Successful treatment of methicillin-resistant Staphylococcus epidermidis prosthetic joint infection with telavancin

2012 ◽  
Vol 67 (8) ◽  
pp. 2052-2053 ◽  
Author(s):  
R. Kaushal ◽  
A. Hassoun
Keyword(s):  
Successful Treatment ◽  
Prosthetic Joint Infection ◽  
Staphylococcus Epidermidis ◽  
Joint Infection ◽  
Methicillin Resistant ◽  
Prosthetic Joint

scholarly journals Successful Treatment of a Prosthetic Joint Infection due toMycobacterium abscessus

2009 ◽  
Vol 20 (3) ◽  
pp. e94-e96 ◽  
Author(s):  
Andrew Petrosoniak ◽  
Paul Kim ◽  
Marc Desjardins ◽  
B Craig Lee
Keyword(s):  
Total Hip Arthroplasty ◽  
Antibacterial Therapy ◽  
Hip Arthroplasty ◽  
Successful Treatment ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Mycobacterium Abscessus ◽  
Successful Outcome ◽  
Prosthetic Joint ◽  
Microbiological Cure

Prosthetic joint infection due toMycobacterium abscessusis uncommon and optimal therapy remains poorly defined. Following a two-stage revision, clinical and microbiological cure was achieved in a patient with aM abscessus-infected total hip arthroplasty. A prolonged course of directed antibacterial therapy comprising clarithromycin and cefoxitin coupled with the application of amikacin-impregnated cement likely contributed to the successful outcome.

scholarly journals Adjunctive Rifampin Is Crucial to Optimizing Daptomycin Efficacy against Rabbit Prosthetic Joint Infection Due to Methicillin-Resistant Staphylococcus aureus

2011 ◽  
Vol 55 (10) ◽  
pp. 4589-4593 ◽  
Author(s):  
Azzam Saleh-Mghir ◽  
Claudette Muller-Serieys ◽  
Aurélien Dinh ◽  
Laurent Massias ◽  
Anne-Claude Crémieux
Keyword(s):  
Staphylococcus Aureus ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Detection Threshold ◽  
High Dose ◽  
Prosthesis Infection ◽  
Methicillin Resistant ◽  
Prosthetic Joint ◽  
Mutant Strains

ABSTRACTDaptomycin is an attractive option for treating prosthetic joint infection, but the 6-mg/kg of body weight/day dose was linked to clinical failure and emergence of resistance. Using a methicillin-resistantStaphylococcus aureus(MRSA) knee prosthesis infection in rabbits, we studied the efficacies of high-dose daptomycin (22 mg/kg given intravenously [i.v.] once daily [o.d.]; equivalent to 8 mg/kg/day in humans) or vancomycin (60 mg/kg given intramuscularly [i.m.] twice daily [b.i.d.]), both either alone or with adjunctive rifampin (10 mg/kg i.m. b.i.d.). After partial knee replacement with a silicone implant, 107MRSA CFU was injected into the knees. Treatment started 7 days postinoculation and lasted 7 days. Positive cultures were screened for the emergence of mutant strains, defined as having 3-fold-increased MICs. Althoughin vivomean log10CFU/g of daptomycin-treated (4.23 ± 1.44;n= 12) or vancomycin-treated (4.63 ± 1.08;n= 12) crushed bone was significantly lower than that of controls (5.93 ± 1.15;n= 9) (P< 0.01), neither treatment sterilized bone (2/12 and 0/12 rabbits with sterile bone, respectively). Daptomycin mutant strains were found in 6/12, 3/12, and 2/9 daptomycin-treated, vancomycin-treated, and control rabbits, respectively; no resistant strains emerged (MIC was always <1 mg/liter). Adjunctive rifampin with daptomycin (1.47 ± 0.04 CFU/g of bone [detection threshold]; 11/11 sterile bones) or vancomycin (1.5 ± 0.12 CFU/g of bone; 6/8 sterile bones) was significantly more effective than monotherapy (P< 0.01) and prevented the emergence of daptomycin mutant strains. In this MRSA joint prosthesis infection model, combining rifampin with daptomycin was highly effective. Daptomycin mutant strains were isolatedin vivoeven without treatment, but adjunctive rifampin prevented this phenomenon, previously found after monotherapy in humans.

scholarly journals Molecular Characterization of an Early Invasive Staphylococcus epidermidis Prosthetic Joint Infection

2011 ◽  
Vol 17 (3) ◽  
pp. 345-350 ◽  
Author(s):  
Marnie E. Rosenthal ◽  
LISA L. Dever ◽  
Calin S. Moucha ◽  
Kalyan D. Chavda ◽  
Michael Otto ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Prosthetic Joint Infection ◽  
Staphylococcus Epidermidis ◽  
Joint Infection ◽  
Prosthetic Joint

scholarly journals A Case Of Recurrent Helicobacter cinaedi Prosthetic Joint Infection In An HIV-Infected Man

2018 ◽  
Vol 3 (4) ◽  
pp. 230-233 ◽  
Author(s):  
Joanna Kedra ◽  
Valérie Zeller ◽  
Beate Heym ◽  
Philippe Lehours ◽  
Vanina Meyssonnier ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Helicobacter Cinaedi ◽  
First Case ◽  
Prosthetic Joint

Abstract. We describe the case of an HIV-infected man who developed twice a Helicobacter cinaedi prosthetic joint infection. In our knowledge, it is the first case to date. Furthermore, it illustrates the fact that this bacterium is difficult to isolate and that recurrences can occur even after apparently successful treatment.

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