◽  
Draft Genome ◽  
Multidrug Resistant ◽  
Draft Genome Sequence ◽  
Content Type ◽  
Prosthetic Joint

ABSTRACT Extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae strain 9120005127 was isolated from a wound infection. We describe the draft genome sequence and antibiotic susceptibility of this strain.

Sign in / Sign up

Export Citation Format

Share Document