scholarly journals Prolonged (6-Month) Shedding of Middle East Respiratory Syndrome Coronavirus RNA in the Sputum of a Lymphoma Patient

2020 ◽  
Vol 7 (8) ◽  
Author(s):  
Pyoeng Gyun Choe ◽  
Wan Beom Park ◽  
Su-Jin Choi ◽  
Chang Kyung Kang ◽  
Yongil Koh ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Middle East ◽  
Middle East Respiratory Syndrome ◽  
Lymphoma Patient ◽  
Chain Reaction ◽  
Illness Onset ◽  
Replication Competent Virus ◽  
Polymerase Chain

Abstract During the 2015 Korea Middle East Respiratory Syndrome coronavirus (MERS-CoV) outbreak, a lymphoma patient developed MERS pneumonia. His pneumonia improved by 45 days after illness onset, but the polymerase chain reaction tests remained (+) for 6 months. However, replication-competent virus was detected by 60 days after illness onset.

scholarly journals Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria, 2015

2015 ◽  
Vol 20 (49) ◽  
Author(s):  
Daniel KW Chu ◽  
Jamiu O Oladipo ◽  
Ranawaka APM Perera ◽  
Sulaiman A Kuranga ◽  
Samuel MS Chan ◽  
...  
Keyword(s):  
Middle East ◽  
Arabian Peninsula ◽  
Phylogenetic Analyses ◽  
Quantitative Polymerase Chain Reaction ◽  
Middle East Respiratory Syndrome ◽  
Dromedary Camels ◽  
Chain Reaction ◽  
Serum Samples ◽  
Nasal Swabs ◽  
Polymerase Chain

Evidence of current and past Middle East respiratory syndrome coronavirus (MERS-CoV) infection in dromedary camels slaughtered at an abattoir in Kano, Nigeria in January 2015, was sought by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and serology. MERS-CoV RNA was detected in 14 (11%) of 132 nasal swabs and antibody in 126 (96%) of 131 serum samples. Phylogenetic analyses demonstrate that the viruses in Nigeria are genetically distinct from those reported in the Arabian peninsula.

scholarly journals Performance of Oropharyngeal Swab Testing Compared With Nasopharyngeal Swab Testing for Diagnosis of Coronavirus Disease 2019—United States, January 2020–February 2020

2020 ◽  
Author(s):  
Monita R Patel ◽  
Darin Carroll ◽  
Emily Ussery ◽  
Hilary Whitham ◽  
Christopher A Elkins ◽  
...  
Keyword(s):  
United States ◽  
Polymerase Chain Reaction ◽  
Severe Acute Respiratory Syndrome ◽  
Nasopharyngeal Swab ◽  
Threshold Values ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Illness Onset ◽  
Oropharyngeal Swab ◽  
Polymerase Chain

Abstract Among 146 nasopharyngeal (NP) and oropharyngeal (OP) swab pairs collected ≤7 days after illness onset, Real-Time Reverse Transcriptase Polymerase Chain Reaction assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 RT-PCR) diagnostic results were 95.2% concordant. However, NP swab cycle threshold values were lower (indicating more virus) in 66.7% of concordant-positive pairs, suggesting NP swabs may more accurately detect the amount of SARS-CoV-2.

scholarly journals Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial

2015 ◽  
Vol 2 (3) ◽  
Author(s):  
Huong Q. McLean ◽  
Edward A. Belongia ◽  
Burney A. Kieke ◽  
Jennifer K. Meece ◽  
Alicia M. Fry
Keyword(s):  
Polymerase Chain Reaction ◽  
Randomized Trial ◽  
Virus Detection ◽  
Outpatient Setting ◽  
Chain Reaction ◽  
Double Blind ◽  
Illness Onset ◽  
Illness Duration ◽  
Polymerase Chain

Abstract We conducted a double-blind, randomized trial of 134 outpatients with polymerase chain reaction-confirmed influenza to assess the effects of oseltamivir initiated 48–119 hours after illness onset. Oseltamivir treatment did not reduce illness duration, severity, or duration of virus detection. However, the power of this study was limited due to lower than expected enrollment.

scholarly journals Improving turnaround time of molecular diagnosis of Middle East respiratory syndrome coronavirus in a hospital in Saudi Arabia

2021 ◽  
Author(s):  
Ali A Rabaan ◽  
Jaffar A Al-Tawfiq
Keyword(s):  
Middle East ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Turnaround Time ◽  
Middle East Respiratory Syndrome ◽  
Control Measures ◽  
Chain Reaction ◽  
Infection Control Measures ◽  
The Mean ◽  
Polymerase Chain

Abstract Background There have been 2562 laboratory-confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) in 27 countries, with a case fatality rate of 34.5%. Data on the turnaround time (TAT) are lacking. We report TAT for MERS-CoV samples over time. Methods This is a monocentric study and the TAT for the reporting of 2664 MERS-CoV polymerase chain reaction (PCR) results were calculated in hours from the time of the receipt of respiratory samples to the reporting of the results. Results The mean TAT±standard deviation was significantly lower in 2018 compared with previous years (19.25±13.8). The percentage of samples processed within 24 h increased from 42.3% to 73.8% in 2015 and 2018, respectively (p<0.0001). The mean TAT was 19.2 h in 2018 and was significantly lower than previous years. Conclusions The TAT for the MERS-CoV results decreased during the study period. Timely reporting of MERS-CoV PCR results may aid in further enhancing infection control measures.

scholarly journals Hypothetical model of disease course of COVID-19 patients and their exit plan

2020 ◽  
Vol 7 (1) ◽  
pp. 58-61
Author(s):  
Abhishek Tiwary ◽  
Bimal Pandey
Keyword(s):  
Polymerase Chain Reaction ◽  
Virus Disease ◽  
Scientific Basis ◽  
Disease Course ◽  
Chain Reaction ◽  
Hypothetical Model ◽  
Illness Onset ◽  
Corona Virus ◽  
Polymerase Chain ◽  
Pcr Test

In view of preparing ourselves for the possible rise of Corona Virus Disease (COVID-19) cases, we have proposed a hypothetical model of disease course in COVID-19 patients admitted in Patan Hospital and the exit plan based on available evidences. This will give us a scientific basis of planning discharge of our future cases. According to it, patients are subjected to repeat Polymerase chain reaction (PCR) on day 20 of illness onset and then every 4 days till negative result. Patients with two negative PCR test repeated 24 hours apart are discharged and advised for 14 days’ home quarantine.

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