scholarly journals Hepatitis C Virus Relapse After Ultrashort Direct-Acting Antiviral Therapy Associates With Expression of Genes Involved With Natural Killer-Cell and CD8+ T-Cell Function

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Cody Orr ◽  
Henry Masur ◽  
Shyam Kottilil ◽  
Eric G Meissner
Keyword(s):  
T Cell ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Cell Function ◽  
Killer Cell ◽  
Cd8 T Cell ◽  
Host Immunity ◽  
Direct Acting Antiviral ◽  
T Cell Function ◽  
Direct Acting

Abstract To identify immunologic correlates of hepatitis C virus (HCV) relapse after direct-acting antiviral (DAA) therapy, we quantified select immune transcripts in whole blood from noncirrhotic HCV subjects treated with 4–6 weeks of DAAs. We identified specific markers of natural killer-cell and CD8+ T-cell function (GZMB, PRF1, NKp46) with higher expression in subjects who relapsed. These findings suggest a role for host immunity in HCV eradication with ultrashort DAA therapy. We quantified whole blood immune transcripts in noncirrhotic HCV subjects treated with shortcourse antiviral therapy. Markers of natural killer-cell and CD8+ T-cell function had higher expression in virologic relapsers, suggesting a role for host immunity in HCV eradication.

scholarly journals Peripheral natural killer cell and allo-stimulated T-cell function in kidney transplant recipients associate with cancer risk and immunosuppression-related complications

2015 ◽  
Vol 88 (6) ◽  
pp. 1374-1382 ◽  
Author(s):  
Christopher M. Hope ◽  
Alexander Troelnikov ◽  
William Hanf ◽  
Shilpanjali Jesudason ◽  
Patrick T. Coates ◽  
...  
Keyword(s):  
T Cell ◽  
Natural Killer Cell ◽  
Cancer Risk ◽  
Natural Killer ◽  
Kidney Transplant ◽  
Cell Function ◽  
Killer Cell ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
T Cell Function

scholarly journals A Framework of All Discovered Immunological Pathways and Their Roles for Four Specific Types of Pathogens and Hypersensitivities

2014 ◽  
Author(s):  
Wan-Chung Hu
Keyword(s):  
Mast Cell ◽  
T Cell ◽  
Natural Killer Cell ◽  
B Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Cd8 T Cell ◽  
Cd4 T Cell ◽  
Delayed Type Hypersensitivity ◽  
Inkt Cells

AbstractTfh initiates four eradicable immunities. Tfh includes FDC, LTi, IL21 CD4 T cell, and IgG/M B cell. Treg initiates four tolerable immunities. Treg includes DCreg, ILCreg, TGFβ CD4 T cell, and IgA B cell. TH1/TH1-like is immunity for intracellular bacteria/protozoa and type 4 delayed type hypersensitivity. TH1 includes M1 macrophage, mDC2, Tc1 CD8 T cell, IFNg CD4 T cell, ILC1, iNKT1, and IgG3 B cell. TH1-like includes M2 macrophage, ILC1, suppressive CD8 T cell, IFNg/TGFβ CD4 T cell, regulatory iNKT cells, and IgA1 B cell. TH2/TH9 is immunity for helminths and type1 IgE mediated hypersensitivity. TH2 includes iEOS eosinophil, Langerhans cell, basophil/MCt mast cell, IL-4 CD4 T cell, ILC2, iNKT2, and IgE/IgG4 B cell. TH9 includes rEOS eosinophil, basophils/mast cell MCct, IL-9 CD4 T cell, ILC2, regulatory iNKT cells, and IgA2 B cell. TH22/TH17 is immunity for extracellular bacteria/fungi and type 3 immune complex hypersensitivity. TH22 includes N1 neutrophils, mDC1, IL-22 CD4 T cell, ILC3(NCR+), iNKT17, and IgG2 B cell. TH17 includes N2 neutrophils, IL-17 CD4 T cell, regulatory iNKT cells, ILC3(NCR−), and IgA2 B cell. THαβ/TH3 is immunity for viruses and type 2 antibody dependent cytotoxic hypersensitivity. THαβ includes NK1 natural killer cell, pDC, Tc2 CD8 T cell, IL10 CD4 T cell, ILC10, iNKT10, and IgG1 B cell. TH3 includes NK2 natural killer cell, suppressive CD8 T cell, ILC10, IL-10/TGFβ CD4 T cell, regulatory iNKT cells, and IgA1 B cell.Summary sentenceThe summarized framework of host immunities to explain their relations to specific pathogens and hypersensitivities

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