scholarly journals Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C)

2021 ◽  
Author(s):  
Allison M Blatz ◽  
Michelle Oboite ◽  
Kathleen Chiotos ◽  
Leslie Castelo-Soccio ◽  
Audrey R Odom John ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Inflammatory Disease ◽  
Clinical Characteristics ◽  
Inflammatory Syndrome ◽  
Post Infectious ◽  
Broad Understanding

Abstract Rash is a common feature of the multisystem inflammatory syndrome in children (MIS-C), a post-infectious hyperinflammatory disease associated with prior SARS-CoV- 2 infection. Because the differential diagnosis of fever and rash in children is broad, understanding clinical characteristics of MIS-C may assist with diagnosis. Here we describe the cutaneous findings observed in a series of children with MIS-C-associated rash.

scholarly journals Epidemiologic and clinical characteristics of multisystem inflammatory syndrome in adults: a rapid review

2021 ◽  
Vol 47 (78) ◽  
pp. 305-315
Author(s):  
Nicole Atchessi ◽  
Rojiemiahd Edjoc ◽  
Megan Striha ◽  
Lisa Waddell ◽  
Natalie Bresee ◽  
...  
Keyword(s):  
Inflammatory Disease ◽  
Clinical Characteristics ◽  
Cardiac Involvement ◽  
Case Reports ◽  
The United States ◽  
Rapid Review ◽  
Improve Treatment ◽  
The United Kingdom ◽  
Starting Point ◽  
Inflammatory Syndrome

Multisystem inflammatory disease in children (MIS-C) is one of the severe presentations of the coronavirus disease 2019 (COVID-19) that has been described in the literature since the beginning of the pandemic. Although MIS-C refers to children, cases with similar clinical characteristics have been recently described in adults. A description of the epidemiologic and clinical characteristics of multisystem inflammatory disease in adults (MIS-A) is a starting point for better knowledge and understanding of this emerging disease. We identified nine case reports of MIS-A in the literature, five from the United States, two from France and two from the United Kingdom. The case descriptions revealed similarities in clinical features, including occurrence during post-acute disease phase, fever, digestive symptoms, cardiac involvement and elevated inflammatory markers. All the patients were hospitalized, three required admission to the intensive care unit and one died. The most common treatments were intravenous immunoglobulin, prednisolone and aspirin. These findings suggest that MIS-A is a severe complication of COVID-19 disease that can lead to death. Further studies to improve our understanding of the pathogenesis of MIS-A, which will help improve treatment decisions and prevent sequelae or death.

COVID-19-associated multisystem inflammatory syndrome in children presenting uniquely with sinus node dysfunction in the setting of shock

2021 ◽  
pp. 1-3
Author(s):  
Lesya G. Tomlinson ◽  
Mitchell I. Cohen ◽  
Rebecca E. Levorson ◽  
Megan B. Tzeng
Keyword(s):  
Inflammatory Process ◽  
Myocardial Dysfunction ◽  
Sinus Node ◽  
Qtc Prolongation ◽  
Mild Disease ◽  
Abnormal Immune Response ◽  
Idioventricular Rhythm ◽  
Inflammatory Syndrome ◽  
Electrocardiographic Abnormalities ◽  
Post Infectious

Abstract SARS-CoV-2, which causes the disease COVID-19, generally has a mild disease course in children. However, a severe post-infectious inflammatory process known as multisystem inflammatory syndrome in children has been observed in association with COVID-19. This inflammatory process is a result of an abnormal immune response with similar clinical features to Kawasaki disease. It is well established that multisystem inflammatory syndrome in children is associated with myocardial dysfunction, coronary artery dilation or aneurysms, and occasionally arrhythmias. The most common electrocardiographic abnormalities seen include premature atrial or ventricular ectopy, variable degrees of atrioventricular block, and QTc prolongation, and rarely, haemodynamically significant arrhythmias necessitating extracorporeal membrane oxygenation support. However, presentation with fever, hypotension, and relative bradycardia with a left axis idioventricular rhythm has not been previously reported. We present a case of a young adolescent with multisystem inflammatory syndrome in children with myocarditis and a profoundly inappropriate sinus node response to shock with complete resolution following intravenous immunoglobulin.

Headache

2018 ◽  
Author(s):  
Benjamin W Friedman
Keyword(s):  
Differential Diagnosis ◽  
Clinical Characteristics ◽  
Sinus Thrombosis ◽  
International Headache Society ◽  
Primary Headache ◽  
Primary Headaches ◽  
Key Words Migraine ◽  
Secondary Headaches ◽  
Primary Headache Disorders ◽  
Greater Occipital Nerve

Headaches are one of the most common complaints of patients seen by emergency physicians. They can be classified as primary headaches, which have no identifiable underlying cause, and secondary headaches, which are classified according to their cause. The majority of headaches are benign in origin, and most patients with headache can be treated successfully in the emergency department and discharged home; however, some have potentially life-threatening causes, and consideration of a broad differential diagnosis for all patients is essential. This review covers the primary headache disorders, pathophysiology, stabilization and assessment, diagnosis and treatment, and disposition and outcomes. The figure shows areas of the brain sensitive to pain. Tables review differential diagnosis of headache, International Headache Society primary headache criteria, clinical characteristics of secondary headaches, high-risk clinical characteristics among patients with a headache peaking in intensity within 1 hour, drugs associated with headache, and parenteral treatment of acute migraine. This review contains 1 figure, 9 tables, and 58 references. Key words: migraine, calcitonin gene related peptide, greater occipital nerve block, venous sinus thrombosis, reversible cerebral vasoconstriction syndrome, Ottawa, subarachnoid, cluster headache, trigeminal autonomic cephalalgias, post-traumatic headache

Clinical Characteristics of Post-Infectious Bronchiolitis Obliterans

2011 ◽  
Vol 21 (3) ◽  
pp. 156 ◽  
Author(s):  
Jin Young Shin ◽  
Mi Ju ◽  
Kye Hyang Lee ◽  
Hye Jin Park ◽  
Kyung Hoon Lee ◽  
...  
Keyword(s):  
Bronchiolitis Obliterans ◽  
Clinical Characteristics ◽  
Post Infectious

Clinical Characteristics and Outcome of Post-Infectious Glomerulonephritis in Children in Southern India: A Prospective Study

2015 ◽  
Vol 82 (10) ◽  
pp. 896-903 ◽  
Author(s):  
Kuralvanan Gunasekaran ◽  
Sriram Krishnamurthy ◽  
Subramanian Mahadevan ◽  
B. N. Harish ◽  
Ajith Prabhu Kumar
Keyword(s):  
Prospective Study ◽  
Clinical Characteristics ◽  
Southern India ◽  
A Prospective Study ◽  
Post Infectious

scholarly journals Tremorography in the clinical practice

2020 ◽  
Vol 9 (4) ◽  
pp. 61-72
Author(s):  
T. G. Govorova ◽  
T. E. Popova ◽  
A. A. Tappakhov
Keyword(s):  
Differential Diagnosis ◽  
Clinical Practice ◽  
Movement Disorders ◽  
Clinical Characteristics ◽  
Objective Assessment ◽  
Diagnostic Value ◽  
Common Type ◽  
Routine Practice ◽  
Pathological Tremor

Tremor is the most common type of movement disorders. In practice this differential diagnosis of hyperkinesis is diagnosed clinically and the use of additional methods of objective assessment of tremor increases the accuracy of diagnosis. The use of paraclinical methods of objective assessment of tremor improves the accuracy of diagnosis. Comparison of the neurophysiological parameters of tremor with clinical characteristics has a high diagnostic value, which justifies its use in the routine practice of neurologists. The purpose of the review is to analysis basic electrophysiological characteristics of pathological tremor, as well as the presentation of the material of its own observation.

scholarly journals A study of 235 cases of human brucellosis in Sana’a, Republic of Yemen

2001 ◽  
Vol 7 (1-2) ◽  
pp. 238-246 ◽  
Author(s):  
H. A. Al Shamahy ◽  
S. G. Wright
Keyword(s):  
Differential Diagnosis ◽  
Lymph Nodes ◽  
Clinical Examination ◽  
Clinical Picture ◽  
Laboratory Tests ◽  
Clinical Characteristics ◽  
Geographical Area ◽  
Human Brucellosis ◽  
Adults And Children ◽  
Spleen And Lymph Nodes

We studied the clinical characteristics of brucellosis among all patients with brucellosis referred to the Central Health Laboratory from the main hospitals in Sana’a during a 2-year period [1992-93] [235 adults and children]. A history was taken from each patient and clinical examination, general laboratory tests and brucellosis laboratory tests carried out. The overall clinical picture of brucellosis in this study is very similar to that reported by other workers in this geographical area. Awareness of the presenting features and the realization that brucellosis should be part of the differential diagnosis of febrile patients with enlarged liver, spleen and lymph nodes will lead to an increasing index of suspicion for this disease.

Multisystem Inflammatory Syndrome (MIS-C) in Neonates (MIS-N) Following Maternal SARS CoV-2 COVID-19 Infection

2021 ◽  
Author(s):  
Satyan Lakshminrusimha ◽  
Mark Hudak ◽  
Victoria Dimitriades ◽  
Rosemary Higgins
Keyword(s):  
Current Literature ◽  
Case Reports ◽  
Maternal Infection ◽  
Diagnosis And Management ◽  
Inflammatory Syndrome ◽  
Post Infectious

Children present with multisystem inflammatory syndrome (MIS-C), a post-infectious syndrome presenting a few weeks following an acute SARS CoV-2 infection. A few case reports of neonates presenting with a similar syndrome following maternal infection have been reported. This article summarizes the current literature and outlines the controversies surrounding the diagnosis and management of MIS-C in neonates (MIS-N).

scholarly journals Orbital pseudotumor: a differential diagnosis of Graves' ophthalmopathy

2011 ◽  
Vol 55 (1) ◽  
pp. 85-88 ◽  
Author(s):  
Luciana Souza Cruz Caminha ◽  
Elisa Rebelo Pinto ◽  
Priscila Alves Medeiros de Sousa ◽  
Ricardo Andrade Oliveira ◽  
Flavia Lucia Conceiçao ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Inflammatory Disease ◽  
Final Diagnosis ◽  
Response To Therapy ◽  
Orbital Pseudotumor ◽  
Graves Ophthalmopathy

The objective of this study is to report and discuss a rare and inflammatory cause of exophthalmos. This report describes a patient with exophthalmos, who was initially diagnosed with euthyroid Graves' with good response to therapy. After 8 years of follow-up, she had recurrence of symptoms and a new evaluation revealed the final diagnosis of orbital pseudotumor. Orbital pseudotumor is an uncommon disorder that both radiologically and clinically mimics a malignant process or other inflammatory disease, such as Graves' ophthalmopathy.

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